An enhanced approach to minimum variance unbiased velocity estimation, incorporating horizontal and vertical handoff in HetNets.

This paper presents an enhanced approach to Minimum Variance Unbiased (MVU) velocity estimation in Heterogeneous-Networks (HetNets) by addressing horizontal and vertical handoffs. In HetNets, the abundance of base stations (BSs) results in frequent unnecessary handoffs and service disruptions for mobile users, posing challenges for mobility management. Accurate velocity estimation is crucial for effective mobility management.

Assessment of Autogenous Cortical Bone Grafting Combined with Guided Tissue Regeneration for Managing Intraosseous Periodontal Defects.

Background: In clinical periodontology, treating intraosseous periodontal abnormalities is still difficult. When combined with guided tissue regeneration (GTR), autogenous cortical bone grafting has shown potential for accelerating the regeneration of periodontal tissue.

Materials And Methods: This randomized controlled clinical study included 30 individuals with intraosseous periodontal abnormalities that were verified by radiography and clinical examination and were between the ages of 25 and 50 years.

An overview on in-vivo generation of CAR-T cells using CRISPR-loaded functionalized nanocarriers for treating B-cell lineage acute lymphoblastic leukemia.

Chimeric antigen receptor T (CAR-T) cell therapy has become a milestone in the management of B cell lineage acute lymphoblastic leukemia. Yet, the traditional method-dependent on ex vivo manipulation, amplification, and reinfusion of autologous T cells-is high-cost, low-scalability, and severely immune-related toxicity. Here, we report a new nano-immunoengineering platform that allows in vivo production of chimeric antigen receptor T cells through the use of functionalized nanoparticles carrying clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein 9 (Cas9) gene editing elements.

Coping and experience post an adverse birth outcome for fathers: a population-based perspective from India.

Introduction: We report on the experience and coping mechanism of the fathers post adverse birth outcome from a population-based representative sample in the Indian state of Bihar.

Methods: A state-representative sample of fathers of stillborn babies and babies who died within neonatal period (newborn deaths) born between July 2020 and June 2021 were interviewed. They reported on socio-demography, supportive experience and coping mechanism post birth/death of their baby, and their opinion on if their baby could have been saved.

Hesitant bi-fuzzy multi-attribute information fusion with expert reliability.

Selecting alternatives wisely is essential in any multi-attribute decision-making (MADM) process, and it requires the participation of multiple experts. Initial decision data and the contributing experts' reliability affect the preciseness of the decision outcomes. However, no expert possesses exhaustive knowledge, and their estimations may exhibit varying preferences.

Evaluation of Dosimetric Efficacy of RapidArc and Intensity-modulated Radiation Therapy Techniques in Head-and-Neck Cancers.

Aim: This study aims to compare the dosimetric efficacy of RapidArc (RA) and intensity-modulated radiation therapy (IMRT) in the treatment of head-and-neck cancer, focusing on treatment efficiency and organ at risk (OAR) dose.

Materials And Methods: A cohort of 10 patients with head-and-neck cancer was recreated for RA, which was earlier treated with IMRT techniques. Dosimetric parameters evaluated or planning target volume (PTV) included monitor units (MUs), beam on time (BoT), gamma passing rate (GP), and various normal tissue dose indices such as V, V, V, V, and gradient indices (gradient index [GI], low GI [LGI], high GI).

Comparative transcriptomic and co-expression network analysis identifies key gene modules involved in heat stress responses in goats.

Heat stress significantly affects livestock production, particularly in tropical regions where temperatures often exceed animals' comfort zones. This study investigates the molecular mechanisms of heat stress tolerance in Jamunapari goats (Capra hircus) through transcriptomic analysis, gene co-expression network construction, and hub gene identification. Female goats (1-2 years old) were monitored during high Thermal Humidity Index (THI) in June and normal THI in March.

Effectiveness of a technical support program with women's self-help groups in catalyzing health and nutrition behaviors in Bihar-a multicomponent analysis.

