Consensus statement on peri-implant disease from the Korean Academy of Periodontology.

This consensus report presents the first official position statement of the Korean Academy of Periodontology on peri-implant diseases, issued in response to South Korea's rapidly aging population and the associated rise in peri-implant disease management. It reviews the prevalence, classification, and definition of peri-implant diseases, emphasizing that these conditions progress more aggressively and unpredictably than periodontal diseases. The report also identifies systemic and local risk indicators, diagnostic criteria, and evidence-based treatment protocols for peri-implant mucositis and peri-implantitis, integrating international standards with Korea-specific clinical data.

"I'm more confident now than I ever used to be": a preliminary qualitative study of British older adults' perception and experience of aging positively.

Background And Objectives: With the changing demographic of older adults population observed around the world, it is important that aging is not simply conceptualized as decline in functioning and physical health, but encompasses positive experiences that impact upon overall well-being. Looking at the aging experience in a particular sociocultural context allows for a more in-depth understanding that could then lead to promotion of positive aging and improvements in aging outcomes in that context.

Research Design And Methods: The current qualitative study explores through Interpretative Phenomenological Analysis how UK adults have experienced aging.

Multi-omics analysis reveals the genetic basis for rapid CO utilization in the acetogenic bacterium KIAC.

KIAC is a novel acetogen isolated from cattle feces that exhibits rapid CO utilization. To investigate the molecular basis of this phenotype, we performed a comprehensive multi-omics analysis, including Genome-seq, RNA-seq, dRNA-seq, and Term-seq, to map its transcriptome architecture. We identified 2,158 transcription start sites and 2,275 transcript 3' ends, enabling high-resolution reconstruction of the transcriptional landscape and associated regulatory features.

Is Delaying Marriage Beneficial in Later Life? Age at Marriage and Psychological and Cognitive Health in Later Life in India.

Background And Objectives: Previous research on the effects of age at marriage in low- and middle-income countries has predominantly examined the influence of child marriage on women's reproductive, sexual, and mental health outcomes. However, this research has focused on younger populations and has not examined how age at marriage may affect health in later life. We posit that the experience of adversities associated with child marriage has an enduring influence on cognitive and psychological health in later life.

Distinct microbiome composition and reduced interactions in patients with pancreatic cancer.

Introduction: The results of microbiome composition in patients with malignancy have been inconsistent across studies and are affected by various factors. This study aimed to identify microbiome composition of saliva, feces, and blood in patients with pancreatic cancer.

Results: Overall, 31 patients with pancreatic cancer and 24 healthy controls were sex- and age-matched.

TRPV1 inhibition sensitizes tumors to PD-1 blockade by reversing resistance to CTL-mediated killing.

Resistance to immune checkpoint blockade (ICB) therapy remains a major obstacle to successful cancer treatment and represents a significant unmet clinical need. Identifying clinically actionable targets to overcome this resistance is therefore essential for developing effective combination strategies with ICB. In this study, using transcriptomic data from cancer patients treated with programmed cell death protein 1 (PD-1) therapy and established mouse preclinical PD-1 blockade-resistant models, we identify transient receptor potential vanilloid 1 (TRPV1) as a crucial mediator that enables tumor cells to resist cytotoxic T lymphocyte (CTL)-mediated killing, thereby facilitating immune escape from PD-1 therapy.

Consequence of Bisphosphonate Use on Dental Implant Removal in Osteoporotic Patient: A Nationwide Cohort Study.

Introduction: This nationwide population-based cohort study aimed to investigate the relationship between bisphosphonate (BP) use and dental implant removal in patients with osteoporosis.

Methods: A total of 389 226 individuals aged ≥ 65 years with osteoporosis who underwent dental implant surgery between 2014 and 2018 were included. Patients were classified into BP and control groups based on their prescription records.

Spousal Loss, Depressive Symptoms, and Religious Involvement: Immediate Impact and Trajectories in Late Life.

Using cross-sectional and longitudinal data, we examined the immediate and long-term buffering effects of religious involvement on late-life spousal loss. Using seven waves of data (2006-2018) from the Health and Retirement Study ( = 4714; = 18,212), we conducted ordinary least squares regression and growth curve analyses. Recent spousal loss was strongly associated with increased depressive symptoms, which gradually decreased over time.

