Experimental assessment of photodynamic therapy effects on 4NQO-induced rat tongue carcinogenesis: Clinical, morphological, and immunohistochemical analysis.

The present study aimed to evaluate the safety of photodynamic therapy (PDT) during oral carcinogenesis using a 4-nitroquinoline 1-oxide (4NQO) rat model, which serves as a surrogate for tobacco-induced oral cancer. Forty male Wistar rats received 4NQO (25 ppm) in drinking water for either 12 or 20 weeks to induce oral lesions. Animals were divided into two groups: Control and PDT.

Deciphering NOTCH1 as a Biomarker in Adenoid Cystic Carcinoma: Insights From a Systematic Review With Meta-Analysis.

Background: Most studies suggest that NOTCH1 alterations are associated with prognosis in adenoid cystic carcinoma (ACC), but findings remain fragmented. We conducted an integrative analysis to evaluate the prognostic value of NOTCH1-related biomarkers in ACC.

Methods: A comprehensive search was conducted across multiple databases.

Clinicopathological Study of Oncocytomas of Head and Neck Region: A Systematic Review.

Background: Salivary gland oncocytomas are infrequent benign salivary gland tumors with few reported cases.

Aims: This study aimed to systematically review case reports and case series studies on oncocytomas in the head and neck region.

Materials & Methods: Electronic searches were performed in PubMed, Scopus, Web of Science, Embase, and LILACS databases.

Non-Profit Organizations Advocating for Head and Neck Cancer Patients: A Scoping Review.

Purpose: To identify and characterize non-profit organizations (NPOs) from English-speaking countries providing advocacy to individuals with head and neck cancer (HNC) and critically analyze the multifaceted roles played by these NPOs for patients, caregivers, healthcare professionals, and researchers.

Methods: A scoping review was conducted through PubMed, Scopus, EMBASE, Web of Science, Google Scholar, ProQuest, and open databases. The data collected on the NPOs were: information on origin, founder background, cancer types addressed, mission, and information and services offered.

Germline Variations in Patients With Oral Squamous Cell Carcinoma-Systematic Review.

Objective: Integrate studies on germline variations (GV) in patients with oral squamous cell carcinoma (OSCC), aiming to assess the highest frequencies of which genes were altered in patients with this diagnosis.

Methods: An electronic search was conducted in four databases and in the gray literature, following the PRISMA 2020 recommendations. Case reports, case series, case-control studies, cross-sectional studies, prospective cohort studies, and retrospective cohort studies reporting GV in patients with OSCC were included for data extraction.

Fluence-dependent infrared photobiomodulation remodels chromatin architecture to enhance chemosensitivity in head and neck tumors.

Photobiomodulation (PBM) therapy has emerged as a noninvasive therapeutic modality capable of modulating cellular processes through the targeted delivery of light. In this study, we investigated the effects of an infrared PBM on adenoid cystic carcinoma (ACC) cells, with a focus on fluence-dependent chromatin remodeling and the potential to enhance chemosensitivity to cisplatin. Using a range of energy densities, we observed that up to 26.

Future Perspectives in Senescence-Based Therapies for Head and Neck Cancer.

Cellular senescence is a complex physiological process in which cells permanently stop dividing and enter a stable state of cell-cycle arrest. This mechanism is typically triggered by various stressors, such as DNA damage, oxidative stress, telomere shortening, and oncogene activation. Senescent cells remain metabolically active and significantly influence their microenvironment through the senescence-associated secretory phenotype (SASP), which includes the secretion of inflammatory cytokines, growth factors, and proteases.

Remote Consultations for Monitoring Actinic Cheilitis: A Preliminary Non-Randomized Clinical Trial.

Objective: To evaluate the feasibility of remote consultation for monitoring actinic cheilitis.

Materials And Methods: A cross-over, non-randomized clinical trial comparing remote and in-person consultations for patients with actinic cheilitis. During the remote consultations, patients were interviewed and submitted clinical photos taken with smartphones.

Shedding light on Brazil's contribution to photobiomodulation research in oral medicine: a bibliometric study.

