Bind: large-scale biological interaction network discovery through knowledge graph-driven machine learning.

Background: Biological systems derive from complex interactions between entities ranging from biomolecules to macroscopic structures, forming intricate networks essential for understanding disease mechanisms and developing therapeutic interventions. Current AI-driven interaction predictors typically operate in isolation, focusing on single tasks and missing the broader picture of how different biological interactions influence each other. Traditional wet-lab approaches for identifying these interactions are expensive, time-consuming, and error-prone.

Protein Sequence Analysis landscape: A Systematic Review of Task Types, Databases, Datasets, Word Embeddings Methods, and Language Models.

Protein sequence analysis examines the order of amino acids within protein sequences to unlock diverse types of a wealth of knowledge about biological processes and genetic disorders. It helps in forecasting disease susceptibility by finding unique protein signatures, or biomarkers that are linked to particular disease states. Protein Sequence analysis through wet-lab experiments is expensive, time-consuming and error prone.

DNA sequence analysis landscape: a comprehensive review of DNA sequence analysis task types, databases, datasets, word embedding methods, and language models.

Deoxyribonucleic acid (DNA) serves as fundamental genetic blueprint that governs development, functioning, growth, and reproduction of all living organisms. DNA can be altered through germline and somatic mutations. Germline mutations underlie hereditary conditions, while somatic mutations can be induced by various factors including environmental influences, chemicals, lifestyle choices, and errors in DNA replication and repair mechanisms which can lead to cancer.

Peptide classification landscape: An in-depth systematic literature review on peptide types, databases, datasets, predictors architectures and performance.

Peptides are gaining significant attention in diverse fields such as the pharmaceutical market has seen a steady rise in peptide-based therapeutics over the past six decades. Peptides have been utilized in the development of distinct applications including inhibitors of SARS-COV-2 and treatments for conditions like cancer and diabetes. Distinct types of peptides possess unique characteristics, and development of peptide-specific applications require the discrimination of one peptide type from others.

Transitioning from wet lab to artificial intelligence: a systematic review of AI predictors in CRISPR.

The revolutionary CRISPR-Cas9 system leverages a programmable guide RNA (gRNA) and Cas9 proteins to precisely cleave problematic regions within DNA sequences. This groundbreaking technology holds immense potential for the development of targeted therapies for a wide range of diseases, including cancers, genetic disorders, and hereditary diseases. CRISPR-Cas9 based genome editing is a multi-step process such as designing a precise gRNA, selecting the appropriate Cas protein, and thoroughly evaluating both on-target and off-target activity of the Cas9-gRNA complex.

RNA sequence analysis landscape: A comprehensive review of task types, databases, datasets, word embedding methods, and language models.

Deciphering information of RNA sequences reveals their diverse roles in living organisms, including gene regulation and protein synthesis. Aberrations in RNA sequence such as dysregulation and mutations can drive a diverse spectrum of diseases including cancers, genetic disorders, and neurodegenerative conditions. Furthermore, researchers are harnessing RNA's therapeutic potential for transforming traditional treatment paradigms into personalized therapies through the development of RNA-based drugs and gene therapies.

MLR-predictor: a versatile and efficient computational framework for multi-label requirements classification.

Introduction: Requirements classification is an essential task for development of a successful software by incorporating all relevant aspects of users' needs. Additionally, it aids in the identification of project failure risks and facilitates to achieve project milestones in more comprehensive way. Several machine learning predictors are developed for binary or multi-class requirements classification.

ProSol-multi: Protein solubility prediction via amino acids multi-level correlation and discriminative distribution.

Protein solubility prediction is useful for the careful selection of highly effective candidate proteins for drug development. In recombinant proteins synthesis, solubility prediction is valuable for optimizing key protein characteristics, including stability, functionality, and ease of purification. It contains valuable information about potential biomarkers or therapeutic targets and helps in early forecasting of neurodegenerative diseases, cancer, and cardiovascular disorders.

Survival prediction landscape: an in-depth systematic literature review on activities, methods, tools, diseases, and databases.

