Clomiphene citrate improves sperm parameters in infertile men with idiopathic oligoasthenozoospermia.

Objective: The aim of this study was to observe the effect of clomiphene citrate on sperm parameters in infertile men diagnosed with idiopathic oligoasthenozoospermia.

Methods: This randomized controlled trial involved 50 infertile men diagnosed with idiopathic oligoasthenozoospermia, all of whom had normal serum testosterone and follicle-stimulating hormone levels. The participants were divided into two groups.

Fabrication of Antibacterial and Functional Films from Starch-Polyvinylpyrrolidone Composite Using Plasma Treatment and Silver Nanoparticles.

Biopolymers and water-soluble nontoxic synthetic polymer composites using silver nanoparticles are astute approaches for antibacterial film fabrication. Moreover, surface treatment of the biopolymeric composite film by cold plasma can enhance the biocidal activity. Silver nanoparticles were synthesized by using the reduction method.

Succinic acid enhances sedative activity of diazepam through GABAergic receptor modulation: Evidence from behavioral approach and computational insights.

Insomnia, a widespread neurological condition, is often managed with diazepam (DZP), a gamma-aminobutyric acid A (GABA) receptor agonist, though prolonged use raises concerns about dependence and cognitive impairment. This study investigated the sedative and locomotor-suppressive effects of succinic acid (SUC), alone and in combination with DZP, supported by behavioral and computational analyses. Swiss albino mice were treated intraperitoneally (i.

Tuning the electrochemical performance of a hierarchical MoO/CdO binary heterostructure for supercapacitor applications.

Cadmium oxide (CdO)-incorporating molybdenum trioxide (MoO) nanocomposites were synthesized using a facile hydrothermal method by varying the CdO content (1%, 3%, and 5%) to comprehend the influence of CdO concentration on the electrochemical performance of MoO. The structural and morphological properties of the synthesized nanomaterials were characterized using X-ray diffraction (XRD) and field emission scanning electron microscopy (FE-SEM). XRD showed that MoO has an orthorhombic structure, and FE-SEM showed that it has a nanobelt shape (0.

Current Insights of the Potential Plant Bioactive Compounds on Modulating the mTOR Signaling Pathway in Regulating Oncological Disorders.

Deregulation of the mechanistic target of the rapamycin (mTOR) pathway plays an important role in cancer genesis and progression, making it an attractive target for cancer treatment. Disrupting the mTOR pathway contributes to uncontrolled cell growth, increased proliferation, and enhanced cell survival, all of which are hallmarks of cancer. The findings imply that the deregulation of the mTOR pathway in cancer provides a compelling basis for therapeutic treatments.

Design, Synthesis, In Vitro, and In Silico Studies of 5-(Diethylamino)-2-Formylphenyl Naphthalene-2-Sulfonate Based Thiosemicarbazones as Potent Anti-Alzheimer Agents.

Alzheimer's disease (AD) is known as one of the more devastating neurodegenerative diseases diagnosed in older people. Cholinesterase inhibitors (ChEI) can be used as an effective palliative treatment for AD. An extensive range of new biologically active 4-(diethylamino) salicylaldehyde-based thiosemicarbazone derivatives 5(a-u) was synthesized and evaluated as inhibitors of cholinesterase (ChE) and monoamine oxidase (MAO) enzymes.

Phytochemical Profiling and Anti-Bacterial Activity of Red Delicious Apple Pomace With Integrated Hydrolysis to Obtain Fermentable Sugars: A Biorefinery Approach.

Apple pomace (AP) is a byproduct of juice processing, rich in nutritionally important compounds like carbohydrates, phenolic compounds, dietary fiber, and minerals. It is a potential feedstock for sugar-based biorefineries. This study explored AP physicochemical and bioactive compounds and their hydrolysis to extract fermentable sugar.

L-quebrachitol Modulates the Anti-convulsant Effects of Carbamazepine Possibly Through Voltage-gated Sodium Channel Blocking Mechanism in Chicks: In Vivo and In Silico Studies.

Introduction: L-Quebrachitol (LQB), a naturally occurring bioactive compound, exhibits anti-inflammatory, anti-oxidant, anti-cancer, and anti-diabetic properties. However, its therapeutic potential in convulsant management remains largely unexplored. The objective of this study was to investigate the anticonvulsant effects of LQB in an In Vivo model and to examine its molecular interactions via In Silico docking simulations.

Synergistic Sedative Activity of Indirubin on Diazepam in Thiopental Sodium-induced Sleeping Mice: A Potential GABAergic Transmission.

