The MdSINA1-MdWOX8-MdHY5 module links strigolactone and gibberellin signals via interaction with MdSMXL8 and MdRGL3a in the regulation of anthocyanin biosynthesis in apple.

The strigolactone (SL) and gibberellin (GA) signals jointly regulate various aspects of plant growth and development. However, the molecular regulatory network underlying the crosstalk between the SL and GA signaling pathways remains poorly understood. In this study, we found that ELONGATED HYPOCOTYL 5 (MdHY5) serves as an integrator of SL and GA signals in apple (Malus × domestica), and the WUSCHEL-related homeobox (WOX) transcription factor MdWOX8 enhances anthocyanin biosynthesis by directly activating MdHY5 expression.

MdDUF506 Enhances Aluminium Tolerance by Interacting With MdCNR8 in Apple.

As soil acidification occurs due to industrial and agricultural production processes, it can induce the release of rhizotoxic aluminium ions (Al) into the soil, ultimately causing aluminium (Al) stress. Excessive Al content in soil exhibits significant phytotoxicity, inhibiting the growth of roots and stems. In this study, we conducted an investigation into the Al stress tolerance of two apple rootstocks, namely 'YZ3' and 'YZ6', and discovered that 'YZ3' exhibited a superior ability to alleviate the inhibitory effects of Al stress on plant growth.

Genome-Wide Analysis of Tea FK506-Binding Proteins (FKBPs) Reveals That Enhances Cold-Stress Tolerance in Transgenic .

FK506-binding proteins (FKBPs) belong to the peptidyl-prolyl cis/trans isomerase (PPIase) superfamily and are involved in a wide range of biological processes including protein folding, hormone signaling, plant growth, and stress responses. However, the FKBPs and their biological functions have not been identified in tea plants. In this study, 21 genes were identified using the conserved FK506-binding domain (PF00254) in the tea-plant genome.

Effect of acupuncture on tic disorder: a randomized controlled clinical trial based on energy metabolomics and infrared thermography.

Background: Acupuncture is a method for treating tic disorder. However, there is a lack of sufficient clinical objective basis in regards of its treatment efficacy. Indeed, there are structural abnormalities present in energy metabolism and infrared thermography in children with tic disorder.

[Research progress on bioactive constituents and pharmacological effects of Tibetan medicine Sinopodophylli Fructus].

Sinopodophylli Fructus is a traditional medicine used by the Tibetan people. It is known for its ability to regulate menstruation and promote blood circulation. Presently, bioactive constituents that have been isolated and identified from Sinopodophylli Fructus mainly include 15 lignans(e.

Quantitative transcriptomic and proteomic analyses reveal the potential maintenance mechanism of female adult reproductive diapause in Chrysoperla nipponensis.

Background: The green lacewing Chrysoperla nipponensis is an important natural enemy of many insect pests and exhibits reproductive diapause to overwinter. Our previous studies showed that adult C. nipponensis enters reproductive diapause under a short-day photoperiod.

Facile synthesis and superior properties of a nitrogen-rich energetic Zn-MOF with a 2D azide-bridged bilayer structure.

Exploring the facile synthesis of Pb-free energetic metal-organic frameworks (EMOFs) with both high nitrogen content and high thermostability is a significant but challenging task in the field of MOF-based green energetic materials. Herein, a new EMOF, [Zn(atz)(N)] (atz = 5-amino-1-tetrazole), has been synthesized by simply using a commercial ligand (atz) under mild conditions. A probable mechanism for the formation of azide groups in the product has been proposed, in which the fraction of C-N and N-N bonds in atz is the key.

[Thunder-fire moxibustion combined with mifepristone for ovarian chocolate cyst dysmenorrhea with kidney deficiency and blood stasis: a randomized controlled trial].

Objective: To observe the clinical efficacy of thunder-fire moxibustion combined with mifepristone for ovarian chocolate cyst dysmenorrhea with kidney deficiency and blood stasis.

Methods: Seventy patients were randomly divided into an observation group and a control group, 35 cases in each group. The patients in the the control group were treated with oral administration of mifepristone, 10 mg each time, once a day; based on the treatment of the control group, the patients in the observation group were treated with thunder-fire moxibustion at Guanyuan (CV 4), Zigong (EX-CA 1), Xuehai (SP 10), once every other day.

A catalytic allylic cation-induced intermolecular allylation-semipinacol rearrangement.

A catalytic intermolecular semipinacol rearrangement induced by allylic carbocations has been realized. This tandem reaction is highly efficient under the catalysis of ZnBr, generating a wide range of α-homoallyl substituted ketones which contain all-carbon quaternary centres in good to excellent yields (up to 98%) with moderate to high diastereoselectivities (up to >20 : 1). Synthetic application of this novel methodology in the construction of core structures of natural products is also reported.

Osteoclast-Derived Extracellular Vesicles: Novel Regulators of Osteoclastogenesis and Osteoclast-Osteoblasts Communication in Bone Remodeling.

Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, play an important role in cellular communication during skeletal growth and homeostasis. Bioactive molecules carried by EVs are transported to neighboring and distant cells to trigger a series of signaling cascades influencing bone homeostasis. The bioactive activities of osteoclast-derived EVs include regulation of osteoclastogenesis and osteoclast-osteoblast communication.

Association of interleukin-18 and asthma.

Cytokine-mediated immunity plays a dominant role in the pathogenesis of various immune diseases, including asthma. The recent identification of the family interleukin (IL)-1-related cytokine IL-18 now contributes to our understanding of the fine-tuning of cellular immunity. IL-18 can act as a cofactor for Th2 cell development and IgE production and also plays an important role in the differentiation of Th1 cells.

