Publications by authors named "Manoj Kumar Nayak"

Lung cancer is the leading cause of cancer and cancer-related deaths, and India ranks the fourth highest country. Lung cancer is a highly aggressive malignancy with a tendency for rapid progression, making early detection and prompt treatment essential for improving patient outcomes. Lung cancer can spread locally into surrounding tissue as well as travel through lymphatics to other parts of the body, most often to bone, brain, liver, and adrenal glands.

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The thalamus, a gray matter structure, is a crucial relay for various afferent and efferent pathways in the brain. It receives its primary blood supply from the thalamoperforating and thalamogeniculate branches of the posterior cerebral arteries. Damage to the thalamus can lead to classical sensorimotor and amnestic syndromes, as well as neuro-ophthalmological manifestations, including vertical gaze palsy (VGP), pseudo-abducens palsy, skew deviation, cerebral ptosis, and Horner's syndrome.

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Background: Percutaneous transhepatic biliary drainage (PTBD) is a widely used palliative intervention to relieve symptoms and reduce bilirubin levels to facilitate further treatments. However, data regarding its clinical outcomes and impact on quality of life (QOL), particularly in the Indian population, are limited. This prospective observational study intends to analyze the clinical outcomes, complication profile, factors affecting the clinical outcomes, and QOL assessment following PTBD in patients with malignant biliary obstruction (MBO).

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A male in his early 70s presented with complaints of bilateral flank pain for seven months, hematuria for 2 days along with the passage of clots associated with an increased frequency of urination and nocturia. The patient had a history of deep vein thrombosis and was on anticoagulation. On ultrasound, multiple calculi with posterior acoustic shadowing were seen in bilateral kidneys, corroborated by (CT) urography.

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 Preoperative magnetic resonance imaging (MRI) has an important role in the management and prognostication of parotid gland tumors. We aim to evaluate the role of multiparametric MRI in differentiating the major subgroup of parotid tumors.  Multiparametric MRI: T1-weighted imaging (T1WI), T2WI, diffusion-weighted imaging (DWI), pseudo-continuous arterial spin labeling (ASL) and dynamic contrast-enhanced (DCE) imaging were acquired in all patients.

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A carotid-cavernous fistula (CCF) is an abnormal communication between the carotid artery and the cavernous sinus, which can be of a direct or indirect type. Treatment decisions are based on factors such as the type of CCF, angioarchitecture, severity of clinical symptoms, and risk of vision loss. While most fistulas necessitate endovascular intervention, there are isolated reports of indirect low-flow fistulas resolving with manual vascular compression therapy alone.

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Castleman disease (CD) is a rare lymphoproliferative disorder that can affect lymph nodes of any part of the body including the neck, chest, abdomen and pelvis. The most common involved site is the mediastinum. Parotid gland may be involved as a part of multicentric CD.

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Encephalocraniocutaneous lipomatosis (ECCL) is a rare neurocutaneous multisystem disorder affecting ectodermal and mesodermal tissues, including the eyes, skin, adipose tissue and the brain. It is hypothesised to be a neural crest disorder. While ECCL presents with various neurological features, the occurrence of brain tumour is an extremely rare association.

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Endovascular stenting has emerged as the gold standard for treating various occlusive vascular disorders. However, it has its own challenges. Reperfusion injury, a paradoxical tissue damage that occurs after the restoration of blood flow, is one such challenge seen with endovascular interventions.

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Extramedullary haematopoiesis (EMH) refers to ectopic haematopoietic elements outside the bone marrow. Although it frequently occurs in the liver, spleen and lymph nodes, EMH presenting as a destructive lytic lesion of the sacrum with associated presacral soft tissue mass masquerading as malignancy has been scarcely reported. Imaging workup on a pregnant woman suspected of having haemolytic anaemia revealed a lytic destructive lesion involving the sacrum with homogeneously enhancing presacral soft tissue density mass.

