O-arm navigation-guided unilateral biportal endoscopic lumbar interbody fusion using a lateral lumbar interbody fusion cage.

Unilateral biportal endoscopic surgery has received attention in the field of minimally invasive spinal surgery because of its various advantages, including minimized musculoligamentous injury, low postoperative pain, and faster recovery, compared with conventional open spinal surgery. Navigation system advancements have improved the precision of instrument placement and cage positioning, thereby facilitating the insertion of larger cages in the unilateral biportal endoscopic transforaminal lumbar interbody fusion (UBE-TLIF). In this study, we demonstrated the safety and efficacy of lateral lumbar interbody fusion cage insertion in UBE-TLIF with the assistance of O-arm navigation.

Respiratory and Other Infections Following COVID.

Background: One hypothesis for the respiratory syncytial virus (RSV) surge in 2022 was suppression of immune responses following SARS-CoV-2 infection. Our objective was to compare the risk of subsequent RSV and other infections among children with and without SARS-CoV-2 infection.

Methods: We conducted a retrospective cohort study using electronic health record data from 27 US health systems analyzing children aged under 5 years with SARS-CoV-2 infection (test/coded) between March and July 2022.

Synthesis of Multifunctional Hyperbranched Polymers via Atom Transfer Radical Self-Condensing Vinyl Polymerization for Applications in Polyurethane-Based Anion Exchange Membranes.

Anion exchange membranes (AEMs) are vital for electrochemical energy devices such as alkaline fuel cells and water electrolyzers, enabling the use of non-precious metal catalysts despite challenges from alkaline degradation. Hyperbranched polymers (hbPs) with their globular structure, high functional group density, and simple synthesis, offer a promising platform for enhancing transport and stability. In this study, multifunctional hbPs were synthesized from 4-vinylbenzyl chloride (VBC) and 2-hydroxyethyl methacrylate (HEMA) via atom transfer radical self-condensing vinyl polymerization (ATR-SCVP) and crosslinked into polyurethane-based AEMs.

Cross-Sectional Study: Associations of A20 and Cezanne with Leukocyte Accumulation in B-Cell Acute Lymphoblastic Leukemia.

Acute lymphoblastic leukemia (ALL) is a hematologic malignancy characterized by the aberrant proliferation of immature lymphoid cells. Lymphoblasts derived from the B-cell lymphoid lineage are identified as B-ALL. A20, CYLD and Cezanne are deubiquitinase genes that inhibit inflammatory response and tumor progression.

The Impact of FSHR Polymorphisms (rs6165 and rs6166) on Ovarian Response to Stimulation in Infertile Women with Diminished Ovarian Reserve.

Background: Diminished ovarian reserve (DOR) remains a significant challenge in IVF, as it is closely associated with poor ovarian response. Beyond well-established predictive of ovarian response, genetic polymorphisms in the FSH receptor (FSHR) gene rs6165 and rs6166 have been reported as potential markers.

Purpose: Evaluating the expression of FSHR rs6165 and rs6166 in DOR patients and their impact on ovarian response to stimulation.

Integrated single cell spatial multi-omics landscape of WHO grades 2-4 diffuse gliomas identifies locoregional metabolomic regulators of glioma growth.

Diffuse infiltrating gliomas are aggressive tumors of the central nervous system driven by intra-tumoral heterogeneity and aberrant normal-tumor cell-cell interactions. Grade specific and locoregional metabolic dependencies driving aberrant cell-states linked to treatment resistance, seizures and infiltration of gliomas remain elusive. Here, we applied spatial transcriptomics (stRNAseq), imaging mass cytometry (IMC) and mass spectrometry imaging (MSI; metabolites, peptides and glycans) to the core and edge tumor tissue from patients with World Health Organization (WHO) grades 2-4 diffuse infiltrating gliomas including isocitrate dehydrogenase (IDH) mutant oligodendrogliomas (WHO Grades 2 and 3) and IDH wildtype astrocytomas including 'anaplastic' astrocytoma (prior 2016 WHO histological grade 3) and glioblastoma (GBM, WHO grade 4) stRNAseq identified regions-specific differentially expressed genes with significant overall survival implications particularly in IDH wildtype GBM.

Single Ag Atoms Induce Ag-N/O Bonds on WO for Ultrastable Acid Ammonia Synthesis.

