Evaluation of Bio-Stimulation Effects of Various Dermal Fillers: Hyaluronic Acid-Based Polynucleotides and Microparticle Fillers in Mouse Model.

Background: Dermal fillers have become prevalent in aesthetic surgery, offering noninvasive solutions for addressing signs of aging and enhancing facial features.

Methods: In this study, the in vivo administration of dermal fillers, including a hyaluronic-cross-linked filler (HA-R), a PDLLA-HA combined filler (HA-PDLLA), a microparticle PDO filler (PDO), a PN filler extracted from salmon milt (PN), and pure hyaluronic acid (HA), along with PBS as a control, was evaluated over a 12 week period.

Results: HA-R exhibited sustained volume retention, contrasting with rapid volume loss observed with PN, and gradual dissolution of PDO by week 12.

Assessment of a Helium/Argon-Generated Cold Atmospheric Plasma Device's Safety Utilizing a Pig Model.

The PlazMagik device is a dual-gas cold atmospheric plasma (CAP) system that was developed and used for skin rejuvenation and inflammation treatment. However, preclinical evaluation and optimization of plasma parameters are crucial for guaranteeing safety. Therefore, this study was performed to evaluate the safety of the PlazMagik device under multiple parameters with different gas resources (helium (He) and argon (Ar) gases) on pig dorsal skin.

HCV RNA Quantification by a Domestic Commercial Assay: A Case Study among People Who Inject Drugs in Vietnam.

The desired performance of nucleic acid testing (NAT) may vary if used for disease diagnosis or for the evaluation of the therapeutic efficacy of a treatment, although in most cases, the same assay is used. However, these tests may not be affordable in many situations including in low/middle income countries that in response have developed domestic assays. Given the example of HCV NAT among people who inject drugs in Vietnam, we aimed at evaluating a domestic assay versus an FDA- and CE-approved assay.

Pathogenicity and fungicide sensitivity of Phytophthora parvispora, a new pathogen causing gummosis and root rot disease on citrus trees.

In 2021, pomelo (Citrus grandi) trees grown in Tuyen Quang and Phu Tho in northern Vietnam suffered from leaf yellowing, gummosis on stems, brown rot on fruit, and black rot on roots. Based on morphological and sequence analysis of the ITS and cox1 gene regions, the pathogen causing gummosis and root rot of citrus trees was identified as Phytophthora parvispora. Pathogenicity assays using mycelial plugs and zoospore suspension showed that P.

Complementary combination of biomarkers for diagnosis of sarcopenia in C57BL/6J mice.

Aims: The objective of this study is to provide a reliable strategy for the diagnosis of sarcopenia based on a complementary combination of biomarkers from various approaches.

Material And Methods: A total of 30 C57BL/6J mice were used for the experiment, in which 15 young mice (YM) at 24 weeks old and 15 aged mice (AM) at 88 weeks old. Extracted features-based digital biomarkers from the electromyography activity of tibialis anterior muscles were evaluated by using receiver operating characteristic analysis.

Long-Term Persistence of Mitochondrial DNA Instability among HCV-Cured People Who Inject Drugs.

People who inject drugs (PWID) are a population exposed to many genotoxicants and with a high prevalence of HCV infection. Direct-acting antiviral (DAA) regimens are now widely used to treat chronic HCV infection. Although side effects to treatment are currently rare, the long-term effects such as suspicions of de novo hepatocellular carcinoma (HCC) occurrence or HCC recurrence and cardiac defects are still up for debate.