The Roles of Acidosis in Osteoclast Biology.

The adverse effect of acidosis on the skeletal system has been recognized for almost a century. Although the underlying mechanism has not been fully elucidated, it appears that acidosis acts as a general stimulator of osteoclasts derived from bone marrow precursors cells and enhances osteoclastic resorption. Prior work suggests that acidosis plays a significant role in osteoclasts formation and activation via up-regulating various genes responsible for its adhesion, migration, survival and bone matrix degradation.

Catalytic Asymmetric Construction of α-Quaternary Cyclopentanones and Its Application to the Syntheses of (-)-1,14-Herbertenediol and (-)-Aphanorphine.

A novel and efficient strategy to build α-benzylic quaternary cyclopentanones with excellent enantioselectivities (up to 96 % ee) and high yields (up to 99 % yield) has been developed, and its application demonstrated by the first catalytic asymmetric total synthesis of (-)-1,14-herbertenediol and the formal synthesis of (-)-aphanorphine.

Involvement of acid-sensing ion channel 1a in matrix metabolism of endplate chondrocytes under extracellular acidic conditions through NF-κB transcriptional activity.

Acidic conditions are present in degenerated intervertebral discs and are believed to be responsible for matrix breakdown. Acid-sensing ion channel 1a (ASIC1a) is expressed in endplate chondrocytes, and its activation is associated with endplate chondrocyte apoptosis. However, the precise role of ASIC1a in regulating the matrix metabolic activity of endplate chondrocytes in response to extracellular acid remains poorly understood.

A Mn(III)/TEMPO-co-mediated tandem azidation-1,2-carbon migration reaction of allylic silyl ethers.

A novel Mn(III)/TEMPO-co-mediated tandem azidation-1,2-carbon migration reaction of allylic silyl ethers with an unactivated C=C bond has been explored, generating α-aryl-alkyl β-azido ketones with an α-quaternary stereocenter.

Validity of factorization of the high-energy photoelectron yield in above-threshold ionization of an atom by a short laser pulse.

An analytic description for the yield, P(p), of high-energy electrons ionized from an atom by a short (few-cycle) laser pulse is obtained quantum mechanically. Factorization of P(p) in terms of an electron wave packet and the cross section for elastic electron scattering (EES) is shown to occur only for an ultrashort pulse, while in general P(p) involves interference of EES amplitudes with laser-field-dependent momenta. The analytic predictions agree well with accurate numerical results.

Attosecond streaking in the low-energy region as a probe of rescattering.

The dynamics of low-energy photoelectrons (PEs) ionized by a single attosecond pulse in the presence of an intense infrared (IR) laser field is investigated. Whereas attosecond streaking usually involves momentum shifts of high-energy PEs, when PEs have low initial kinetic energies, the IR field can control the continuum-electron dynamics by inducing PE scattering from the residual ion. A semiclassical model is used to show that particular PE trajectories in the continuum involving electron-ion scattering explain the interference patterns exhibited in the low-energy PE spectrum.

[Protein profiles of multinodular hepatocellular carcinoma with multicentric occurrence or with intrahepatic metastasis].

Objective: To analyze the protein expression profiles of multinodular hepatocellular carcinoma (HCC) with multicentric occurrence (MO) or with intrahepatic metastasis (IM).

Methods: 5 IM and 6 MO patients were divided into groups of IM1, IM2, MO1 and MO2 according to the size of node of HCC. Two dimensional gel electrophoresis (2-DE) and mass spectrum were used to analyze the protein expression profiles.

[Comparison of indirect immunofluorescence assay and ELISA for detecting antinuclear antibodies and anti-double-stranded DNA antibodies].

Objective: To compare indirect immunofluorescence assay (IIFA) and enzyme-linked immunosorbent assay (ELISA) for detecting antinuclear antibodies (ANA) and anti-double-stranded DNA antibodies (anti-dsDNA).

Methods: A total of 125 serum samples were obtained from patients with established or suspected autoimmune disease, and 82 samples were used for ANA detection and 57 for anti-dsDNA detection using both IIFA and ELISA. Fourteen samples were examined for both ANA and anti-dsDNA.

[Comparison between Coulter LH-750 and URIT-12 for measuring hemoglobin concentration].

Objective: To evaluate the feasibility of URIT-12 hemoglobin analyzer for fast measurement of hemoglobin concentration.

Methods: Hemoglobin concentration was detected in 100 random blood samples using URIT-12 hemoglobin analyzer and Coulter LH-750 hematology analyzer.

Results: The two analyzers showed good correlation of the results (r=0.

[Frequency and distribution of variable-number tandem repeats in the genome of Aspergillus niculans].

A total of 30.1 Mb of publicly available DNA sequence in Aspergillus niculans was researched for mono- to hexanucleotide variable-number tandem repeat (VNTR) to determine its type, size and frequency. A total of 4 837 VNTRs were observed in whole genomic DNA sequence with criteria of VNTR length > 15 bp and 80% matches.

[The germinating characters of the transgenic rice seeds in the stress condition of antibiotic G418 and their application in crop breeding].

The seeds of transgenic rice line D2-1-2 and the receptor cultivar Zhonghua No.9 were germinated on the stress condition of the antibiotic G418. The number of taking root seed, the length of root and the length of shoot of two used materials were checked in different concentrations of the antibiotic G418, but the ratio of germinating seed was not affected.