The Cognitive Cost of AI: How AI Anxiety and Attitudes Influence Decision Fatigue in Daily Technology Use.

Background: Artificial intelligence (AI) is increasingly shaping daily decision-making by enhancing efficiency and consistency. However, prolonged AI use may impose cognitive strain, attention depletion, information overload, and decision fatigue.

Aim: To investigate the relationships among AI anxiety, attitudes toward AI, cognitive performance, trust in AI, and decision fatigue, particularly emphasising long-term AI interaction.

Cupressuflavone Isolated from Cupressus torulosa Ameliorates Diabetic Nephropathy by Inhibiting Oxidative Stress and Inflammation Through Nrf-2/NF-κB Signalling Axis.

Cupressuflavone (CTM-01), a potential biflavonoid isolated from exhibited antimicrobial, analgesic, cytotoxic and wound-healing properties. The present study aims to evaluate the renoprotective effects through and models as well as elucidate the underlying mechanisms of its nephroprotective action under diabetic conditions. The effects of CTM-01 on cell viability (25, 50, and 100 µM) and intracellular ROS production were evaluated in cultured normal rat proximal epithelial cells (NRK-52E) grown under high glucose conditions (30 mM) while streptozotocin (STZ) induced rats were treated with CTM-01 at 25 mg/kg for four weeks and the effects on different biochemical, histological, and molecular parameters were studied.

Correlation, Path Coefficient and Genetic Diversity Analysis in EMS Induced Cultivars of Ashwagandha [Withania somnifera (L.) Dunal].

Withania somnifera (L.) Dunal, commonly known as ashwagandha, belongs to the family Solanaceae is a significant medicinal plant in Ayurveda, valued for its high-quality roots and usage to treat an extensive physiological disorder. To enhance sustainable production and genetic gains, mutagenic treatment was applied to generate genetic variation.

Screening Withania somnifera as biostimulant for crop plants and chemical profiling of its active fractions.

Studies have highlighted that Withania somnifera contain endogenous molecules, with varying biological activities. In light of this, the current experiment aimed the plant growth-promoting potential of Withania somnifera leaf extract (WsLE) through seed priming. Twenty crop plants were tested to assess the bio-stimulatory effects of WsLE.

Magnetodynamics in exchange coupled composite magnets.

Tailoring magnetization using all-optical methods in exchange-coupled composite magnets holds significant scientific potential for advancing ultrafast magneto-optic devices. Here, we investigate the femtosecond laser-activated magnetization dynamics in FeNi/FePt composites using time-resolved magneto-optical Kerr effect (tr-MOKE) spectroscopy across the both visible and extreme ultraviolet spectral ranges. Observations from visible tr-MOKE reveal ultrafast demagnetization and an initial magnetization reorientation, characterized by a transient increase in the in-plane magnetization vector occurring on timescales shorter than 500 fs.

A simplified and efficient method for isolating small extracellular vesicles for comparative and comprehensive translational research.

Small extracellular vesicles (sEVs) can provide information about the pathophysiology of the cells; therefore, sEVs have attracted considerable interest as possible diagnostic biomarkers. A key challenge lies in the necessity for simple and cost-effective sEV isolation methods to achieve high purity and yield suitable for research and clinical applications. We are introducing a comprehensive study on isolating sEVs using a novel cocktail strategy that integrates chemical precipitation and ultrafiltration with a two-step filtering process to ensure a highly pure and homogeneous population and further compared with PEG-based precipitation, ultra-centrifugation, and size-exclusion-chromatography columns.

Comparative chemical profiling, antimicrobial activity of (Pers.) Sprague ex Britton and P. Wilson essential oil and evaluation of their integrative network pharmacology.

is an annual herb of the Apiaceae family. This study aims to investigate the chemical compositions of aerial, fruits, leaves, and stem parts and evaluate their potential anti-microbial activity. For the identification and quantification of essential oil (EO) constituents gas chromatography-mass spectrometry and gas chromatography-flame ionisation detector techniques was used.

A new sesquiterpene lactone isolated from and cytotoxic activity against the A549 cancer cell line.

A new sesquiterpene lactone ainslialide and eighteen known compounds were isolated from aq. methanolic extract of Mattf (Compositae). All the isolates were structurally elucidated by the analysis of spectroscopic data 1D, 2D-NMR, HR-ESI-MS and previously reported literature for the known compounds.

Correction: Investigating the role of prognostic mitophagy-related genes in non-small cell lung cancer pathogenesis via multiomics and network-based approach.

[This corrects the article DOI: 10.1007/s13205-024-04127-y.].

LATS2 and FAT4 as key candidate genes of hippo pathway associated with the risk and progression of breast cancer: an in-silico approach.

Background: The 2020 cancer report states that breast cancer remains a significant cause of death for females, despite the use of various strategies for early detection and treatment. However, there are still gaps in the fight against this disease. Researchers are exploring the hippo pathway, one of eight significant pathways involved in cancer progression, for potential biomarkers to use in personalized therapeutics.

Nucleos(t)ide analogues potentially activate T lymphocytes through inducing interferon expression in hepatic cells and patients with chronic hepatitis B.

