Liposomal irinotecan with fluorouracil and leucovorin as salvage treatment for advanced biliary tract cancer refractory to gemcitabine and cisplatin.

Introduction: The combination of liposomal irinotecan with fluorouracil and leucovorin (Nal-IRI/FL) has shown efficacy in phase II trials for advanced biliary tract cancer (BTC) following gemcitabine-cisplatin (GP) therapy. However, its effectiveness and safety in real-world clinical settings have not been well established. This study aimed to assess the real-world outcomes of Nal-IRI/FL in BTC patients who experienced disease progression after gemcitabine-based treatment.

All-flexible chronoepifluidic nanoplasmonic patch for label-free metabolite profiling in sweat.

Wearable sensors allow non-invasive monitoring of sweat metabolites, but their reliance on molecular recognition elements limits both physiological coverage and temporal resolution. Here we report an all-flexible chronoepifluidic surface-enhanced Raman spectroscopy (CEP-SERS) patch for label-free and chronometric profiling of sweat metabolites. The CEP-SERS patch integrates plasmonic nanostructures in epifluidic microchannels for chronological sweat sampling and molecular analysis.

A soft 3-DOF interaction force measurement system for estimating the biomechanical effects of a soft wearable robot on the human joint.

Recent advancements in wearable robots have focused on developing soft, compliant, and lightweight structures to provide comfort for the users and to achieve the primary function of assisting body motions. The interaction forces induced by physical human-robot interaction (pHRI) not only cause skin discomfort or pain due to relatively high localized pressures but also degrade the wearability and the safety of the wearer's joints by unnaturally altering the joint reaction forces (JRFs) and the joint reaction moments (JRMs). Although the correlation between excessive JRFs/JRMs and joint-related conditions has been reported by researchers, the biomechanical effects of forces and moments caused by the pHRI of a wearable robot on the wearer's joints remain under-analyzed.

Kinematics Estimation Using a Skin-Adhesive Strain Patch for Shoulder Rehabilitation: A Preliminary Study.

Shoulder kinematics has been required to be estimated using compact sensors to provide visual feedback on joint movements for patients undergoing home rehabilitation due to musculoskeletal diseases, such as stroke. Multiple strain patches have been used for shoulder kinematics estimation, either embedded in tight shirts or attached directly to the skin. However, it is desirable to eliminate the tight shirt while minimizing the number of strain patches for convenient use in home rehabilitation.

Development of Multimodal EEG-EMG Human Machine Interface for Hand-Wrist Rehabilitation: A Preliminary Study.

Patients with neurological disorders, such as stroke, often undergo upper limb motor impairments, severely limiting their ability to perform activities of daily living (ADL). Wearable robots have been developed to provide intensive and precise repetitive training for upper limb rehabilitation. Effective rehabilitation requires aligning robotic assistance with patient movement intention to promote brain plasticity.

Increased CSF drainage by non-invasive manipulation of cervical lymphatics.

Cerebrospinal fluid (CSF) in the subarachnoid space around the brain drains to lymph nodes in the neck, but the connections and regulation have been challenging to identify. Here we used fluorescent tracers in Prox1-GFP lymphatic reporter mice to map the pathway of CSF outflow through lymphatics to superficial cervical lymph nodes. CSF entered initial lymphatics in the meninges at the skull base and continued through extracranial periorbital, olfactory, nasopharyngeal and hard palate lymphatics, and then through smooth muscle-covered superficial cervical lymphatics to submandibular lymph nodes.

Real-world outcomes of fluorouracil-based second-line therapy in patients with advanced biliary tract cancer refractory to gemcitabine and cisplatin-based treatment.

Background: The prognosis for patients with advanced biliary tract cancer (BTC) who have not responded to gemcitabine and cisplatin (GP)-based therapy is dismal. Fluorouracil (5-FU)-based chemotherapy could be considered for those patients who are refractory to GP-based treatments. Our study aimed to evaluate the real-world efficacy and safety of 5-FU-based chemotherapy for BTC patients who had progressed after gemcitabine-based treatment.