Introduction: Bihar Rural Livelihoods Promotion Society launched the JEEViKA program in 2007 to improve livelihoods through the Self-Help Group (SHG) platform. Women's SHGs have shown members' health improvements by promoting awareness, practices and access to services. This study investigates whether Health & Nutrition (HN) interventions delivered by JEEViKA Technical Support Program (JTSP) via SHG platforms could improve maternal and newborn health and nutritional behaviors in rural Bihar.

Curcumin enhances developmental competence and ameliorates heat stress in buffalo ) embryos.

Background And Aim: Buffalo is the principal dairy animal and plays a major role in the economic growth of the dairy industry, contributing nearly 50% of the country's milk production. The Buffalo core body temperature is typically 38.5°C, but it can rise to 41.

Enhanced post-thaw functional characteristics of cryopreserved caprine dermal fibroblasts through adhesion to extracellular matrix proteins.

Background: Extracellular matrix (ECM) proteins play a crucial role in regulating the biological properties of adherent cells. For cryopreserved fibroblasts, a favourable ECM environment can help restore their natural morphology and function more rapidly, minimizing post-thaw stress responses.

Methods And Results: This study explored the functional responses of cryopreserved enriched caprine adult dermal fibroblast (cadFibroblast) cells to structural [collagen-IV and rat tail collagen (RTC)] and adhesion ECM proteins (laminin, fibronectin, and vitronectin) under in vitro culture conditions.

A review on effect of nanoparticle addition on thermal behavior of natural fiber-reinforced composites.

Always, the environment in which humans live needs to be saved from various calamities, and one such calamity is usage of petroleum-based products. Petroleum-based products are derived from various synthetic processes that adversely affect the environment. It may not reflect immediately, but it affects in the near future.

Deciphering the molecular mechanisms of heat stress tolerance in goats: Insights from transcriptome and Gene Co-expression analysis.

Climate change poses a significant threat to the sustainability of livestock production systems in developing countries, particularly impacting small ruminants like goats, which are highly susceptible to heat stress. This stressor not only reduces productivity but also undermines economic viability. This study aimed to delve into the molecular mechanisms underlying heat stress tolerance in goats by conducting a comprehensive transcriptome analysis of heat-tolerant (HT, n = 4) and heat-susceptible (HS, n = 6) Jamunapari goats.

Exploring transcriptomic mechanisms underlying pulmonary adaptation to diverse environments in Indian rams.

Background: The Changthangi sheep thrive at high altitudes in the cold desert regions of Ladakh, India while Muzaffarnagri sheep are well-suited to the low altitude plains of northern India. This study investigates the molecular mechanisms of pulmonary adaptation to diverse environments by analyzing gene expression profiles of lung tissues through RNA sequencing.

Methods And Results: Four biological replicates of lung tissue from each breed were utilized to generate the transcriptomic data.

Transcriptomic analysis reveals molecular insights into lactation dynamics in Jakhrana goat mammary gland.

Background: Goat milk is gaining popularity as a superior alternative to bovine milk due to its closer resemblance to human milk. Understanding the molecular processes underlying lactation is crucial for improving milk quality and production in goats. However, the genetic mechanisms governing lactation in goats, particularly in indigenous breeds like the Jakhrana, remain largely unexplored.

Extraction of microcrystalline cellulose from Ficus benghalensis leaf and its characterization.

Microcrystalline cellulose (MCC) is a crucial component in various industries, including pharmaceuticals, culinary, and cosmetics. The growing demand for MCC has spurred research into extraction methods. This study focused on extracting MCC from Ficus benghalensis using acid hydrolysis to convert the alpha-cellulose content of its leaves into MCC.

Characterization of plant leaves biomass-based bioplasticizers for biofilm applications.

The present surge in environmental consciousness has pushed for the use of biodegradable plasticizers, which are sustainable and abundant in plant resources. As a result of their biocompatibility and biodegradability, leaf plasticizers (CLP) serve as viable alternatives to chemical plasticizers. First time, the natural plasticizers from the Calotropis leaves were extracted for this study using a suitable chemical approach that was also environmentally friendly.

The Role of Satellites in the Evolution of Begomoviruses.

