Dynamic Relevance Between Reflux Events and Esophageal Motility in Patients With Proton Pump Inhibitor-Refractory Gastroesophageal Reflux Disease.

Objectives: The association between reflux events and esophageal motility abnormality is unclear. We aimed to determine the relevance between reflux events and esophageal motility in proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD).

Methods: Patients with PPI-refractory or PPI-responsive GERD were enrolled.

Concordance of Oral and Anal Human Papillomavirus in Men Who Have Sex With Men Living With Human Immunodeficiency Virus.

Background: To detect human papillomavirus (HPV) at oral and anal sites and assess genotype concordance among men who have sex with men (MSM) living with human immunodeficiency virus (HIV) in Taiwan.

Methods: HIV-positive men aged 20 years or older attending outpatient clinics at Taoyuan General Hospital, Taiwan, were enrolled. Oral gargle and anal swab samples were collected for HPV genotyping using linear array testing.

Isorhamnetin protects against D-GalN/LPS-induced acute liver injury in mice through anti-oxidative stress, anti-inflammation, and anti-apoptosis.

Background: Acute liver injury (ALI), which can progress to cirrhosis, hepatocellular carcinoma and acute liver failure, has become a global concern and a serious threat to human life and health. Isorhamnetin (ISO) is an O-methylated flavonol from the class of flavonoids. It has a protective effect on various organs, but its effect on ALI is still unclear in current studies.

Visual Learning in Electrocardiography Training for Medical Residents: Comparative Intervention Study.

Background: Although electrocardiogram (ECG) interpretation training begins early in medical school, achieving accuracy in interpretation of 12-lead ECG remains a persistent challenge. We conducted a pilot educational program to compare the effectiveness of a conventional didactic lecture, self-drawing, and self-drawing following a flipped classroom (SDFC) approach.

Unlabelled: This study aimed to evaluate the effectiveness of three instructional strategies-traditional didactic lecture, self-drawing, and SDFC approach-in improving ECG interpretation skills among first-year postgraduate (PGY-I) medical residents.

Comparative Evaluation of Dental Clinical Surface Treatments for Polyetheretherketone with Airborne-Particle Abrasion, Hydrofluoric Acid Etching, and Handheld Nonthermal Plasma Activation on Long-Term Bond Performance.

Polyaryletherketone (PAEK) materials, including polyetheretherketone (PEEK) and polyetherketoneketone (PEKK), possess excellent mechanical properties and biocompatibility; however, their inherently low surface energy limits effective bonding with resin cements. This study investigated the effects of hydrofluoric acid (HF) etching and handheld nonthermal plasma (HNP) treatment on enhancing the adhesive performance of PAEK surfaces. Disk-shaped PEEK (BP) and PEKK (PK) specimens were divided into four groups: APA (airborne-particle abrasion), PLA (nonthermal plasma treatment), LHF (5.

Functional Mobility and Its Relationship With Cognition in Older Adults With Normal Cognition, Motoric Cognitive Risk Syndrome, and Mild Alzheimer's Disease.

Background And Purpose: Motoric cognitive risk syndrome (MCR) is a predementia syndrome and is a strong predictor of Alzheimer's disease (AD). Functional mobility, such as balance, sit-stand transitions, and turning, has not been clearly investigated in this population. This study aimed to compare functional mobility among older adults with normal cognition (NC), MCR, and mild AD.

Corrigendum: Efficacy and survival outcome of allogeneic stem-cell transplantation in multiple myeloma: meta-analysis in the recent 10 years.

[This corrects the article DOI: 10.3389/fonc.2024.

HDL Cholesterol Levels and Pancreatic Cancer Risk: Protective Effects Revealed.

Background: The causal relationship between lipoprotein traits and the risk of pancre-atic cancer (PC) remains unclear. In this study, we employed a two-sample Mendelian randomiza-tion (MR) approach to explore the untangled relationship between lipoprotein traits and PC.

Methods: Univariable MR analyses were used to determine the causal connection between lipo-protein traits and PC.

Multicenter Experience of Percutaneous Left Atrial Appendage Occlusion in Current Indications and Different Anesthetic Approaches.

Background: Stroke remains a concern in patients with atrial fibrillation despite the efficacy of oral anticoagulants. Left atrial appendage closure has emerged as a treatment option for patients with suboptimal pharmacological therapy.

Objectives: This retrospective multicenter study aimed to evaluate the feasibility, safety, and outcomes of left atrial appendage occlusion procedures for two different indications.

Developing a Screening Strategy to Identify Hepatotoxicity and Drug Interaction Potential of Botanicals.

