Application of machine learning based on habitat imaging and vision transformer to predict treatment response of locally advanced esophageal squamous cell carcinoma following neoadjuvant chemoimmunotherapy: a multi-center study.

Objective: Current medical examinations and biomarkers struggle to assess the efficacy of chemoimmunotherapy (nICT) for locally advanced esophageal squamous cell carcinoma (ESCC). This study aimed to develop a machine learning model integrating habitat imaging and deep learning (DL) to predict the treatment response of ESCC patients to nICT.

Methods: The study retrospectively collected 309 ESCC patients from 6 medical centers, divided into training and external validation cohorts.

reprograms CASP8 (caspase 8) signaling to evade cell death and Xenophagy.

Regulated cell death and xenophagy constitute fundamental cellular mechanisms against invading microorganisms. , a notorious pathogen, can invade and persist within host cells for extended periods. Here, we describe a novel mechanism by which subverts these host defenses through the manipulation of the CASP8 (caspase 8) signaling pathway.

Isolation and characterization of Bacillus subtilis strain 1-L-29, an endophytic bacteria from Camellia oleifera with antimicrobial activity and efficient plant-root colonization.

Endophytic bacteria, which are common in plant tissues, may help to control plant pathogens and enhance plant growth. Camellia oleifera, an oil-producing plant, is widely grown in warm, subtropical, hilly regions in China. However, C.

[Anti-angiogenic effects of genistein on synovium in a rat model of type II collagen-induced arthritis].

Objective: To explore the anti-angiogenic effects of genistein on synovium in a rat model of type II collagen-induced arthritis (CIA).

Methods: Forty SD rats were randomly divided into normal group, model group, genistein group, methotrexate (MTX) group and Gen plus MTX group with 8 rats in each group. Arthritis in rats was induced by subcutaneous injection of type II collagen combined with complete Freund's adjuvant (CFA).