Publications by authors named "Agnieszka Wieczorek"
This review comprehensively compares lymphoma in humans and dogs, highlighting the canine model's utility in translational research. Canine lymphoma (cL), predominantly diffuse large B-cell lymphoma (DLBCL), mirrors human non-Hodgkin's lymphoma (NHL) in its clinical presentation, including lymphadenopathy, systemic symptoms (e.g.
View Article and Find Full Text PDFPredictors of outcomes of patients ≥ 80 years old admitted to intensive care units in Poland - a post-hoc analysis of the VIP2 prospective observational study.
Anaesthesiol Intensive Ther
May 2024
Article Synopsis
- The study investigates elderly patients (over 80 years old) in Polish ICUs, aiming to understand their clinical features and outcomes.
- Researchers collected data from 371 patients, comparing frail (CFS > 4) to non-frail patients and assessing mortality rates.
- Findings indicate higher ICU and 30-day mortality in frail patients, with clinical frailty scale (CFS) and SOFA score being significant predictors of ICU mortality.
Article Synopsis
- A study was conducted to evaluate if the tendency to limit life-sustaining treatment (LST) among elderly patients in Poland increased from 2016-2017 to 2018-2019.
- The research involved analyzing data from two cohorts of critically ill patients aged over 80, finding that the prevalence of LST limitations rose from 16.1% to 20.5% over the years.
- Although the increase wasn't statistically significant in basic analyses, further investigation showed a stronger inclination to limit LST in the later cohort, along with higher mortality and longer hospital stays for patients with LST limitations.
Management of Chronic Myeloid Leukemia Patients Resistant to Tyrosine Kinase Inhibitors Treatment.
Biomark Insights
February 2016
Chronic myeloid leukemia (CML) is a myeloproliferative disorder associated with a characteristic chromosomal translocation called the Philadelphia chromosome. This oncogene is generated by the fusion of breakpoint cluster region (BCR) and Abelson leukemia virus (ABL) genes and encodes a novel fusion gene translating into a protein with constitutive tyrosine kinase activity. The discovery and introduction of tyrosine kinase inhibitors (TKIs) irreversibly changed the landscape of CML treatment, leading to dramatic improvement in long-term survival rates.
View Article and Find Full Text PDFGenetically modified T cells for the treatment of malignant disease.
Transfus Med Hemother
December 2013
The broaden application of adoptive T-cell transfer has been constrained by the technical abilities to isolate and expand antigen-specific T cells potent to selectively kill tumor cells. With the recent progress in the design and manufacturing of cellular products, T cells used in the treatment of malignant diseases may be regarded as anticancer biopharmaceuticals. Genetical manipulation of T cells has given T cells desired specificity but also enable to tailor their activation and proliferation potential.
View Article and Find Full Text PDFThe activity of multidrug resistance (MDR) proteins in tumour cells is associated with an increased resistance to therapy and in consequence with a decreased effectiveness of chemotherapy. The majority of MDR molecules belong to a family of ABC (ATP binding cassette) transporters. Neuroblastoma (NBL) and rhabdomyosarcoma (RMS) are common solid tumours of childhood.
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