Brassinosteroid-Mediated Resistance to Cobalt-Induced Toxicity by Regulating Hormonal Balance, Cellular Metabolism, and Antioxidant Defense in Maize.

Brassinosteroids (BRs) play an essential role in regulating plant metabolic pathways that influence growth, development, and stress responses. However, their role in alleviating cobalt (Co) stress has not been extensively studied. This research aimed to assess the impact of exogenous BRs (0.

The Broadleaf Weeds Control Efficiency of Drip Irrigation Herbicides in Cotton Fields and the Cotton Safety Assessment.

The aim of this study is to precisely elucidate the control efficacy of drip irrigation herbicide application against broadleaf weeds and comprehensively assess its safety to cotton. Broadleaf weeds were managed through the application of herbicide in the cotton field. The herbicide was dispensed from a fertilizer tank in tandem with water droplets.

Cerium Oxide Nanoparticle Protects Maize from Cobalt Stress: Insights from Transcriptomics and Oxidative Stress Response Analysis.

Nanozymes are a class of functional nanomaterials and potential next-generation artificial enzymes that exhibit catalytic properties. However, their role against cobalt (Co) stress and the underlying mechanisms remain largely unexplored. This study aimed to investigate the potential of cerium oxide nanoparticles (CeO NPs as nanozymes) against Co-induced stress in maize and to uncover the underlying physiological and molecular mechanisms.

Antifungal activity and potential inhibition mechanism of 4-(diethylamino)salicylaldehyde against Rhizoctonia solani.

Rhizoctonia solani is a significant soil-borne pathogenic fungus that poses a significant threat to the economically important agricultural crops. 4-(Diethylamino)salicylaldehyde (DSA) is a secondary metabolite produced by Streptomyces sp. KN37, which has antifungal activity, meanwhile its inhibitory mechanism is still unclear.

Liquid Phase Modeling in Porous Media: Adsorption of Methanol and Ethanol in H-MFI in Condensed Water.

Zeolites are used in the chemical and separation industries for their exceptional selectivity, adsorption capacity, regenerability, and stability in gas and liquid phase processing. Here, we developed an explicit solvation method for predicting solvent/condensed phase effects on adsorption free energies in microporous media such as zeolites based on the hybrid quantum mechanical/molecular mechanical free energy perturbation (QM/MM-FEP) technique. Our explicit solvation method for zeolite systems, called eSZS, aims to capture site-specific interactions during the adsorption process at the Brønsted acid sites of H-MFI zeolite while still considering the diverse configuration space of the solvent molecules.

Multidisciplinary Management and Staged Surgical Treatment for Chronic Thromboembolic Pulmonary Hypertension and Subclavian Vein Thrombosis Caused by Venous Thoracic Outlet Syndrome.

Chronic thromboembolic pulmonary hypertension (CTEPH) is an uncommon complication of deep vein thrombosis (DVT) and pulmonary embolism (PE), occurring in 3-5% of patients despite therapeutic anticoagulation. Venous thoracic outlet syndrome (VTOS) causing subclavian vein (SCV) thrombosis is also an uncommon condition, not frequently associated with clinically significant PE. In this report, we present two patients with CTEPH and SCV thrombosis caused by VTOS who had successful multidisciplinary management and staged surgical treatment for both conditions.

Nano-selenium mitigates arsenate toxicity in soybean roots by modulating phenylalanine and salicylic acid pathways.

Background: Soybean (Glycine max L. Merrill), a vital source of edible oil and protein, ranks seventh in global agricultural production, yet its productivity is significantly hindered by potential toxic metal/liods (PTM) stress. Arsenic (As), a highly toxic soil contaminant, poses substantial risks to both plants and humans, even at trace concentrations, particularly in China.

Therapeutic applications of quercetin-metallic complexes: a review.

Flavonoids, especially quercetin, are widely recognized for their antioxidant, anti-inflammatory, anti-microbial, anti-diabetic, and anti-tumor properties, but their clinical application is limited by poor permeability. Different techniques of permeability enhancement of quercetin, i.e.

SPLIF-Enhanced Attention-Driven 3D CNNs for Precise and Reliable Protein-Ligand Interaction Modeling for METTL3.

