CNS Non-Hodgkin's Lymphoma With Atypical T2 Hyperintensity and Necrosis Mimicking Glioblastoma Multiforme: A Radiological Enigma.

A 45-year-old female presented with a 15-day history of headache and blurred vision. MRI of the brain revealed multiple irregular, T2-hyperintense lesions with significant surrounding edema, central necrosis, peripheral rim enhancement, and corpus callosum involvement resulting in a "butterfly" appearance. These imaging features led to an initial radiological impression of multifocal glioblastoma multiforme.

Cardiovascular-kidney-metabolic syndrome: A new frontier or simple rebranding?

Cardiovascular-kidney-metabolic (CKM) syndrome is an emerging framework proposed by the American Heart Association for management of patients with cardio-metabolic multimorbidity. This novel framework offers several improvements over existing paradigms; however, it remains unclear whether it represents a new frontier, or a simple rebranding of known clinical principles.

Comparison of a direct consultative advanced heart failure role in the outcomes of extracorporeal membrane oxygenation patients.

Background: Advanced heart failure and transplant (AHFTC) teams are crucial in the management of patients in cardiogenic shock. We sought to explore the impact of AHFTC physicians on outcomes in patients receiving extracorporeal membrane oxygenation (ECMO) support.

Aim: To determine whether outcomes differ in the care of ECMO patients when AHFTC physicians serve in a primary consultative role.

Human bone marrow derived stem cell differentiation on 3D printed bioactive glass scaffolds.

Bioactive glass particles have previously been found to stimulate new bone growth in vivo and have a long clinical track record. The effect of bioactive glasses on human bone marrow derived stromal cells (hBMSCs) has not been clearly ascertained previously. Recently, 3D printed scaffolds of the ICIE16 glass composition (49.

Implementation of a Standardized Surgical Operative Note: A Clinical Audit at Atbara Teaching Hospital.

Background And Aim: High-quality surgical operation notes are essential for patient safety, clinical communication, and medicolegal accountability. In low-resource settings like Sudan, inconsistent and incomplete documentation remains a challenge. This study aimed to evaluate and improve the quality of surgical operation notes at the Atbara Teaching Hospital using a closed-loop clinical audit.

Phenolic profiling unravels the chemopreventive components of (Curtis) Dum.Cours. fruits by integrating LC-MS/MS, in vitro studies, docking and molecular dynamic simulation.

Chemoprevention is one of the most effective strategies for reducing the global prevalence of cancer. (Curtis) Dum.Cours.

Access to child-feeding counseling service and determinant factors among breastfeeding mothers in Ethiopia: a multilevel complex data analysis of 2019 Ethiopian mini demographic and health survey.

Background: Inappropriate child-feeding practices lead to child morbidity and mortality in many countries around the world. In many low- and middle-income countries, mothers often lack access to appropriate child-feeding counseling services within healthcare settings. While several studies have examined recommended infant and child feeding practices, there is insufficient information regarding the accessibility of child-feeding counseling services in Ethiopia.

Exact wave structures with stochastic effects in birefringent optical fibers modeled by cubic-quintic-septic nonlinear Schrödinger equation.

Stochastic optical solitons are a fascinating phenomenon in nonlinear optics where soliton-like behavior emerges in systems affected by stochastic noise. This study establishes a fundamental framework for stochastic wave propagation in birefringent fibers through the cubic-quintic-septic nonlinear Schrödinger equation (NLSE). Our modified extended mapping technique yields exact analytical solutions (bright, dark, and singular solitons, periodic structures, and Weierstrass elliptic waves) that explicitly incorporate multiplicative noise and birefringent coupling.

Dynamic shifts in trophoblast nucleos(t)ide metabolism, transport, and adenosine signaling during gestation and preterm birth.

