[Left Ventriculoplasty for Ventricular Septal Rupture and Left Ventricular Aneurysm Following Acute Myocardial Infarction:Report of a Case].

A 70-year-old man with acute myocardial infarction underwent percutaneous coronary intervention (PCI) for the diagonal branch. Eight days after PCI, the patient presented worsening heart failure. Transthoracic echocardiography( TTE) and enhanced computed tomography( CT) revealed ventricular septal rupture( VSR) and left ventricular aneurysm( LVA).

Heterotopic Ossification After COVID-19: A Case Report and Review of Literature.

We report a 31-year-old woman hospitalized for approximately two months for coronavirus disease 2019 (COVID-19) pneumonia. Under sedation, she received physiotherapy to prevent joint contractures. When weaning from the mechanical ventilator began, she complained of pain and limited range of motion in her bilateral hip and knee joints.

Generation and functional characterization of tuft cells in non-human primate pancreatic ducts through organoid culture systems.

The pancreatic duct plays a key role in collecting pancreatic juice, which is rich in digestive enzymes. The fluid flows unidirectionally into the duodenum, where it mixes with partially digested food to further facilitate digestion. In this study, we report the generation of pancreatic ductal organoids from non-human primates for the first time, aimed at investigating the role of tuft cells that reside in the pancreatic duct since no studies have addressed the role of tuft cells in the pancreas.

Fibronectin in the olfactory mucus increases sensitivity of olfactory receptor response to odorants.

Olfaction is a highly sensitive chemical detection system, but the origins of this sensitivity remain poorly understood. In terrestrial vertebrates, inhaled odorants diffuse through olfactory epithelial mucus (OEM) before activating olfactory receptors (ORs) on olfactory sensory neurons and initiating adenosine 3',5'-monophosphate (cAMP)-mediated signaling. Impaired OEM secretion is associated with impaired olfactory sensitivity in humans and mice, but it remains unclear whether OEM directly improves sensitivity and whether specific active factors exist.

Chronic intake of Dioscorea esculenta suppresses testicular atrophy, enhances the ability of protection from inflammation in type 2 diabetes rats.

Dioscorea esculenta increases sex steroid hormones in obesity and type 2 diabetes that impairs steroidogenesis. However, the effects of chronic D. esculenta intake on testicular sex steroid hormone concentrations and testicular function especially protection from oxidative stress and inflammation is still unclear.

A hands-free wearable electrolarynx for communication in tracheostomized mechanically ventilated critically ill patients: a case series.

The electrolarynx facilitates communication for tracheostomized mechanically ventilated patients. However, its effectiveness is often constrained by patient weakness. A hands-free electrolarynx offers a potential solution, enabling speech without the need to hold the device.

Complete Endotracheal Tube Obstruction Due to Highly Viscous Secretions Immediately After Tracheal Intubation: A Case Report.

Obstruction of the endotracheal tube (ETT) from secretions can cause severe respiratory distress and potentially life-threatening complications; therefore, prompt decisions and management are needed. Cases of ETT obstruction have been observed in patients who have been ventilated for extended periods but are rare in patients immediately after endotracheal intubation. Herein, we present a rare case of ETT obstruction after endotracheal intubation.

A surgical case of right ventricular outpouching.

Unlabelled: Outpouching of the heart ventricles, especially of the right ventricle, is rare. Here, we report the case of a 60-year-old male, referred to our institution with an outpouched structure at the right ventricular apex. The patient had no cardiac events.

Early therapeutic efficacy of condoliase chemonucleolysis for lumbar disc herniation.

Background: Low back pain is often caused by lumbar disc herniation (LDH). Treatment of LDH is possible using chemonucleolysis of the nucleus pulposus with condoliase injection. However, onset of the therapeutic effect varies among patients, with improvement from an early stage to 3 months post-injection.

Characterization of a Cancer-Induced Bone Pain Model for Use as a Model of Cancer Cachexia.

Cancer cachexia is a debilitating syndrome characterized by progressive weight loss, muscle wasting, and systemic inflammation. Despite the prevalence and severe consequences of cancer cachexia, effective treatments for this syndrome remain elusive. Therefore, there is a greater need for well-characterized animal models to identify novel therapeutic targets.

Pinhole Descending Aortic Rupture with Systemic Sclerosis and Dermatomyositis: A Case Report.

Thoracic descending aortic perforation with overlap syndrome (systemic sclerosis and dermatomyositis) is a rare, unreported vascular pathology. We describe the case of a 75-year-old woman who presented with chest tightness, back pain, and dyspnea. Computed tomography revealed a pinhole rupture in the descending aorta.

Achieving the United Nations Sustainable Development Goals in Spinal Surgery: Patient-Centered Care and Social Contribution.

Background: In recent years, achieving a sustainable society has become an international challenge. The medical field is also being called upon to contribute to the United Nations Sustainable Development Goals (SDGs). However, awareness of the SDGs in Japan is low, and relevant efforts in the healthcare sector are particularly lagging behind.

Association between sodium-glucose cotransporter-2 inhibitor and adverse events in patients with moderate to severe chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials.

Purpose: Although there is concern about the association of sodium-glucose cotransporter-2 inhibitor (SGLT2i) use with musculoskeletal pain, hypovolemia, and urinary tract infection in patients with severe chronic kidney disease (CKD), information on these adverse events is insufficient. The aim of this systematic review and meta-analysis was to assess whether SGLT2i increases the risk of urinary tract infection, hypovolemia, and musculoskeletal pain in these patients.

Methods: MEDLINE via PubMed, the Cochrane Central Register of Controlled Trials, and the ClinicalTrials.

Delayed Trastuzumab-induced Cardiotoxicity Leading to Severe Left Ventricular Dysfunction.

An 81-year-old woman presented to our hospital with dyspnea. She had been treated with trastuzumab for nine years. Chest radiography revealed pleural effusion.

Clinical Case Report: Neonatal Mesenteric Traction Syndrome During Surgery for Congenital Duodenal Stenosis.

Mesenteric traction syndrome (MTS) is a common complication of major abdominal surgery, characterized by flushing, hypotension, and tachycardia. However, its occurrence in neonates has not yet been documented. This report details a neonatal case of MTS that emerged during surgery for congenital duodenal stenosis.

Suppression of gp130 attenuated insulin-mediated signaling and glucose uptake in skeletal muscle cells.

The aim of the present study was to investigate the effects of Oncostatin M receptor (OSMR) subunit gp130 knockdown on insulin-stimulated glucose metabolism-related signaling pathways and glucose uptake in skeletal muscle cells. siRNA-mediated gp130 knockdown was conducted in C2C12 muscle cells, and insulin was added and incubated for 1 h. The cells were cultivated to analyze the mRNA levels of gp130, phosphorylation of STAT3, and glucose metabolism-regulated signaling pathways, and OSM levels in the culture medium were analyzed.

GDE5/Gpcpd1 activity determines phosphatidylcholine composition in skeletal muscle and regulates contractile force in mice.

Glycerophosphocholine (GPC) is an important precursor for intracellular choline supply in phosphatidylcholine (PC) metabolism. GDE5/Gpcpd1 hydrolyzes GPC into choline and glycerol 3-phosphate; this study aimed to elucidate its physiological function in vivo. Heterozygous whole-body GDE5-deficient mice reveal a significant GPC accumulation across tissues, while homozygous whole-body knockout results in embryonic lethality.