Publications by authors named "Marco Nassisi"
: In rhegmatogenous retinal detachment (RRD), vitreous cortex remnants (VCRs) may contribute to the development and progression of proliferative vitreoretinopathy (PVR). This study aimed to evaluate potential toxicity and trauma secondary to VCRs visualization and removal during pars plana vitrectomy (PPV) for RRD. : Prospective study on patients with primary RRD who underwent PPV.
View Article and Find Full Text PDFAutoimmune Retinopathy in a Patient with Common Variable Immunodeficiency.
Ocul Immunol Inflamm
May 2025
Purpose: To describe a rare case of posterior ocular involvement consistent with an autoimmune retinopathy (AIR) on multimodal retinal imaging in a patient with common variable immunodeficiency (CVID).
Methods: Observational case report.
Results: A 34-year-old male patient with a recent diagnosis of CVID was referred to our clinic following the incidental finding of retinal lesions in his eyes.
Background: to analyze, at one year, the efficacy and safety of treat-and-extend (T&E) intravitreal (IV) Brolucizumab in patients affected by macular neovascularization (MNV). Both naïve and previously treated (i.e.
View Article and Find Full Text PDFAcute Retinal Necrosis Caused by Varicella Zoster Virus and Cytomegalovirus Co-Infection.
Ocul Immunol Inflamm
July 2025
Article Synopsis
- The study reports two cases of acute retinal necrosis (ARN) caused by co-infection of varicella zoster virus (VZV) and cytomegalovirus (CMV), confirmed through polymerase chain reaction (PCR) testing on aqueous fluid.
- Both patients presented with unilateral panuveitis and underwent empirical therapy; PCR results indicated the dual viral infection, which helped tailor their treatment.
- Follow-up imaging showed resolution of the active retinitis, highlighting the critical role of PCR in diagnosing and managing complicated ARN cases in various patient backgrounds.*
Objectives: This independent prospective study evaluated the short-term effects and safety of photobiomodulation (PBM) in early and intermediate age-related macular degeneration.
Methods: patients were treated with PBM in one eye. Functional parameters and drusen volume were measured at one (W4), three- (W12) and six-months (W24) after PBM.
Purpose: To determine the 10-year morphologic outcomes and identify potential risk factors of exudative age-related macular degeneration (AMD) in the fellow eyes (FEs) in patients with naive exudative AMD.
Methods: Data from 100 patients were retrospectively reviewed. Baseline macular neovascularization (MNV) type in the exudative AMD eye and presence of drusen, intraretinal hyperreflective foci, nonfoveal incomplete retinal pigment epithelium and outer retinal atrophy, central retinal thickness, and subfoveal choroidal thickness in the FEs were analyzed as biomarkers for progression in the second eye.
Article Synopsis
- - The study investigated changes in biological, clinical, and imaging markers in carriers of spinocerebellar ataxia (SCA) types 2 and 7 over one year, focusing on MRI and neurofilament light chain (NfL) levels.
- - It included assessments of neurological function, quality of life, and brain imaging among 15 SCA2 carriers, 15 SCA7 carriers, and 10 control subjects, while noting differences in SARA scores and brain volume from baseline measurements.
- - Results indicated significant brain volume loss and worsening motor function in SCA2 carriers, an increase in SARA scores and thinning of retinal layers in SCA7, highlighting the progressive nature of these at
Article Synopsis
- The study investigates the changes in intraretinal hyper-reflective foci (IHRF) over two years in patients with intermediate age-related macular degeneration (AMD) using optical coherence tomography (OCT).
- It found a significant increase in the average number of IHRF per eye after 24 months, with most eyes showing an increase in these foci.
- The results suggest that IHRF predominantly occur in the outer retinal layers and indicate a need for further research on their role in AMD progression.
Article Synopsis
- Reliable biomarkers are essential for gene therapy trials in spinocerebellar ataxias, particularly SCA7 patients.
- The study, conducted in Paris, examined ophthalmological characteristics in 15 SCA7 carriers to explore the relationship between eye health and disease severity.
- Results showed a significant correlation between CAG repeat lengths, disease severity, and various eye conditions, with many participants exhibiting cone or cone-rod dystrophy related to their ataxia scores.
Predictors of lack of response to methotrexate in juvenile idiopathic arthritis associated uveitis.
Rheumatology (Oxford)
February 2025
Objectives: To investigate clinical features associated with lack of response to MTX in juvenile idiopathic arthritis associated uveitis (JIA-U).
Methods: Clinical records of JIA-U patients were retrospectively reviewed. Differences among variables were assessed by Mann-Whitney and χ2 or Fisher's exact tests as appropriate.
Article Synopsis
- The study focuses on inherited retinal degenerations (IRDs) that can lead to blindness, particularly investigating genetic variations in a North African cohort, which has been less studied compared to European and Asian populations.
- Researchers used advanced sequencing techniques and expression analyses on various cell types to identify a new gene defect in the UBAP1L gene in four cases of autosomal recessive IRD from Tunisia.
- Findings suggest that these biallelic UBAP1L variants play a significant role in IRDs, indicating a potential genetic prevalence in the North African population.
Iris Neovascularization After Vitreous Metastasis of a Cutaneous Melanoma.
JAMA Ophthalmol
December 2023
Optical coherence tomography angiography findings in Williams-Beuren syndrome.
