Evaluation of collapsible deformation of foundation under rectangular load based on the improved binary medium model.

The increasing frequency of extreme weather events and climate change can substantially impact the collapse phenomenon and other challenges associated with the deformation of foundation soils. These can also affect soil moisture regimes, particularly soil suction. The global engineering and geotechnical hazards related to the deformation of foundation soil collapsibility require immediate attention from engineers.

Association Between Perceived Stress and Fatigue Severity in Patients With Chronic Illnesses.

Background: Stress and fatigue are two of the most important contributing factors to the declining physical and mental well-being of patients suffering from chronic illnesses. This research aims to identify the direct relationship between stress and fatigue to improve treatment guidelines and patient care.

Methodology: This observational study was conducted from February to April 2025 in Islamabad, Pakistan.

Integrative analysis of T cell-associated markers in Ewing sarcoma reveals prognostic signatures and immune dynamics.

Background: Ewing sarcoma (ES) is a rare and aggressive pediatric bone malignancy with poor prognosis, driven by therapy-resistant tumor microenvironments (TME). The TME plays a critical role in tumor progression through a complex and dynamic network of reciprocal interactions among immune cells (dysfunctional T cells, immunosuppressive macrophages), stromal components (cancer-associated fibroblasts), and tumor cells. These interactions collectively shape the immune landscape, promote immune evasion, and contribute to therapeutic resistance.

Association Between Gastrointestinal Symptoms and Anxiety Levels in Patients with Functional Dyspepsia.

Background Functional dyspepsia (FD) is a common gastrointestinal disorder characterized by chronic upper abdominal symptoms, such as epigastric pain, burning, postprandial fullness, or early satiation, in the absence of structural abnormalities, as defined by the Rome IV criteria. Anxiety, together with other psychological factors, is now understood to intensify symptoms while degrading the quality of life for patients with FD. Methods A cross-sectional correlational study involving 300 FD participants was performed in a gastroenterology outpatient clinic located in Islamabad.

Artificial intelligence-large language models (AI-LLMs) for reliable and accurate cardiotocography (CTG) interpretation in obstetric practice.

Background: Accurate cardiotocography (CTG) interpretation is vital for the monitoring of fetal well-being during pregnancy and labor. Advanced artificial intelligence (AI) tools such as AI-large language models (AI-LLMs) may enhance the accuracy of CTG interpretation, but their potential has not been extensively evaluated.

Objective: This study aimed to assess the performance of three AI-LLMs (ChatGPT-4o, Gemini Advanced, and Copilot) in CTG image interpretation, compare their results to those of junior (JHDs) and senior human doctors (SHDs), and evaluate their reliability in clinical decision-making.

Fetal origins of adult disease: transforming prenatal care by integrating Barker's Hypothesis with AI-driven 4D ultrasound.

Introduction: The fetal origins of adult disease, widely known as Barker's Hypothesis, suggest that adverse fetal environments significantly impact the risk of developing chronic diseases, such as diabetes and cardiovascular conditions, in adulthood. Recent advancements in 4D ultrasound (4D US) and artificial intelligence (AI) technologies offer a promising avenue for improving prenatal diagnostics and validating this hypothesis. These innovations provide detailed insights into fetal behavior and neurodevelopment, linking early developmental markers to long-term health outcomes.

Analysis, Design, and Implementation of a User-Friendly Differential Privacy Application.

In the era of artificial intelligence, ensuring privacy in publicly released data is critical to prevent linkage attacks that can reveal sensitive information about individuals. Differential privacy (DP) has emerged as a robust approach for safeguarding privacy, but its mathematical complexity often limits its accessibility to non-experts. This paper introduces a novel, user-friendly web application that bridges the gap between theoretical DP concepts and their practical application.

A DFT study of monolayer magnesium carbide (MgC) as a potential anode for (Li, Na, K) alkali metal-ion batteries.

Magnesium carbide (MgC) is the latest two-dimensional monolayer material with semiconductor properties containing 0.25 eV band gap. Upon adsorption of the Li/Na/K the semiconducting behavior of material changes to metallic.

First-trimester Doppler Ultrasound for Predicting Successful Management of Pregnancy with Recurrent Pregnancy Losses Due to Antiphospholipid Syndrome and Thrombophilia: A Cohort Study.

Background: Recurrent pregnancy loss (RPL) often stems from a hypercoagulable state that exacerbates conditions such as antiphospholipid syndrome (APS) and thrombophilia, leading to early placental issues. Although treatments such as low-molecular-weight heparin (LMWH) and low-dose aspirin (LDA) are used, outcomes vary. This study proposes using first-trimester Doppler ultrasound - specifically, uterine radial artery resistance index (URa-RI) at 8 weeks and uterine artery pulsatility index (Ut-PI) with pre-diastolic notching (Ut-notch) at 11-13 weeks - to better predict successful pregnancies and reduce risks of adverse outcomes.

Simulation studies to identify high-affinity probiotic peptides for inhibiting PAK1 gastric cancer protein: A comparative approach.