Insomnia remains one of the most common sleep disorders and causes significant discomfort as well as impairment in social, interpersonal, and vocational aspects of life. This study focuses on assessing the sedative activity of indigo naturalis indirubin (IND) on thiopental sodium (TS)-induced sleeping mice and evaluating the underlying molecular mechanisms through an in silico study. The adult male Swiss albino mice were used and given IND (5 and 10 mg/kg, i.

Coumarin derivatives as anticancer agents targeting PI3K-AKT-mTOR pathway: a comprehensive literature review.

Coumarin is a natural benzopyrone compound known for its diverse pharmacological activities, including anticancer, anti-inflammatory, and antioxidant properties. But its derivatives' exploration in cancer, specially PI3K-AKT-mTOR pathways-based cancer activity not explored yet. This review aims to evaluate the anticancer potential of coumarin derivatives' by exploring their modulatory effects on the PI3K-AKT-mTOR signaling pathway across diverse cancer types.

SPAS-Dataset-BD: Dataset for smart precision agriculture system in Bangladesh.

Precision agriculture harnesses data-driven techniques to optimize crop production, resource use, and sustainability. However, low-income countries like Bangladesh face a shortage of localized, high-quality datasets that reflect regional agroclimatic conditions and cropping practices. To address this gap, we present SPAS-Dataset-BD, a robust dataset compiled through a hybrid approach: secondary extraction from the Bangladesh Bureau of Statistics (BBS) 2022 Yearbook and primary on-field surveys of 223 farmers across ten diverse districts.

Understanding Cancer Risk Among Bangladeshi Women: An Explainable Machine Learning Approach to Socio-Reproductive Factors Using Tertiary Hospital Data.

Background: Breast cancer poses a significant health challenge in Bangladesh, where limited screening and unique reproductive patterns contribute to delayed diagnoses and subtype-specific disparities. While reproductive risk factors such as age at menarche, parity, and contraceptive use are well studied in high-income countries, their associations with hormone-receptor-positive (HR+) and triple-negative breast cancer (TNBC) remain underexplored in low-resource settings.

Methods: A case-control study was conducted at the National Institute of Cancer Research and Hospital (NICRH) including 486 histopathologically confirmed breast cancer cases (246 HR+, 240 TNBC) and 443 cancer-free controls.

Molecular Identification and Antimicrobial Resistance Characteristics of Extended-Spectrum Beta-Lactamase Producing Isolated from Captive Wild and Migratory Birds.

The emergence and dissemination of antibiotic-resistant , particularly those are extended-spectrum beta-lactamase (ESBL) producers, thought to pose a serious threat to global health. This study aimed to isolate and identify the ESBL-producing from captive wild and migratory birds in Bangladesh along with their antimicrobial resistance characteristics. In this investigation, standard bacteriological methods were used to detect in 219 fecal samples.

Ethnopharmacological Profile, Phytochemistry and Therapeutic Potential of L. for the Treatment of Neurological Disorders.

(L.) Corrêa, commonly known as the bael fruit tree, is a member of the Rutaceae family and holds significance in Ayurvedic herbal medicine due to its myriad therapeutic properties. This paper seeks to delve into the diverse benefits offered by the bael fruit tree, exploring various plant parts, including leaves, fruit, bark, and seeds, all of which contain bioactive compounds with therapeutic potential.

Determinants of incomplete immunization and factors for missed opportunities in urban Dhaka: A cross-sectional study.

Most vaccinations in the immunization schedule need two or more doses to elicit a protective immune response. Therefore, completion of all doses is crucial for achieving the best possible immunity. The objective of this study was to investigate the factors influencing missed opportunities of polio vaccination in children between the ages of 1-3 years in urban Dhaka.

Unveiling the anticancer potential of Pinostrobin: mechanisms of action, pharmacokinetic insights, and therapeutic prospects.

Pinostrobin (PIN), a natural flavonoid found in Boesenbergia rotunda, Alpinia zerumbet, and other botanicals, has shown promising anticancer potential due to its multitargeted mechanisms and favorable safety profile. This review consolidates current evidence on PIN's anticancer properties, focusing on its molecular mechanisms, pharmacokinetics (PKs), and therapeutic potential. A systematic literature search was conducted using PubMed, Scopus, ScienceDirect, and Google Scholar to identify preclinical studies on PIN's bioactivity, PK, and toxicity.

BanglaHealth: A Bengali paraphrase dataset on health domain.

In the landscape of natural language processing (NLP) research, the availability of comprehensive datasets plays a pivotal role in advancing various tasks, including paraphrasing. However, for languages such as Bengali, the availability of such datasets remains limited, particularly in specialized domains like health. Recognizing this gap, this study endeavours to address the scarcity of resources by presenting a novel Bengali paraphrasing dataset specifically tailored to the health domain.

