Comparison of Disease Progression From Prostate Cancer Diagnosis to Metastatic or Nonmetastatic Castrate-Resistant Prostate Cancer (CRPC) Patients: CaPA Study.

Background: Prostate cancer (PC) patients resistant to castration have decreased survival. Analysis of patient characteristics and disease management can contribute to new strategies to prevent or delay progression to castrate-resistant prostate cancer (CRPC). This study aimed to characterize and compare PC patients from initial PC diagnosis to metastatic CRPC (mCRPC) versus nonmetastatic (nmCRPC) stages in a real-world setting in Portugal.

Cognitive Impairment in Prostate Cancer Patients Receiving Androgen Deprivation Therapy: A Scoping Review.

Androgen deprivation therapy (ADT) is a primary treatment for prostate cancer (PCa) that effectively reduces androgen levels to suppress tumor progression. However, growing evidence suggests potential cognitive side effects, raising concerns about the long-term neurological consequences of this treatment. This scoping review aims to synthesize the existing evidence linking ADT to cognitive changes in men with PCa, identifying the key cognitive domains affected and outlining gaps in the existing literature.

Isotope tracking of anthropogenic Cu and Zn in urbanized coastal environments: A review.

Copper (Cu) and zinc (Zn) are common trace metal contaminants in marine environments that, despite their importance for the health of marine organisms, can be toxic. Recently, the stable isotopes of these elements have emerged as powerful tracers for studying their cycles. Thus, this review aims to connect urban and marine interfaces under a "land-sea continuum" framework to understand the complex sources, pathways, and transformations of Cu and Zn in urbanized coastal environments, a perspective currently lacking in the literature.

Application of encapsulated tomato by-product extract as a colorant in mascarpone.

Agricultural by-products, often underutilized, represent a significant opportunity to obtain sustainable value-added products to develop new functional foods. In this context, the (typically discarded) aerial parts of tomato plants (Solanum lycopersicum L. var.

How do the physical and physiological demands of training and official football match for recreational players compare to those of semi-professionals?

Playing football at very different competitive levels can lead to different physical and physiological demands. Daily routines of these practitioners can also show differences in terms of leisure time, main professional occupations, among other activities. Therefore, understanding the physical and physiological demands between recreational and Semi-Professional players is crucial for designing appropriate training programs and assessing potential health benefits.

Zinc stable isotopes in mangrove crabs as tracers of anthropogenic contamination in a tropical estuary.

Our study presents a novel approach for tracing anthropogenic zinc (Zn) bioaccumulation in mangrove crabs using Zn stable isotope compositions (δZn). We analyzed δZn and elemental composition in crab tissues from Brazilian mangroves within a coastal lagoon historically impacted by electroplating waste. Crabs from the mangrove area near the old electroplating plant exhibited the highest Zn concentrations in both muscle and hepatopancreas, likely reflecting the high Zn bioavailability in these sediments.

Translation and Validation of the Portuguese Version of the Rating-of-Fatigue Scale.

Background: The Rating-of-Fatigue (ROF) scale is a validated tool to measure changes in perceived fatigue in sports and everyday contexts; thus, this study aimed to translate and validate the Portuguese version of the ROF scale. For this, the study was composed of three phases. Phase 1 involved a comprehensive translation of the ROF scale into Portuguese, followed by a back-translation and a consolidation process to obtain the final version of the ROF scale in Portuguese.

Combined action of dietary-based approaches and therapeutic agents on cholesterol metabolism and main related diseases.

Background: Dyslipidaemia is among the major causes of severe diseases and, despite being well-established, the hypocholesterolaemic therapies still face significant concerns about potential side effects (such as myopathy, myalgia, liver injury digestive problems, or mental fuzziness in some people taking statins), interaction with other drugs or specific foods. Accordingly, this review describes the latest developments in the most effective therapies to control and regulate dyslipidaemia.

Scope And Approach: Herein, the metabolic dynamics of cholesterol and their integration with the current therapies: statins, bile acid sequestrants, fibrates, niacin, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, reconstituted high-density lipoprotein (rHDL), or anti-inflammatory and immune-modulating therapies), were compared focusing their effectiveness, patients' adhesion and typical side-effects.

No match, more sleep: Greater weekend catch-up sleep in youth soccer players on free weekends.

This study aimed to compare young soccer players' week and weekend sleep behaviors in two different microcycle types: with and without an official match (no sporting commitments). Twenty-three youth male players (mean ± SD; age: 17.2 ± 0.

Metabolite Profiling of Macroalgae: Biosynthesis and Beneficial Biological Properties of Active Compounds.

Macroalgae are known as abundant sources of phytochemicals, which offer a plethora of beneficial biological properties. Besides being the most notable classes of compounds found in macroalgae, phlorotannins, bromophenols, and terpenoids comprise some of the most relevant for their biological properties. Phlorotannins, mainly prevalent in brown algae and structurally characterized as complex polyphenolic compounds derived from phloroglucinol units, possess robust antioxidant, anti-inflammatory, antitumor, and cytotoxic activities, modulated by factors such as the degree of polymerization and environmental conditions.

Characterizing microcycles' workload when combining two days structure within single training sessions during congested fixtures in an elite male soccer team.

This study aimed to describe and compare specific matchdays sessions and playing positions external load during congested fixtures in elite football when combining the objectives from two different training days in one session. Data was collected from 27 players from the 1 Brazilian division (28.7 ± 18.

Composition and Quality of Honey Bee Feed: The Methodology and Monitoring of Candy Boards.

