Clinical evaluation of a novel fixed-dose combination tablet (Sentorphil ForteGold) versus compounded powdered medications in dogs with myxomatous mitral valve disease: a randomized, double-blind study.

Introduction: Myxomatous mitral valve disease (MMVD) is a prevalent cardiac condition in older, small-breed dogs, often managed with multiple medications. Traditional administration involves compounded powdered mixtures, which may lead to dosing inaccuracies and reduced compliance.

Methods: In a randomized, double-blind clinical trial, 60 client-owned dogs diagnosed with ACVIM stage C MMVD were assigned to receive either a novel fixed-dose combination tablet (Sentorphil ForteGold) or a compounded powdered mixture of torsemide, pimobendan, enalapril, and spironolactone.

Inula britannica exerts antioxidant and anti-inflammatory effects in SH-SY5Y cells through the Nrf2-Keap1 signaling pathway.

The yellow flower of the Asteraceae family, Inula britannica (IB) of have been used as a medicinal herb since ancient times. Modern studies have widely known the anti-inflammatory effects and antioxidant effects of IB. Therefore, this study aimed to analyze the neuroprotective effects of IB extract based on its antioxidant and anti-inflammatory effects and to assess its potential for development as a functional material.

Immunosuppression induced by co-exposure to allergens and PM2.5 increases the risk of lung disease upon viral protein challenge.

Particulate matter (PM2.5) and allergens are common environmental exposures. However, their combined effects and their risks are still poorly understood.

Targeting the COP9 signalosome overcomes platinum resistance in ovarian cancer through two distinct genome stability mechanisms.

Unlabelled: Tubo-ovarian high-grade serous carcinoma (HGSC) is a leading cause of gynecologic cancer mortality, largely due to the emergence of platinum resistance, which serves as the mainstay of chemotherapy. Here, we identify COPS5 as a therapeutic target and use an available small molecule inhibitor to overcome platinum resistance. A genetic screen for platinum-induced DNA damage in a platinum resistant ovarian cancer model identified COPS5 and COPS6, two components of the COP9 signalosome.

Protecting the Frontline: How Paid Sick Leave Access Influences Perceived Risk, Job Stress and Job Satisfaction Among Home Service Workers.

Objective: This study examined whether access to paid sick leave (PSL) for COVID-19 symptoms is associated with lower perceived risk, reduced job stress, and greater job satisfaction.

Methods: A cross-sectional survey of 1,643 in-home service workers was conducted (response rate: 83%). Path analysis assessed the effects of sick leave type (paid, unpaid, no access, unsure) on perceived risk, job stress, and satisfaction, controlling for demographics and occupation.

Differentiating oncocytic carcinoma from oncocytic adenoma: a comprehensive evaluation of preoperative characteristics and diagnostic approaches in a retrospective cohort study.

Purpose: Oncocytic carcinoma (OCA) has been reclassified from follicular thyroid carcinoma due to its unique features. Its rarity has resulted in limited studies on differentiating OCA from oncocytic adenoma (OA). This study aimed to compare the clinicopathologic and preoperative features of OCA and OA and evaluate the effectiveness of ultrasonography and cytology.

Biomechanical Usability Evaluation of a Novel Detachable Push-Pull Device for Rehabilitation in Manual Wheelchair Users.

Manual wheelchair users are at high risk of upper limb overuse injuries due to repetitive propulsion mechanics. To address this, we developed a novel detachable push-pull dual-propulsion device that enables both forward and backward propulsion, aiming to reduce shoulder strain and promote balanced muscle engagement. This study presents a protocol to evaluate the device's biomechanical impact and ergonomic effects, focusing on objective, quantitative analysis using a repeated-measures within-subject design.

Inhibition of FAM19A5 reverses synaptic loss and cognitive decline in mouse models of Alzheimer's disease.

Background: FAM19A5 is a secretory protein primarily expressed in neurons. Although its role in synaptic function has been suggested, the precise molecular mechanisms underlying its effects at the synapse remain unclear. Given that synaptic loss is a critical hallmark of Alzheimer's disease (AD), elucidating the mechanisms involving FAM19A5 could provide valuable insights into reversing synaptic loss in AD.

Comparisons of pharmacokinetics of glimepiride in combination with Ojeok-san versus glimepiride alone: an open-label, one-sequence, two-treatment controlled clinical study.

