A qualitative exploration of self-compassion for caregivers of children with physical disabilities.

Purpose/objective: Caregivers of children with physical disabilities face unique stressors and experience high levels of anxiety, depression, and burnout. In general, self-compassion-based skills are associated with decreased psychological distress and increased well-being. However, the nuances of why or how self-compassion may promote the psychological well-being in caregivers of children with physical disabilities are unknown.

A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies.

Parkinson's disease and multiple system atrophy are members of a class of devastating neurodegenerative diseases called synucleinopathies, which are characterized by the presence of alpha-synuclein (α-Syn) rich aggregates in the brains of patients. Passive immunotherapy targeting these aggregates is an attractive disease-modifying strategy, which must not only demonstrate target selectivity towards α-Syn aggregates, but also achieve appropriate brain exposure to have the desired therapeutic effect. Here we present preclinical data for SAR446159, a next-generation antibody for the treatment of synucleinopathies.

Virtual reality-assisted rehabilitation for postoperative C5 palsy: a pilot exploratory randomized controlled trial.

Background: C5 palsy is a debilitating complication that may occur after posterior cervical decompression or fusion surgery, characterized by acute deltoid and biceps weakness. While most cases resolve spontaneously, prolonged dysfunction imposes significant physical, psychological, and socioeconomic burdens. Virtual reality (VR) has emerged as a promising adjunct in neurorehabilitation, offering immersive environments that promote engagement and motor learning.

Comparative Morphometric and Histometric Evaluation of Power-Dependent Tissue Ablation Using Fractional Carbon Dioxide Laser.

Background: Fractional carbon dioxide (CO) lasers are commonly used in dermatological resurfacing, offering precise ablation and controlled dermal remodeling. Although clinical outcomes vary with the energy and pulse settings, comparative morphometric and histometric data on power-dependent tissue interactions are limited.

Objective: To evaluate and compare fractional CO laser-induced microscopic thermal zones (MTZs) ablation characteristics at peak powers of 30 W and 40 W using an ex vivo porcine skin model.

Does Early Re-Entry Surgery Following Simultaneous Guided Bone Regeneration Compromise the Dimension of Peri-Implant Tissues?

Aim: To investigate whether early re-entry surgery following simultaneous guided bone regeneration (GBR) and implant placement has a negative impact on the outcome of bone regeneration and osseointegration.

Materials And Methods: In the edentulous mandible of six mongrel dogs, buccal peri-implant dehiscence defects were surgically created. Bone-level implants were placed with GBR, followed by submerged healing.

Rainbow Trout () Spleen-Derived Bioactive Compounds Suppress Pro-Inflammatory Gene Networks via NF-κB Pathway Modulation.

: Natural products are key sources of anti-inflammatory agents, yet the potential of fish visceral extracts remains largely unexplored. This study evaluated the anti-inflammatory activity of a spleen extract from rainbow trout (). : A crude spleen extract and its four solvent fractions were tested in LPS-stimulated RAW264.

Bioinspired Morphing in Aerodynamics and Hydrodynamics: Engineering Innovations for Aerospace and Renewable Energy.

Bioinspired morphing offers a powerful route to higher aerodynamic and hydrodynamic efficiency. Birds reposition feathers, bats extend compliant membrane wings, and fish modulate fin stiffness, tailoring lift, drag, and thrust in real time. To capture these advantages, engineers are developing airfoils, rotor blades, and hydrofoils that actively change shape, reducing drag, improving maneuverability, and harvesting energy from unsteady flows.

Exploring the Therapeutic Potential of : A Network Pharmacology and Molecular Docking Analysis Across Multiple Diseases.

(RG), a fundamental herb in traditional Chinese medicine belonging to the Orobanchaceae family, has been widely used for centuries due to its diverse therapeutic properties, including promoting blood circulation, enhancing immunity, managing diabetes, reducing inflammation, and supporting kidney function. Despite its traditional significance, scientific studies on RG's therapeutic mechanisms remain limited, and its underlying pharmacological pathways are not extensively elucidated. This study employed network pharmacology and molecular docking to identify RG's active compounds and investigate their therapeutic potential in allergy, anemia, diabetes, and menopause.

A First-in-Human Study of Givastomig, a CLDN18.2 and 4-1BB Bispecific Antibody, as Monotherapy in Patients with CLDN18.2-Positive Advanced or Metastatic Solid Tumors.