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Immunoglobulin G4-related disease (IgG4-RD) is a distinct immunoinflammatory disorder of unknown aetiology that may involve one or more organs, either synchronously or metachronously. Nonetheless, the pathophysiological mechanism is complex and poorly understood. The hepatobiliary manifestations of IgG4-RD [IgG4-hepatobiliary (IgG4-HB)], per se, have been sporadically reported in the literature.

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Stroke is one of the major causes of mortality and morbidity, particularly among the elderly population. As the general population ages, cerebrovascular disease is anticipated to increase in prevalence. Strokes can manifest as either hemorrhagic or ischemic events.

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Budd-Chiari syndrome with obstruction in the inferior vena cava causes increased venous pressure in the azygous-hemiazygous system and paravertebral venous plexus, which is transmitted to the epidural venous plexus, devoid of the valves. It causes epidural venous plexus engorgement and venous congestion and may present rarely with low back pain or radiating pain. However, patients developing lower limb weakness as a complication of Budd-Chiari syndrome is an infrequent and severe presentation.

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Objective: Transthoracic CT-guided lung biopsy is associated with risk of pneumothorax, requiring chest tube placement at times. From available literature, we tried to compare the incidence rate of pneumothorax in cases undergoing CT-guided lung biopsy with versus without use of gelfoam slurry for tract occlusion.

Methods: Databases like SCOPUS, PubMed, Google Scholar, and EMBASE were searched for original studies analysing the efficacy of gelfoam for needle tract embolization following CT-guided lung biopsy till September 2023.

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EAST syndrome - Epilepsy, Ataxia, Sensorineural hearing loss, and renal Tubulopathy - is an autosomal recessive disorder affecting the potassium channel in the brain, inner ear, and basolateral membrane of the distal nephron of the kidney. The mutation in the gene is responsible for defective potassium transport in those locations, resulting in seizures, hearing loss, and hypokalemia. Imaging findings of this disease are typical, such as cerebellar hypoplasia and signal changes in bilateral dentate nuclei, midbrain, pons, and medulla, with variable restricted diffusion due to intramyelinic edema.

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Tinnitus refers to the perception of sound without any external stimuli which can be pulsatile or non-pulsatile. Dilated mastoid emissary vein (MEV) can cause pulsatile tinnitus. Herein, we report a case of persistent pulsatile tinnitus with dilated MEV managed successfully with percutaneous coiling of MEV in a 36 years male.

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Posterior pituitary ectopia is a very rare entity in the development of the pituitary gland. Several factors and multiple genes are associated with this entity causing both pituitary and extrapituitary abnormalities. Pituitary abnormalities can be various endocrine problems and extrapituitary abnormalities can be optic nerves and cerebellar hypoplasia, heterotopia, and abnormal vessels.

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In this study, the impact of formulated emulsion was studied on strawberries which were coated using dip and electrostatic spray coating methods. The coated strawberries were kept at room temperature for a period of 12 days. A significant level of chargeability of w/o emulsion was achieved in terms of charge-to-mass ratio of 2.

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We wanted to evaluate if optical coherence tomography angiography OCTA findings could predict the functional outcome in extracranial carotid artery atherosclerotic disease (ECAD) associated stroke. This exploratory study was performed on adults with acute ischaemic stroke due to ECAD at 3-6 weeks following stroke onset with risk factor matched controls without carotid artery stenosis. Twenty-three stroke patients (cases) and 23 controls were enrolled.

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Background: Splenic sequestration crisis is a potentially fatal complication of sickle cell disease, mainly seen in young children. Only a few case series describe the acute splenic sequestration crisis in adults and its management, which primarily consists of supportive care and, in some cases, splenectomy. Splenic artery embolization has seldom been described in sickle cell disease.

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Simultaneous occlusion of both middle cerebral arteries (MCAs) is very rare and usually devastating. Few case reports are available in the literature where bilateral thrombectomy was done simultaneously to remove the clot. High NIH stroke scale with a low level of consciousness can be a clue for the diagnosis.

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