Structure-based virtual screening (SBVS) is a cornerstone of modern drug discovery pipelines. However, conventional scoring functions often fail to capture the complexities of protein-ligand binding interactions. To address this limitation, we developed DeepMETTL3, a novel scoring function that integrates 3D convolutional neural networks (CNNs) with multihead attention mechanisms and high-dimensional Structural Protein-Ligand Interaction Fingerprints (SPLIF).

Computer-aided drug design for the double-membrane vesicle pore complex inhibitors against SARS-CoV-2.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of the ongoing global pandemic, has constituted the worst global health disaster in recent years. However, no antiviral drugs have proved clinically efficacious to combat SARS-CoV-2 infection. The SARS-CoV-2 double-membrane vesicle (DMV) pore complex, particularly for its positively charged residues R1613, R1614, R303, R305, and R306, which are highly conserved across β-coronaviruses and play a critical role in mediating RNA transport and virus replication, has been validated as an effective drug target.

Efficient CO/CH Separation Using Polysulfone/NH-MIL-125(Ti) Mixed Matrix Membranes.

This study investigates the fabrication and optimization of mixed matrix membranes (MMMs) composed of NH-MIL-125(Ti), a metal-organic framework (MOF), dispersed within a polysulfone (PSf) polymer matrix, for efficient CO/CH separation. The MMMs were prepared by using a solution casting method, and their morphology and gas separation performance were systematically characterized. The effect of MOF addition into the polymer matrix, gas permeability, and selectivity were evaluated using a gas permeation setup.

Toward Sustainable Redox-Flow Batteries: The Role of Aqueous Organic Polymeric Electrolytes.

Aqueous organic polymeric electrolytes have garnered substantial interest in the development of redox flow batteries (RFBs) because of their significant potential to enhance energy storage capacity and scalability. These materials provide several advantages, including high water solubility, excellent ionic conductivity, robust chemical resistance, and low viscosity, making them highly effective in energy storage applications. This review explores five critical categories of polymeric redox-active materials, primarily focusing on π-conjugated compounds, fused-ring aromatics, viologens, stable radicals, and organometallic materials.

Moderate-to-Severe Preoperative Anemia is Associated with Increased Postoperative Myocardial Infarction and Mortality in Patients Undergoing Transcarotid Artery Revascularization.

Background: While preoperative anemia is prevalent among surgical patients, its impact on patients undergoing transcarotid artery revascularization (TCAR) remains poorly understood. This study aims to assess the relationship between the severity of preoperative anemia and outcomes following TCAR.

Methods: A retrospective analysis of the Vascular Quality Initiative database (2016-2021) was performed to identify patients who underwent TCAR for carotid stenosis.

Super-resolution imaging reveals resistance to mass transfer in functionalized stationary phases.

Chemical separations are costly in terms of energy, time, and money. Separation methods are optimized with inefficient trial-and-error approaches that lack insight into the molecular dynamics that lead to the success or failure of a separation and, hence, ways to improve the process. We perform super-resolution imaging of fluorescent analytes in five different commercial liquid chromatography materials.

Compositions and concentrations of dissolved organic matter, selected elements and anions in German drinking waters.

Dissolved organic matter (DOM) in water resources can lead to various drinking water quality issues, including undesirable color, taste, and odor, while also enhancing the mobility of heavy metals and promoting the formation of disinfection byproducts. This study investigated DOM concentrations and compositions in German drinking waters using fluorescence spectroscopy and size-exclusion chromatography coupled with organic carbon detection (LC-OCD). Additionally, the occurrence of selected elements and other inorganic ions were studied.

Evaluating Forelimb and Hindlimb Joint Conformation of Morna Racehorses ().

Measuring limb joint angles is crucial for understanding horse conformation, performance, injury diagnosis, and prevention. While Thoroughbred horses have been extensively studied, local Pakistani breeds (e.g.

Optimization of fermentation conditions to increase the production of antifungal metabolites from Streptomyces sp. KN37.

The bacterium Streptomyces sp. KN37 was isolated from the soil of Kanas, Xinjiang. The broth dilution of strain KN37 has a strong inhibitory effect against a variety of crop pathogenic fungi.