The aim of this study was to verify the role of Brazilian researchers in publications related to photobiomodulation (PBM) in the field of oral medicine. We examined ten years from 2012 to 2022 across 16 journals. Our analysis included scientific publications with a Brazilian author either in the first or last position and publications from international collaborations.

Effects of ovariectomy-induced osteoporosis and two photobiomodulation protocols on the repair of apical periodontitis in Wistar rats: A microCT study.

Aim: Osteoporosis is a disease that is related to a higher prevalence and greater volumes of apical periodontitis. The purpose of this study was to evaluate the effect of ovariectomy-induced osteoporosis and high- or low-level laser photobiomodulation (PBM) on the repair of apical periodontitis (AP) in adult female Wistar rats.

Methodology: Sixty female Wistar rats (n = 120) were randomly allocated into four control (n = 6 teeth) and 8 experimental (n = 12 teeth) groups, according to procedure and time of evaluation: healthy control (GCS14/GCS28), osteoporotic control (GCO14/GCO28), sham (SHAM14/SHAM28), osteoporotic (OVX14/OVX28), low-level laser (OVX-LLL14/OVX-LLL28) and high-level laser (OVX-GEM14/OVX-GEM28).

Oral adverse effects of head and neck radiotherapy with/without chemotherapy in a southern Brazil hospital.

The aim of this study was to evaluate the main oral adverse effects and their relationship with dental care before radiotherapy (RT) and combined RT and chemotherapy (RT+CT). Additionally, we assessed the association of other risk factors with the development of these adverse effects. This paper is a retrospective cross-sectional analytical study of data from medical records of patients with head and neck cancer (HNC) who underwent RT or RT+CT attended at the stomatology unit in a southern Brazil hospital.

Wound healing and pain evaluation following diode laser surgery vs. conventional scalpel surgery in the surgical treatment of oral leukoplakia: a randomized controlled trial.

Objectives: This study aimed to compare patient-reported pain scores and clinician-assessed healing outcomes following the treatment of oral leukoplakia (OL) with a diode laser vs. a conventional scalpel.

Methods: A randomized, double-blind clinical trial (Brazilian Clinical Trials Registry (RBR-7pgcyq) was conducted involving histopathologically confirmed OL patients.

Targeted Therapy for the Management of Oral Potentially Malignant Disorders: A Systematic Review.

Objective: This study aimed to integrate the available data published in the literature to identify and elucidate the impact of targeted therapy for oral potentially malignant disorders (OPMDs).

Material And Methods: This systematic review was conducted according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) 2020 statement. An electronic search across five databases with no publication date restriction was conducted in January 2023 and subsequently updated in January 2024.

Preventive Photobiomodulation for Chemotherapy-Induced Oral Mucositis: A Systematic Review of Randomized Clinical Trials.

Oral mucositis (OM) is the most common acute complication among cancer patients. It initially manifests as an inflammatory process, beginning with erythema and edema of the oral mucosa, progressing to erosive lesions, and ultimately leading to highly painful ulcers. This systematic review seeks to evaluate the efficacy of preventive PBM protocols in mitigating chemotherapy-induced OM.

Artificial intelligence in healthcare applications targeting cancer diagnosis-part II: interpreting the model outputs and spotlighting the performance metrics.

Background: The lack of standardized performance assessment metrics and the inconsistent reporting of results can lead to the presentation of overly optimistic outcomes that fail to accurately represent key aspects of the Machine Learning framework and may not align with real-world clinical needs.

Methods: This conceptual review of the literature compiled the theoretical basis for performance analysis of binary and multiclass models.

Results: Accuracy and error rates are straightforward but not ideal if dataset is imbalanced.

Artificial intelligence in healthcare applications targeting cancer diagnosis-part I: data structure, preprocessing and data organization.

Background: Machine learning techniques hold significant potential to support the diagnosis and prognosis of diseases. However, the success of these approaches is heavily dependent on rigorous data acquisition, preprocessing and data organization.

