Treatment targets of cellular senescence and circadian rhythms in ischemic stroke.

Ischemic stroke poses a substantial public health burden due to its high incidence, rendering it an urgent medical concern. Emerging evidence suggests that cellular senescence and circadian rhythms are closely linked to the onset of cerebral infarction and may represent promising therapeutic targets. Accordingly, we retrieved datasets GSE16561 and GSE22255 from the Gene Expression Omnibus and extracted cellular senescence- and circadian rhythm-related genes from the GeneCards database.

The global, regional, and national brain and central nervous system cancer burden and trends from 1990 to 2021: an analysis based on the Global Burden of Disease Study 2021.

Background: Brain and central nervous system (CNS) cancers remain a significant contributor to mortality worldwide. This study aims to provide the latest assessment of the prevalence, incidence, mortality, and disability-adjusted life years (DALY) rates of brain and CNS cancers from 1990 to 2021 at the global, regional, and national levels, stratified by sex, age, and the Sociodemographic Index (SDI).

Methods: Data from the Global Burden of Disease (GBD) database were used to analyze the age-standardized prevalence (ASPR), incidence (ASIR), mortality (ASDR), and DALY rates of brain and CNS cancers.

Proteome-wide Mendelian randomization and colocalization analysis identify therapeutic targets for stroke.

Background: Stroke is a leading cause of death and disability worldwide, yet its treatment still faces significant challenges. Mendelian randomization (MR) has been widely used to discover new biomarkers and therapeutic targets. This study aimed to identify therapeutic targets for stroke within the plasma proteome range using MR.

Gastrodin: Modulating the xCT/GPX4 and ACSL4/LPCAT3 pathways to inhibit ferroptosis after ischemic stroke.

Unlabelled: Ischemic stroke ranks as the second leading cause of global mortality and disability. Although reperfusion is crucial for salvaging brain tissue, it carries the risk of secondary injuries, such as ferroptosis. Gastrodin, a neuroprotective compound found in Chinese herbal medicine, may regulate this process.

Causal relationship between human blood metabolites and risk of ischemic stroke: a Mendelian randomization study.

Ischemic stroke (IS) is a major cause of death and disability worldwide. Previous studies have reported associations between metabolic disorders and IS. However, evidence regarding the causal relationship between blood metabolites and IS lacking.