Time since last intravenous bisphosphonate and risk of osteonecrosis of the jaw in osteoporotic patients.

Medication-related osteonecrosis of the jaw is a rare but serious condition in which the jawbone fails to heal and becomes necrotic, typically after dental surgery in patients treated with bisphosphonates. However, clear evidence guiding how long bisphosphonate treatment should be paused before dental surgery remains limited. Here we show that a longer time since the last dose of intravenous bisphosphonate is associated with a reduced risk of jawbone necrosis.

Regenerative effect of human cell-derived BMP-2 cultured within a collagen bone graft in a rat calvaria defect model.

Bone morphogenetic protein-2 (BMP-2) is a potent osteoinductive factor; however, current clinical applications using -derived recombinant human BMP-2 are constrained by structural deficiencies and high-dose requirements, which increases the risk of adverse effects. In this study, we aimed to address these limitations by developing a novel approach leveraging genetically engineered human retinal pigment epithelial cells (ARPE-19) to synthesize human cell-derived BMP-2 (hBMP-2) within a collagen-based bone graft matrix. ARPE-19 cells were transduced using a lentiviral vector encoding BMP-2 and subsequently cultured in a porcine-collagen mixed graft material.

Association between root canals and gingival sulci microbiota in secondary and persistent endodontic infections.

Secondary/persistent endodontic infections (SPEIs) result from failed root canal therapy, causing persistent apical periodontitis. Current diagnostic methods for SPEIs predominantly rely on clinical and radiographic indicators, which often lack adequate sensitivity and specificity. Consequently, there is an urgent need to effectively detect SPEIs or monitor their progression.

Oral microbiome changes in subjects with obesity following bariatric surgery compared to lean counterparts.

Introduction: This study aimed to compare oral microbiome profiles between obese and lean individuals without clinical periodontitis, and to assess changes in the oral microbiome of obese subjects following bariatric surgery.

Methods: Individuals with a body mass index (BMI) > 30 were enrolled in the obese group, whereas those with a BMI < 23 served as controls. The obese surgery group, which consented to bariatric surgery, was followed up at 1, 3, and 6 months with clinical examinations.

Cytoplasmic WEE1 Promotes Resistance to PD-1 Blockade Through Hyperactivation of the HSP90A/TCL1/AKT Signaling Axis in NANOGhigh Tumors.

Immune checkpoint blockade (ICB) has revolutionized the therapeutic landscape across various cancer types. However, the emergence of resistance to ICB therapy limits its clinical application. Therefore, it is necessary to better understand immune-resistance mechanisms that could be targeted by actionable drugs and important to identify predictive markers for selecting patients.

The Impact of Hospital Volume and Region on Mortality, Medical Costs, and Length of Hospital Stay in Elderly Patients Following Hip Fracture: A Nationwide Claims Database Analysis.

Backgroud: The purpose of our study was to analyze the effects of hospital volume and region on in-hospital and long-term mortality, direct medical costs (DMCs), and length of hospital stay (LOS) in elderly patients following hip fracture, utilizing nationwide claims data.

Methods: This retrospective nationwide study sourced its subjects from the Korean National Health Insurance Review and Assessment Service database spanning from January 2011 to December 2018. A generalized estimating equation model with a Poisson distribution and logarithmic link function was used to estimate adjusted odds ratios (aORs) and 95% CIs to assess the association of hospital volume with in-hospital and 1-year mortality, DMCs, and LOS.

Current understanding of the etiology, diagnosis, treatment, and management of peri-implant diseases: a narrative review for the consensus report of the Korean Academy of Periodontology.

Over the past few decades, dental implants have been successfully utilized to replace teeth lost due to periodontal disease and other conditions. However, similar to natural teeth, dental implants are vulnerable to inflammatory peri-implant diseases, which can compromise their long-term viability. This review aims to summarize the current understanding of peri-implant diseases and discuss effective strategies for their diagnosis, treatment, and long-term management.

Metagenomic characterization of oral microbiome signatures to predict upper gastrointestinal and pancreaticobiliary cancers: a case-control study.

Background: This study investigated the oral microbiome signatures associated with upper gastrointestinal (GI) and pancreaticobiliary cancers.

