Identification of lactate-related subgroups and prognostic model in triple-negative breast cancer.

Background: Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer that exhibits elevated glycolytic capacity. Lactate, as a byproduct of glycolysis, is considered a major oncometabolite that plays an important role in oncogenesis and remodeling of the tumor microenvironment. However, the potential roles of lactate in TNBC are not yet fully understood.

The Beneficial Role of Exercise on Treating Alzheimer's Disease by Inhibiting β-Amyloid Peptide.

Alzheimer's disease (AD) is associated with a very large burden on global healthcare systems. Thus, it is imperative to find effective treatments of the disease. One feature of AD is the accumulation of neurotoxic β-amyloid peptide (Aβ).

The involvement of NLRP3 inflammasome in the treatment of neurodegenerative diseases.

In an ageing society, neurodegenerative diseases have attracted attention because of their high incidence worldwide. Despite extensive research, there is a lack of conclusive insights into the pathogenesis of neurodegenerative diseases, which limit the strategies for symptomatic treatment. Therefore, better elucidation of the molecular mechanisms involved in neurodegenerative diseases can provide an important theoretical basis for the discovery of new and effective prevention and treatment methods.

The involvement of NLRP3 inflammasome in the treatment of Alzheimer's disease.

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, and it is characterised by progressive deterioration in cognitive and memory abilities, which can severely influence the elderly population's daily living abilities. Although researchers have made great efforts in the field of AD, there are still no well-established strategies to prevent and treat this disease. Therefore, better clarification of the molecular mechanisms associated with the onset and progression of AD is critical to provide a theoretical basis for the establishment of novel preventive and therapeutic strategies.

Disulfiram as a potent metallo-β-lactamase inhibitor with dual functional mechanisms.

We report a promising NDM-1 inhibitor, disulfiram, which can covalently bind to NDM-1 by forming an S-S bond with the Cys208 residue. Its copper-containing metabolite in vivo, Cu(DTC), also inactivated NDM-1 through oxidizing the Zn(ii) thiolate site of the enzyme, therefore exhibiting dual functional inhibitory potential against B1 and B2 subclass MβLs.

Combining proton and silaborane-based superhalogen anions - an effective route to new superacids as verified via systematic DFT calculations.

Based on systematic DFT calculations, silaborane-based superhalogen anions, which obey the Wade-Mingos rule, are shown to be capable of giving rise to superacids via their combination with protons. Compared to previous carborane-based systems, the acidities of the composites here are stronger in both the gas phase and solution phase. Thus, the potential of candidates based on silaborane could be greater than those based on carborane in the search for ultra-strong acidic systems.

Exploring the structure, bonding and stability of noble gas compounds promoted by superhalogens. A case study on HNgMX (Ng = Ar-Rn, M = Be-Ca, X = F-Br) via combined high-level ab initio and DFT calculations.

A series of complexes (HNgMX), formed from superhalogen MX (M = Be-Ca, X = F-Br) noble gas (Ar-Rn) and the hydrogen atom, were investigated via combined high-level ab initio and DFT calculations. The high vertical electron detachment energy (VDE) of the superhalogen part will lead to charge transfer from the noble gas hydride to it. This charge transfer gives rise to attractive ionic interaction between the two components and to the existence of these complexes as local minima on the potential energy surface eventually.