Nucleos(t)ides are essential for DNA/RNA synthesis, energy metabolism, and signaling, yet their roles in placental development remain poorly understood. The placenta undergoes dynamic metabolic adaptations throughout gestation to support fetal growth. This study investigates gene expression shifts in nucleos(t)ide metabolism, transport, and adenosine signaling during placental development and in the pathological condition of spontaneous preterm birth (PTB).

Weight change from incretin-based weight loss medications across categories of second-generation antipsychotics.

Objective: Patients prescribed second-generation antipsychotics (SGA) are at risk of antipsychotic induced weight gain (AIWG). The objective was to estimate weight changes after prescription of incretin-based weight loss medications by category of expected AIWG: high (olanzapine, clozapine), intermediate (risperidone, quetiapine, paliperidone) and low (e.g.

Hospital health information exchange participation and heart failure discharges to skilled nursing facilities: a cohort study.

Objectives: Health information technologies, such as telehealth and remote monitoring, show promise in preventing admission to skilled nursing facilities (SNF) following hospital discharges among older adults with heart failure (HF). Other health information technologies such as health information exchange (HIE), have not been examined as a potential means to reduce the use of SNF following HF hospitalization in older adults.

Materials And Methods: Using the 2018 Medicare Provider Analysis and Review (MedPar) file, we identified Medicare beneficiaries admitted for HF in 2018 and used unadjusted and adjusted logistic regression to examine associations between hospital HIE participation and the odds of being discharged to SNF; models were stratified by whether the beneficiary was admitted from a SNF or not.

TP-ML: A Machine-Learning-Based Tool to Identify Threonine Proteases Using Sequence-Derived Optimal Features.

Threonine proteases (TPs) are enzymes vital for several biological processes and diseases including Alzheimer's disease and cancer. Their potential to target and degrade proteins intracellularly makes them valuable for various therapeutic and industrial applications. However, traditional experimental methods for identifying and characterizing novel TPs are exhaustive, time-consuming, and expensive.

The Influence of Depression, Positive Health Behaviors, and Weight Status on Glycated Hemoglobin: A Sequential Mediation Analysis of the INDEPENDENT Trial.

Background: Collaborative care models (CoCM) improve both depression and cardiometabolic outcomes, but the mechanisms driving these effects remain unclear.

Objective: To determine whether changes in depressive symptoms, positive health behaviors (PHBs), body mass index (BMI), and waist circumference mediate the effect of an adapted CoCM on glycemic control among adults with cardiometabolic risk in India.

Design: Longitudinal structural equation modeling of data from the INtegrating DEPrEssioN and Diabetes TreatmENT (INDEPENDENT) Randomized Control Trial.

Insights into the tripartite relationship between cervical cancer, human papillomavirus, and the vaginal microbiome: a mega-analysis.

Background: Cervical cancer (CC) is the fourth most prevalent malignancy among women worldwide, where 99.7% of the cases are linked to persistent human papillomavirus (HPV) infections. While emerging evidence suggests a role for vaginal microbiome dysbiosis in HPV-driven CC, the specific microbial alterations and their functional implications remain unclear.

Comparison of microcurrent and low level laser therapy on matrix metalloproteinases and tissue inhibitors of metalloproteinases expressions in surgical wound healing.

Purpose: The purpose of this study was to compare the modulation effects of Microcurrent Therapy (MT) and Low-Level Laser Therapy (LLLT) on Matrix Metalloproteinases (MMPs) and tissue inhibitors of Metalloproteinases (TIMPs) expressions during healing of surgical wounds using appendectomy wound as a model.

Methods: Ninety patients who recently underwent appendectomy were randomly divided into 3 main groups of equal numbers. All cases in the three groups received ordinary medical therapy.

Prevalence, awareness, treatment, and control of diabetes in India: a nationally representative survey of adults aged 45 years and older.

Background: India is a country of 1·4 billion people that contributes to much of the global diabetes burden. Updated evidence on the state of the diabetes epidemic among middle-aged and older adults is imperative given that the risk of diabetes increases with age and that clinical and public health interventions can prevent diabetes complications. We aimed to estimate the prevalence, awareness, treatment, and control of diabetes in a nationally representative and state-representative sample of Indians aged 45 years and older.