Glimepiride remains a cost-effective antidiabetic treatment despite its potential risks. However, its interaction with traditional medicines like Ojeok-san (OJS), a commonly used herbal medication, warrants investigation. This open-label, fixed-sequence, two-period, two-treatment crossover study involved 17 healthy male volunteers.

Rapid Screening of Plastic-Degrading Enzymes Using an Optimized Cell-Free Protein Synthesis Platform.

The accumulation of plastic waste poses a significant environmental challenge, necessitating the development of efficient plastic-degrading enzymes for bioremediation and recycling. However, traditional enzyme engineering approaches rely on microbial expression systems and are time-consuming and prone to unintended interactions between host cells and recombinant circuits. To address these limitations, a cell-free protein synthesis (CFPS) platform was developed for rapidly screening plastic-degrading enzymes.

Structural and functional characterization of a novel GmKASII-A allele associated with saturated fatty acid composition in EMS-induced mutant PE1544.

Background: Soybean is an extensively utilized oilseed crop, and improved cultivars and cultivation efficiency of soybean have contributed to the increased use of soybean in edible oil applications. The food industry necessitates the development of soybean oil with an optimized balance of polyunsaturated and saturated fatty acids to meet both nutritional requirements and industrial applications.

Results: This study aimed to elucidate the protein structure and functional characterization of a novel allele of derived from an EMS-induced mutant line and assess its potential as a genetic resource for developing soybean cultivars with elevated saturated fatty acid composition.

Idarucizumab more effectively reverses the anticoagulant effects of dabigatran acylglucuronide than dabigatran.

Dabigatran acylglucuronide, an active metabolite of dabigatran, exhibits higher plasma concentrations and distinct anticoagulant effects compared to dabigatran, suggesting that it may play a more significant role in overall anticoagulant activity than previously assumed. Idarucizumab, a monoclonal antibody fragment, binds to both free and thrombin-bound dabigatran, neutralizing its anticoagulant effects. However, its efficacy in reversing anticoagulation induced by dabigatran acylglucuronide remains unclear.

Cultural shaping of emotion differentiation: Socially engaging and disengaging emotions.

There is a growing consensus that emotion differentiation-the ability to discern specific emotions-is healthy. To assess this ability, studies so far have exclusively relied on the dimension of emotion pleasantness by lumping together various types of emotions that fall within the same valence category. However, this approach neglects the possibility that individuals may represent certain types of emotions in a more differentiated fashion, if these emotions are functionally adaptive and therefore are more frequently experienced in their cultural environments.

The interaction of XPG with TFIIH through p62 and XPD is required for the completion of nucleotide excision repair.

Nucleotide excision repair (NER) is the key pathway for the removal of DNA damage induced by UV irradiation and chemotherapeutic reagents. Protein-protein interactions are crucial for the dynamic and coordinated assembly of the proteins involved at DNA lesion. Here we focus on the role of interactions between the multi-subunit helicase/translocase complex TFIIH and the 3' endonuclease XPG.

A Community-Based Resistance Training Exercise for Post-Stroke Patients with Sarcopenia: Bridging Institutional and Community-Based Rehabilitation in a Multicenter, Randomized Controlled Trial.

Sarcopenia is a prevalent and debilitating condition among stroke survivors, characterized by the progressive loss of muscle mass and function. This multicenter, randomized controlled trial aims to evaluate the effects of a community-based high-speed power training (HSPT) program tailored for individuals with post-stroke sarcopenia. The intervention bridges the gap between hospital-based rehabilitation and long-term community reintegration by offering physician-supervised, progressive resistance training sessions conducted twice weekly for eight weeks.

The Role of EMP2 in Triple-negative Breast Cancer.

Background/aim: The poor prognosis of triple-negative breast cancer (TNBC) is largely due to the lack of targeted therapies, as a result of the absence of estrogen, progesterone, and HER2 receptors. Our previous studies highlighted Del-1 as a potential therapeutic target and biomarker for TNBC. This study further explores molecules regulated by Del-1 through transcriptomic analysis.

Emergence of material-driven two-dimensional electron gas by thermodynamically robust layers in AlO/InO/AlO nanolaminate structures.

