Ferritinophagy activation states determine the susceptibility to ferroptosis of macrophages in bone marrow and spleen.

Macrophages exhibit heterogeneity due to their presence in different tissues that have distinct cell fates. Ferroptosis is one type of cellular fate, but the sensitivity of different types of macrophages to ferroptosis and the associated molecular mechanisms are not clear. This study explored the ferroptosis sensitivity of bone marrow and splenic macrophage, focusing on the contribution of ferritinophagy.

Sub-regional radiomics combining multichannel 2-dimensional or 3-dimensional deep learning for predicting neoadjuvant chemo-immunotherapy response in esophageal squamous cell carcinoma: a multicenter study.

This study aimed to develop and compare fusion models combining sub-regional radiomics with multichannel 2D and 3D DL to predict pCR in patients with LA-ESCC undergoing NACI. A total of 271 patients from three hospitals were divided into training, internal validation, and external validation cohorts. Tumor sub-regions were identified using K-means clustering based on radiomic features, and predictive features were extracted using PyRadiomics.

Nanozyme-synbiotics to improve iron-deficiency anemia.

Iron deficiency anemia (IDA) affects approximately one-third of the global population, and conventional treatments often face challenges such as poor absorption and adverse effects. This study investigated the therapeutic potential of Bacteroides ovatus (BO) and its synergistic combination with MIL-101(CuFe) nanozyme for IDA. The results demonstrated that BO significantly enhanced intestinal iron absorption by upregulating the expression of the duodenal iron transporter ZIP14 and ferroportin (Fpn).

Oxidative balance score and menopausal status: insights from epidemiological analysis and machine learning models.

Background: Unhealthy lifestyle habits, such as smoking, can impact oxidative stress. During oxidative stress, unnaturalized free radicals can damage DNA, proteins, and lipids, leading to cellular damage and death. A comprehensive measurement of various pro-oxidative and antioxidative exposures can reflect an individual's oxidative stress burden.

Atomically-Thin Freestanding Racetrack Memory Devices.

Advances in freestanding membranes allow novel heterostructures to be formed from distinct families of materials in 2D or 3D configurations. Recently, this technique has been used to form a 3D racetrack memory device by transferring a complex magnetic thin film heterostructure, in the form of a membrane, onto a corrugated surface. The membrane is released using a water-soluble oxide layer (SrAlO).

Associations between the Chinese Visceral Adiposity Index and the Self-Reported Menopausal Status: Results from Two Nationally Representative Population-Based Studies.

Purpose: The menopausal transition is accompanied by metabolic changes in women. This study explores the Chinese visceral adiposity index (CVAI) as a potential indicator of menopausal status to aid in disease prevention.

Patients And Methods: A cohort of 404 premenopausal Chinese women aged 45 years and above, from the China Health and Retirement Longitudinal Study (CHARLS), was included.

Amuc_1434 From Akkermansia muciniphila Enhances CD8+ T Cell-Mediated Anti-Tumor Immunity by Suppressing PD-L1 in Colorectal Cancer.

Colorectal cancer (CRC) shows a limited response to programmed death-ligand 1 (PD-L1) immunotherapies. Akkermansia muciniphila (AKK) may enhance tumor immunity. This study examines how its Outer Membrane Vesicles (OMVs) and Amuc_1434 influence PD-L1 expression and CD8+ T cell activity in CRC.

Absence of gut microbiota alleviates iron overload-induced colitis by modulating ferroptosis in mice.

Introduction: Iron overload disrupts gut microbiota and induces ferroptosis, contributing to colitis. However, whether gut microbiota directly drives iron overload-induced colitis and its underlying mechanism remain unclear.

Objectives: The study aimed to explore whether gut microbiota can directly regulate iron overload-induced colitis and its underling mechanism.

Yes-associated protein-mediated melatonin regulates the function of periodontal ligament stem cells under oxidative stress conditions.

Background: Human periodontal ligament stem cells (PDLSCs) regenerate oral tissue. expansion causes replicative senescence in stem cells. This causes intracellular reactive oxygen species (ROS) accumulation, which can impair stem cell function.

Readout circuit noise analysis and low-noise design for piezoelectric micro-machined ultrasonic transducers with large parasitic capacitance.

Readout circuits are fundamental components in many application systems that utilize piezoelectric micro-machined ultrasonic transducers (pMUTs). This study models the noise and signal transfer functions of trans-impedance amplifiers (TIAs), charge-sensitive circuits, and voltage-mode readout circuits in detail. A series of simulations and experiments were conducted to elucidate the advantages and disadvantages of these circuit types.

Predictive and prognostic value of preoperative pan-immune-inflammation value in patients with locally advanced rectal cancer.

This study aimed to investigate the prognostic value of the pan-immune-inflammation value (PIV) in patients with locally advanced rectal cancer (LARC) who received neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision. We retrospectively collected and analyzed the clinicopathological data of 215 resected LARC patients. X-tile software was used to determine the optimal threshold value for PIV in predicting overall survival (OS).

Prognostic value of Naples Prognostic Score in locally advanced cervical cancer patients undergoing concurrent chemoradiotherapy.

This study aimed to investigate the prognostic value of the Naples Prognostic Score (NPS) in patients with locally advanced cervical cancer (LACC) who received curative concurrent chemoradiotherapy (CCRT). Clinicopathological data from 213 (training set) and 106 (validation set) LACC cases undergoing CCRT were retrospectively analyzed. The receiver operating characteristic curve (ROC) was used to compare the predictive ability of NPS and other indicators for survival.