Ammonia from nitrate-containing wastewater demands the catalysts with high activity, stability, and selectivity toward acidic electrochemical nitrate reduction owing to the corrosion effect of the catalyst and the competitive hydrogen evolution reaction (HER). Herein, we synthesized single Ag atoms induced Ag-N/O bonds on one-dimensional WO nanowires for highly efficient and stable electrochemical nitrate reduction to ammonia under acidic conditions. The resultant catalyst achieved a Faradaic efficiency (FE) of ammonia exceeding ∼90% over a potential range of -0.

Direct ammonia and dihydroxyacetone production in an unbiased photoelectrochemical cell.

Photoelectrochemical production of ammonia usually suffers from a low solar-to-ammonia efficiency and a high overpotential, which influences the bias-free operation of sustainable photoelectrochemistry. Herein, we realize solar-driven ammonia production from waste nitrate by constructing copper-osmium catalysts deposited on the Sb(S,Se) semiconductor, enabling optimized photo-carrier transport pathways and a beneficial co-adsorption configuration of *NO-HO moieties. The photocathode reaches a photocurrent density of 5.

Accuracy of virtual mounting at centric relation using personalized 3D-printed transfer key: a clinical in vivo study.

Aim: Previously, we developed a 3D-printed customized transfer key for virtual mounting of the face and maxillomandibular relationship at centric occlusion. The accuracy was evaluated in vitro using a phantom head model with simulated soft tissue. In the present study, we aimed to investigate the effect of the transfer key in humans with clinical situations.

Enhanced Recovery and Bioactivity of Flavonoids From Peanut Shells (): Antioxidant and Acetylcholinesterase Inhibitory Properties.

Peanut shells, a by-product of the peanut processing industry, are rich in flavonoid compounds with a range of bioactivities. This study aimed to develop an efficient extraction and fractionation process to enhance the recovery and in vitro antioxidant and acetylcholinesterase (AChE) inhibition activities of these compounds from peanut shells cultivated in Vietnam. Peanut shell samples were subjected to maceration with ethanol, followed by liquid-liquid partitioning (LLP) and column chromatography (CC) using a hexane and ethyl acetate solvent system at varying ratios.

A Validation Workflow for Novel Oligonucleotide Sequences to Expand the Multiplexing Capacity of the CO-Detection by indEXing (CODEX) Platform.

Antibody-based multiplexed tissue imaging has the potential to provide critical advances in biological discoveries and their translation for clinical applications. With the increasing introduction of markers and modalities for spatial analysis, there is an according demand for the expansion of multiplexing capacities of such imaging platforms. CO-Detection by indEXing (CODEX) is a widely used multiplexed tissue imaging platform that utilizes DNA-conjugated antibodies for imaging.

Herbal Medicine in Diabetes Treatment: An Updated Strategy With Flavonoid Compounds in Preclinical and Clinical Studies.

Diabetes is a complex and increasingly prevalent condition, affecting a significant portion of the global population and associated with multiple risk factors. Managing the disease remains a significant challenge, especially with the risks and severe side effects of current treatments, underscoring the need for safer and more effective therapies. Natural sources, particularly flavonoids, have shown considerable promise in reducing blood glucose levels.

Influence of composite resin core buildup translucency on the accuracy of an anterior CAD-CAM bridge fabricated with a digital impression.

Background: Composite resin build-up translucency affects the accuracy of digital impressions generated by an intraoral scanning system (IOS). Here, we evaluated the influence of composite core translucency on the accuracy of a CAD-CAM bridge (Fixed Partial Denture) using an intraoral scanner.

Material And Methods: We investigated the accuracy (the trueness and precision) of 2 different composites (EverX Flow-EX and G-aenial Universal Injectable A3) for core build up in 3-unit CAD/CAM bridge on anterior teeth using an intra-oral scanner (Trios 3, 3Shape) and injectable technique.

Neuromuscular junction transcriptome analysis of spinal and bulbar muscular atrophy mice implicates sarcomere gene expression and calcium flux dysregulation in disease pathogenesis.

X-linked Spinal and Bulbar Muscular Atrophy (SBMA) is a rare, late-onset neuromuscular disease caused by a CAG repeat expansion mutation in the androgen receptor (AR) gene. SBMA is characterized by progressive muscle atrophy of both neurogenic and myopathic etiologies. Previous work has established that mutant AR expression in skeletal muscle could be a significant contributor to neuromuscular decline, yet the mechanisms involved remain ill-defined.

Epidemiologic Trends in Pediatric Urinary Tract Infections Among United States Emergency Departments from 2016-2023.

