Correction: The Open Anchoring Quest Dataset: Anchored Estimates from 96 Studies on Anchoring Effects.

[This corrects the article DOI: 10.5334/jopd.67.

A 3D SVZonChip Model for In Vitro Mimicry of the Subventricular Zone Neural Stem Cell Niche.

Neural stem cells (NSCs) are crucial components of the nervous system, primarily located in the subventricular zone (SVZ) and subgranular zone (SGZ). The SVZ neural stem cell niche (NSCN) is a specialized microenvironment where growth factors and extracellular matrix (ECM) components collaborate to regulate NSC self-renewal and differentiation. Despite its importance, our understanding of the SVZ remains incomplete due to the inherent challenges of animal research, particularly given the tissue's dynamic nature.

The value of mental science: we publish what matters.

Recent changes to US research funding are having far-reaching consequences that imperil the integrity of science and the provision of care to vulnerable populations. Resisting these changes, the reaffirms its commitment to publishing mental science and advancing psychiatric knowledge that improves the mental health of one and all.

Determination of Surface Characteristics, Solubility and Ion Release of a Calcium Silicate Root Canal Sealer.

This study investigated the solubility of AH Plus Bioceramic sealer (AHPB), the ion release, and the modification of surface characteristics compared to AH Plus (AHP). Solubility was examined according to ISO guidelines in deionised water and phosphate buffer saline (PBS) for 3 months. Surface characteristics and elemental analysis were conducted with scanning electron microscopy and energy-dispersive X-ray spectroscopy, while ion release was determined with ICP-OES.

Transdiagnostic Compulsivity Traits in Problematic Use of the Internet Among UK Residents: Cross-Sectional Network Analysis Study.

Background: The societal and public health costs of problematic use of the internet (PUI) are increasingly recognized as a concern across all age groups, presenting a growing challenge for mental health research. International scientific initiatives have emphasized the need to explore the potential roles of personality features in PUI. Compulsivity is a key personality trait associated with PUI and has been recognized by experts as a critical factor that should be prioritized in PUI research.

Translation and validation of the Portuguese version of the internet severity and activities addiction questionnaire (ISAAQ-10) towards the identification of problematic social media use: A population study.

Background: Problematic usage of the internet (PUI) refers to a pattern of internet use that results in negative consequences in an individual's life. It encompasses a broad spectrum of activities, which require assessment in terms of both severity and diversity, for a comprehensive understanding. This study aimed to translate the Internet Severity and Activities Questionnaire (ISAAQ-10) into Portuguese, to analyze its psychometric properties and to explore the validity of the ISAAQ-10 social networking use activity score towards identifying problematic social media use.

Recent advances in understanding how compulsivity is related to behavioural addictions over their timecourse.

Purpose Of Review: Behavioural addictions involve loss of control over initially rewarding behaviours, which continue despite adverse consequences. Theoretical models suggest that these patterns of behaviour evolve over time, with compulsive and habitual behaviours held to reflect a loss of behavioural control. Compulsivity can be broadly described as a propensity for (or engagement in) repetitive behaviours that are not aligned with overall goals.

CylinDeRS: A Benchmark Visual Dataset for Robust Gas Cylinder Detection and Attribute Classification in Real-World Scenes.

Gas cylinder detection and the identification of their characteristics hold considerable potential for enhancing safety and operational efficiency in several applications, including industrial and warehouse operations. These tasks gain significance with the growth of online trade, emerging as critical instruments to combat environmental crimes associated with hazardous substances' illegal commerce. However, the lack of relevant datasets hinders the effective utilization of deep learning techniques within this domain.

4D Biofabrication of Magnetically Augmented Callus Assembloid Implants Enables Rapid Endochondral Ossification via Activation of Mechanosensitive Pathways.

The use of magnetic-driven strategies for non-contact manipulation of engineered living modules opens up new possibilities for tissue engineering. The integration of magnetic nanoparticles (MNPs) with cartilaginous microtissues enables model-driven 4D bottom-up biofabrication of remotely actuated assembloids, providing unique properties to mechanoresponsive tissues, particularly skeletal constructs. However, for clinical use, the long-term effects of magnetic stimulation on phenotype and in vivo functionality need further exploration.

Structurally defined cartilaginous MEW-assembloids for critical-size long bone healing.

Bone defects exceeding a critical size pose significant clinical challenges due to their inability to heal spontaneously. Traditional treatments including autografts and synthetic implants, are often suffer from limitations such as donor site morbidity, infection risk, and poor integration. This study explores a novel approach using MEW-assembloid which combine Melt electrowriting (MEW) scaffolds with cartilaginous microtissues to enhance bone healing.

Stepping into day treatment approach versus inpatient treatment for adults with anorexia nervosa: the DAISIES RCT.

Background: A substantial proportion of anorexia nervosa patients require intensive treatments, commonly inpatient or day-patient treatment. The relative merits of these treatments for adults with anorexia nervosa are unknown. Therefore, a trial investigating the clinical effectiveness and cost-effectiveness of inpatient treatment-as-usual versus a stepped-care day-patient approach in adults with anorexia nervosa (DAISIES) was commissioned.