TAZ reverses the inhibitory effects of LPS on the osteogenic differentiation of human periodontal ligament stem cells through the NF-κB signaling pathway.

Background: Human periodontal ligament stem cells (hPDLSCs) are important candidate seed cells for periodontal tissue engineering, but the presence of lipopolysaccharide(LPS) in periodontal tissues inhibits the self-renewal and osteogenic differentiation of hPDLSCs. Our previous studies demonstrated that TAZ is a positive regulator of osteogenic differentiation of hPDLSCs, but whether TAZ can protect hPDLSCs from LPS is still unknown. The present study aimed to explore the regulatory effect of TAZ on the osteogenic differentiation of hPDLSCs in an LPS-induced inflammatory model, and to preliminarily reveal the molecular mechanisms related to the NF-κB signaling pathway.

ANOS1 accelerates the progression of esophageal cancer identified by multi-omic approaches.

To assess the role of ANOS1 in esophageal cancer (ESCA) progression, multi-omic analysis and experimental validation were employed. It was revealed that ANOS1 expression is significantly enhanced in ESCA patients and cell lines. The expression level of ANOS1 in ESCA patients can distinguish the malignancy from normal tissue with an area under curve (AUC) >0.

Current-induced domain wall motion in a van der Waals ferromagnet FeGeTe.

The manipulation of spin textures by spin currents is of fundamental and technological interest. A particularly interesting system is the 2D van der Waals ferromagnet FeGeTe in which Néel-type skyrmions have recently been observed. The origin of these chiral spin textures is of considerable interest.

A low noise capacitance to voltage readout circuit based on active feedback charge sensitive amplifier for micro-gyro.

Trans-impedance amplifier (TIA) based capacitance-voltage (C-V) readout circuits are widely used in micro-machined gyroscopes' control system. In this work, the noise performance of a TIA and charge sensitive amplifier (CSA) based C-V readout circuit is analyzed in detail. The theoretical derivation and simulation experiments carried out in this paper show that the thermal noise of high value feedback resistors in TIA dominates the output noise of the circuit, while a CSA-based readout circuit can overcome this shortcoming.

Multi-mechanism antitumor/antibacterial effects of Cu-EGCG self-assembling nanocomposite in tumor nanotherapy and drug-resistant bacterial wound infections.

Chemotherapy and surgery stand as primary cancer treatments, yet the unique traits of the tumor microenvironment hinder their effectiveness. The natural compound epigallocatechin gallate (EGCG) possesses potent anti-tumor and antibacterial traits. However, the tumor's adaptability to chemotherapy due to its acidic pH and elevated glutathione (GSH) levels, coupled with the challenges posed by drug-resistant bacterial infections post-surgery, impede treatment outcomes.

Prognostic prediction of oxidative stress related hematological biomarkers in locally advanced cervical cancer patients undergoing chemoradiotherapy.

Objective: This investigation aimed to develop and validate a novel oxidative stress score for prognostic prediction in locally advanced cervical cancer (LACC) patients receiving chemoradiotherapy.

Methods: A total of 301 LACC patients were enrolled and randomly divided into a training and a validation set. The association between oxidative stress parameters and prognosis was analyzed for oxidative stress score (OSS) establishment.

Genetic Evidence for a Causal Relationship Between Innate Leukocytes and the Risk of Digestive System Cancers in East Asians and Europeans.

Background: Peripheral traditional immune cell disorder plays an important role in cancer onset and development. The causal relationships between leukocytes prior to cancer and the risk of digestive system cancer remain unknown. This study assesses the causal correlations between leukocytes and digestive system cancer risk in East Asians and Europeans.

Cross-talk between disulfidptosis and immune check point genes defines the tumor microenvironment for the prediction of prognosis and immunotherapies in glioblastoma.

Disulfidptosis is a condition where dysregulated NAPDH levels and abnormal accumulation of cystine and other disulfides occur in cells with high SLC7A11 expression under glucose deficiency. This disrupts normal formation of disulfide bonds among cytoskeletal proteins, leading to histone skeleton collapse and triggering cellular apoptosis. However, the correlation between disulfidptosis and immune responses in relation to glioblastoma survival rates and immunotherapy sensitivity remains understudied.

Effect of bolus materials on dose deposition in deep tissues during electron beam radiotherapy.

Several materials are utilized in the production of bolus, which is essential for superficial tumor radiotherapy. This research aimed to compare the variations in dose deposition in deep tissues during electron beam radiotherapy when employing different bolus materials. Specifically, the study developed general superficial tumor models (S-T models) and postoperative breast cancer models (P-B models).

Ferroptosis: a new mechanism of traditional Chinese medicine for cancer treatment.

Ferroptosis, distinct from apoptosis, is a novel cellular death pathway characterized by the build-up of lipid peroxidation and reactive oxygen species (ROS) derived from lipids within cells. Recent studies demonstrated the efficacy of ferroptosis inducers in targeting malignant cells, thereby establishing a promising avenue for combating cancer. Traditional Chinese medicine (TCM) has a long history of use and is widely used in cancer treatment.

X-ray-downregulated nucleophosmin induces abnormal polarization by anchoring to G-actin.

Ionizing radiation poses significant risks to astronauts during deep space exploration. This study investigates the impact of radiation on nucleophosmin (NPM), a protein involved in DNA repair, cell cycle regulation, and proliferation. Using X-rays, a common space radiation, we found that radiation suppresses NPM expression.