Publications by authors named "Hirotaka Ishioka"
During mammalian development, production sites of the erythroid growth factor erythropoietin (EPO) shift from the neural tissues to the liver in embryos and to the kidneys in adults. Embryonic neural EPO-producing (NEP) cells, a subpopulation of neuroepithelial and neural crest cells, express the gene between embryonic day (E) 8.5 and E11.
View Article and Find Full Text PDFCrosstalk between oxygen signaling and iron metabolism in renal interstitial fibroblasts.
J Clin Biochem Nutr
May 2024
Article Synopsis
- Erythropoiesis, or the production of red blood cells, is stimulated by low-oxygen conditions (hypoxia) to ensure adequate oxygen supply, primarily involving hemoglobin which contains iron.
- Iron metabolism is closely regulated to prevent oxidative stress, and hypoxia triggers the mobilization of stored iron for hemoglobin production via the erythroid growth factor, erythropoietin (EPO), secreted by renal EPO-producing cells in the kidneys.
- Recent studies highlight the connections between hypoxia-induced EPO production, red blood cell formation, and iron regulation, while also exploring disease mechanisms related to these processes and suggesting future research into using renal cells from kidney patients for better understanding and treatment of chronic kidney disease
We report a case of eosinophilia and an allergic reaction that caused a cerebellar haemorrhage.An woman in her 80s presented with headache, dyspnoea and vomiting with severe hypotension soon after switching the dialysis membrane, and a CT scan revealed cerebellar haemorrhage. In the subsequent clinical course, the patient developed an allergic reaction to multiple membranes and required corticosteroids to continue haemodialysis (HD).
View Article and Find Full Text PDFArticle Synopsis
- A 69-year-old woman was hospitalized due to severe proteinuria and hematuria, leading to a renal biopsy.
- The biopsy showed signs similar to membranoproliferative glomerulonephritis with specific immunofluorescence findings of IgG, C1q, and C3 deposits, suggesting a potential diagnosis of IgG3-heavy-chain deposition disease (HCDD).
- However, the absence of a characteristic heavy-chain deletion and unique electron microscopy results prevented a definitive HCDD diagnosis, marking this as the first documented case of monoclonal IgG3-heavy-chain glomerulonephritis with distinctive microtubular structures.