Intensive care unit outcomes and prognostic factors of esophageal cancer: A cross-sectional study in Chinese cancer-specialized hospitals.

Background: Esophageal cancer patients had the highest intensive care unit (ICU) admitted rate in cancer patients. But their prognosis and evaluation methods were rarely studied.

Aim: To depict the short-term mortality outcome and identify the potential prognostic factors of esophageal cancer patients admitted into ICU.

Non-solvent cinnamic acid-based gel patch for transdermal drug delivery.

Introduction: Drugs entitled polymeric network special functions in bio-applications. However, the introduction of appropriate solvent for drugs generally incurred tedious inclusion methods, intensive chemical design and aging caused by solvent loss. Herein, a novel non-solvent gel system was proposed for water-insoluble drug loading and subsequent controlled transdermal drug release.

Triazine-Based Porous Organic Polymers with High CO Adsorption Capacity: Enhancing Flame Retardancy and Preventing Molten Dripping in Biobased Nylon 56.

Biobased Nylon 56 is inherently flammable and prone to producing significant melt droplets during combustion, presenting substantial challenges for flame-retardant applications. Herein, we propose a novel and eco-friendly flame-retardant strategy for Nylon 56 by leveraging the high CO adsorption capacity of triazine-based organic porous polymers. These triazine-based organic porous polymers (PTs), constructed within the fabric through a simple in situ polymerization process, form a robust protective barrier during combustion.

Transcription factors ERF74/77/108/125 enhance thermotolerance in rice by regulating common and distinct heat-responsive gene expression.

Heat stress severely impacts crop productivity, necessitating the identification of key regulatory genes for improving thermotolerance. Here, we demonstrate that the rice nuclear-localized AP2/ERF transcription factors ERF74/77/108/125 function as critical regulators of heat stress responses. Loss-of-function mutant seedlings of ERF74/77 or ERF108/125 exhibit increased heat sensitivity, whereas overexpression of each ERF74, ERF77, ERF108 or ERF125 individually enhances thermotolerance, indicating their positive role in heat adaptation.

[Characteristics of Gut Microbiota Changes and Their Relationship with Infectious Complications During Induction Chemotherapy in AML Patients].

Objective: To investigate the characteristics of gut microbiota changes in patients with acute myeloid leukemia (AML) undergoing induction chemotherapy and to explore the relationship between infectious complications and gut microbiota.

Methods: Fecal samples were collected from 37 newly diagnosed AML patients at four time points: before induction chemotherapy, during chemotherapy, during the neutropenic phase, and during the recovery phase. Metagenomic sequencing was used to analyze the dynamic changes in gut microbiota.

Prognostic value of preoperative fibrinogen, neutrophil-to-lymphocyte ratio, serum alpha-fetoprotein, and prealbumin for patients with primary liver cancer undergoing transarterial chemoembolization.

Background: Primary liver cancer, predominantly hepatocellular carcinoma (HCC), is a major cause of cancer-related mortality. Transarterial chemoembolization (TACE) is a key palliative option for unresectable HCC. However, prognostic outcomes after TACE vary significantly.

Development and Initial Validation of the Multi-dimensional Attention Rating Scale in Highly Educated Adults.

Objectives: To report the development, validation, and findings of the Multi-dimensional Attention Rating Scale (MARS), a self-report tool crafted to evaluate six-dimension attention levels.

Methods: The MARS was developed based on Classical Test Theory (CTT) , with initial item selection and content validation conducted by six experts in psychiatry and psychology using the Delphi method. Healthy adult participants were recruited to complete the MARS and related scales, along with on-site measures.

expression in stomach adenocarcinoma and its preliminary role in predicting immunotherapy response.

Background: is abnormally expressed in various malignancies, especially in stomach adenocarcinoma (STAD), which is related to tumor invasiveness and prognosis of patients. This study examined the expression pattern of in STAD and predicted immunotherapy response.