Begomoviruses have emerged as destructive pathogens of crops, particularly in the tropics and subtropics, causing enormous economic losses and threatening food security. Epidemics caused by begomoviruses have even spread in regions and crops that were previously free from these viruses. The most seriously affected crops include cassava; cotton; grain legumes; and cucurbitaceous, malvaceous, and solanaceous vegetables.

Comparative transcriptome profile of embryos at different developmental stages derived from somatic cell nuclear transfer (SCNT) and in-vitro fertilization (IVF) in riverine buffalo (Bubalus bubalis).

Somatic cell nuclear transfer (SCNT) is a very important reproductive technology with many diverse applications, such as fast multiplication of elite animals, the production of transgenic animals and embryonic stem (ES) cells. However, low cloning efficiency, a low live birth rate and the abnormally high incidence of abnormalities in the offspring born are attributed to incomplete or aberrant nuclear reprogramming. In SCNT embryos, the aberrant expression pattern of the genes throughout embryonic development is responsible for the incomplete nuclear reprogramming.

Skeletal muscle transcriptomics of sheep acclimated to cold desert and tropical regions identifies genes and pathways accentuating their diversity.

The current study attempts to investigate the differences in gene expression in longissimus thoracis muscles between sheep breeds acclimated to diverse environments. Changthangi sheep inhabits the cold arid plateau of Ladakh, at an altitude above 3000 m with prevalence of rarefied atmosphere. Muzzafarnagri sheep, on the other hand is found in the sub-tropical hot and humid plains at an altitude of about 250 m.

Ecological weed management and square planting influenced the weed management, and crop productivity in direct-seeded rice.

Herbicide use may pose a risk of environmental pollution or evolution of resistant weeds. As a result, an experiment was carried out to assess the influence of different non-chemical weed management tactics (one hoeing (HH) at 12 DAS followed by (fb) one hand weeding at 30 DAS, one HH at 12 DAS fb Sesbania co-culture and its mulching, one HH at 12 DAS fb rice straw mulching @ 4t ha, one HH at 12 DAS fb rice straw mulching @ 6 t ha) on weed control, crop growth and yield, and economic returns in direct-seeded rice (DSR). Experiment was conducted during kharif season in a split-plot design and replicated thrice.

Technical NEMA NU2-2018 Performance Assessment of Time-of-Flight-Integrated Digital PET-CT System.

 The objective of this study includes the NEMA (National Electrical Manufacturer Association) NU2-2018 performance evaluation of the uMIvista PET-CT (positron emission tomography-computed tomography) system.  The latest NEMA NU2-2018 guidelines have been followed for the evaluation of performance parameters of this PET-CT scanner: axial, tangential, and radial spatial resolution, sensitivity, counting losses, scatter, randomness, random and counting loss correction, image quality, time and energy resolution, image uniformity, and image registration alignment post installation of country first uMIvista PET-CT.  The measured NEMA sensitivity of the uMIvista PET scanner was 12.

Molecular insights into Pashmina fiber production: comparative skin transcriptomic analysis of Changthangi goats and sheep.

Ladakh, one of the highest inhabited regions globally, hosts the unique Changthangi goat, renowned for producing Pashmina, the world's most luxurious natural fiber. In comparison, the fiber derived from Changthangi sheep is considered next only to Pashmina. This research endeavors to compare the skin transcriptome profiles of Changthangi goats and Changthangi sheep, aiming to discern the molecular determinants behind the recognition of Changthangi goats as the source of Pashmina.

Comprehensive evaluation and validation of optimal reference genes for normalization of qPCR data in different caprine tissues.

Background: Quantitative real-time PCR (qPCR) is a highly reliable method for validating gene expression data in molecular studies due to its sensitivity, specificity, and efficiency. To ensure accurate qPCR results, it's essential to normalize the expression data using stable reference genes.

Methods: This study aimed to identify suitable reference genes for qPCR studies in goats by evaluating 18 candidate reference genes (ACTB, BACH1, B2M, GAPDH, HMBS, HPRT1, PGK1, PPIA, PPIB, RPLP0, RPL19, RPS9, RPS15, RPS28, SDHA, TBP, UXT, and YWHAZ) in 10 different caprine tissues (heart, intestine, kidney, liver, lung, muscle, rumen, skin, spleen, and testis).