Computation-aided design of rod-shaped nanoparticles for tumoral targeting.

Various nanomaterials have been developed for drug delivery, but the vast majority are spherical nanoparticles (50-500 nm in diameter). This limits their ability to target and infiltrate hard-to-penetrate tissues, such as certain solid tumors with a dense extracellular matrix (ECM). To investigate how the key physical parameter of shape influences tumor targeting, we developed Janus base nanoparticles (JBNps), a family of rod-shaped delivery vehicles that self-assemble into nanotube bundles with encapsulated drug cargos.

Screen-based sedentary behavior and BMI among Chinese adolescents: weight concern as a mediator moderated by body image perception.

Objective: Screen-based sedentary behavior (SB) is associated with elevated BMI; however, the underlying mechanisms remain poorly understood. This study investigates the mediating role of weight concern in the SB-BMI relationship and examines how body image perception and gender moderate this mediation. By focusing on body image as a critical contextual factor, the study aims to inform targeted interventions for adolescent obesity and overweight.

Accuracy of Two Robotic Computer-Aided Implant System Registration Methods for Dental Implantation: A Prospective Study.

Background: Robot-assisted implant surgery has been shown to achieve high levels of accuracy. However, there is currently a paucity of clinical studies evaluating the accuracy of marker-based intraoral scanner (IOS) registration (IR) methods.

Purpose: The purpose of this study was to compare the accuracy of the marker-based cone beam computed tomography (CBCT) registration (CR) method and the IR method in the dental implant in the robotic computer-aided implant system (R-CAIS).

Design and Evaluation of an Omnidirectional Wheel-Driven Endoscope-Assisted Robotic System Based on Motion Capture Control.

Background: In endoscopic surgery, surgeons collaborate with assistants to manipulate the endoscope and instruments, making it impossible to perform the surgery independently.

Methods: We propose an endoscopic assistive robot based on motion capture control, enabling surgeons to control the endoscope with one hand. The system uses cameras at the master end to capture real-time motion information from the marker accessory, determining the surgeon's intent.

Study on the biosafety and in vivo metabolic patterns of DNA-inspired Janus Base nanotubes.

Janus base nanotubes (JBNTs), also known as Rosette nanotubes, are synthesized from DNA-inspired base molecular monomers and show promise for biomedical applications. However, their clinical translation has been hindered by a lack of comprehensive biocompatibility and biodistribution studies. In this study, we evaluated the in vitro and in vivo biocompatibility of JBNTs and their biodistribution following intravenous and knee intra-articular injections.

Construction of Shamrock-Shaped Giant Molecule Acceptors for Efficient Organic Solar Cells.

The discovery of non-fullerene small molecule acceptor materials has breathed new development into organic solar cells (OSCs). However, it has also introduced the issue of insufficient device stability. Enhancing the glass transition temperature (T) of materials by connecting small molecules into giant molecules, thereby improving morphological stability, represents an effective material design strategy to address this issue.

Bionic ECM scaffolds for directional articular hyaline cartilage regeneration and long-term homeostasis maintenance.

Cartilage defects play a key role in osteoarthritis, causing functional impairment as the disease progresses. Microfracture surgery is commonly used to treat articular cartilage defects, providing early pain relief and functional improvement. However, the blood clot formed during the procedure differs from the natural cartilage microenvironment, hindering hyaline cartilage formation and promoting fibrocartilage, which limits long-term outcomes.

In vitro evaluation of six intraoral scanners for cone beam computed tomography data registration in robotic-assisted implant surgery: Impact of scanning experience.

Objectives: This study evaluated the accuracy of intraoral scanning (IOS) and cone beam computed tomography (CBCT) data registration (ICR) in robotic computer-assisted implant surgery (r-CAIS) using six different intraoral scanners, considering the impact of surgeon experience.

Methods: A total of 112 standardized mandibular partially edentulous models were assigned to six experimental groups and one control group based on the intraoral scanner used. In the control group, preoperative CBCT data were registered with CBCT data from a model containing an optical tracking marker (OT-Marker).