The nutritional status of a honey bee colony is recognized as a key factor in ensuring a healthy hive. A deficient flow of nectar and pollen in the honey bee colony immediately affects its development, making room for pathogen proliferation and, consequently, for a reduction in the activities and strength of the colony. It is, therefore, urgent for the beekeepers to use more food supplements and/or substitutes in apiary management, allowing them to address colony nutritional imbalances according to the beekeeper's desired results.

Chemical and Bioactive Properties of Red Rice with Potential Pharmaceutical Use.

Red rice has been proposed as a super-food. Accordingly, the nutritional properties (AOAC), as well as its chemical composition, including sugars (HPLC-RI), organic acids (UFLC-PDA), tocopherols (HPLD-FD), and phenolic compounds (LC-DAD-ESI/MSn), together with the main bioactive properties (antioxidant, cytotoxic, antiproliferative, and antibacterial activities), were evaluated to access its nutritional benefits and health improvement potential. The most abundant macronutrients found were carbohydrates (87.

Human-Deer Relations during Late Prehistory: The Zooarchaeological Data from Central and Southern Portugal in Perspective.

Human-animal relations have been a fruitful research topic worldwide. The importance of deer in hunter-gatherer societies is undeniable, with cervids being commonly found in archaeological and past artistic records, with a notable amount of information recovered in the Iberian Peninsula. This relevance continues during Late Prehistory, but the attempt to discuss cervids under broader perspectives and based on different types of data is not as common.

Giant Cell Arteritis Presenting as Multiple Ischaemic Strokes: A Successful case of Endovascular Treatment.

Unlabelled: Giant cell arteritis (GCA) may manifest with aggressive intracranial stenosis resistant to medical therapy, and patients may develop refractory neurologic deficits and cerebral infarcts, making GCA a life-threatening condition. We report the case of a 68-year-old woman recently diagnosed with GCA, medicated with prednisolone 60 mg daily. Two weeks later, the patient was admitted to our Stroke Unit after a sudden episode of global aphasia.

Copper and zinc isotope systematics in different bivalve mollusk species from the French coastline: Implications for biomonitoring.

Zinc (Zn) and copper (Cu) stable isotopic compositions have been analyzed in various species of bivalve mollusks worldwide, but no comprehensive systematic interspecies comparison exists. Thus, we assessed isotope differences between species harvested in emblematic French coastal ecosystems to unveil biologically driven Cu and Zn isotope fractionation patterns. Inter-species isotopic variability of Cu is larger than Zn, with organisms that regulate internal concentrations displaying preferential bioaccumulation of heavy isotopes.

Improving the identification of high-risk non-metastatic castration-resistant prostate cancer patients in clinical practice.

Non-metastatic castration-resistant prostate cancer (nmCRPC) represents a challenging disease state in prostate cancer care. nmCRPC patients with a high risk of progression to metastatic disease who are identified by a prostate-specific antigen doubling time (PSADT) ≤10 months are eligible for treatment with the novel androgen receptor inhibitors (ARIs), shown to delay disease progression and extend survival. However, nmCRPC is often unexploited in clinical practice due to a lack of standardization in the methodology and in the tools used for its identification.

The French Mussel Watch Program reveals the attenuation of coastal lead contamination over four decades.

The mid-20th century industrial peak caused severe global lead (Pb) marine contamination. Although Europe initiated Pb emission reduction regulations in the 1980s, the short- and long-term impacts remain unclear. This study investigates the evolution of Pb contamination on the French coast through elemental and isotope analysis in oysters and mussels from the French "Mussel Watch" Program.

Personalized medicine: paradigm shift in ALK positive non-small cell lung cancer: a case report.

Background: Since the identification of multiple therapeutic targets, as is the case of anaplastic lymphoma kinase (ALK) translocation, the paradigm of treating patients with non-small cell lung cancer (NSCLC) has improved. In order to guarantee the possibility of longer survival outcomes with a better quality of life we must invest in the determination, in suitable time, of the consensual biomarkers and in the availability of the best treatments to our patients.

Case Presentation: We present a case of a caucasian male in his fifth decade of life, non-smoker, who highlights the complex journey of ALK-positive patients.

Flowers as a Source of Nutritional and Bioactive Compounds.

In recent decades, plants have strengthened their relevance as sources of molecules potentially beneficial for health. This underpinning effect also arises from the extensive research that has been conducted on plants that are typically undervalued, besides being scarcely used. This is the case with Camellia japonica in Galicia (NW Spain), where, despite its abundance, it is exclusively used for ornamental purposes and has been studied only for its proximate composition.

Using Bar Velocity to Assess Post-match Neuromuscular Fatigue in Young Soccer Players.

This study aimed to investigate the recovery of neuromuscular performance using mechanical parameters collected during jump (vertical and horizontal) and strength-power exercises in youth soccer players after official soccer matches. Twenty-one outfield highly trained youth male soccer athletes (age: 18.23±0.

Transient Perivascular Inflammation of the Carotid Artery (TIPIC) Syndrome: An Atypical Cause of Neck Pain.

Transient perivascular inflammation of the carotid artery (TIPIC) is an uncommon condition characterized by inflammation of the carotid artery wall, leading to unilateral neck pain. While TIPIC has been acknowledged by the International Classification of Headache Disorders, only a few patient series have been published thus far. The clinical presentation of TIPIC syndrome typically manifests as unilateral neck pain localized specifically over the carotid artery.

The antihyperuricemia activity of Astragali Radix through regulating the expression of uric acid transporters via PI3K/Akt signalling pathway.

Ethnopharmacological Relevance: Astragali Radix (AR) is the dry root of the leguminous plants Astragalus membranaceus (Fisch) Beg. var. mongholicus (Beg) Hsiao, and Astragalus membranaceus (Fisch) Bge.