A MnO-based tumor-seeking nanoplatform for enhanced chemoimmunotherapy against 4T1 breast cancer.

A significant obstacle in oncological therapy lies in surmounting the immunosuppressive microenvironment while enhancing the anti-tumor efficacy of chemotherapeutic agents. STING agonists such as Mn have demonstrated substantial promise in this regard. Squamocin (Squ), a naturally derived compound, exhibits potent anti-tumor activity with minimal drug resistance; however, its application is hampered by poor water solubility (approximately 7.

[Pharmacokinetics and tissue distribution of fluorescent-labeled Astragalus polysaccharides in mice].

In this study, the reductive amination method was used to label IR783 on Astragalus polysaccharides(APS) for the first time, which was verified by ultraviolet-visible spectroscopy and infrared spectroscopy. Quantitative analysis methods of APS-IR783 in plasma and various tissue were established using a multifunctional microplate reader. The pharmacokinetics and tissue distribution of APS-IR783 in mice were investigated after a single intravenous injection of 30 mg·kg~(-1) APS-IR783, and pharmacokinetic parameters were calculated using DAS 2.

Self-assembly of paclitaxel derivative and fructose as a potent inducer of immunogenic cell death to enhance cancer immunotherapy.

Immunotherapy shows promise for tumor control but is limited by low response rates. Paclitaxel (PTX) induces immunogenic cell death (ICD), yet conventional delivery systems face challenges like low drug loading and insufficient intracellular accumulation, reducing ICD efficacy. Small-molecule self-assembled PTX nanoparticles offer a promising solution due to high drug loading and dose delivery.

Enhanced transcytosis and therapeutic efficacy of paclitaxel nanoparticles: Pyridylboronic acid modification and sialic acid targeting.

Efficient drug delivery and deeper penetration into tumors have become a primary focus of anti-tumor nanomedicine. In this study, pyridylboronic acid (BPA), as a targeting ligand for sialic acid, which is highly expressed on the surface of tumor cells, was conjugated with DSPE-PEG2k-NH to synthesize DSPE-PEG2k-BPA and used to encapsulate PTX. The resultant PTX@DSPE-PEG2k-BPA nanoparticles (DPB NPs) showed a mean particle size of 189.

The role of depth of general anesthesia in serum CGRP and SP level in diabetes patients.

Background: Diabetes, which is associated with cardiovascular disease and related microvascular complications, affects life expectancy and decrease quality of life. A trial reports that the risk of patients with diabetes having cardiovascular disease is 2-4 times compared with that in patients without diabetes.

Objective: This study aims to investigate the relationship between depth of general anesthesia in patients with diabetes mellitus.

Designing Surface-Defect Engineering to Enhance the Solar-Driven Conversion of CO to C Products over ZnInS/ZnS.

The manipulation of electronic structure and prevention of photogenerated carriers from being quenched in bulk defects during the photocatalytic CO reduction reaction (CRR) have been effectively demonstrated through surface vacancy and defect engineering. In this work, the electronic structure on the surface of ZnInS/ZnS (ZIS/ZnS) is significantly modified by the introduction and control of the surface S vacancies (S) through Ar-plasma treatment. EPR and XPS analyses confirmed that S was exclusively present on the ZIS/ZnS surface.

A quasi-3D SbS/reduced graphene oxide/MXene (TiCT) hybrid for high-rate and durable sodium-ion batteries.

Antimony sulfide (SbS) is a promising anode material for sodium-ion batteries (SIBs) owing to its high theoretical capacity and superior reversibility. However, its cycling life and rate performance are seriously impeded by the inferior inherent electroconductibility and tremendous volume change in the charging/discharging processes. Herein, a quasi three-dimensional (3D) SbS/RGO/MXene composite, with SbS nanoparticles (∼15 nm) uniformly distributed in the quasi-3D RGO/MXene architecture, was prepared by a toilless hydrothermal treatment.

Eco-green C, O co-doped porous BN adsorbent for aqueous solution with superior adsorption efficiency and selectivity.

Toxic dyes in wastewater will become a significant hazard to human health if they are not treated effectively. Therefore, it is significant to separate and remove dyes from the aqueous solution. C and O co-doped BN (BCNO) with high adsorption capacity and outstanding cycle efficiency is a simple and efficient adsorbent for the cationic dye malachite green (MG).

