Perioperative and postoperative analgesic strategies in live donor hepatectomy: A national survey.

Donor safety is of paramount importance in live donor hepatectomy, and acute pain is the most frequent complaint reported by donors. There are various approaches to managing perioperative and postoperative pain following live donor hepatectomy. These include the administration of opioid and nonopioid analgesics and neuraxial, regional, and local anesthesia.

Percutaneous n-butyl cyanoacrylate glue embolization combined with arterial embolization for extracranial arteriovenous malformations.

Objectives: Congenital arteriovenous malformations (AVMs) are characterized by abnormal connections between arteries and veins, often presenting challenges in treatment due to their complex vascular structure. Endovascular therapies, including embolization techniques, have become integral in managing AVMs, yet optimal treatment strategies remain under investigation. This retrospective study aimed to evaluate the safety and efficacy of percutaneous glue embolization of n-butyl cyanoacrylate (nBCA) combined with arterial embolization in treating extracranial AVMs.

Engineering a Meltable MOF to Tune Liquid Transition and Promote Coenzyme Regeneration.

Modulating the liquid phase of metal-organic frameworks (MOFs) presents new opportunities for functionalizing glassy MOFs, expanding the fundamental science and practical application for this emerging family of materials. Herein, we report the fabrication of a bimetallic glassy MOF via a liquid-liquid transition process. This is achieved by introducing a robust Schiff base-cobalt functional group into Zn-ZIF-62, which attracts negatively charged imidazolate ligands, facilitating low-temperature melting.

Identification and characterization of TCP transcription factor GmTCP670 associated with soybean development.

TCP (TEOSINTEB RANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR) is a plant-specific transcription factor family that is closely associated with plant growth and development. To date, a few studies have been conducted on the TCP family of soybean. To investigate the function of the TCP transcription factor family in soybeans, we conducted a series of experiments and obtained significant results.

Role of alphaII-spectrin and XPF interaction in Hepatocellular carcinoma.

Background: Hepatocellular carcinoma (HCC) is a highly malignant digestive tumor with a poor prognosis. AlphaII-spectrin shows altered levels in various tumor tissues, indicating its significant role in tumor development. Xeroderma pigmentosum group F (XPF) is a nucleotide excision repair (NER)-related DNA repair endonuclease.

CD163 macrophages drive rapid pulmonary fibrosis via osteopontin secretion.

Background: Rapid pulmonary fibrosis (RPF) is a severe condition characterized by the rapid accumulation of excessive extracellular matrix (ECM), resulting in high mortality among patients with severe respiratory infections. CD163 macrophages were found to be enriched in RPF patients, their role in this disease requires elucidation.

Methods: We integrated single-cell RNA sequencing (scRNA-seq) and single-nucleus RNA sequencing (snRNA-seq) analyses of COVID-19-associated RPF patients, alongside an LPS three-hit-induced murine RPF model and in vitro co-culture systems.

Effectiveness of stationary cycling with electromyographic biofeedback on neuromuscular control and function in individuals with knee osteoarthritis: a feasibility study.

Background: To evaluate the effects of stationary cycling with electromyographic (EMG) biofeedback on neuromuscular control and function in individuals with knee osteoarthritis (OA).

Methods: Fourteen knee OA patients were randomized into two groups: cycling with EMG biofeedback of the vastus medialis (EBF group) and cycling without biofeedback (Cycling group). Both groups underwent a six-week cycling program, 30 min per session, twice a week.

Antigen persistence and TLR stimulation contribute to induction of a durable HIV-1-specific neutralizing antibody response.

HIV-1 Env glycoprotein (Env) immunogenicity is limited in part by structural instability and extensive glycan shielding and is likely the greatest obstacle to an HIV-1 vaccine. Stabilized Env trimers can elicit serum neutralizing antibodies, but the response is short-lived. Here we use Newcastle Disease Virus-like particle (NDV-VLP) platform to present stabilized versions of HIV-1 Env at high valency and in the context of varied conformational stability, adjuvants, dose, and antigen persistence.

rs73530508 polymorphism affects susceptibility to esophageal cancer by regulating indolepropionic acid levels.

Background: Tryptophan metabolism is involved in esophageal carcinogenesis. However, its genetic mechanisms remain unclear. This study aimed to investigate the effect of genetic variants that encode tryptophan metabolism on susceptibility to esophageal cancer (EC) and elucidate the mechanisms underlying genetic variation in EC progression.

Generational Differences in Age-Specific Dementia Prevalence Rates.

