Burnout related factors of infection control nurses in long-term care hospitals.

Aim: This study aimed to investigate the burnout and related factors of infection control nurses in long-term care hospitals.

Methods: An anonymous, self-administered survey was conducted among 177 nursing home infection control nurses. The questionnaire included stress levels, self-efficacy, social support, and burnout.

Association between triglyceride-glucose index and incidence risk of gout: a nationwide cohort study.

The global burden of gout is substantial and expected to increase. We investigated the relationship between the triglyceride-glucose (TyG) index, a biomarker of insulin resistance, and gout risk in the general population over time. This study was conducted using data from the National Health Screening Cohort Database of South Korea (2002-2019) among 300,107 participants who had no history of gout and underwent more than three repeated TyG index measurements.

Cardiovascular Risk with Prokinetics: A Self-Controlled Case Series Study Using a Korean Nationwide Health Claims Database.

There have been concerns about potential adverse cardiovascular (CV) events associated with prokinetics that enhance gastrointestinal (GI) motility. To evaluate whether prokinetics use was associated with increased CV risk. We conducted a self-controlled case series (SCCS) study using the National Health Claims Database in South Korea.

Investigation of Proteome-Tetrazine Reactivity for a Highly Selective Tetrazine Ligation in Live Cells.

Tetrazine has been widely used in bio-orthogonal click chemistry for diverse biological applications due to its short reaction time and excellent bio-orthogonality. For efficient click reaction, the stability of tetrazine in physiological conditions is one of the key issues in biological applications. However, the reactions between tetrazine and biomolecules have barely been studied.

The Effect of a Collagen-Elastin Implantation on Infraorbital Hallowing in Lower Lid Surgery for Aging Patients.

This study investigates the efficacy of integrating a collagen-elastin matrix (MatriDerm) with lower blepharoplasty to address infraorbital hollowness and fine wrinkles in aging patients, conditions often inadequately treated with conventional techniques. Twenty patients (40 eyelids) aged 40 to 70 years with Barton's grade II to III periorbital hollowness were included. Lower blepharoplasty was performed using a subciliary approach, and the collagen-elastin matrix was implanted in two submuscular layers along the lid-cheek groove.

The association of hemorrhoids with the incidence of heart failure: a nationwide cohort study.

Background: Studies evaluating the association between hemorrhoids and heart failure (HF) have been limited. We aimed to evaluate the association between increased incidence of HF and the presence of hemorrhoids using a population-based longitudinal cohort.

Methods: We included 356,033 participants in this study, derived from health screening data collected between 2003 and 2007 from the South Korean health screening cohort database.

Association between varicose veins and occurrence of dementia: A nationwide population-based cohort study.

While varicose vein (VV) and dementia are frequent health problems, research investigating association between these conditions has been limited. We aimed to investigate the relationship between the presence of VV and the development of dementia, as well as to evaluate whether treatment for VV correlates with the occurrence of dementia in a longitudinal study involving the general population. Our study included 430,875 participants based on health screening results conducted from 2005 to 2010 in the South Korean health screening cohort database.

Meaning of Work, Ageism Experience, Social Exclusion, and Quality of Life in Working Older Adults.

Purpose: The current study examined the mediating effect of the meaning of work in the relationship between quality of life and experiences with ageism and social exclusion among working older adults.

Method: A cross-sectional correlational design was used. Data were collected using self-administered questionnaires between October 1 and November 30, 2019, and were analyzed using Pearson correlation coefficients and multiple linear regression.

Effect of Axis Change on Shrinkage Rate of 3D-Printed Bioceramic Zirconia Fabricated via Digital Light Processing.

Isotropic shrinkage is critical for producing dimensionally accurate prostheses using zirconia. However, the anisotropic shrinkage of 3D-printed zirconia limits its utility in clinical applications. We aimed to evaluate the impact of specimen axis alterations on the shrinkage of digital light processing (DLP)-printed zirconia.

The Usefulness of AI-Based Cornea Exposure Rate (CER) Analysis Utilizing the Anigma View System in Evaluating Ptosis Surgery Outcomes.