Two Birds with One Stone: FeS@C Yolk-Shell Composite for High-Performance Sodium-Ion Energy Storage and Electromagnetic Wave Absorption.

Cost-effective material with a rational design is significant for both sodium-ion batteries (SIBs) and electromagnetic wave (EMW) absorption. Herein, we report an elaborate yolk-shell FeS@C nanocomposite as a promising material for application in both SIBs and EMW absorption. When applied as an anode material in SIBs, the yolk-shell structure not only facilitates a fast electron transport and shortens Na ion diffusion paths but also eases the huge volume change of FeS during repeated discharge/charge processes.

Combination of Microwave Ablation and Percutaneous Osteoplasty for Treatment of Painful Extraspinal Bone Metastasis.

Purpose: To evaluate the efficacy and safety of microwave (MW) ablation combined with percutaneous osteoplasty (POP) on painful extraspinal bone metastases.

Materials And Methods: In this retrospective study, 50 adult patients with 56 extraspinal bone metastasis lesions, who suffered from refractory moderate to severe pain, were treated with MW ablation and POP. Changes in quality of life were evaluated based on the Visual Analog Scale (VAS), daily morphine consumption, and the Oswestry Disability Index (ODI) before and immediately after the procedure and during follow-up times.

Porous NaV(PO)/C nanoplates for high-performance sodium storage.

Sodium super-ionic conductor (NASICON) structured NaV(PO) (NVP), a promising cathode material for sodium-ion batteries (SIBs), benefits by its unique three-dimensional (3D) channel structure. However, the inherent characteristics of NVP (such as low electrical conductivity) usually lead to inferior rate and long-cycling performance, which miss the requirements of practical application in electrical energy storage systems (ESSs). Herein, we propose the synthesis of porous high-crystalline NaV(PO)/C nanoplates (NVP/C-P) via hydrothermal method and post-calcination.

SnS /Sb S Heterostructures Anchored on Reduced Graphene Oxide Nanosheets with Superior Rate Capability for Sodium-Ion Batteries.

Tin disulfide, as a promising high-capacity anode material for sodium-ion batteries, exhibits high theoretical capacity but poor practical electrochemical properties due to its low electrical conductivity. Constructing heterostructures has been considered to be an effective approach to enhance charge transfer and ion-diffusion kinetics. In this work, composites of SnS /Sb S heterostructures with reduced graphene oxide nanosheets were synthesized by a facile one-pot hydrothermal method.

High Crystalline Prussian White Nanocubes as a Promising Cathode for Sodium-ion Batteries.

Prussian blue and its analogues (PBAs) have been recognized as one of the most promising cathode materials for room-temperature sodium-ion batteries (SIBs). Herein, we report high crystalline and Na-rich Prussian white Na CoFe(CN) nanocubes synthesized by an optimized and facile co-precipitation method. The influence of crystallinity and sodium content on the electrochemical properties was systematically investigated.

Antimony/Porous Biomass Carbon Nanocomposites as High-Capacity Anode Materials for Sodium-Ion Batteries.

Antimony/porous biomass carbon nanocomposites have been prepared by a chemical reduction method and applied as anodes for sodium-ion batteries. The porous biomass carbon derived from a black fungus had a large Brunauer-Emmett-Teller (BET) surface area of 2233 m  g in which antimony nanoparticles were uniformly distributed in the porous carbon. The as-prepared antimony/porous biomass carbon nanocomposites exhibited a high reversible sodium storage capacity of 567 mA h g at a current density of 100 mA g , extended cycling stability, and good rate capability.

Effect of temperature on development and reproduction of Neoseiulus barkeri (Acari: Phytoseiidae) fed on Aleuroglyphus ovatus.

The effect of five constant temperatures (16, 20, 24, 28 and 32°C) on the development, survival and reproduction of Neoseiulus barkeri Hughes fed on Aleuroglyphus ovatus Toupeau (Acari: Acaridae) was examined in the laboratory at 85% relative humidity. Development time of different immature stages decreased with increasing temperature, total egg-to-adult development time varied from 5.0 ± 0.