Botanical supplements, herbal remedies, and plant-derived products are used globally. However, botanical dietary supplements are rarely subjected to robust safety testing unless there are adverse reports in post-market surveillance. Botanicals are complex and difficult to assess using current frameworks designed for single constituent substances (e.

Patient Preference for Catheter-Based Hypertension Therapy and Subgroup Analysis: A Pilot Study Based on Taiwan Consensus on Renal Denervation.

Ojective: To understand hypertensive patients' preference for catheter-based therapy to manage hypertension.

Methods: Survey data regarding catheter-based therapies performed at MacKay Memorial Hospital in Taipei, Taiwan, between 2019-2020 were analyzed. The questionnaire was circulated either in the clinics or during admission.

Self-Healing B ← N-Based Hydrogen-Bonded Organic Framework for Exclusive Recognition and Separation of Toluene from Methyl-Cyclohexane.

The effective separation of aromatic and aliphatic hydrocarbons remains a notable challenge in the petrochemical industry. Herein, we report a self-healing three-dimensional B ← N-based hydrogen-bonded organic framework (HOF), BN-HOF-1, constructed from discrete B ← N inclusive dimers through weak C-H···F and C-H···N hydrogen-bonding interactions. To make use of the specific recognition of the B ← N inclusive dimers for the toluene molecules and the reversible ad/desorption nature of this novel HOF, BN-HOF-1 can exclusively recognize and separate toluene from the mixtures of toluene-methylcyclohexane, thus generating 99.

An injectable bone paste of poly (lactic acid)/zinc-doped nano hydroxyapatite composite microspheres for skull repair.

In this study, poly (lactic acid)/zinc-doped nano hydroxyapatite (PLA/nano-ZnHA) composite microspheres were prepared and formed into injectable bone paste with sodium alginate (SA) and polyvinyl alcohol (PVA) for bone defect repair. The effect of component of bone paste on injectability and zinc doping content related biological properties were mainly discussed. An injectable bone paste of PLA/nano-ZnHA composite microspheres (CM) was formed in mass ratio of (2.

Searching for Two-Neutrino and Neutrinoless Double Beta Decay of ^{134}Xe with the PandaX-4T Experiment.

^{134}Xe is a candidate isotope for neutrinoless double beta decay (0νββ) search. In addition, the two-neutrino case (2νββ) allowed by the standard model of particle physics has not yet been observed. With the 656-kg natural xenon in the fiducial volume of the PandaX-4T detector, which contains 10.

Application of eco-friendly natural deep eutectic solvents (NADES) in HPLC for separation of complex natural products: Current limitations and future directions.

Natural deep eutectic solvents (NADES) have been used in chromatography as extraction media and HPLC mobile phase additives, but only once have they been used as HPLC major mobile phase component. This review illustrates current knowledge and major limitations on use of NADES in HPLC mobile phase as well as to propose possible NADES may be ready for use as HPLC mobile phases and the detectors they can be used with. High viscosity is one of the major roadblocks encountered when using NADES as a mobile phase component in HPLC regardless of detectors employed.

Mechanisms of vascular invasion after cartilage injury and potential engineering cartilage treatment strategies.

Articular cartilage injury is one of the most common diseases in orthopedic clinics. Following an articular cartilage injury, an inability to resist vascular invasion can result in cartilage calcification by newly formed blood vessels. This process ultimately leads to the loss of joint function, significantly impacting the patient's quality of life.

Ipsilateral lower limb motor performance and its association with gait after stroke.

Background And Purpose: Motor deficits of the ipsilateral lower limb could occur after stroke and may be associated with walking performance. This study aimed to determine whether the accuracy and movement path of targeted movement in the ipsilateral lower limb would be impaired in the chronic stage of stroke and whether this impairment would contribution to gait.

Methods: Twenty adults with chronic stroke and 20 age-matched controls went through Mini Mental Status Examination (MMSE), and a series of sensorimotor tests.

Fully Integrated Microfluidic Device for Magnetic Bead Manipulation to Assist Rapid Reaction and Cleaning.

Methods to manipulate magnetic beads are essential factors to determine the efficiency and dimension of an in vitro diagnostic system. Currently, using movable permanent magnets and planar electromagnets is still the major approach to achieve magnetic bead control, causing significant constraint in the miniaturization of in vitro diagnostic systems. Here, we propose techniques to construct a fully integrated microfluidic device that can conduct automatic magnetic bead manipulation as well as rapid chemical reaction and cleaning in a minimized dimension similar to a USB disk.