Introduction: Urinary tract infections are a common consideration among pediatric patients with fever. With rising resistance rates and increased focus on antibiotic stewardship, there is a need to better understand the current management. This study reports the incidence and antibiotic distribution among a nationwide cohort of Emergency Department (ED) patients with cystitis and pyelonephritis over an eight-year period.

Delayed rupture of extensor indicis proprius (EIP) and extensor pollicis longus (EPL) following volar plating of distal radius fracture: A case report.

Distal radius fractures are the most common upper limb fractures, with volar plating being the preferred surgical approach, particularly for intra-articular and unstable fractures. While complications primarily involve flexor tendon irritation or rupture, extensor tendon injuries associated with volar plating are rare. This report discusses a 23-year-old male who experienced limited active range of motion (ROM) in the thumb and index finger of his right hand 2 years after volar plating for a distal radius fracture.

Survey of Structural Autosomal Abnormalities and Autosomal Variants in Infertile Patients Treated at Some IVF Centers in Vietnam.

Background: Chromosomal abnormalities and variations are significant contributors to reproductive challenges. This study aims to investigate the types and incidence of structural autosomal anomalies and autosomal variations in a large Vietnamese population undergoing infertility treatment.  .

Epidemiology of eye injuries in swimming and water sports presenting to United States emergency departments.

Purpose: To describe the demographics and diagnoses of swimming and water sports-related eye injuries (SWSEI) presenting to United States (US) emergency departments (EDs).

Methods: The National Electronic Injury Surveillance System (NEISS) database was used to identify cases of eye injury related to swimming, pools, water sports, and associated equipment from 2013 to 2022. National injury rates were estimated using US Census data at the midpoint of the study (January 1, 2017).

Recent advances in microneedles for enhanced functional angiogenesis and vascular drug delivery.

Many therapeutic applications use the transdermal method to avoid the severe restrictions associated with oral medication delivery. Given the limitations of traditional drug delivery via skin, transdermal microneedle (MN) arrays have been reported to be versatile and very efficient devices due to their outstanding characteristics such as painless penetration, affordability, excellent medicinal efficacy, and relative safety. MNs have recently received increased attention for their ability to cure vascular illnesses such as hypertension and thrombosis, as well as promote wound healing via the angiogenesis impact.

Epigenetic Regulation by lncRNA GAS5/miRNA/mRNA Network in Human Diseases.

The interplay between long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) is crucial in the epigenetic regulation of mRNA and protein expression, impacting the development and progression of a plethora of human diseases, such as cancer, cardiovascular disease, inflammatory-associated diseases, and viral infection. Among the many lncRNAs, growth arrest-specific 5 (GAS5) has garnered substantial attention for its evident role in the regulation of significant biological processes such as proliferation, differentiation, senescence, and apoptosis. Through miRNA-mediated signaling pathways, GAS5 modulates disease progression in a cell-type-specific manner, typically by influencing proteins involved in inflammation and cell death.

Long-term migration of a bullet to the bladder after 47 years of trauma: A literature review.

Foreign bodies in the urinary tract are uncommon and can arise from self-insertion or migration from other organs. Documented cases include various objects such as intrauterine devices, fragments of Foley catheters, toothpicks, and fish bones. However, the migration of bullet fragments into the urinary tract from another location is extremely rare with only a few cases reported in the current literature.

In-vitro accuracy of the virtual patient model with maxillomandibular relationship at centric occlusion using 3D-printed customized transfer key.

Objective: This study aimed to create a 3D-printed customized transfer key and evaluate the accuracy of the virtual patient model with maxillomandibular relationship at centric occlusion using the transfer key.

Methods: A 3D-printed transfer key was designed, combining facial and intraoral (IOS) scans. The design included components that recorded the 3D upper and lower arch at centric occlusion.

Temperature Dependence of Optical Properties of MoS and WS Heterostructures Assessed by Spectroscopic Ellipsometry.

We report the complex dielectric function = + of MoS/WS and WS/MoS heterostructures and their constituent monolayers MoS and WS for an energy range from 1.5 to 6.0 eV and temperatures from 39 to 300 K.

Combination of Hotspot Mutations With Methylation and Fragmentomic Profiles to Enhance Multi-Cancer Early Detection.

Background: Multi-cancer early detection (MCED) through a single blood test significantly advances cancer diagnosis. However, most MCED tests rely on a single type of biomarkers, leading to limited sensitivity, particularly for early-stage cancers. We previously developed SPOT-MAS, a multimodal ctDNA-based assay analyzing methylation and fragmentomic profiles to detect five common cancers.