Importance: Dementia is a significant public health challenge, with its prevalence expected to increase as life expectancy continues to extend globally.

Objective: To estimate generational differences in age-specific dementia prevalence across the US, Europe, and England.

Design, Setting, And Participants: This cross-sectional study used data from 1994 to 2021 from the United States Health and Retirement Study (HRS), from 2004 to 2020 from the Survey of Health, Ageing and Retirement in Europe (SHARE), and from 2002 to 2019 from the English Longitudinal Study of Ageing (ELSA).

Speed of Processing Training for Stress Adaptation in Caregivers of a Family Member With Dementia: A Randomized Controlled Trial.

Background And Objectives: The chronic stress of caregiving for a family member with Alzheimer's disease and related dementias (ADRD) is associated with a host of health risks, including accelerated cognitive aging and poor emotional well-being. Despite known links between cognitive and emotion regulatory pathways, cognitive training has not been tested in ADRD caregivers as a means to strengthen cognitive capacity and concomitant emotion regulation, domains undergirding stress adaptation. This study aimed to identify effects of computerized cognitive training on cognitive and emotion indicators of caregivers' capacity for stress adaptation, a key mechanism for healthy aging.

Melatonin: A Potential Therapy for Osteoporosis With Insights Into Molecular Mechanisms.

Melatonin is a versatile neurohormone with diverse molecular functions, including sleep regulation, inflammation reduction, antioxidant activity, immune modulation, and anticancer properties. In bone metabolism, it promotes osteoblast formation, inhibits osteoclast activity, and synchronizes skeletal tissue rhythms to support bone health. As melatonin is not yet clinically used for osteoporosis and concerns about the current treatments' side effects remain, this review highlights its role in modulating osteoblast and osteoclast interactions, particularly through regulation of the receptor activator of nuclear factor-κB ligand and osteoprotegerin, to achieve bone-forming and antiresorptive effects.

Healthcare services for low-wage migrant workers: A systematic review.

Low-wage labour migrants often face health-damaging living and working conditions, but are frequently excluded from healthcare. The othering of migrants, bordering of healthcare and simple oversight and negligence create widening health inequalities for a society's essential workers. This review aimed to identify the forms and effectiveness of healthcare services designed to make healthcare accessible for migrant workers.

Development of an immune scoring system based on exosome-related gene expression for prognosis and treatment response prediction in breast cancer.

Breast cancer (BC) is a heterogeneous disease with diverse subtypes that influence prognosis and treatment outcomes. While advances have been made in molecular subtyping, the role of exosome-related genes in BC remains underexplored. This study aimed to identify exosome-related gene expression profiles in BC and develop a novel immune score to predict clinical outcomes.

A systematic Mendelian randomized study of the effects of the gut microbiome and immune cells on pancreatic neuroendocrine tumors.

Pancreatic neuroendocrine tumors (pNETs) are a rare subset of pancreatic cancers often diagnosed late and characterized by complex behaviors. Recent evidence suggests the gut microbiome (GM) significantly influences various diseases by modulating the immune system. This study utilized a Mendelian randomization (MR) approach to investigate the causal relationship between GM and pNETs, using single nucleotide polymorphism data as instrumental variables.

The association between A Body Shape Index and total bone mineral density in adults aged 20 to 59 NHANES 2011 to 2018.

Obesity impacts skeletal health. A Body Shape Index (ABSI), a novel obesity metric based on epidemiological data, offers advantages over traditional measures such as body mass index and waist circumference. This study investigates the association between ABSI and total bone mineral density (BMD) in American adults.

Protective Role of Sustained Positive Emotions in Mitigating Negative Mood Responses Following Acute Laboratory Stressor in Middle-Aged and Older Dementia Caregivers.

Positive emotions can buffer stress-related negative emotions; however, it remains unclear whether such protective benefits extend to middle-aged and older adult caregivers of family members with dementia, a population particularly vulnerable to stress and its health consequences. This secondary analysis of laboratory data from a parent clinical trial (R01AG049764) examined the role of sustaining positive affect in buffering the effects of stress-related emotional reactivity on subsequent negative mood. This study recruited 192 cognitively healthy, middle-aged, and older adults who were dementia caregivers (mean age = 68.

Knowledge map of artificial intelligence in neurodegenerative diseases: a decade-long bibliometric and visualization study.