Survival prediction integrates patient-specific molecular information and clinical signatures to forecast the anticipated time of an event, such as recurrence, death, or disease progression. Survival prediction proves valuable in guiding treatment decisions, optimizing resource allocation, and interventions of precision medicine. The wide range of diseases, the existence of various variants within the same disease, and the reliance on available data necessitate disease-specific computational survival predictors.

CAPTURE: Comprehensive anti-cancer peptide predictor with a unique amino acid sequence encoder.

Anticancer peptides (ACPs) key properties including bioactivity, high efficacy, low toxicity, and lack of drug resistance make them ideal candidates for cancer therapies. To deeply explore the potential of ACPs and accelerate development of cancer therapies, although 53 Artificial Intelligence supported computational predictors have been developed for ACPs and non ACPs classification but only one predictor has been developed for ACPs functional types annotations. Moreover, these predictors extract amino acids distribution patterns to transform peptides sequences into statistical vectors that are further fed to classifiers for discriminating peptides sequences and annotating peptides functional classes.

Long extrachromosomal circular DNA identification by fusing sequence-derived features of physicochemical properties and nucleotide distribution patterns.

Long extrachromosomal circular DNA (leccDNA) regulates several biological processes such as genomic instability, gene amplification, and oncogenesis. The identification of leccDNA holds significant importance to investigate its potential associations with cancer, autoimmune, cardiovascular, and neurological diseases. In addition, understanding these associations can provide valuable insights about disease mechanisms and potential therapeutic approaches.

NTpred: a robust and precise machine learning framework for in silico identification of Tyrosine nitration sites in protein sequences.

Post-translational modifications (PTMs) either enhance a protein's activity in various sub-cellular processes, or degrade their activity which leads toward failure of intracellular processes. Tyrosine nitration (NT) modification degrades protein's activity that initiates and propagates various diseases including neurodegenerative, cardiovascular, autoimmune diseases and carcinogenesis. Identification of NT modification supports development of novel therapies and drug discoveries for associated diseases.

DNA-MP: a generalized DNA modifications predictor for multiple species based on powerful sequence encoding method.

Accurate prediction of deoxyribonucleic acid (DNA) modifications is essential to explore and discern the process of cell differentiation, gene expression and epigenetic regulation. Several computational approaches have been proposed for particular type-specific DNA modification prediction. Two recent generalized computational predictors are capable of detecting three different types of DNA modifications; however, type-specific and generalized modifications predictors produce limited performance across multiple species mainly due to the use of ineffective sequence encoding methods.

MP-VHPPI: Meta predictor for viral host protein-protein interaction prediction in multiple hosts and viruses.

Viral-host protein-protein interaction (VHPPI) prediction is essential to decoding molecular mechanisms of viral pathogens and host immunity processes that eventually help to control the propagation of viral diseases and to design optimized therapeutics. Multiple AI-based predictors have been developed to predict diverse VHPPIs across a wide range of viruses and hosts, however, these predictors produce better performance only for specific types of hosts and viruses. The prime objective of this research is to develop a robust meta predictor (MP-VHPPI) capable of more accurately predicting VHPPI across multiple hosts and viruses.

EL-RMLocNet: An explainable LSTM network for RNA-associated multi-compartment localization prediction.

Subcellular localization of Ribonucleic Acid (RNA) molecules provide significant insights into the functionality of RNAs and helps to explore their association with various diseases. Predominantly developed single-compartment localization predictors (SCLPs) lack to demystify RNA association with diverse biochemical and pathological processes mainly happen through RNA co-localization in multiple compartments. Limited multi-compartment localization predictors (MCLPs) manage to produce decent performance only for target RNA class of particular sub-type.

BoT-Net: a lightweight bag of tricks-based neural network for efficient LncRNA-miRNA interaction prediction.

Background And Objective: Interactions of long non-coding ribonucleic acids (lncRNAs) with micro-ribonucleic acids (miRNAs) play an essential role in gene regulation, cellular metabolic, and pathological processes. Existing purely sequence based computational approaches lack robustness and efficiency mainly due to the high length variability of lncRNA sequences. Hence, the prime focus of the current study is to find optimal length trade-offs between highly flexible length lncRNA sequences.