Muscle-to-action mapping for intuitive training of muscle synergies in post-stroke upper-limb rehabilitation.

Background: Effective motor task execution relies on precise muscle coordination, which is often disrupted after a stroke, leading to impaired motor functions. Post-stroke, alterations in intermuscular coordination, including abnormal coupling of shoulder abductor muscles, are commonly observed and contribute to these impairments. Traditional rehabilitation often overlooks this complex intermuscular coordination, and there is a need for intuitive strategies to modify abnormal muscle synergies.

Wearable Hyperspectral Photoplethysmography Allows Continuous Monitoring of Exercise-Induced Hypertension.

Continuous blood pressure (BP) monitoring is essential for cardiovascular health, yet current BP sensors face cuff-dependent limitations. Cuff-free alternatives still suffer from discomfort and discontinuous measurement. Here a wearable hyperspectral photoplethysmography (HS-PPG) is reported for continuous and nonconscious BP monitoring.

Improving impaired intermuscular coordination after stroke through synergy-guided human-machine interaction: a pilot study.

Stroke survivors often experience motor impairments that include abnormal intermuscular coordination, which negatively affects individualized joint control. This lack of individualization is one of the fundamental motor control problems that largely explain voluntary movement impairment after stroke. Over the last decade, the concept of muscle synergy, here defined as a consistent ratio of muscle co-activation across muscles necessary to perform motor tasks, has been effectively applied to characterize intermuscular coordination following stroke.

Electro-tactile modulation of muscle activation and intermuscular coordination in the human upper extremity.

Electro-tactile stimulation (ETS) can be a promising aid in augmenting sensation for those with sensory deficits. Although applications of ETS have been explored, the impact of ETS on the underlying strategies of neuromuscular coordination remains largely unexplored. We investigated how ETS, alone or in the presence of mechano-tactile environment change, modulated the electromyogram (EMG) of individual muscles during force control and how the stimulation modulated the attributes of intermuscular coordination, assessed by muscle synergy analysis, in human upper extremities.

Paraoxonase-2 agonist vutiglabridin promotes autophagy activation and mitochondrial function to alleviate non-alcoholic steatohepatitis.

Background And Purpose: Only limited therapeutic agents have been developed for non-alcoholic steatohepatitis (NASH). Glabridin, a promising anti-obesity candidate, has only limited druggability due to its low in vivo chemical stability and bioavailability. Therefore, we developed vutiglabridin (VUTI), which is based on a glabridin backbone, and investigated its mechanism of action in treating NASH in animal models.

New insights into ATR inhibition in muscle invasive bladder cancer: The role of apolipoprotein B mRNA editing catalytic subunit 3B.

Background: Apolipoprotein B mRNA editing catalytic polypeptide (APOBEC), an endogenous mutator, induces DNA damage and activates the ataxia telangiectasia and Rad3-related (ATR)-checkpoint kinase 1 (Chk1) pathway. Although cisplatin-based therapy is the mainstay for muscle-invasive bladder cancer (MIBC), it has a poor survival rate. Therefore, this study aimed to evaluate the efficacy of an ATR inhibitor combined with cisplatin in the treatment of APOBEC catalytic subunit 3B (APOBEC3B) expressing MIBC.

Design Optimization of a Soft Robotic Rehabilitation Glove Based on Finger Workspace Analysis.

The finger workspace is crucial for performing various grasping tasks. Thus, various soft rehabilitation gloves have been developed to assist individuals with paralyzed hands in activities of daily living (ADLs) or rehabilitation training. However, most soft robotic glove designs are insufficient to assist with various hand postures because most of them use an underactuated mechanism for design simplicity.

Exploring histological predictive biomarkers for immune checkpoint inhibitor therapy response in non-small cell lung cancer.

