Automotive Augmented Reality Head-Up Displays.

As the next generation of in-vehicle intelligent platforms, the augmented reality heads-up display (AR-HUD) has a huge information interaction capacity, can provide drivers with auxiliary driving information, avoid the distractions caused by the lower head during the driving process, and greatly improve driving safety. However, AR-HUD systems still face great challenges in the realization of multi-plane full-color display, and they cannot truly achieve the integration of virtual information and real road conditions. To overcome these problems, many new devices and materials have been applied to AR-HUDs, and many novel systems have been developed.

Diffractive Achromat with Freeform Slope for Broadband Imaging over a Long Focal Depth.

We propose a method for designing a long-focal-depth diffractive achromat (LFDA). By applying rotational symmetric parameterization, an LFDA with a diameter of 10.89 mm is designed over three wavelengths at six focal planes.

Construction of a microcavity-based microfluidic chip with simultaneous SERS quantification of dual biomarkers for early diagnosis of Alzheimer's disease.

Since there is no effective Alzheimer's disease (AD)-modifying therapy available currently, early analysis of AD core biomarkers has become one of great significance and common concern in clinical diagnosis. Herein, we designed an Au-plasmonic shell attached polystyrene (PS) microsphere in a microfluidic chip for simultaneous detection of Aβ1-42 and p-Tau181 protein. The corresponding Raman reporters were identified in femto gram level by ultrasensitive surface enhanced Raman spectroscopy (SERS).

Mitochondrial pyruvate carrier 1 alleviates hypoxic-ischemic brain injury in rats.

Aims: Mitochondrial dysfunction is a critical pathological change in cerebral ischemia. Mitochondrial pyruvate carrier 1 (MPC1) is a mitochondrial inner membrane protein carrier participating in pyruvate transport. The work is aiming to figure out the effect of MPC1 on cerebral ischemia.

Large-scale metagrating complex-based light field 3D display with space-variant resolution for non-uniform distribution of information and energy.

Glasses-free three-dimensional (3D) display has attracted wide interest for providing stereoscopic virtual contents with depth cues. However, how to achieve high spatial and angular resolution while keeping ultrawide field of view (FOV) remains a significant challenge in 3D display. Here, we propose a light field 3D display with space-variant resolution for non-uniform distribution of information and energy.

Pixelated volume holographic optical element for augmented reality 3D display.

Augmented reality (AR) three-dimensional (3D) display is the hardware entrance of metaverse and attracts great interest. The fusion of physical world with 3D virtual images is non-trivial. In this paper, we proposed an AR 3D display based on a pixelated volume holographic optical element (P-VHOE).

Dynamic Surface Wrinkles for Light-Driven Dynamic Gratings.

Dynamic diffraction gratings (DDGs) are considered as one of the most promising technologies for application in smart optical devices because of their dynamic regulation of light propagation on demand; however, it is still a challenge to fabricate dynamic periodic micro/nanostructures due to limited materials and processes. Here, a facile and feasible strategy to construct a near-infrared (NIR) radiation-driven DDG is developed based on a double-sided surface pattern, which is fabricated by dynamic wrinkles and/or soft-imprinted static wrinkles. Poly(dimethylsiloxane) (PDMS) containing carbon nanotubes (CNTs) serves as the substrate, and wrinkles are formed on both sides.

Leflunomide Inhibits rat-to-Mouse Cardiac Xenograft Rejection by Suppressing Adaptive Immune Cell Response and NF-κB Signaling Activation.

Xenotransplantation is a potential solution for the severe shortage of human donor organs and tissues. The generation of humanized animal models attenuates strong innate immune responses, such as complement-mediated hyperacute rejection. However, acute vascular rejection and cell mediated rejection remain primary barriers to xenotransplantation, which limits its clinical application.

Foveated glasses-free 3D display with ultrawide field of view via a large-scale 2D-metagrating complex.

Glasses-free three-dimensional (3D) displays are one of the game-changing technologies that will redefine the display industry in portable electronic devices. However, because of the limited resolution in state-of-the-art display panels, current 3D displays suffer from a critical trade-off among the spatial resolution, angular resolution, and viewing angle. Inspired by the so-called spatially variant resolution imaging found in vertebrate eyes, we propose 3D display with spatially variant information density.

miR-539 activates the SAPK/JNK signaling pathway to promote ferropotosis in colorectal cancer by directly targeting TIPE.

Colorectal cancer (CRC) is a common tumor that harms human health with a high recurrence rate. It has been reported that the expression of microRNA-539 (miR-539) is low in several types of cancer, including CRC. Tumor necrosis factor (TNF)-α-induced protein 8 (TNFAIP8/TIPE) is highly expressed in CRC and promotes the proliferation, migration and angiogenesis of CRC.

Current research status of TNFAIP8 in tumours and other inflammatory conditions (Review).

Tumour necrosis factor (TNF)‑α‑inducible protein 8 (TNFAIP8) is the founding member of the TIPE family. According to accumulating evidence, TNFAIP8 plays a pivotal role in the regulation of a variety of tumours, as well as inflammatory diseases. TNFAIP8 is suggested to act as an anti‑apoptotic protein, affecting proliferation, metastasis, invasion, angiogenesis, drug resistance and immune response through multiple signalling pathways.

TIPE regulates VEGFR2 expression and promotes angiogenesis in colorectal cancer.

Metastasis is the leading cause of death in colorectal cancer (CRC) patients. It is regulated mainly by tumor cell angiogenesis, and angiogenesis is caused by the binding of vascular endothelial growth factor (VEGF) to vascular endothelial growth factor receptor 2 (VEGFR2). Tumor necrosis factor-α-induced protein 8 (TNFAIP8, hereto after TIPE) plays an important role in tumorigenesis, development, and prognosis.

A highly reproducible cervical cuff technique for rat-to-mouse heterotopic heart xenotransplantation.

Xenotransplantation is an effective way to solve the problem of donor shortage in clinical transplantation. However, clinical use of xenotransplantation is currently limited due to immunological challenges such as acute vascular rejection and cell-mediated rejection. To finally surpass this immunological barrier, more preclinical research is needed into the molecular mechanisms of rejection and the possible effects of new immunosuppressants.

The effect of imidazole on the enhancement of gadolinium-porphyrin phosphorescence at room temperature.

A mechanism for the enhanced room-temperature phosphorescence (RTP) of gadolinium-coordinated hematoporphyrin monomethyl ether (Gd-HMME) in the presence of imidazole and free gadolinium ions (Gd) is revealed. Imidazole, the molten solvent used in the synthesis of Gd-HMME, was effective in enhancing the Gd-HMME RTP. In the presence of imidazole, further enhancement of the Gd-HMME RTP was observed upon adding Gd.