Potential Therapeutic Efficacy of Ferulic Acid and Its Derivatives in the Management of Cancers: A Comprehensive Analysis With Mechanistic Insight.

Due to the increasing rate of cancer and the undesirable consequences of manufactured drugs, there is a growing interest in the development of natural products as potential remedies. Ferulic acid (FA), a phenolic substance, is found naturally present in the plant's cell walls with therapeutic activities. The objective of this study is to determine the botanical sources, pharmacokinetics, and anticancer activity of FA and its derivatives, focusing on the molecular mechanism by using the data obtained from the literature database.

Evaluation of the Sedative Activity of Naringenin: In Vivo Study with Pharmacokinetics and Molecular Docking Insights.

This research is designed to investigate the sedative effects of naringenin (NAR) and diazepam against thiopental sodium-induced sleeping mice. NAR (5 and 10 mg kg), diazepam (DZP) (2 mg kg), flumazenil (FLN) (0.1 mg kg), and their combinations are administered intraperitoneally to mice.

Scalable antimicrobial air filters: polypropylene/rose bengal melt-blown nonwoven filters.

The COVID-19 pandemic has highlighted the limitations of conventional face masks, which primarily function as aerosol physical filters without inherent antibacterial or antiviral properties. Surgical masks, which depend on electrostatic filtration, lose their efficacy as these charges dissipate within a few hours of use. This study aims to address these shortcomings by developing advanced melt-blown nonwoven filters using polypropylene (PP) and Rose bengal (RB) as a photosensitizer.

Memory-Enhancing Effects of Dauricine in Swiss Mice: Possible Molecular Interventions Through In Vivo and In Silico Studies.

The bisbenzylisoquinoline alkaloid dauricine (DAU) is known for its neuroprotective effects in animals. This study investigates the memory-enhancing effects of DAU in Swiss albino mice using both in vivo and in silico approaches, focusing on its interaction with the D2 dopamine (DOP) receptor. Behavioral tests, including marble burying, dust removal, and trained swimming, were used to assess cognitive performance, anxiety, and motor coordination.

Oleuropein modulates anti-inflammatory activity of celecoxib and ketoprofen through cyclooxygenase pathway: in vivo, in silico and pharmacokinetics approaches.

Oleuropein (OLP), a bioactive compound mainly found in olive leaves, is recognized for its wide range of biological effects, such as antioxidant, anti-inflammatory, and antimicrobial activities. This study aimed to assess the anti-inflammatory effects of OLP in an in vivo model and explore its molecular interactions through in silico docking studies. We investigated the individual and combined effects of OLP (10 and 20 mg/kg) alongside standard anti-inflammatory drugs, celecoxib (CXB) and ketoprofen (KPN), at 42 mg/kg (p.

Advancing food security and proposing future strategies: A comparative performance analysis of Global Food Security Index and Annual Population Changes of top five populous countries.

Rising global food insecurity driven by population growth needs urgent measure for universal access to food. This research employs Comparative Performance Analysis (CPA) to evaluate the Global Food Security Index (GFSI), its components [Affordability (AF), Availability (AV), Quality & Safety (Q&S) and Sustainability & Adaptation (S&A)] in tandem with Annual Population Change (APC) for world's five most populous countries (India, China, USA, Indonesia and Pakistan) using dataset spanning from 2012 to 2022. CPA is applied using descriptive analysis, correlation analysis, Rule of Thumb (RoT) and testing of hypothesis etc.

Patriarchal dominance and relationship: couple communication's mediating effect on sexual and reproductive health outcomes among Rohingya refugee women.

Background: Considering the patriarchal dominance, power dynamics, and relational issues in the Rohingya society, this study used dyadic power theory and social penetration theory to examine how husbands' dominance in sexual and reproductive health (SRH) and couples' disclosure influence their couple communication about SRH. It also explored the mediated effect of couple communication on their SRH-related outcomes.

Methods: This quantitative study was designed with a cross-sectional survey ( = 408) at the Rohingya refugee camp in Cox's Bazar district of Bangladesh.

Memory-Enhancing Effects of Daidzin, Possibly Through Dopaminergic and AChEergic Dependent Pathways.

Background: The soy isoflavone daidzin (DZN) possesses cognitive-enhancing effects in animals.

Objectives: However, the mechanism for this effect is yet to be discovered.

Methods: For this, we investigate its memory-enhancing capacity using the mouse models of marble burying, dust removal, an open-field study, and in silico studies.