Blood Pressure Measurements From Self-Service Health Kiosks in US Retail Stores, 2017-2024.

Importance: Hypertension is the leading risk factor for mortality in the US. Current national estimates of the prevalence of high blood pressure (BP) are derived from lagged averages based on complex, multistage, probability sampling designs to be representative of the US population.

Objective: To describe the distribution of BP readings among a convenience sample of individuals aged 18 to 99 years.

Best practice guidelines on reference interval harmonization in Canada: Evidence-based recommendations from the CSCC working group on reference interval harmonization (CSCC WG-hRI).

Unnecessary variation in reference intervals across clinical laboratories increases the risk of inconsistent or misinformed clinical decision-making. Development of harmonized or common reference intervals for assays that demonstrate minimal bias across measurement procedures and laboratories is an important step towards standardized quality healthcare. The aim of this document is to recommend evidence-based harmonized reference intervals for routine clinical laboratory tests that can be implemented in hospital and community settings across Canada.

National evidence on glucose-lowering medication use for diabetes from 62 low- and middle-income countries.

Given rising diabetes prevalence globally, access to diabetes treatments is gaining urgency. Yet, it remains unknown which glucose-lowering medication types people with diabetes across low- and middle-income countries (LMICs) use. In this cross-sectional analysis, we pooled nationally representative data of 223,283 adults aged ≥25 years in 62 LMICs from 2009 to 2019.

Population-based cross-sectional study of the correlation of physical inactivity and sedentary behaviour with sociodemographic factors among Bangladeshi adults.

Background: Physical inactivity and sedentary behaviour are influenced by various interconnected variables. In Bangladesh, studies on physical inactivity and sedentary behaviour are scarce, regardless of age in the adult population. This study aims to determine the correlates of adults' physical inactivity and sedentary behaviour with sociodemographic factors, including gender, age, residential, educational, and occupational status.

Assessing and Enhancing the Interpretation Quality of Arterial Blood Gas Among Junior Doctors.

Background:  Arterial blood gas (ABG) analysis is a critical diagnostic tool used in emergency and intensive care settings to assess a patient's acid-base balance, ventilation, and oxygenation. Despite its importance, ABG interpretation remains challenging for junior doctors, particularly when dealing with complex cases involving mixed respiratory and metabolic disturbances. This clinical audit was conducted to evaluate the baseline competency of junior doctors in ABG interpretation and to measure the impact of targeted educational interventions.

Perceptions of body size and non-communicable disease risk among people with HIV in Nairobi, Kenya: an explanatory mixed-methods study.

Introduction: Burden of non-communicable diseases (NCDs) continues to rise in low- and middle-income countries like Kenya. People with HIV (PWH) may be at greater risk for obesity and NCDs. National health policies recommend integrated approaches to manage these conditions, but have not been widely implemented.

Contrastive Self-Supervised Ensemble Transfer Learning for Robust Skin Cancer Classification and Early Detection.

Objective: Melanoma is one of the most dreaded types of cancer in the world today, and therefore, early detection becomes crucial. Deep learning models need annotated training data, and such training data are difficult and expensive to acquire. To solve this challenge, we introduce a new framework called the Contrastive Self-Supervised Ensemble Transfer Learning (CSSL-ETL) that combines the techniques of CSSL and ETL to improve the feature learning and classification accuracy of the model.

Retrospective Analysis of Carpal Tunnel Syndrome: Clinical Profile, Demographics, and Risk Factors at Sohar Hospital Over a Two-Year Period.

Background Carpal tunnel syndrome (CTS) is a common entrapment neuropathy caused by compression of the median nerve within the carpal tunnel. Despite its prevalence, the clinical profile, demographics, and associated risk factors vary across populations. In Oman, CTS is increasingly recognized as a significant health concern, particularly among individuals engaged in repetitive hand activities.