Accuracy of dental implant surgery with freehand, static computer-aided, dynamic computer-aided, and robotic computer-aided implant systems: An in vitro study.

Statement Of Problem: The static computer-aided implant system (S-CAIS), dynamic computer-aided implant system (D-CAIS), and robotic computer-aided implant system (R-CAIS) have been used to improve the accuracy of implant placement. However, the accuracy of freehand (FH),S-CAIS, D-CAIS, and R-CAIS implant placement has not been compared and verified under identical conditions.

Purpose: The purpose of this in vitro study was to compare the accuracy of dental implant placement using S-CAIS, D-CAIS, R-CAIS, and FH techniques under identical conditions.

Clinical outcomes of autologous adipose-derived mesenchymal stem cell combined with high tibial osteotomy for knee osteoarthritis are correlated with stem cell stemness and senescence.

Background: Mesenchymal stem cells (MSCs) have been proposed to treat osteoarthritis (OA) for many years. However, clinical outcomes have been inconsistent due to biological variation between patients, differences in tissue source and preparation of the MSCs, and type of donor (e.g.

Recent Progress of Electrospun Nanofiber Dressing in the Promotion of Wound Healing.

The nanofiber materials of three-dimensional spatial structure synthesized by electrospun have the characteristics of high porosity, high specific surface area, and high similarity to the natural extracellular matrix (ECM) of the human body. These are beneficial for absorbing wound exudate, effectively blocking the invasion of external bacteria, and promoting cell respiration and proliferation, which provides an ideal microenvironment for wound healing. Moreover, electrospun nanofiber dressings can flexibly load drugs according to the condition of the wound, further promoting wound healing.

Transport-Friendly Microstructure in SSC-MEA: Unveiling the SSC Ionomer-Based Membrane Electrode Assemblies for Enhanced Fuel Cell Performance.

The significant role of the cathodic binder in modulating mass transport within the catalyst layer (CL) of fuel cells is essential for optimizing cell performance. This investigation focuses on enhancing the membrane electrode assembly (MEA) through the utilization of a short-side-chain perfluoro-sulfonic acid (SSC-PFSA) ionomer as the cathode binder, referred to as SSC-MEA. This study meticulously visualizes the distinctive interpenetrating networks of ionomers and catalysts, and explicitly clarifies the triple-phase interface, unveiling the transport-friendly microstructure and transport mechanisms inherent in SSC-MEA.

SOX11 as a prognostic biomarker linked to m6A modification and immune infiltration in renal clear cell carcinoma.

Background: The prognosis for patients with kidney renal clear cell carcinoma (KIRC) remains unfavorable, and the understanding of SRY-box transcription factor 11 (SOX11) in KIRC is still limited. The purpose of this paper is to explore the role of SOX11 in the prognosis of KIRC.

Methods: We analyzed SOX11 expression in KIRC and adjacent normal tissues using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases.

Bone and Extracellular Signal-Related Kinase 5 (ERK5).

Bones are vital for anchoring muscles, tendons, and ligaments, serving as a fundamental element of the human skeletal structure. However, our understanding of bone development mechanisms and the maintenance of bone homeostasis is still limited. Extracellular signal-related kinase 5 (ERK5), a recently identified member of the mitogen-activated protein kinase (MAPK) family, plays a critical role in the pathogenesis and progression of various diseases, especially neoplasms.

Effects of endoplasmic reticulum stress on chondrocyte apoptosis via the PI3K/AKT signaling pathway.

Chondrocytes undergo endoplasmic reticulum stress (ERS)-induced apoptosis under abnormal stimulation. However, the underlying molecular mechanism remains unclear. We investigated the regulatory effect of the PI3K/AKT signaling pathway on ERS and its effect on chondrocyte apoptosis.

Computation-aided Design of Rod-Shaped Janus Base Nanopieces for Improved Tissue Penetration and Therapeutics Delivery.