Treatment challenges persist in advanced lung cancer despite the development of therapies beyond the traditional platinum-based chemotherapy. The early 2000s marked a shift to tyrosine kinase inhibitors targeting epidermal growth factor receptor, ushering in personalized genetic-based treatment. A further significant advance was the development of immune checkpoint inhibitors (ICIs), especially for non-small cell lung cancer.

A Lightweight Dynamic Hand Orthosis With Sequential Joint Flexion Movement for Postoperative Rehabilitation of Flexor Tendon Repair Surgery.

During the postoperative hand rehabilitation period, it is recommended that the repaired flexor tendons be continuously glided with sufficient tendon excursion and carefully managed protection to prevent adhesion with adjacent tissues. Thus, finger joints should be passively mobilized through a wide range of motion (ROM) with physiotherapy. During passive mobilization, sequential flexion of the metacarpophalangeal (MCP) joint followed by the proximal interphalangeal (PIP) joint is recommended for maximizing tendon excursion.

Shape Memory Alloy-Based Reactive Tubular (SMART) Brake for Compact and Energy-Efficient Wearable Robot Design.

Soft wearable robots have been gaining increasing popularity for enhancing human physical abilities and assisting people who have physical limitations. These robots typically use tendon-driven mechanisms (TDMs) to enable remote actuation to provide better usability with compact design. TDMs comprise an actuator, an end-effector, and a transmission system by using cables or tendons to transfer forces from the actuator to the end-effector.

Vutiglabridin Alleviates Cellular Senescence with Metabolic Regulation and Circadian Clock in Human Dermal Fibroblasts.

The process of cellular senescence, which is characterized by stable cell cycle arrest, is strongly associated with dysfunctional cellular metabolism and circadian rhythmicity, both of which are reported to result from and also be causal to cellular senescence. As a result, modifying any of them-senescence, metabolism, or the circadian clock-may affect all three simultaneously. Obesity accelerates aging by disrupting the homeostasis of reactive oxygen species (ROS) via an increased mitochondrial burden of fatty acid oxidation.

EEG-controlled tele-grasping for undefined objects.

This paper presents a teleoperation system of robot grasping for undefined objects based on a real-time EEG (Electroencephalography) measurement and shared autonomy. When grasping an undefined object in an unstructured environment, real-time human decision is necessary since fully autonomous grasping may not handle uncertain situations. The proposed system allows involvement of a wide range of human decisions throughout the entire grasping procedure, including 3D movement of the gripper, selecting proper grasping posture, and adjusting the amount of grip force.

Expanding the repertoire of intermuscular coordination patterns and modulating intermuscular connectivity in stroke-affected upper extremity through electromyogram-guided training: a pilot study.

Abnormal intermuscular coordination is a major stroke-induced functional motor impairment in the upper extremity (UE). Previous studies have computationally identified the abnormalities in the intermuscular coordination in the stroke-affected UE and their negative impacts on motor outputs. Therefore, targeting the aberrant muscle synergies has the potential as an effective approach for stroke rehabilitation.

Comparative Analysis of Muscle Synergy between Patients with Shoulder Impingement Syndrome and Healthy Controls: A Preliminary Study.

Shoulder impingement syndrome can be caused by a muscle imbalance around the shoulder joint. It would be beneficial for therapy to implement rehabilitation exercises based on intermuscular coordination in order to achieve muscle balance. This study presents the muscle synergy characteristics of patients with shoulder impingement syndrome, which can be used to develop rehabilitation exercises.

Hand Grasp Motion Intention Recognition Based on High-Density Electromyography in Chronic Stroke Patients.

Stroke is a debilitating condition that leads to a loss of motor function, inability to perform daily life activities, and ultimately worsening quality of life. Robot-based rehabilitation is a more effective method than conventional rehabilitation but needs to accurately recognize the patient's intention so that the robot can assist the patient's voluntary motion. This study focuses on recognizing hand grasp motion intention using high-density electromyography (HD-EMG) in patients with chronic stroke.