Chronic hepatitis B (CHB) leads to liver inflammation and dysfunction, resulting in liver fibrosis and cancer. Nucleos(t)ide analogues (NAs), inhibitors of hepatitis B virus (HBV), specifically suppress HBV replication. We proposed that immune modulation benefits seroconversion by HBsAg loss.

Hallmarks of diabetes mellitus and insights into the therapeutic potential of synergy-based combinations of phytochemicals in reducing oxidative stress-induced diabetic complications.

Diabetes mellitus (DM) is a serious health issue and is still one of the major causes of mortality around the globe. Natural products have progressively integrated into modern, advanced medical practices. Phytoconstituents from some medicinal plants have demonstrated therapeutic activity in treating different metabolic disorders and have been used to treat DM and its severe complications.

Baicalein isolated from acts as a potent µ- and κ-opioid receptor antagonist agent via the reversal of agonist-mediated cAMP inhibition.

The opioid receptors play a pivotal role in the treatment of several neuropsychiatric and neurological disorders. (L.) Kurtz is a very important medicinal plant with several therapeutic applications.

Tumor-intrinsic IFNα and CXCL10 are critical for immunotherapeutic efficacy by recruiting and activating T lymphocytes in tumor microenvironment.

Tumor immunotherapies targeting PD-(L)1 exhibit anti-tumor efficacy in only 10-30% of patients with various cancers. Literature has demonstrated that a "hot tumor" which contains high T lymphocytes in the tumor microenvironment exhibits a better response to immunotherapies than a "cold tumor." This study aimed to investigate whether tumor-intrinsic IFNα and CXCL10 determine the recruitment and activation of CD8 T cells to become "hot tumor.

Circulating small extracellular vesicles in Alzheimer's disease: a case-control study of neuro-inflammation and synaptic dysfunction.

Background: Alzheimer's disease (AD) is a neurodegenerative disease characterized by Aβ plaques and neurofibrillary tangles. Chronic inflammation and synaptic dysfunction lead to disease progression and cognitive decline. Small extracellular vesicles (sEVs) are implicated in AD progression by facilitating the spread of pathological proteins and inflammatory cytokines.

Identification of potential therapeutic targets for COVID-19 through a structural-based similarity approach between SARS-CoV-2 and its human host proteins.

The COVID-19 pandemic caused by SARS-CoV-2 has led to millions of deaths worldwide, and vaccination efficacy has been decreasing with each lineage, necessitating the need for alternative antiviral therapies. Predicting host-virus protein-protein interactions (HV-PPIs) is essential for identifying potential host-targeting drug targets against SARS-CoV-2 infection. This study aims to identify therapeutic target proteins in humans that could act as virus-host-targeting drug targets against SARS-CoV-2 and study their interaction against antiviral inhibitors.

Psiguanol, a novel α-pyrone derivative from Psidium guajava leaves and vasorelaxant activity in rat aorta cells through intracellular cGMP-dependent opening of calcium-activated potassium channels.

The phytochemical investigation of leaves led to the isolation of total nineteen compounds which belongs to meroterpenoids, flavonoid, phenolics, and triterpenoids. The compounds were isolated using extensive chromatography techniques and identified as psiguanol (), as new compound along with guajadial (), psidial A (), -caryophyllene (), quercetin (), avicularin (), guaijaverin (), hyperin (), rutin (), ursolic acid (), corosolic acid (), asiatic acid (), -sitosterol (), -sitosterol-D-glucoside (), ellagic acid (), 3,3',4'-trimethylellagic acid 4-O-glucoside (), protocatechuic acid (), gallic acid (), and tricosanoic acid () as known molecules. The compound was isolated for the first time from this plant.

Yoga Pose Estimation Using Angle-Based Feature Extraction.

Objective: This research addresses the challenges of maintaining proper yoga postures, an issue that has been exacerbated by the COVID-19 pandemic and the subsequent shift to virtual platforms for yoga instruction. This research aims to develop a mechanism for detecting correct yoga poses and providing real-time feedback through the application of computer vision and machine learning (ML) techniques.

Methods And Procedures: This study utilized computer vision-based pose estimation methods to extract features and calculate yoga pose angles.

Therapeutic importance of : an alternative medicine.

Aim: To summarise a detailed up-to-date review of the traditional uses, phytoconstituents, and pharmacological activities of various parts of .

Materials And Methods: Google Scholar, PubMed, PubChem, Elsevier, King Draw, indianbiodiversity.org.

Role of Fork-Head Box Genes in Breast Cancer: From Drug Resistance to Therapeutic Targets.

Breast cancer has been acknowledged as one of the most notorious cancers, responsible for millions of deaths around the globe. Understanding the various factors, genetic mutations, comprehensive pathways, etc., that are involved in the development of breast cancer and how these affect the development of the disease is very important for improving and revitalizing the treatment of this global health issue.

Inhibition of Autophagy and the Cytoprotective Role of Smac Mimetic against ROS-Induced Cancer: A Potential Therapeutic Strategy in Relapse and Chemoresistance Cases in Breast Cancer.

With more than a million deaths each year, breast cancer is the top cause of death in women. Around 70% of breast cancers are hormonally responsive. Although several therapeutic options exist, cancer resistance and recurrence render them inefficient and insufficient.