Friendship buffering effects on mental health symptoms before and during the COVID-19 pandemic: A UK longitudinal study of young people with childhood adversity.

Young people with childhood adversity (CA) were at increased risk to experience mental health problems during the COVID-19 pandemic. Pre-pandemic research identified high-quality friendship support as a protective factor that can buffer against the emergence of mental health problems in young people with CA. This longitudinal study investigated friendship buffering effects on mental health symptoms before and at three timepoints during the pandemic in 102 young people (aged 16-26) with low to moderate CA.

Trait Impulsivity Predicts Treatment Response in Gambling Disorder.

Objectives: Impulsivity is thought to be a core feature of gambling disorder, yet little is known as to whether trait impulsivity predicts treatment response.

Methods: Data were pooled from 2 previous randomized controlled pharmacological trials using naltrexone and N-acetyl cysteine.

Results: Trait impulsivity statistically explained variation in medication treatment response ( P = 0.

Cartilaginous microtissues exhibit extreme resilience under compression with size-dependent mechanical properties.

Self-assembled cartilaginous microtissues provide a promising means of repairing challenging skeletal defects and connective tissues. However, despite their considerable promise in tissue engineering, the mechanical response of these engineered microtissues is not well understood. Here we examine the mechanical and viscoelastic response of progenitor cell aggregates formed from human primary periosteal cells and the resulting cartilaginous microtissues under large deformations as might be encountered in vivo.

Ceftazidime-avibactam (CAZ-AVI) pharmacokinetics in critically ill patients undergoing continuous venovenous hemodiafiltration (CVVHDF).

Purpose: To investigate the pharmacokinetics (PK) of ceftazidime-avibactam (CAZ-AVI) in critically ill patients undergoing continuous venovenous hemodiafiltration (CVVHDF), and compare with a general phase III trial population.

Methods: A prospective PK study was conducted in critically ill patients who received CVVHDF for acute kidney injury, treated with CAZ-AVI (1000/250 mg or 2000/500 mg q8h). Plasma and CVVHDF-circuit samples were collected to determine CAZ-AVI concentrations.

Placebo and nocebo effects in gambling disorder pharmacological trials: a meta-analysis.

Background: Placebo and nocebo effects are widely reported across psychiatric conditions, yet have seldom been examined in the context of gambling disorder. Through meta-analysis, we examined placebo effects, their moderating factors, and nocebo effects, from available randomised, controlled pharmacological clinical trials in gambling disorder.

Methods: We searched, up to 19 February 2024, a broad range of databases, for double-blind randomised controlled trials (RCTs) of medications for gambling disorder.

Defining treatment response in gambling disorder.

Background: Gambling disorder is a common mental health condition, and a growing cause of concern globally. Despite the availability of well-validated self-report and clinical instruments to measure symptom severity, there has been no study to establish optimal thresholds for determining treatment response based on these measures.

Methods: Data from 553 participants (aged 18-65 years) who had participated in previous pharmacological and psychotherapeutic clinical trials for gambling disorder were aggregated.

Placebo effects in randomized trials of pharmacological and neurostimulation interventions for mental disorders: An umbrella review.

There is a growing literature exploring the placebo response within specific mental disorders, but no overarching quantitative synthesis of this research has analyzed evidence across mental disorders. We carried out an umbrella review of meta-analyses of randomized controlled trials (RCTs) of biological treatments (pharmacotherapy or neurostimulation) for mental disorders. We explored whether placebo effect size differs across distinct disorders, and the correlates of increased placebo effects.

Lifetime alcohol use disorder and gambling disorder: clinical profile and treatment response.

Objectives: Gambling disorder affects 0.5-2.4% of the population and shows strong associations with lifetime alcohol use disorder.

Treatment discontinuation in pharmacological clinical trials for gambling disorder.

Background: Gambling disorder affects 0.5-2% of the population, and of those who receive treatment, dropout tends to be relatively high. Very little is known about participant-specific variables linked to treatment discontinuation/dropout in gambling disorder, especially in pharmacological clinical trial settings.

A systematic review of the cognitive effects of the COMT inhibitor, tolcapone, in adult humans.

Objective: The catechol--methyltransferase (COMT) inhibitor tolcapone constitutes a potentially useful probe of frontal cortical dopaminergic function. The aim of this systematic review was to examine what is known of effects of tolcapone on human cognition in randomized controlled studies.

Methods: The study protocol was preregistered on the Open Science Framework.

Cognition in trichotillomania: a meta-analysis.

Objective: Trichotillomania (TTM) is a mental health disorder characterized by repetitive urges to pull out one's hair. Cognitive deficits have been reported in people with TTM compared to controls; however, the current literature is sparse and inconclusive about affected domains. We aimed to synthesize research on cognitive functioning in TTM and investigate which cognitive domains are impaired.

The stress-buffering role of friendships in young people with childhood threat experiences: a preliminary report.

High-quality friendships have a positive impact on the mental health of young people with childhood adversity (CA). Social stress buffering, the phenomenon of a social partner attenuating acute stress responses, is a potential yet unexplored mechanism that may underlie this relationship. This study examined whether perceived friendship quality was related to better mental health and lower neural stress response in young people with CA.