Background: As the incidence of neurodegenerative diseases increases, the related AI research is getting more and more advanced. In this study, we analyze the literature in this field over the last decade through bibliometric and visualization methods with the aim of mining the prominent journals, institutions, authors, and countries in this field and analyzing the keywords in order to speculate on possible future research trends.

Methods: Our study extracted 1,921 relevant publications spanning 2015-2025 from the Web of Science Core Collection database.

Olverembatinib (HQP1351)-based therapy in adults with relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukemia or chronic myeloid leukemia in blast phase: results from a real-world study.

Background: Relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukemia (R/R Ph ALL) and chronic myeloid leukemia in the blast phase (CML-BP) are associated with poor prognoses. Olverembatinib (HQP1351), a novel third-generation tyrosine kinase inhibitor (TKI), has shown promising efficacy and safety in clinical trials against nearly all BCR-ABL1 kinase mutations, including .

Methods: Data were collected and analyzed to evaluate the efficacy and safety of olverembatinib-based therapy for advanced Ph leukemia.

High-dose cytarabine with idarubicin consolidation for acute myeloid leukemia in first complete remission: a randomized controlled trial.

Whether adding anthracycline to intermediate- or high-dose cytarabine as consolidation is beneficial remains unclear in acute myeloid leukemia (AML). Eligible AML patients in first complete remission were randomly assigned (1:1) to receive either high-dose cytarabine with idarubicin (IA3 + 3) (idarubicin 10 mg/m, d1-3 and cytarabine 2 g/m, every 12 h, d1-3) or high-dose cytarabine (HDAC) (cytarabine 3 g/m, every 12 h, d1-3) regimens as first consolidation. The primary endpoint was the rate of negative measurable residual disease (MRD) after first consolidation.

Manifold fitting reveals metabolomic heterogeneity and disease associations in UK Biobank populations.

NMR-based metabolic biomarkers provide comprehensive insights into human metabolism; however, extracting biologically meaningful patterns from such high-dimensional data remains a significant challenge. In this study, we propose a manifold-fitting-based framework to analyze metabolic heterogeneity within the UK Biobank population, utilizing measurements of 251 NMR biomarkers from 212,853 participants. Initially, our method clusters these biomarkers into seven distinct metabolic categories that reflect the modular organization of human metabolism.

Efficacy and safety of third-generation CD19-CAR T cells incorporating CD28 and TLR2 intracellular domains for B-cell malignancies with central nervous system involvement: results of a pivotal trial.

Background: Third‑generation CAR-T cells demonstrated promising efficacy and remarkably low toxicity in refractory or relapsed (R/R) B-cell malignancies. However, data on the patients with central nervous system (CNS) involvement are limited due to concerns regarding treatment-related neurotoxicity. This study aimed to evaluate the safety and efficacy of a novel third-generation anti-CD19 CAR T cells in patients with CNS involvement of B-cell malignancies.

Boron Catalysis-Enabled Regioselective Ring-Retentive Hydrosilylation of Methylenecyclopropanes.

Herein, we report the highly regioselective ring-retentive hydrosilylation of methylenecyclopropanes (MCPs) with hydrosilanes by a B(CF) catalyst. The catalytic protocol affords an atom-efficient route for the synthesis of silylcyclopropanes, featuring 100% atom-efficiency, broad substrate scope (42 examples), mild conditions, and high regio-, and chemoselectivity. The current metal-free catalytic hydrosilylation also provides a complementary pathway for the synthesis of structurally diverse organosilicon compounds from MCPs over transition metal-catalyzed variants.

Prognostic implication of six m6A-modulated genes signature in the ferroptosis for hepatocellular carcinoma patients.

Hepatocellular carcinoma (HCC) remains one of the most prevalent and lethal malignancies worldwide, with survival rates still falling short of expectations. Emerging evidence highlights the pivotal roles of both m6A methylation and ferroptosis-related genes (FRGs) in HCC progression. However, the prognostic significance of m6A-modulated FRGs remains largely unexplored.

Bongkrekic Acid and Its Novel Isomers: Separation, Identification, and Determination in Food Matrices.

The toxicity associated with bongkrekic acid (BKA) is severe due to its chemical structure, which also facilitates high mortality rates; however, its isomer, isobongkrekic acid (iBKA), with only minor structural variance, demonstrates marked differences in toxicity. This discrepancy in structural properties and toxicity highlights that risks have been potentially underestimated within current detection standards for BKAs. In this study, a novel BKA trans isomer at the C8 and C9 double carbon bonds (E-configuration), termed iBKA-neo, was successfully separated and identified.