In this study, the formation of two-dimensional electron gas (2DEG) at both AlO (AO)/InO (IO) and reversed IO/AO interfaces was demonstrated, enabling its integration into both channel-first and channel-last processes. While conventional reductive-precursor-driven 2DEG was generated at AO/IO interfaces, material-driven 2DEG was developed at IO/AO with no effect from the fabrication process. An optimized AO/IO nanolaminate showed a mobility of 217.

Strain and sex differences in chloromethylisothiazolinone and methylisothiazolinone-induced lung injury in mice.

Mouse strain and sex variability may provide a better understanding of the isothiazolinone-associated respiratory toxicity profile; however, this remains poorly understood. In this study, we investigated and compared the respiratory effects of repeated exposure to a mixture of chloromethylisothiazolinone and methylisothiazolinone (CMIT/MIT) in two commonly used mouse strains, BALB/c and C57BL/6, including both males and females. CMIT/MIT-induced lung injury was analyzed after six times intratracheal instillation of CMIT/MIT using differential cell counts and cytokine measurements in bronchoalveolar lavage fluid (BALF), histological analysis, and gene expression profiling of lung tissue.

Systematic Review of Usability Tests for Manual Wheelchairs: Enhancing Mobility and Reducing Shoulder Injuries in Individuals with Spinal Cord Injuries.

Manual wheelchairs (MWCs) are critical assistive devices for individuals with spinal cord injury (SCI) and other mobility impairments. However, inconsistencies exist in evaluating usability across different manual wheelchair designs. Usability evaluation methods are essential to ensure optimal design and function.

Concept of digital health literacy revisited: Using text network and topic model analysis.

Background: The rapid integration of ICT into healthcare has elevated the critical role of digital health literacy (DHL). However, the conceptual relationship between DHL and electronic health (eHealth), along with the impact of transformative events such as the Fourth Industrial Revolution and the COVID-19 pandemic, remains inadequately investigated.

Objective: This study seeks to analyze research trends in DHL across four distinct historical periods to uncover key themes and their temporal evolution.

Dendranthema oreastrum (Hance) Y.Ling Attenuates Oxidative Stress and Airway Inflammation in a Murine Model of Lipopolysaccharide-Induced Acute Lung Injury.

We examined the antioxidant and anti-inflammatory effects of the methanolic extract of Dendranthema oreastrum (Hance) Y.Ling, commonly known as "Gu-Jeol-Cho" in Korea and widely found across East Asia, using an LPS-induced acute lung injury (ALI) mouse model and TNF-α-stimulated NCI-H292 cells. LPS was intratracheally administered at 20 μg/50 μL/mouse for 3 days.

Clinical characteristics of pneumonia in hemodialysis patients.

Background: Limited research exists on pneumonia (PJP) in hemodialysis (HD) patients. This retrospective study aimed to compare clinical features and outcomes of PJP in HD and non-HD patients.

Methods: We retrospectively analyzed 10 HD PJP cases and 40 non-HD PJP cases which were matched propensity scoring.

Recent advancements in the evolution, production, and degradation of biodegradable mulch films: A review.

Biomass-based plastic production systems play a crucial role in fostering a sustainable society. Biodegradable mulch films (BDMs) have emerged as a practical solution to environmental pollution in agriculture. Various types of BDMs, including polybutylene adipate-co-terephthalate, polybutylene succinate, and polybutylene succinate-co-adipate, have been developed, though many are still derived from fossil-fuel-based plastics.

var. leaves ameliorate inflammatory responses and oxidative stress in PPE/LPS-induced chronic obstructive pulmonary disease mouse model.

: var. (SP) is a known medical food that is used to treat emesis, malaria, and fever. This study investigated the therapeutic potential of SP leaf extract on oxidative stress and airway inflammation using a chronic obstructive pulmonary disease (COPD) mouse model induced by porcine pancreatic elastase (PPE) and lipopolysaccharide (LPS).

Comparison of five preservation methods for fascia allograft.

Importance: Research on tissue preservation, including cortical bone, skin, nerves, and vessels in glycerol and cortical bone in honey, has shown positive results. On the other hand, relatively few studies have been performed on fascia preservation, and comparisons between different fascia preservation methods remain scarce.

Objective: This study compared the biomechanical properties of five different methods of preserving fascia lata.