Aldehyde dehydrogenase 2 deficiency impairs liver progenitor cell proliferation in alcohol-fed mice.

Aldehyde dehydrogenase 2 (ALDH2) is a critical enzyme involved in the detoxification of acetaldehyde. Although numerous studies have demonstrated the significance of ALDH2 in alcohol-associated liver disease (ALD), its role in alcohol-induced activation of liver progenitor cells (LPCs) has not been thoroughly investigated. Proteomic analysis of serum samples from patients with either normal ALDH2 genotype or ALDH2 mutation following alcohol consumption revealed that ALDH2 deficiency may suppress LPC proliferation.

Dendritic Cell-Depleted Mice Develop the Autoimmune Biliary Disease That Serologically and Pathogenically Models Human Primary Biliary Cholangitis.

Aim: Primary biliary cholangitis (PBC) is an autoimmune liver disease marked by progressive bile duct damage, leading to bile retention. Dendritic cells (DCs), as antigen-presenting cells, are crucial for immune regulation, and their dysfunction is linked to autoimmunity. This study demonstrates that DC-depleted mice manifest an autoimmune biliary disease resembling human PBC and investigates its mechanism.

Low-Temperature Alloying Mechanism in Magic Size Clusters: A Pathway toward Alloy Nanocrystal Synthesis.

The non-classical nucleation process achieves controlled growth of nanomaterials at low temperatures by reducing energy barriers in stages. However, the synthesis of alloys remains challenging due to thermodynamic limitations and the unclear critical steps in the nonclassical nucleation process, often resulting in insufficient reaction driving forces and difficulties in compositional control. In this study, a covalent inorganic complex (CIC)-mediated alloying mechanism is proposed, which enables precise bonding control through ion-exchange reactions in the pre-nucleation stage at room temperature.

Safranal ameliorates atherosclerosis progression partly via repressing PI3K/Akt and NF-κB signaling pathways in ApoE (-/-) mice.

Atherosclerosis (AS) remains the main cause of vascular diseases. This study reveals the effects of safranal and underlying mechanisms in RAW264.7 macrophages under AS context, which is hoped to facilitate its clinical application.

MORTALITY OF SEPTIC SHOCK SECONDARY TO PEDIATRIC PRIMARY PERITONITIS PREDICTED BY RESPIRATORY QUOTIENT COMBINED WITH LACTATE: A SURVEY FROM TWO CHILDREN'S HOSPITALS IN NORTHWEST CHINA.

Background: Pediatric sepsis is a life-threatening condition, with extremely high incidence and mortality among critically ill children worldwide. Patients with septic shock are susceptible to intestinal complications due to altered blood flow distribution, and these complications often correlate directly with a poor prognosis. Early detection of low perfusion and appropriate resuscitation are critical components in the management of patients experiencing shock.

Optimizing the design of a pediatric blood pump through orthogonal experimentation.

Background: Pediatric heart failure patients weighing less than 30 kg are prioritized for small axial flow blood pumps due to their smaller body size. This study aims to optimize the blade design of pediatric axial flow blood pumps by conducting orthogonal experiments on blade parameters and integrating hydraulic experiments with hemodynamic numerical simulations, so as to improve the hydraulic performance of pediatric blood pumps while reducing blood damage.

Methods: This study employs a combination of computational fluid dynamics (CFD) and orthogonal experimentation to optimize six key parameters of the impeller blade.

Ultra-lightweight tomatoes disease recognition method based on efficient attention mechanism in complex environment.

A variety of diseased leaves and background noise types are present in images of diseased tomatoes captured in real-world environments. However, existing tomato leaf disease recognition models are limited to recognizing only a single leaf, rendering them unsuitable for practical applications in real-world scenarios. Additionally, these models consume significant hardware resources, making their implementation challenging for agricultural production and promotion.

An automatic deep-learning approach for the prediction of post-stroke epilepsy after an initial intracerebral hemorrhage based on non-contrast computed tomography imaging.

Background: Post-stroke epilepsy (PSE) is a common and significant complication that often occurs after stroke, and affects patients' prognosis and overall quality of life. In recent years, non-contrast computed tomography (NCCT) has become the preferred method for the clinical diagnosis of intracerebral hemorrhage (ICH). This study aimed to develop and validate a triple deep-learning model, simply named, the post-stroke epilepsy network (PSENet), to predict PSE in ICH patients based on NCCT.