Circ-LocNet: A Computational Framework for Circular RNA Sub-Cellular Localization Prediction.

Circular ribonucleic acids (circRNAs) are novel non-coding RNAs that emanate from alternative splicing of precursor mRNA in reversed order across exons. Despite the abundant presence of circRNAs in human genes and their involvement in diverse physiological processes, the functionality of most circRNAs remains a mystery. Like other non-coding RNAs, sub-cellular localization knowledge of circRNAs has the aptitude to demystify the influence of circRNAs on protein synthesis, degradation, destination, their association with different diseases, and potential for drug development.

LGCA-VHPPI: A local-global residue context aware viral-host protein-protein interaction predictor.

Viral-host protein protein interaction (PPI) analysis is essential to decode the molecular mechanism of viral pathogen and host immunity processes which eventually help to control viral diseases and optimize therapeutics. The state-of-the-art viral-host PPI predictor leverages unsupervised embedding learning technique (doc2vec) to generate statistical representations of viral-host protein sequences and a Random Forest classifier for interaction prediction. However, doc2vec approach generates the statistical representations of viral-host protein sequences by merely modelling the local context of residues which only partially captures residue semantics.

Advances in Computational Methodologies for Classification and Sub-Cellular Locality Prediction of Non-Coding RNAs.

Apart from protein-coding Ribonucleic acids (RNAs), there exists a variety of non-coding RNAs (ncRNAs) which regulate complex cellular and molecular processes. High-throughput sequencing technologies and bioinformatics approaches have largely promoted the exploration of ncRNAs which revealed their crucial roles in gene regulation, miRNA binding, protein interactions, and splicing. Furthermore, ncRNAs are involved in the development of complicated diseases like cancer.

GHS-NET a generic hybridized shallow neural network for multi-label biomedical text classification.

Exponential growth of biomedical literature and clinical data demands more robust yet precise computational methodologies to extract useful insights from biomedical literature and to perform accurate assignment of disease-specific codes. Such approaches can largely enhance the effectiveness of diverse biomedicine and bioinformatics applications. State-of-the-art computational biomedical text classification methodologies either solely leverage discrimintaive features extracted through convolution operations performed by deep convolutional neural network or contextual information extracted by recurrent neural network.

MirLocPredictor: A ConvNet-Based Multi-Label MicroRNA Subcellular Localization Predictor by Incorporating k-Mer Positional Information.

MicroRNAs (miRNA) are small noncoding RNA sequences consisting of about 22 nucleotides that are involved in the regulation of almost 60% of mammalian genes. Presently, there are very limited approaches for the visualization of miRNA locations present inside cells to support the elucidation of pathways and mechanisms behind miRNA function, transport, and biogenesis. MIRLocator, a state-of-the-art tool for the prediction of subcellular localization of miRNAs makes use of a sequence-to-sequence model along with pretrained k-mer embeddings.

Multi-label biomedical question classification for lexical answer type prediction.

Question classification is considered one of the most significant phases of a typical Question Answering (QA) system. It assigns certain answer types to each question which leads to narrow down the search space of possible answers for factoid and list type questions. The process of assigning certain answer types to each question is also known as Lexical Answer Type (LAT) Prediction.

A survey of ontology learning techniques and applications.

Ontologies have gained a lot of popularity and recognition in the semantic web because of their extensive use in Internet-based applications. Ontologies are often considered a fine source of semantics and interoperability in all artificially smart systems. Exponential increase in unstructured data on the web has made automated acquisition of ontology from unstructured text a most prominent research area.

Improved biomedical term selection in pseudo relevance feedback.

Biomedical information retrieval systems are becoming popular and complex due to massive amount of ever-growing biomedical literature. Users are unable to construct a precise and accurate query that represents the intended information in a clear manner. Therefore, query is expanded with the terms or features that retrieve more relevant information.