Methods: This article reviews the literature to evaluate key factors in dataset construction, focusing on data structure, preprocessing, and data organization, particularly in the context of imaging data.

Oral microbiota in head and neck cancer patients during radiotherapy: a systematic review.

Purpose: Radiotherapy (RT) in the head and neck (HN) area causes a series of oral complications and the oral microbiota may play an important role in these complications. The aim of this systematic review was to explore alterations in the oral microbiota among individuals undergoing RT in the HN region.

Methods: A comprehensive search across six databases and grey literature was made.

Oral cancer immunology: state of the art and future perspectives.

Oral cancer is a multifactorial disease involving genetic, epigenetic, and environmental factors. The literature indicates that inflammatory cells at the advancing front of the tumor induce a host immune response, preventing the spread of the tumor. However, cancer cells adopt various continued strategies to circumvent this immune surveillance.

Comparative Study of OLP and OLL: Demographic and Clinical Profile in a Reference Center in Brazil.

Objective: To compare the demographic and clinical profiles of oral lichen planus (OLP) and oral lichenoid lesions (OLL) diagnosed at a reference center in Southern Brazil from 2010 to 2019.

Methods: This retrospective study included 117 cases of suspected OLP submitted for biopsy. Investigated variables comprised sociodemographic profiles, medical history, harmful habits, clinical characteristics, and histopathological features.

Evaluation of vascular photobiomodulation for orofacial pain and tension type headache following COVID 19 in a pragmatic randomized clinical trial.

This pragmatic double-blind randomized clinical trial aims to assess the impact of vascular photobiomodulation on post-COVID-19 patients experiencing tension-type headache, orofacial pain, or both persisting for more than 3 months. Participants were divided into two groups: vascular photobiomodulation (VPBM) and simulated VPBM. Their conditions were evaluated using the Brief Pain Inventory (BPI), Visual Analogue Scale, and Headache Impact Test (HIT-6).

Invasive cervical root resorption in a cancer patient: A rare case report with 2 years of follow-up and literature review.

Introduction: Cases involving invasive cervical root resorption (ICRR) in oncological patients are rare, in addition, follow-up of these patients has not yet been reported in the literature.

Objective: This study aims to present a literature review and report a case of denosumab as a possible cause of ICRR in a patient with breast cancer with 2 years of follow-up.

Case Report: A 39-year-old female with a history of luminal breast cancer was treated with denosumab semiannually for osteopenia with discontinuation 1 year ago.

Genetic Variants Influence the Severity of Oral Mucositis in Pediatric Osteosarcoma Patients.

Background: The variability in patients' risk of oral mucositis (OM) has been, in part, attributed to differences in host genomics. The aim better define the role of genomics as an OM risk by investigating the association between genetic variants and the presence and severity of OM in pediatric patients with osteosarcoma (OS) undergoing chemotherapy (CT).

Methods: A longitudinal observational retrospective study was conducted.

Investigating the safety of photobiomodulation in oral carcinogenesis: insights into cell proliferation, invasion, and apoptosis via the 4NQO model.

The present investigation aimed to assess the safety of photobiomodulation (PBM) on the oral carcinogenesis process induced by 4NQO, focusing on cell proliferation and apoptosis. Sixty-six Wistar rats received systemic 4NQO for 12 (n = 33) and 20 weeks (n = 33), divided into Control group, PBM 0.3 J, and PBM 1 J.

Impact of an educational intervention regarding tobacco counseling on dentists and dental students.

The present study aimed to assess the knowledge, attitudes, and perceptions of dental professionals and students regarding tobacco cessation counseling (TCC) after their participation in a continuing education activity (CEA) entitled "Smoking cessation: How does the dentist participate in this decision?" at the Oral Cancer Seminar: Projeto Maio Vermelho 2021. This study utilized a pre-/post-intervention design, including a pre-intervention questionnaire with 20 close-ended questions, an educational intervention, and a post-intervention questionnaire with nine close-ended questions. Descriptive and statistical analyses were performed using SPSS 25 and GraphPad Prism 8 software.