Spatiotemporal Control of Photoisomerization Dynamics via Domino Barriers for Programmatically Responsive Heterostructures.

Controlling the photoisomerization reaction at the micro-/nanoscale is important for the realization of high-end photonic components. Unfortunately, spatiotemporal manipulation of the photoisomerization dynamics still faces a significant challenge. Here, we propose an effective strategy to control the photoisomerization reaction spatiotemporally through introducing a steric-hindrance effect by the aid of alloy engineering.

Levofloxacin combined with azithromycin shows greater efficacy in cervicitis treatment compared to azithromycin monotherapy.

Objective: To evaluate the efficacy of levofloxacin combined with azithromycin in the treatment of cervicitis and its effect on serum inflammatory markers.

Methods: A retrospective analysis was conducted on the clinical records of 102 patients with cervicitis treated at Gansu Provincial Maternity and Child-care Hospital between March 2022 and March 2023. The control group (47 patients) received azithromycin, while the study group (55 patients) was treated with a combination of levofloxacin and azithromycin.

Generation of a human induced pluripotent stem cell line from a female patient carrying LZTR1 gene mutation.

The leucine zipper-like transcriptional regulator 1 (LZTR1) gene has been reported to be associated with many kinds of human diseases, including cardiac disease, Noonan syndrome, and schwannomatosis. In this study, peripheral blood mononuclear cells (PBMCs) derived from patient diagnosed with dilated cardiomyopathy (DCM) was successfully reprogrammed into the human induced pluripotent stem cells (iPSCs) line, harboring a distinct heterozygous mutation in the LZTR1 gene. The established patient-derived iPSCs expressed endogenous pluripotent markers, demonstrated the potential to differentiate into three germ layers (endoderm, mesoderm, and ectoderm), and exhibited a normal karyotype.

Proton beam therapy for craniopharyngioma: a systematic review and meta-analysis.

Background: Craniopharyngioma is a rare and slow-growing benign sellar or parasellar epithelial tumor. The number of patients receiving proton beam therapy (PBT) has increased. This study aimed to systematically evaluate and analyze the comprehensive evidence regarding the safety and efficacy of PBT for craniopharyngioma.

Transnasal endoscopic orbital inner wall decompression combined with penetrating keratoplasty for corneal ulcer perforation in Graves' ophthalmopathy: A case report.

Rationale: To report a unique case of corneal ulcer perforation associated with a severe manifestation of Graves' ophthalmopathy that was treated with unilateral transnasal endoscopic orbital inner wall decompression combined with penetrating keratoplasty.

Patient Concerns: A 66-year-old male with Graves' disease experiencing unilateral corneal ulcer perforation, a rarity in medical literature. He presented with a 9-month history of bilateral exophthalmos accompanied by decreased vision, and over the past month, he experienced loss of vision and painful swelling in the right eye (RE).

Design and construction of light-regulated gene transcription and protein translation systems in yeast P. Pastoris.

Introduction: P. pastoris is a common host for effective biosynthesis of heterologous proteins as well as small molecules. Accurate regulation of gene transcription and protein synthesis is necessary to coordinate synthetic gene circuits and optimize cellular energy distribution.

Development and validation of radiology-clinical statistical and machine learning model for stroke-associated pneumonia after first intracerebral haemorrhage.

Background: Society is burdened with stroke-associated pneumonia (SAP) after intracerebral haemorrhage (ICH). Cerebral small vessel disease (CSVD) complicates clinical manifestations of stroke. In this study, we redefined the CSVD burden score and incorporated it into a novel radiological-clinical prediction model for SAP.

Conformation-Driven Responsive 1D and 2D Lanthanide-Metal-Organic Framework Heterostructures for High-Security Photonic Barcodes.

Development of luminescent segmented heterostructures featuring multiple spatial-responsive blocks is important to achieve miniaturized photonic barcodes toward anti-counterfeit applications. Unfortunately, dynamic manipulation of the spatial color at micro/nanoscale still remains a formidable challenge. Here, a straightforward strategy is proposed to construct spatially varied heterostructures through amplifying the conformation-driven response in flexible lanthanide-metal-organic frameworks (Ln-MOFs), where the thermally induced minor conformational changes in organic donors dramatically modulate the photoluminescence of Ln acceptors.