Methods: Data were derived from The Cancer Gene Atlas (TCGA), Gene Expression Omnibus (GEO), and Gene Expression Profiling Interactive Analysis (GEPIA) to analyze the expression pattern of in pan-cancer and STAD, as well as its correlation with clinical features.

The impact of remimazolam sedation during neuraxial anesthesia on perioperative cognitive function in elderly patients: a multicenter randomized controlled study.

Background: Remimazolam, a novel ultra-short-acting benzodiazepine, is a potential sedative for non-general anesthesia surgery in the elderly. This study aimed to investigate the appropriate sedative dosage of remimazolam and its effects on perioperative cognitive function in elderly patients undergoing non-general anesthesia surgery.

Methods: This multicenter, placebo-controlled trial enrolled 330 elderly patients undergoing non-general anesthesia procedures at eight centers in China from July 2021 to February 2022, with 238 ultimately completing the study.

The HECT-family protein UPL3 suppresses thermomorphogenesis by modulating BZR1 accumulation.

Brassinosteroid (BR) promotes hypocotyl growth at warm temperatures through BZR1 by directly regulating the expression of PIF4, or by interacting with PIF4 to enhance its downstream gene expression; however, how BZR1 level is modulated by warm temperature is not known. We found that the Homology to E6-Associated Carboxy-Terminus (HECT) E3 ubiquitin ligase UPL3 plays an important role in regulating the accumulation of BZR1 under warm temperature conditions. UPL3 interacted with BZR1 both in vitro and in vivo; mutations in UPL3 led to increased BZR1 accumulation levels and accelerated hypocotyl growth under warm temperature conditions, which was inhibited by the BR biosynthesis inhibitor BRZ.

Structural modification of β-Lactoglobulin by cold plasma and its stability on astaxanthin-loaded high internal phase emulsions.

The impact of cold plasma (CP) treatment on the structure of β-Lactoglobulin (β-LG) and its role in stabilizing astaxanthin-loaded high internal phase emulsions (HIPEs) were studied. The results indicated that CP induced partial cleavage in the backbone of β-LG, as confirmed by SDS-PAGE analysis. Secondary and tertiary structural analyses revealed the unfolding of the compact spherical structure of β-LG, accompanied by exposure of its internal hydrophobic groups.

Construction of a nomogram prediction model for early postoperative stoma complications of colorectal cancer.

Background: Postoperative enterostomy is increasing in patients with colorectal cancer, but there is a lack of a model that can predict the probability of early complications.

Aim: To explore the factors influencing early postoperative stoma complications in colorectal cancer patients and to construct a nomogram prediction model for predicting the probability of these complications.

Methods: A retrospective study of 462 patients who underwent postoperative ostomy for colorectal cancer in the Gastrointestinal Department of the Anhui Provincial Cancer Hospital.

Progress in the study of anti-Alzheimer's disease activity of pyrimidine-containing bioactive molecules.

Pyrimidines are aromatic, heterocyclic organic compounds characterized by a six-membered ring that contains four carbon atoms and two nitrogen atoms. They have been reported to exhibit a variety of biological activities such as antifungal, antiviral, and anti-Parkinsonian effects. Recently, there has been an increased focus on their potential anti-Alzheimer's properties.

Mmu_circ_0001148 promotes endothlial-mesenchymal transition via regulating miR-218-5p/JMY axis and drives progression of atherosclerosis.

Atherosclerosis (AS) is a common cardiovascular disease and responsible for the high mortality of cardiovascular emergencies. Circular RNAs (circRNAs) show a potential role in atherogenesis. We identified an aberrantly expressed circRNA (circ_0001148) in atherosclerotic tissues.

[Analysis of polyetheretherketone framework on the stress distribution of implant-supported fixed maxillary prosthesis: 3-D finite element analysis].

Purpose: To analyze the stress distribution of polyetheretherketone framework of implant-supported fixed maxillary prosthesis by three-dimensional finite element method.

Methods: Three dimensional finite element model of implant-supported fixed maxillary prosthesis was established. Polyetheretherketone as framework material, resin, zirconia, PEEK, baked plastic and lithium silicate were used to make crown prosthesis as experimental group, pure titanium and monolithic zirconia prosthesis model was used as control group.

