Natural Microbiota of Dogs and Cats as a Source and Vector of Resistance Genes-Clinical Significance.

Antimicrobial resistance (AMR) presents a growing global threat, driven by widespread antibiotic misuse across human and veterinary medicine. Companion animals, particularly dogs and cats, harbor complex natural microbiota-including skin, mucosal, and gastrointestinal communities-that are essential to their health yet also serve as reservoirs of antibiotic resistance genes (ARGs). These ARGs can spread through horizontal gene transfer (HGT), especially during bacterial imbalances such as endogenous infections or surgical interventions, increasing the risk of difficult-to-treat infections.

Molecular Cardiac Changes in Feline Hyperthyroidism and Hypertrophic Cardiomyopathy: Focus on Desmin, Calreticulin, and Interleukin-10 Expression.

Feline hyperthyroidism is the most frequent endocrinopathy in adult and senior cats, frequently leading to cardiac changes characterised by a hypertrophic cardiomyopathy (HCM) phenotype, which may partially reverse with appropriate treatment. However, the structural and molecular alterations in the myocardium can persist and closely resemble those observed in hypertrophic cardiomyopathy. Despite this clinical overlap, protein expression patterns in the hearts of hyperthyroid cats remain poorly understood.

Exploring the Potential of Novel Animal-Origin Probiotics as Key Players in One Health: Opportunities and Challenges.

Probiotics play a critical role in promoting the health of both humans and animals, with growing interest in the potential of animal-derived strains. Safety and efficacy assessments are crucial, with rigorous testing required to ensure the absence of harmful effects. The health benefits of animal-derived probiotic strains include improved digestion, balanced microbiota, behavioral impact, reduced inflammation, and minimized risk of infections.

Correction: Będkowska et al. What We Know and Do Not Yet Know About the Canine Model of Lymphoma in Human Medicine-The Current State of Knowledge. 2025, , 596.

In the original publication [...

The Pathological and Histopathological Findings in Cats with Clinically Recognised Hypertrophic Cardiomyopathy Are Related to the Severity of Clinical Signs and Disease Duration.

Hypertrophic cardiomyopathy (HCM) is the most frequent type of cardiac disease in cats. Due to its high prevalence and risk of sudden and severe signs, the disease is an important topic of various research. Despite the focus on the clinical course of the disease, studies presenting the pathological and histopathological patterns are rare.

What We Know and Do Not Yet Know About the Canine Model of Lymphoma in Human Medicine-The Current State of Knowledge.

This review comprehensively compares lymphoma in humans and dogs, highlighting the canine model's utility in translational research. Canine lymphoma (cL), predominantly diffuse large B-cell lymphoma (DLBCL), mirrors human non-Hodgkin's lymphoma (NHL) in its clinical presentation, including lymphadenopathy, systemic symptoms (e.g.

The Impact of Short-Term Formalin Fixation on Weight and Ventricular Dimensions in the Hearts of Cats and Small-to-Medium-Sized Dogs.

Organ weight and size are important data collected during post-mortem examination not only in neoplastic diseases but also in other conditions, like cardiomyopathies. As post-mortem cardiac examination is challenging, it should be performed by experienced specialists. Nonetheless, the low number of referral centres in veterinary medicine requires the shipment of formalin-fixed specimens to perform detailed post-mortem cardiac examinations.

Atrial septal pouch in cats: first report on interatrial septum anatomical variations.

Objectives: The atrial septal pouch was first recognised in humans in 2006 and, since 2010, has been described in more detail. The first reports on the left-sided atrial septal pouch linked its occurrence with a higher risk of thromboembolic stroke resulting from left atrial thrombus formation. However, subsequent studies have challenged this theory; therefore, the consequences of septal pouch occurrence remain disputed.

The Importance of Intestinal Microbiota and Dysbiosis in the Context of the Development of Intestinal Lymphoma in Dogs and Cats.

Recent advancements have significantly enhanced our understanding of the crucial role animal microbiomes play in veterinary medicine. Their importance in the complex intestinal environment spans immune modulation, metabolic homeostasis, and the pathogenesis of chronic diseases. Dysbiosis, a microbial imbalance, can lead to a range of diseases affecting both individual organs and the entire organism.

Comparative cardiac macroscopic and microscopic study in cats with hyperthyroidism vs. cats with hypertrophic cardiomyopathy.

Hyperthyroidism is considered the most common endocrinopathy in middle-aged and old cats. The increased level of thyroid hormones influences many organs, including the heart. Cardiac functional and structural abnormalities in cats with hyperthyroidism have indeed been previously described.

Expression of Foxp3 in Fibromas and Fibrosarcomas of Skin and Subcutaneous Tissue in Dogs.

Background/aim: Foxp3 is a transcription factor responsible for the formation of T regulatory lymphocytes. Foxp3 expression can be associated with either neoplastic progression or regression. The aim of the study was to evaluate Foxp3 expression in soft tissue tumours (fibromas and fibrosarcomas) of skin and subcutaneous tissue in dogs and to describe its relationship with tumour malignancy grade.

Endosialin (CD248) Expression in Fibromas and Soft-tissue Fibrosarcomas in Dogs.

Background/aim: Endosialin is present in human fibrosarcoma neoplastic cells. This study aimed to analyse the expression of selected cellular proteins found in fibrosarcomas and soft-tissue fibroids in dogs.

Materials And Methods: A total of 71 skin tumours obtained from dogs were used.

Expression of Periostin in Mammary Cancer Cells of Female Dogs.

Background/aim: Periostin (POSTN) has a significant role in proliferation and migration of tumour cells as well as tumour progression. This study aimed to determinate POSTN expression in cancer cells in malignant and benign tumours of the mammary gland in female dogs.

Materials And Methods: All together 83 cancers, 24 adenomas and 7 unchanged fragments of the mammary glands of bitches were investigated.