Outcomes in pediatric extracorporeal cardiopulmonary resuscitation: A single-center retrospective study from 2007 to 2022 in China.

Objective: We aimed to investigate the prognostic factors of pediatric extracorporeal cardiopulmonary resuscitation (ECPR).

Methods: The retrospective study included a total of 77 pediatric cases (7 neonates and 70 children) who underwent ECPR after in-hospital and out-of-hospital cardiac arrest between July 2007 and December 2022. Primary endpoints were complications, while secondary endpoints included all-cause in-hospital mortality.

Inorganic-organic hybrid Cu-dipyridyl semiconducting polymers based on the redox-active cluster [SFe(CO)]: filling the gap in iron carbonyl chalcogenide polymers.

The construction of sulfur-incorporated cluster-based coordination polymers was limited and underexplored due to the lack of efficient synthetic routes. Herein, we report facile mechanochemical ways toward a new series of SFe(CO)-based dipyridyl-Cu polymers by three-component reactions of [EtN][SFe(CO)] ([EtN][1]) and [Cu(MeCN)][BF] with conjugated or conjugation-interrupted dipyridyl ligands, 1,2-bis(4-pyridyl)ethylene (bpee), 1,2-bis(4-pyridyl)ethane (bpea), 4,4'-dipyridyl (dpy), or 1,3-bis(4-pyridyl)propane (bpp), respectively. X-ray analysis showed that bpee-containing 2D polymers demonstrated unique SFe(CO) cluster-armed and cluster-one-armed coordination modes the hypervalent μ-S atom.

Low blood flow ratio is associated with hemorrhagic transformation secondary to mechanical thrombectomy in patients with acute ischemic stroke.

Background And Purpose: A significant decrease of cerebral blood flow (CBF) is a risk factor for hemorrhagic transformation (HT) in acute ischemic stroke (AIS). This study aimed to ascertain whether the ratio of different CBF thresholds derived from computed tomography perfusion (CTP) is an independent risk factor for HT after mechanical thrombectomy (MT).

Methods: A retrospective single center cohort study was conducted on patients with AIS undergoing MT at the First Affiliated Hospital of Wenzhou Medical University from August 2018 to December 2023.

Anisotropic Growth of Covalent Inorganic Complexes to Nanoplatelets.

Colloidal II-VI semiconductor nanoplatelets (NPLs) provide a new platform in material science due to their unique growth mode and advanced optical properties. However, in contrast to the rapid development of zinc blend structured NPLs, studies on the formation of wurtzite (WZ) NPLs have been limited to the lamellar assembly of specific magic-sized nanoclusters (MSCs). Therefore, the study of new precursors is important for enriching the synthesis strategy, improving the study of two-dimensional (2D) nanocrystal growth mechanisms, and constructing complex nanostructures.

Alter codon bias of the P. pastoris genome to overcome a bottleneck in codon optimization strategy development and improve protein expression.

Apart from its role in translation, codon bias is also an important mechanism to regulate mRNA levels. The traditional frequency-based codon optimization strategy is rather efficient in organisms such as N. crassa, but much less in yeast P.

A Patient Similarity Network (CHDmap) to Predict Outcomes After Congenital Heart Surgery: Development and Validation Study.

Background: Although evidence-based medicine proposes personalized care that considers the best evidence, it still fails to address personal treatment in many real clinical scenarios where the complexity of the situation makes none of the available evidence applicable. "Medicine-based evidence" (MBE), in which big data and machine learning techniques are embraced to derive treatment responses from appropriately matched patients in real-world clinical practice, was proposed. However, many challenges remain in translating this conceptual framework into practice.

Recommended Values for the Hydrophobicity and Mechanical Properties of Coating Materials Usable for Preparing Controlled-Release Fertilizers.

The hydrophobicity and mechanical properties of coating materials and the nitrogen (N) release rates of 11 kinds of controlled-release fertilizers (CRFs) were determined in this study. The results show that the N release periods of the CRFs had negative correlations with the water absorption (WA) of the coating materials (y = 166.06x, r = 0.