: Ptosis surgery corrects drooping upper eyelids, improving function and esthetics. Traditional methods like marginal reflex distance (MRD) and palpebral fissure height (PFH) offer limited one-dimensional measurements. This study evaluates AI-based corneal exposure ratio (CER) analysis, a two-dimensional approach, compared to manual ImageJ methods for assessing ptosis surgery outcomes.

Type I interferon exposure of an implantation-on-a-chip device alters invasive extravillous trophoblast function.

Inappropriate type I interferon (IFN) signaling during embryo implantation and placentation is linked to poor pregnancy outcomes. Here, we evaluate the consequence of elevated type I IFN exposure on implantation using a human implantation in an organ-on-a-chip device. We reveal that type I IFN reduces extravillous trophoblast (EVT) invasion capacity.

Multimodal Biomedical Signal Acquisition Setup to Assess Chronic Pain in Older Adults With Alzheimer's Disease.

Chronic pain often goes unrecognized and untreated in individuals with Alzheimer's disease and related dementias (ADRD), mainly due to limited capacity to verbalize pain. Addressing this issue requires the development of reliable objective biomarkers for pain. In the present pilot study, we explored the feasibility and acceptability of using a wearable electroencephalograph (EEG) and a screen-based eye tracker system to identify neural signatures of chronic pain in this population.

Endogenous extraction yielded high quality sulforaphane from broccoli sprouts unveils potent antioxidant and anti-Alzheimer's activities.

The extraction of sulforaphane (SFN) is challenging due to its instability and low water solubility, with existing methods often involving toxic solvents or yielding low SFN. We optimized an endogenous extraction protocol for high SFN content, characterized by HPLC and LC-MS analyses. SFN remained stable in refrigerated broccoli sprout extract powder (BSEP) for over a month.

The Association between the Triglyceride-Glucose Index and the Incidence Risk of Parkinson's Disease: A Nationwide Cohort Study.

Objective: We aimed to investigate the associations of the triglyceride-glucose index, which measures insulin resistance, and the incidence of Parkinson's disease.

Methods: Our study used the Health Screening Cohort database of the National Health Insurance Service of South Korea (2002-2019). We included 310,021 participants who had no previous history of Parkinson's disease and for whom more than 3 triglyceride-glucose index measurements were available.

Association Between Triglyceride/High-Density Lipoprotein Ratio and Incidence Risk of Heart Failure: A Population-Based Cohort Study.

: The triglyceride/high-density lipoprotein (TG/HDL) ratio serves as a simple marker for insulin resistance. We investigated whether the TG/HDL ratio would be associated with the incidence risk of heart failure (HF). : The study utilized data from the National Health Insurance Service-Health Screening Cohort database of South Korea from 2002 to 2019.

Enhanced Bioprinting of 3D Corneal Stroma Patches with Reliability, Assessing Product Consistency and Quality through Optimized Electron Beam Sterilization.

This study focuses on the optimization of sterilization methods for bioprinted three-dimensional (3D) corneal stroma patches prepared using cornea-derived decellularized extracellular matrix (Co-dECM) hydrogels and human keratocytes, with the aim of enhancing clinical applications in corneal tissue engineering. An essential aspect of this study is to refine the sterilization processes, particularly focusing on electron beam (EB) sterilization, to maintain the structural and functional integrity of the Co-dECM hydrogels while ensuring sterility. The study reveals that EB sterilization outperformed traditional methods like ethylene oxide (EtO) gas and autoclaving, which tend to degrade the biochemical properties of hydrogels.

Association between the triglyceride/high-density lipoprotein (TG/HDL) ratio and incidence of gout: A nationwide cohort study.

Introduction: The global burden of gout, a severe and painful arthralgia, is of note and is expected to increase in the future. We aimed to investigate the association between the triglyceride/high-density lipoprotein (TG/HDL) ratio, a simple and validated biomarker for insulin resistance, and the incidence of gout in a longitudinal setting in the general population.

Methods: Our study was conducted using the National Health Insurance Service-Health Screening Cohort database of Republic of Korea (2002-2019).

Association between triglyceride/high density lipoprotein ratio and incidence risk of Parkinson's disease: a population-based cohort study.