Graefes Arch Clin Exp Ophthalmol
April 2024
Article Synopsis
- Williams-Beuren syndrome (WBS) is a rare genetic condition causing various health issues, including potential retinal problems, prompting this study to analyze the eye characteristics in WBS patients using advanced imaging techniques (OCT and OCTA).
- The study included 22 patients with confirmed WBS, revealing significantly reduced retinal thickness, especially in the inner layers, and altered foveal structure compared to an age-matched control group.
- Findings indicated decreased microvascular density and perfusion in patients with WBS, marking the first quantification of these eye changes, suggesting the need for further research to understand their clinical implications.
Background: To compare 24-month real-world outcomes of Vascular Endothelial Growth Factor (VEGF) inhibitors for Polypoidal Choroidal Vasculopathy (PCV) and type 1 Macular Neovascularization (MNV) in a Caucasian population.
Methods: Retrospective analysis from a prospectively designed observational database. Data from Italian centres participating in the Fight Retinal Blindness! (FRB!) project were collected.
Objective: To evaluate the effect of changing slab position on the correlation between choriocapillaris (CC) flow deficits (FD) in eyes with geographic atrophy (GA) and yearly enlargement rate (yER) of GA.
Methods: OCT and OCTA images obtained on Cirrus HD-OCT device were collected from patients with GA. Each patient underwent OCTA scan at baseline and two OCT scans, one at baseline and one after at least 12 months.
Purpose: Intraretinal hyper-reflective foci (IHRF) are optical coherence tomography (OCT) risk factors for progression of age-related macular degeneration (AMD). In this study we assess the change in the number and distribution of IHRF over two years.
Methods: The axial distribution of IHRF were quantified in eyes with intermediate AMD (iAMD) at baseline and 24 months, using a series of 5 sequential equidistant en face OCT retinal slabs generated between the outer border of the internal limiting membrane (ILM) and the inner border of the retinal pigment epithelium (RPE).
The Extraordinary Phenotypic and Genetic Variability of Retinal and Macular Degenerations: The Relevance to Therapeutic Developments.
Cold Spring Harb Perspect Med
June 2024
Article Synopsis
- Inherited retinal diseases (IRDs) are a diverse group of rare conditions that can lead to varying levels of vision impairment and even blindness.
- Current therapeutic options are limited, but the recent approval of the first gene therapy for certain IRDs offers hope for future advancements in treatment.
- The article discusses the challenges posed by the genetic and phenotypic variability of IRDs, the need for accurate phenotypic characterization before genetic testing, and implications for designing clinical trials.
Ocular features in Williams-Beuren syndrome: a review of the literature.
Curr Opin Ophthalmol
November 2023
Purpose Of Review: The current review will discuss the pathophysiology, work-up and clinical relevance of the ocular phenotype in Williams-Beuren syndrome in detail.
Recent Findings: Few case reports, case series and retrospective studies reported the ophthalmic features in Williams-Beuren syndrome, focusing on specific aspects of the ocular involvement. Recently, novel retinal findings have been described in association with the disease.
Relationship between the distribution of intra-retinal hyper-reflective foci and the progression of intermediate age-related macular degeneration.
Graefes Arch Clin Exp Ophthalmol
December 2023
Article Synopsis
- The study examines how intra-retinal hyper-reflective foci (IHRF) seen on optical coherence tomography (OCT) relates to the progression of intermediate age-related macular degeneration (iAMD) over two years.
- Researchers analyzed data from a cohort of iAMD patients, counting IHRF across different retinal layers and correlating changes with the development of late AMD.
- Results indicated a significant increase in IHRF over two years, particularly in the outer retinal layers, which were linked to a higher risk of progression to late AMD, suggesting important differences in how IHRF behaves across different retinal layers.
Purpose: To assess a new optical coherence tomography angiography (OCTA) technology and its contribution to retinal vascularization and choriocapillaris (CC) exploration.
Methods: A new module, named "Beam expander" (BE), which increases the lateral resolution of OCTA, was used in combination with a prototype software in the PLEX® Elite 9000 Swept-Source OCT instrument (ZEISS, Dublin, CA). This prospective study involved 22 healthy subjects imaged with and without BE.
Objectives: To evaluate the outcomes of delayed intravitreal injections (IVIs) caused by the outbreak of coronavirus disease 2019 (COVID-19), in patients with neovascular age-related macular degeneration (nAMD).
Methods: nAMD patients with scheduled IVIs between March 1 and April 30, 2020 were stratified through a risk-based selection into a non-adherent group (NA-group) if they skipped at least one IVI and an adherent group (A-group) if they followed their treatment schedule. During the pandemic visit (v), if a significant worsening of the disease was detected, a rescue therapy of three-monthly IVIs was performed.
Purpose: To report the incidence and risk factors for fibrosis at 10 years in a large cohort of persons with neovascular age-related macular degeneration (nAMD).
Design: Retrospective, multicenter, cohort study.
Methods: We included 225 naive nAMD eyes that underwent intravitreal anti-vascular endothelial growth factor treatment over 10 years of follow-up at two Italian referral centers.
Update on Retinal Vein Occlusion.
Asia Pac J Ophthalmol (Phila)
March 2023
Article Synopsis
- * Advances in diagnosis and treatment over the past 30 years now include newer options like antivascular endothelial growth factors and steroids, moving beyond traditional laser treatment.
- * This review aims to combine established knowledge with recent research, offering insights into the disease's development, features, imaging techniques, and treatment strategies for retina specialists.