Purpose: Givastomig is a bispecific antibody that targets CLDN18.2 and conditionally activates local 4-1BB-expressing T cells. This first-in-human study evaluated the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity of givastomig in advanced solid tumors.

Missed diagnosis of giant hydronephrosis mimicking abdominal lymphatic malformation or omental cyst in a 16-year-old girl: A case report.

Introduction And Importance: Giant hydronephrosis (GH) is an uncommon urological disease most often identified and managed during infancy or childhood. Diagnosing GH prior to surgical intervention can be difficult, resulting in potential misdiagnoses as ovarian tumors or intraabdominal cystic masses. Management of GH depends on the underlying pathology and the renal function of the affected kidney.

Surgical removal of ingested magnets in children: A retrospective clinical analysis of 16 patients and review of the literature.

Foreign body ingestion is a common pediatric emergency. Notably, the inadvertent ingestion of magnets is frequently initially asymptomatic, only to be detected days later when gastrointestinal damage has already manifested. We conducted a retrospective review of the medical records of 16 pediatric patients who underwent surgical removal of ingested magnets at our hospital between January 2018 and December 2023.

Adjunctive effect of soft tissue grafting in the surgical treatment of peri-implantitis: clinical and radiographic outcomes from a preclinical canine experiment.

Purpose: The aim of this study was to clinically and radiographically investigate the effect of soft tissue grafting as an adjunct in the surgical treatment of ligature-induced peri-implantitis lesions in canines.

Methods: Seven Mongrel dogs received implant placements on both sides of the posterior mandible (3 fixtures per side). After inducing peri-implantitis via ligation with suture material, surgical treatment was performed on each implant according to randomly assigned groups: DI, implantoplasty only; DIB, implantoplasty followed by collagenated, deproteinized bovine bone mineral (DBBM-C) grafting; DIC, implantoplasty followed by autogenous connective tissue graft (CTG); DIV, implantoplasty followed by volume-stable collagen matrix (VCMX) grafting; DIBC, implantoplasty followed by DBBM-C grafting and CTG; and DIBV, implantoplasty followed by DBBM-C and VCMX grafting.

Analysis of Regulatory Botanical Submission Profile for Cancer Management from the U.S. FDA Perspectives.

Background: The United States Food and Drug Administration (FDA) has received over 700 botanical investigational new drug applications (INDs) in a broad spectrum of therapeutic areas since 1984. The greatest numbers were for cancer management. The aims of our study were to conduct a first-time, in-depth analysis of the regulatory submission profiles for botanical INDs with oncologic indications, in comparison with non-oncologic indications, and to share our regulatory review experience of oncologic botanical drug research and development.

Migration and population characteristics of white-naped cranes wintering on the Korean Peninsula.

The white-naped crane (Antigone vipio), distributed across East Asia, is classified into two distinct populations: eastern and western. The eastern population breeds in the Amur region of China and Russia and winters in Korea, whereas the western population breeds in northeastern Mongolia and winters at Poyang Lake in China. The aim of this study was to examine the population characteristics of white-naped cranes wintering in Korea and clarify the migratory behavior of the western population, which has been poorly understood.

Mass Spectral Data of Primary and Secondary Metabolites Changes in Medicinal Plants by Solvent Polarity.

Solvent polarity is a critical factor in metabolite extraction from plants, influencing the recovery of primary and secondary metabolites. Plants contain not only the primary metabolites but also a variety of secondary metabolites with low polarity, which favor a higher proportion of organic solvents. In this repository, 248 representative Korean medicinal plants were examined, and a total of 744 samples were prepared using water and ethanol as extraction solvents with three different polarities (100% water, 50% ethanol, and 100% ethanol).

Rebamipide (Mucosta®), a clinically approved drug, alleviates neuroinflammation and dopaminergic neurodegeneration in a Parkinson's disease model.

Background: Parkinson's disease (PD) is characterized by dopaminergic neuron loss, neuroinflammation, and motor dysfunction. PD is a multifactorial disease, with neuroinflammation driven by NLRP3 inflammasome activation representing an important component of its pathological progression. Therefore, we aimed to evaluate the therapeutic potential of rebamipide (Mucosta®), a clinically approved anti-inflammatory agent, in PD by targeting the NLRP3 inflammasome.

Investigating Natural Product Inhibitors of IKKα: Insights from Integrative In Silico and Experimental Validation.