Methods: Saliva samples from cancer patients and age- and sex-matched healthy controls were analyzed using 16S rRNA-targeted sequencing, followed by comprehensive bioinformatics analysis.

Results: Significant dissimilarities in microbial composition were observed between cancer patients and controls across esophageal cancer (EC), gastric cancer (GC), biliary tract cancer (BC), and pancreatic cancer (PC) groups (R = 0.

Effectiveness of Bisphosphonates in Young Adults With Fragility Fractures: Representative Population-based Cohort Study.

Context: Fragility fractures in young adults present significant clinical challenges due to the limited evidence on the effectiveness of bisphosphonates in preventing subsequent fractures.

Objective: To evaluate the effectiveness of bisphosphonate therapy in reducing the fracture risk among premenopausal women with a history of osteoporotic fractures.

Design: A population-based retrospective cohort study was conducted using data from the National Health Insurance Service-National Sample Cohort in South Korea, covering the years 2003 to 2014.

Analysis of the progression of cervical cancer in a low-and-middle-income country: From pre-malignancy to invasive disease.

To better understand cervical cancer progression, we analyzed RNA from 262 biopsies from women referred for colposcopy. We determined the HPV type and analyzed the expression of 51 genes. HPV31 was significantly more prevalent in precancer than stage 1 cancer and invasive cancer (p < 0.

Homologous Targeting Effect of Cancer Cell-Derived Liposomes (Memposomes) Mediated by Cell Adhesion Molecules: Role of E-cadherin.

Cell membrane-derived liposomes, termed Memposomes, serve as promising carriers for drug delivery due to their ability to closely mimic cells and efficiently target specific cells. Liposomes derived from cancer cell membranes, in particular, exhibit homologous targeting capabilities, making them potential candidates for cancer-specific drug delivery. However, the underlying mechanisms and specific proteins responsible for this homologous targeting phenomenon remain debated.

Anti-Warburg Mechanism of Ginsenoside F2 in Human Cervical Cancer Cells via Activation of miR193a-5p and Inhibition of β-Catenin/c-Myc/Hexokinase 2 Signaling Axis.

Though Ginsenoside F2 (GF2), a protopanaxadiol saponin from Panax ginseng, is known to have an anticancer effect, its underlying mechanism still remains unclear. In our model, the anti-glycolytic mechanism of GF2 was investigated in human cervical cancer cells in association with miR193a-5p and the β-catenin/c-Myc/Hexokinase 2 (HK2) signaling axis. Here, GF2 exerted significant cytotoxicity and antiproliferation activity, increased sub-G1, and attenuated the expression of pro-Poly (ADPribose) polymerase (pro-PARP) and pro-cysteine aspartyl-specific protease (procaspase3) in HeLa and SiHa cells.

Saliva assay: a call for methodological standardization.

The oral cavity provides an ideal environment for microorganisms, including bacteria, viruses, and fungi, to flourish. Increasing attention has been focused on the connection between the oral microbiome and both oral and systemic diseases, spurring active research into the collection and analysis of specimens for healthcare purposes. Among the various methods for analyzing the oral microbiome, saliva analysis is especially prominent.

Negative Regulation of CPSF6 Suppresses the Warburg Effect and Angiogenesis Leading to Tumor Progression Via c-Myc Signaling Network: Potential Therapeutic Target for Liver Cancer Therapy.

In this study, we explored the oncogenic mechanism of cleavage and polyadenylation-specific factor 6 (CPSF6) in hepatocellular carcinoma (HCC). CPSF6 was overexpressed in HCC tissues with poor survival rates compared to normal tissues. Hence, CPSF6 depletion suppressed cell viability and colony formation, induced apoptosis via PARP cleavage, and increased the sub-G1 population of Hep3B and Huh7 cells.

Modeling of the brain-lung axis using organoids in traumatic brain injury: an updated review.

Clinical outcome after traumatic brain injury (TBI) is closely associated conditions of other organs, especially lungs as well as degree of brain injury. Even if there is no direct lung damage, severe brain injury can enhance sympathetic tones on blood vessels and vascular resistance, resulting in neurogenic pulmonary edema. Conversely, lung damage can worsen brain damage by dysregulating immunity.