A major threat to world health is the high death rate from gastrointestinal (GI) cancer, especially in Asia, South America, and Europe. The new approaches are needed because of the complexity and heterogeneity of gastrointestinal (GI) cancer, which has made the development of effective treatments difficult. To investigate the potential of peptide-based therapies that target the P21 Activated Kinase 1 (PAK1) in GI cancer, we are using the DBsORF database to predict peptides from the genomes of two bacterial strains: Lactobacillus plantarum and Pediococcus pentosaceus.

Enhanced neurological anomaly detection in MRI images using deep convolutional neural networks.

Introduction: Neurodegenerative diseases, including Parkinson's, Alzheimer's, and epilepsy, pose significant diagnostic and treatment challenges due to their complexity and the gradual degeneration of central nervous system structures. This study introduces a deep learning framework designed to automate neuro-diagnostics, addressing the limitations of current manual interpretation methods, which are often time-consuming and prone to variability.

Methods: We propose a specialized deep convolutional neural network (DCNN) framework aimed at detecting and classifying neurological anomalies in MRI data.

Antibacterial activity of camel colostrum against pathogenic strain of F17-associated with calf diarrhea.

Background: Many protective proteins, including lactoferrin and heavy chain antibodies, are present in camel colostrum, giving it a distinctive composition. Beyond a broad spectrum of pathogens, these proteins demonstrate antibacterial properties.

Aim: The current research assessed the prophylactic properties of camel colostrum against F17.

Evaluation of the Effect of Precursor NMC622@TiO Core-Shell Powders Using a Prelithiated Anode from Fig Seeds: Spotlight on Li-ion Full-Cell Performance.

In this study, innovative electrode materials for lithium-ion batteries (LIBs) were developed and characterized, demonstrating significant performance enhancements. Initially, NMC622@TiO was synthesized using a wet-chemical method with titanium(IV) ethoxide as the Ti source. Advanced structural investigations confirmed the successful formation of a core@shell structure with negligible cation mixing (Li/Ni) at the NMC622 surface, contributing to enhanced electrochemical performance.

Survival case of cardiac strangulation from epicardial pacemaker leads in an adult: A case report.

Cardiac strangulation from leads of an epicardial pacemaker is a rarely reported life-threatening complication. We report the case of a 72-year-old female with history of supraventricular tachycardia status post sino-atrial node ablation with epicardial pacemaker placement who presented to the outpatient setting with shortness of breath. Heart catheterization was performed which showed elevated right and left heart pressures.

Allelopathic interactions of Carthamus oxyacantha, Macrophomina phaseolina and maize: Implications for the use of Carthamus oxyacantha as a natural disease management strategy in maize.

Fungicides are used to control phytopathogens but all these fungicides have deleterious effects. Allelopathic interactions can be harnessed as a natural way to control the pathogens but there are no reports that show the allelopathic interactions of donor plant, recipient crop, as well as the target plant pathogen and the material used for inoculum production. So, in the present study, the suitability of Carthamus oxyacantha M.

Seismic response comparison of various geogrid reinforced earth-retaining walls: based on shaking table and 3D FE analysis.

The performance of various geogrid earth-retaining walls integrated with a non-cohesion granular backfill for reducing earth pressure has been investigated through small-scale shaking table tests and full-scale 3D finite element analysis. This purpose involved a series of physical modeling tests involving different earth-retaining walls (0.83 cm, height 7.

Perindopril and losartan affect ACE-2 and IL- 6 expression in obese rat model.

Obesity has emerged as a worldwide health concern due to its increasing prevalence. Adipocytes have the ability to express angiotensin-converting enzyme 2 receptors (ACE2) and several adipocytokines. These expressions could lead to the activation of a cytokine storm, which in turn promotes the development of cardiovascular diseases.

Optical coherence tomography catheter-induced vasospasm of the left anterior descending artery: A case report.

Optical coherence tomography (OCT) helps identify coronary artery disease of different etiologies. Vasospasm from OCT catheter is a rarely reported complication that is more commonly seen in the right coronary artery. We report a case of OCT-catheter induced vasospasm of the left anterior descending artery that resolved with administration of nitroglycerine.

Exploration of the Family in the Gut Microbiota: Diversity, Metabolism, and Function.

The gut microbiota are mainly composed of and and are crucial for metabolism and immunity. are a family of bacteria within the order . produce short-chain fatty acids via endogenous (mucin glycans) and exogenous polysaccharides (dietary fibres).

Predictor of left main coronary artery size: an intravascular ultrasound study in Southeast Asia population.

Left main (LM) percutaneous coronary intervention (PCI) has expanded rapidly in the past decade, with up to fourfold increase annually. Recent trials found that intravascular imaging (IVI)-guided LM PCI resulted in lower risks of cardiac death and stent failure due to suboptimal PCI compared to angiography-guided PCI. IVI usage has increased in recent years; however, its utilization remains variable across regions and is still incredibly low in developing countries.

based formulations control the wilt disease of chickpea ( L.) caused by f. sp. , better when inoculated as consortia: findings from pot experiments under field conditions.

Background: Commercial/chemical pesticides are available to control wilt of chickpea, but these antifungals have numerous environmental and human health hazards. Amongst various organic alternatives, use of antagonistic fungi like , is the most promising option. Although, spp.