Publications by authors named "Neng-Ping Li"
The aim of the present study was to investigate the effect of metformin on endothelial progenitor cell (EPC) migration and to explore the possible mechanisms. EPCs were treated with metformin, and the migration of EPCs was evaluated by wound healing and Matrigel invasion assays. We also examined the expression levels of of MMP-2 and MMP-9 in EPCs with or without metformin treatment via RT-PCR and western blot analysis, and activities of MMP-2 and MMP-9 in EPCs under different conditions was examined by zymography.
View Article and Find Full Text PDFHigh expression of CD39 in gastric cancer reduces patient outcome following radical resection.
Oncol Lett
November 2016
Article Synopsis
- Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1, or CD39) is a key enzyme that produces immunosuppressive adenosine and influences tumor growth in gastric cancer (GC).
- The study found that CD39 is significantly more expressed in tumor tissues than in surrounding tissues and that higher levels of CD39 are linked to worse overall survival (OS) for GC patients post-surgery.
- Additionally, the CD39 FoxP3 regulatory T cell ratio in tumor tissues indicates that these specific Treg cells could be a better predictor of survival compared to FoxP3 Treg cells alone, suggesting they might be a valuable target for cancer immunotherapy.
Overexpression of CD39 and high tumoral CD39⁺/CD8⁺ ratio are associated with adverse prognosis in resectable gastric cancer.
Int J Clin Exp Pathol
October 2016
CD39/ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1) is a cell surface-located, rate-limiting enzyme in the generation of adenosine, and plays a crucial role in tumor development. We examined co-expression of CD39 and CD8in gastric cancer (GC) and showed that the expression of CD39 and CD8 increased significantly in tumor tissues compared to paired peritumor tissues. The expression of tumoral CD39 (tCD39), but not tumoral CD8 (tCD8), was related to overall survival.
View Article and Find Full Text PDFThe Value of Performing Early Non-enhanced CT in Developing Strategies for Treating Acute Gallstone Pancreatitis.
J Gastrointest Surg
March 2016
Background: The purpose of this study is to assess the value of early abdominal non-enhanced computed tomography (NECT) in developing strategies for treating acute gallstone pancreatitis (AGP).
Methods: AGP patients underwent NECT within 48 h after symptom onset to determine the presence of peripancreatic fluid collection, gallstones, and common bile duct stones. Patients with mild AGP who had neither organ failure by clinical data nor peripancreatic fluid collection by NECT (classified as grade A, B, or C based on the Balthazar CT grading system) were randomized to undergo an early laparoscopic cholecystomy (ELC; LC performed within 7 days after a pancreatitis attack, without waiting for symptom resolution) or late laparoscopic cholecystomy (LLC; LC performed ≥ 7 days following an attack, with the patient being completely free of AGP symptoms).
Ampulla dilation with different sized balloons to remove common bile duct stones.
World J Gastroenterol
February 2013
Aim: To assess the outcomes of ampulla dilation with different sized balloons to remove common bile duct (CBD) stones.
Methods: Patients (n = 208) were divided into five groups based on the largest CBD stone size of < 5, 6-8, 8-12, 12-14, and > 14 mm. Patients underwent limited endoscopic sphincterotomy (EST) alone or limited EST followed by endoscopic papillary balloon dilation with 8, 10, 12 and 14 mm balloons, such that the size of each balloon did not exceed the size of the CBD.
Dynamic activity of NF-kappaB in multiple trauma patients and protective effects of ulinastain.
Chin J Traumatol
April 2016
Objective: To investigate the dynamic activity of NF-kappaB at the early stage of injury in multiple trauma patients and the protective effects of ulinastain.
Methods: From January 2008 to May 2010, patients with multiple traumas admitted to our emergency department were enrolled in this study. Their age varied from 20-55 years.
Comparison of severe trauma care effect before and after advanced trauma life support training.
Chin J Traumatol
December 2010
Article Synopsis
- The study aimed to assess the impact of Advanced Trauma Life Support (ATLS) training on care outcomes for in-hospital severe trauma patients with an Injury Severity Score (ISS) of 16 or higher.
- Researchers compared emergency care metrics two years before and after implementing ATLS training, reviewing data from a total of 820 severe trauma cases.
- Results showed a significant reduction in mortality and time spent in the emergency department and from admission to surgery after ATLS training, highlighting its effectiveness and suggesting the need for broader adoption in China.
First aid strategy for severe traumatic patients in hospital.
Chin J Traumatol
December 2007
Article Synopsis
- The study aimed to explore emergency management principles for severely injured patients with an Injury Severity Score (ISS) of 16 or higher.
- Researchers implemented the ATP principle, which focuses on immediate initial management by attending surgeons, teamwork coordination upon patient admission, and conducting emergency procedures simultaneously.
- Results indicated that using the ATP principle significantly reduced both the mortality rate and the time spent in the emergency department and before surgery, improving patient outcomes compared to traditional methods.
Duodenoscopy in treatment of acute gallstone pancreatitis.
Hepatobiliary Pancreat Dis Int
November 2002
Objective: To probe the potential use of duodenoscopy in the diagnosis and treatment of acute gallstone pancreatitis (GP).
Methods: Fourty-five patients with acute GP were randomly divided into endoscopic retrograde cholangiopancreatography (ERCP) group (n=20) and non-ERCP group (n=25). Each group was subdivided into mild and severe groups according to APACHE II scores.