Despite the development of various drug delivery technologies, there remains a significant need for vehicles that can improve targeting and biodistribution in "hard-to-penetrate" tissues. Some solid tumors, for example, are particularly challenging to penetrate due to their dense extracellular matrix (ECM). In this study, we have formulated a new family of rod-shaped delivery vehicles named Janus base nanopieces (Rod JBNps), which are more slender than conventional spherical nanoparticles, such as lipid nanoparticles (LNPs).

Comparing the accuracies of freehand, static computer-assisted and robot-assisted dental implant placements: an in vitro study.

Objective: To compare the accuracies among three oral implant surgical techniques: freehand (FH), static computer-assisted implant surgery (sCAIS), and robotic computer-assisted implant surgery (rCAIS).

Methods: The polyurethane and bovine femur implant models were fabricated, and 126 and 96 implant sites were designed on them. The implant sites were divided into three groups: FH, sCAIS, and rCAIS, according to the implantation method.

Accuracy of an optical robotic computer-aided implant system and the trueness of virtual techniques for measuring robot accuracy evaluated with a coordinate measuring machine in vitro.

Statement Of Problem: A unified standard for measuring robot implantation errors has not yet been established. A coordinate measuring machine (CMM) measures the coordinates of an object with high accuracy. However, evaluations of the accuracy of a robotic computer-assisted implant system (R-CAIS) using CMM are lacking.

Development and validation of a combined hypoxia- and metabolism-related prognostic signature to predict clinical prognosis and immunotherapy responses in clear cell renal cell carcinoma.

Background: Hypoxia and metabolism are closely correlated with the progression of cancer. We aimed to construct a combined hypoxia- and metabolism-related genes (HMRGs) prognostic signature to predict survival and immunotherapy responses in patients with clear cell renal cell carcinoma (ccRCC).

Methods: The RNA-seq profiles and clinical data of ccRCC were acquired from the TCGA and the ArrayExpress (E-MTAB-1980) databases.

Integrative analysis identifies AKAP8L as an immunological and prognostic biomarker of pan-cancer.

A-kinase anchoring protein 8L (AKAP8L) belong to the A-kinase anchoring protein (AKAP) family. Recent studies have proved that AKAP8L is associated with the progression of various tumors. To establish a more complete understanding of the significance of AKAP8L across various types of cancers, we conducted a detailed analysis of multiple histological datasets, including the level of gene expression in pancancer, biological function, molecular characteristics, as well as the diagnostic and prognostic value of AKAP8L in pancancer.

A structural and functional comparison between two recombinant human lubricin proteins: Recombinant human proteoglycan-4 (rhPRG4) vs ECF843.

Proteoglycan 4 (PRG4, lubricin) is a mucin-like glycoprotein present on the ocular surface that has both boundary lubricating and anti-inflammatory properties. Full-length recombinant human PRG4 (rhPRG4) has been shown to be clinically effective in improving signs and symptoms of dry eye disease (DED). In vitro, rhPRG4 has been shown to reduce inflammation-induced cytokine production and NFκB activity in corneal epithelial cells, as well as to bind to and inhibit MMP-9 activity.

Rational Materials and Structure Design for Improving the Performance and Durability of High Temperature Proton Exchange Membranes (HT-PEMs).

Hydrogen energy as the next-generation clean energy carrier has attracted the attention of both academic and industrial fields. A key limit in the current stage is the operation temperature of hydrogen fuel cells, which lies in the slow development of high-temperature and high-efficiency proton exchange membranes. Currently, much research effort has been devoted to this field, and very innovative material systems have been developed.

A novel oxidative stress-related genes signature associated with clinical prognosis and immunotherapy responses in clear cell renal cell carcinoma.

Background: Oxidative stress plays a significant role in the tumorigenesis and progression of tumors. We aimed to develop a prognostic signature using oxidative stress-related genes (ORGs) to predict clinical outcome and provide light on the immunotherapy responses of clear cell renal cell carcinoma (ccRCC).

Methods: The information of ccRCC patients were collected from the TCGA and the E-MTAB-1980 datasets.