PRSS50-mediated inhibition of MKP3/ERK signaling is crucial for meiotic progression and sperm quality.

Serine protease 50 (PRSS50/TSP50) is highly expressed in spermatocytes. Our study investigated its role in testicular development and spermatogenesis. Initially, PRSS50 knockdown was observed to impair DNA synthesis in spermatocytes.

Research on the mechanism of Ursolic acid for treating Parkinson's disease by network pharmacology and experimental verification.

The objective of this study was to investigate the potential targets and mechanisms of UA in the treatment of PD. The efficacy of UA in PD was assessed through network pharmacology, molecular docking, and experimental methods. Common target protein-protein interaction (PPI) networks were constructed and visualized using Cytoscape.

[The effect of erbium laser pretreatment on bond strength between dentin and enamel and microleakage at the edge of CAD/CAM glass ionomer cement restorations for repairing tooth defects].

Purpose: To investigate the effects of erbium laser pretreatment on the bond strength of dentin and enamel,as well as microleakage at the edge of tooth defects repaired with computer-aided design (CAD) and computer-assisted manufacturing (CAM) glass-ceramic restorations for repairing dental defects.

Methods: A total of 62 fresh, nondecayed, nondiscoloration and noncracked wisdom teeth were collected from the Oral Surgery Clinic between January 2020 and January 2023. According to different pretreatment methods, they were randomly divided into two groups, erbium laser group and phosphoric acid group, with 31 teeth in each group.

Rapid redox-response featured visual ascorbic acid sensor based on simple-assembled europium metal-organic framework.

A facile, fast and visible sensing platform for ascorbic acid (AA) detection has been developed based on self-assembled hydrangea-like europium metal-organic framework (HL-EuMOF). HL-EuMOF was synthesized through a simple one-step mixing process with Eu and 1, 10-phenanthroline-2, 9-dicarboxylic acid at room temperature, which exhibited excellent properties including strong red fluorescence, long decay lifetime (548.623 μs) and good luminescent stability.

Effect of Dental Implant System-Assisted Tooth Intentional Replantation in the Treatment of Anterior Teeth with Pathological Tooth Flaring, Drifting and Elongation in Patients with Stage III/IV Periodontitis: a Case Series.

Objective: To investigate the clinical effect of implant-assisted dental intentional replantation (IR) for the treatment of "drifted" anterior periodontally hopeless teeth (PHT).

Methods: The present authors recruited 22 patients with stage III/IV periodontitis who suffered drifting of the maxillary anterior teeth, with a total of 25 teeth. The PHT were extracted for in vitro root canal treatment (RCT).

[Effect of CD8 CD28 T Cells on Acute Graft-Versus-Host Disease after Haploidentical Hematopoietic Stem Cell Transplantation].

Objective: To investigate the effect of CD8 CD28 T cells on acute graft-versus-host disease(aGVHD) after haploidentical hematopoietic stem cell transplantation(haplo-HSCT).

Methods: The relationship between absolute count of CD8 CD28 T cells and aGVHD in 60 patients with malignant hematological diseases was retrospectively analyzed after haplo-HSCT, and the differences in the incidence rate of chronic graft-versus host disease(cGVHD), infection and prognosis between different CD8 CD28 T absolute cells count groups were compared.

Results: aGVHD occurred in 40 of 60 patients after haplo-HSCT, with an incidence rate of 66.

XBAT31 regulates reproductive thermotolerance through controlling the accumulation of HSFB2a/B2b under heat stress conditions.

Heat shock transcription factors (HSFs) play a crucial role in heat stress tolerance in vegetative tissues. However, their involvement in reproductive tissues and their post-translational modifications are not well understood. In this study, we identify the E3 ligase XB3 ORTHOLOG 1 IN ARABIDOPSIS THALIANA (XBAT31) as a key player in the ubiquitination and degradation of HSFB2a/B2b.