Entomopathogenic Fungi as Alternatives to Chemical Acaricides: Challenges, Opportunities and Prospects for Sustainable Tick Control.

Entomopathogenic fungi (EPFs) can infect and kill a diverse range of arthropods, including ticks (Acari: Ixodidae) that can transmit various diseases to animals and humans. Consequently, the use of EPFs as a biocontrol method for managing tick populations has been explored as an alternative to chemical acaricides, which may have harmful effects on the environment and non-target species. This review summarizes studies conducted on EPFs for tick control between 1998 and 2024, identifying 9 different EPF species that have been used against 15 different species of ticks.

The Effect of Glycemic Control on Cardiovascular Disease Progression in Adults With Early-Onset Type 2 Diabetes: A Longitudinal Cohort Analysis.

Introduction Rising prevalence rates of type 2 diabetes mellitus (T2DM), particularly in younger populations, have made early-onset T2DM (diagnosed before age 40) an increasingly significant health concern. Early-onset T2DM is often associated with more rapid progression and increased complications, including cardiovascular disease (CVD). However, its specific impact on cardiovascular outcomes remains inadequately understood, particularly compared to T2DM in older populations.

Vermicompost application improves leaf physiological activity, 2-acetyl-1-pyrroline, and grain yield of fragrant rice through efficient nitrogen assimilation under Cd stress.

Cadmium (Cd) pollution in arable soils and its accumulation in rice plants have become a global concern because of their harmful effects on crop yield and human health. The stabilization method which involves the application of organic amendments such as vermicompost (VC), is frequently utilized for the remediation of Cd-contaminated soils. This study investigated the effects of VC on the soil chemical properties and the physio-biochemical functions of fragrant rice, as well as nitrogen (N) metabolism and assimilatory enzyme activities, 2-acetyl-1-pyrroline (2AP) content in rice grains, and the grain yields of fragrant rice cultivars, i.

Mechanisms of selectivity for azadirachtin in honeybees (Apis cerana): A new strategy for avoiding thiamethoxam ingestion.

The high toxicity of thiamethoxam (Thi) to foragers has threatened the development of bee populations and the use of neonicotinoid pesticides. In this study, we explored the mechanism of selective feeding on azadirachtin (Aza) by foragers to reduce the feeding of Aza-Thi and improve foragers' safety. The results showed that foragers under selective feeding significantly reduced the Aza sucrose solution intake.

Hypothermia on admission predicts poor outcomes in adult trauma patients.

Background: Hypothermia is known to contribute to poor outcomes in trauma patients during acute phases. The aim of our study is to evaluate the effect of hypothermia on admission, upon in-hospital complications and mortality in adult trauma patients.

Methods: We performed a 5-year analysis of ACS-TQIP database (2017-2021).

Zinc Oxide Nanoparticle-Mediated Root Metabolic Reprogramming for Arsenic Tolerance in Soybean.

Arsenate (AsV) is absorbed and accumulated by plants, which can affect their physiological activities, disrupt gene expression, alter metabolite content, and influence growth. Despite the potential of zinc oxide nanoparticles (ZnONPs) to mitigate the adverse effects of arsenic stress in plants, the underlying mechanisms of ZnONPs-mediated detoxification of AsV, as well as the specific metabolites and metabolic pathways involved, remain largely unexplored. In this study, we demonstrated root metabolomic profiling of soybean germinating seedlings subjected to 25 μmol L arsenate (NaHAsO) and ZnONPs at concentrations of 25 μmol L (ZnO25) and 50 μmol L (ZnO50).

Non-steroidal anti-inflammatory drugs influence cartilage healing.

Background: Retrograde intramedullary nailing is commonly performed to stabilize distal femoral shaft fractures which may lead to iatrogenic injuries of the knee articular cartilage. The limited regenerative capability of cartilage may further be hindered by intake of non-steroidal anti-inflammatory drugs (NSAIDs) which are usually advised for injuries of the musculoskeletal system. The current study was designed to evaluate the histological changes in the femoral articular cartilage of knee joint after retrograde femoral nailing of rats.