The association between insulin resistance and increased risk of Parkinson's disease (PD) has rarely been investigated. Our study aimed to investigate the association between the triglyceride/high-density lipoprotein (TG/HDL) ratio (which represents insulin resistance), and the incidence risk of PD in the general population. This study was conducted using data from the National Health Insurance Service-Health Screening Cohort Database of South Korea (2002-2019).

Association of varicose veins with the risk of heart failure: A nationwide cohort study.

Background: Research investigating the association between varicose veins (VV) and heart failure has been limited. Here, we examine this association within a nationwide longitudinal cohort, hypothesizing an increased risk of heart failure associated with the presence of VV.

Methods: Our study included 390,436 participants based on health screening results conducted from 2005 to 2010 in the South Korean health screening cohort database.

Effectiveness of Bisphosphonates in Young Adults With Fragility Fractures: Representative Population-based Cohort Study.

Context: Fragility fractures in young adults present significant clinical challenges due to the limited evidence on the effectiveness of bisphosphonates in preventing subsequent fractures.

Objective: To evaluate the effectiveness of bisphosphonate therapy in reducing the fracture risk among premenopausal women with a history of osteoporotic fractures.

Design: A population-based retrospective cohort study was conducted using data from the National Health Insurance Service-National Sample Cohort in South Korea, covering the years 2003 to 2014.

Healthcare workers' experiences in long-term care facilities during cohort quarantine for the COVID-19 pandemic in South Korea: a qualitative study.

Objectives: This study aimed to investigate the experiences of healthcare workers in long-term care facilities (LTCFs) during cohort quarantine for the COVID-19 pandemic in South Korea.

Design: A qualitative study using thematic analysis.

Setting And Participants: Ten workers from two LTCFs that underwent cohort quarantine due to COVID-19 in South Korea, including direct-care staff and administrators.

Developmental Characteristics of High-Risk Infants According to the Bayley Scales of Infant and Toddler Development-Third Edition.

Background: The present study aimed to determine the developmental characteristics of high-risk infants with birth and perinatal risk factors according to gestational age using the Bayley Scales of Infant and Toddler Development-Third Edition (Bayley-III) and to assess the clinical utility of the scale.

Methods: This study included 100 high-risk infants < 12 months' corrected age who presented to a hospital in Korea. Developmental levels of cognitive, language and motor scales were confirmed using Bayley-III and analysed by dividing the infants according to gestational age as follows: high-risk full-term, moderate-to-late preterm and very preterm.

Effects of Late-Passage Small Umbilical Cord-Derived Fast Proliferating Cells on Tenocytes from Degenerative Rotator Cuff Tears under an Interleukin 1β-Induced Tendinopathic Environment.

Background: Tendinopathy is a chronic tendon disease. Mesenchymal stem cells (MSCs), known for their anti-inflammatory properties, may lose effectiveness with extensive culturing. Previous research introduced "small umbilical cord-derived fast proliferating cells" (smumf cells), isolated using a novel minimal cube explant method.

Effects of stress on burnout among infection control nurses during the COVID-19 pandemic: the mediating effects of social support and self-efficacy.

Background: This study investigated the mediating effects of self-efficacy and social support on the relationship between stress and burnout among infection control nurses (ICNs) during an emerging infectious disease pandemic.

Methods: The study participants encompassed 210 ICNs with at least six months' experience in an infection control unit at a general hospital in South Korea during the COVID-19 pandemic. Data were analyzed using independent t-tests or one-way analysis of variance (ANOVA), while descriptive statistics were performed using SPSS/WIN 26.

Hypnotic effect of AR-001 through adenosine A receptor.

Insomnia is one of the most common sleep disorders, affecting 10-15% of the global population. Because classical remedies used to treat insomnia have various side effects, new therapeutics for insomnia are attracting attention. In the present study, we found that N-Ethyl-N-(furan-2-ylmethyl) quinazoline-2,4-diamine (AR-001) has adenosine A receptor agonistic activity and exhibits hypnotic efficacy by decreasing sleep onset latency and increasing total sleep time in a pentobarbital-induced sleep model.