Nuclear factor-κB (NF-κB) signaling plays a pivotal role in regulating immune responses and is strongly implicated in cancer progression and inflammation-related diseases. The inhibitory κB kinases (IKKs), particularly IKKα, are central to modulating NF-κB activity, with distinct roles in the canonical and non-canonical signaling pathways. This study investigates the potential of selectively targeting IKKα to develop novel therapeutic strategies.

Development of reference-based model for improved analysis of bacterial community.

Probiotic bacteria play a vital role in maintaining gut microbial homeostasis and are widely used in various commercial products. Although 16S rRNA amplicon-based next-generation sequencing (NGS) is commonly used to analyze probiotic products, biases can arise from various 16S rRNA amplification regions, sequencing platforms, and library kits. In this study, a reference-based bias correction model was developed to correct sequencing biases.

Long-term clinical and radiographic outcomes of a bone-level, 2-piece, internal connection implant system with coronal microthreads over 10 years of follow-up: a retrospective clinical study.

Purpose: This study retrospectively investigated the long-term clinical and radiographic outcomes of a bone-level type, 2-piece, internal connection dental implant system characterized by coronal microthreads.

Methods: A total of 872 implants placed in 284 patients were selected from 1,845 implants placed in 691 patients by experienced periodontists at Yonsei University Dental Hospital. These selected implants had been followed up for over 10 years and were included in the present study.

Roots of the Large-Scale Household Humidifier Disinfectant Poisoning Tragedy: Regulatory and Surveillance Shortcomings in Korea.

The multi-decade household humidifier disinfectant poisoning tragedy (HHDT) in South Korea highlights the importance of investigating government failures. This study aims to identify and discuss key failures and shortcomings in the South Korean authorities' approach to regulating humidifier disinfectants (HDs) and monitoring cases of chemical poisoning. We reviewed both the HD risk prevention measures that the South Korean Ministry of Environment (KME) should have implemented under the Toxic Chemicals Control Act (TCCA) (1991-2013).

Integrating Cementum to the Dental Implant Abutment to Facilitate Connective Tissue Insertion: Histologic and FE-SEM Observations.

The peri-implant mucosal barrier 'seal' plays a significant role in maintaining peri-implant health, but its efficacy in the presence of inflammation is lower than that of natural teeth due, primarily, to the absence of collagen fiber insertion into the implant/abutment surface. To test the influence of cementum upon collagen fiber insertion/orientation after tooth removal, a customized root-cementum abutment was fabricated using a natural tooth root fragment. For that, an extracted root fragment, preserving both cementum and periodontal ligament, was cemented to the titanium abutment and used as a healing abutment of an immediate implant placed into the fresh extraction socket.

Lactobacillus paracasei-derived extracellular vesicles reverse molecular and behavioral deficits in mouse models of autism spectrum disorder.

Autism spectrum disorder (ASD) is a heterogeneous group of neurodevelopmental disorders characterized by social communication deficits and repetitive behaviors. Although our current understanding the mechanisms underlying ASD is growing, effective treatment options are still underdevelopment. Extracellular vesicles derived from the probiotic Lactobacillus paracasei (LpEV) have shown neuroprotective effects in both in vitro and in vivo models.

Outcomes of suture bridge repair reinforced using a biceps rerouting technique.

Background: Many techniques are available for arthroscopic rotator cuff repair, and autografts or allografts can be used in cases of poor tendon quality or large size tears. The long head of the biceps tendon is a good material for autografts. Rerouting of the biceps long head tendon during arthroscopic rotator cuff repair is a good option when repair is otherwise difficult.

Efficacy of collagenated bone substitutes for bone regeneration in two-wall-damaged extraction sockets without barrier membranes.

Objectives: To evaluate ridge dimensional changes following alveolar ridge augmentation in two-wall-damaged extraction sockets without a barrier membrane, using two types of collagenated bone substitutes i. cross-linked (CL-CB) and ii. non-cross-linked (NCL-CB).

The trajectory of sedative adverse events caused by antipsychotics: a meta-analysis of individual participant data from randomised, placebo-controlled, clinical trials in acute phase schizophrenia.

Background: Sedative adverse events are common in patients with schizophrenia undergoing antipsychotic treatment, which affects treatment adherence and the patients' quality of life. Although tolerance to sedation is believed to develop, robust evidence documenting the timing of sedation onset and resolution remains elusive. To address this gap, we aimed to assess the dynamics of onset and resolution of sedation across various antipsychotics in patients with schizophrenia.