Publications by authors named "Mahdi Babaie"

As a highly fundamental crop with a strategic role in human and animal nutrition, corn is frequently contaminated with mycotoxins. Mycotoxin contamination of corn poses substantial risks to human health. This study aimed to evaluate the concentration of aflatoxins levels in three popular brands of cheese puffs prepared from corn flour.

View Article and Find Full Text PDF
Article Synopsis
  • Antivenom serums, derived mainly from equine and sheep, are the primary treatment for snake bites and other animal venoms, and this study explores using caprylic acid (CA) for their purification.
  • The method involves obtaining plasma from animals immunized with multiple venom types, where different concentrations of CA are tested against traditional ammonium sulfate precipitation for protein purification.
  • Results show that while ammonium sulfate yields higher protein precipitation, 5% CA achieves the strongest purification results and has the potential to address antivenom shortages in Iran.
View Article and Find Full Text PDF

Objectives: Nowadays cancer treatment is an important challenge in the medical world that needs better therapies. Many active secretions produced by insects such as honey bees used to discover new anticancer drugs. Bee venom (BV) has a potent anti inflammatory, anti cancer and tumor effects.

View Article and Find Full Text PDF

Objectives: Venomous fishes have different pharmacological effects and are useful. Among the venomous fish, stonefishes; especially Pseudosynanceia melanostigma has various pharmacological effects on the nervous, muscular and cardiovascular system of humans. In this study, toxicological characteristics, some blood effects, pharmacological and enzymatic properties of Pseudosynanceia melanostigma venom was investigated.

View Article and Find Full Text PDF
Article Synopsis
  • - The study focused on Mycobacterium bovis, the bacteria causing bovine tuberculosis, and its transmission to humans through unpasteurized milk and contaminated meat, aiming to compare its genomic patterns in human cases from Zanjan province with cattle strains in Iran.
  • - DNA was collected from two M. bovis strains from human patients, and analysis was conducted using advanced fingerprinting methods (RFLP and DNA hybridization) to identify genetic variations compared to a larger set of cattle strains.
  • - Results showed no genetic correlation between M. bovis strains from Zanjan and those from the Razi Tuberculin Reference Laboratory, indicating past M. bovis infections in Zanjan may have recurred independently without
View Article and Find Full Text PDF

Objective/background: Tuberculosis (TB) is one of the most common infectious diseases in Iran and around the world. Diagnosis of this disease in many cases is difficult and often requires the use of paraclinical methods. Current diagnostic methods are either too slow or lack enough sensitivity or specificity.

View Article and Find Full Text PDF

Objectives: Mellitine, a major component of bee venom (BV, ), is more active against gram positive than gram negative bacteria. Moreover, BV has been reported to have multiple effects, including antibacterial, antivirus, and anti-inflammation effects, in various types of cells. In addition, wasp venom has been reported to have antibacterial properties.

View Article and Find Full Text PDF

Objectives: Bee venom (BV) is a complex mixture of proteins and contains proteins such as phospholipase and melittin, which have an effect on blood clotting and blood clots. The mechanism of action of honey bee venom (HBV, Apis mellifera) on human plasma proteins and its anti-thrombotic effect were studied. The purpose of this study was to investigate the anti-coagulation effect of BV and its effects on blood coagulation and purification.

View Article and Find Full Text PDF

Objective(s): Echis carinatus is one of the venomous snakes in Iran. The venom of Iranian Echis carinatus is a rich source of protein with various factors affecting the plasma protein and blood coagulation factor. Some of these proteins exhibit types of enzymatic activities.

View Article and Find Full Text PDF

Background: The venom of the family Viperidae, including the saw-scaled viper, is rich in serine proteinases and metalloproteinases, which affect the nervous system, complementary system, blood coagulation, platelet aggregation and blood pressure. One of the most prominent effects of the snake venom of Echis carinatus (Ec) is its coagulation activity, used for killing prey.

Materials And Methods: Subfractions F1A and F1B were isolated from Ec crude venom by a combination of gel chromatography (Sephadex G-75) and ion exchange chromatography on a DEAE-Sepharose (DE-52).

View Article and Find Full Text PDF

Many snake venoms comprise different factors, which can either promote or inhibit the blood coagulation pathway. Coagulation disorders and hemorrhage belong to the most prominent features of bites of the many vipers. A number of these factors interact with components of the human blood coagulation.

View Article and Find Full Text PDF