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During the postoperative hand rehabilitation period, it is recommended that the repaired flexor tendons be continuously glided with sufficient tendon excursion and carefully managed protection to prevent adhesion with adjacent tissues. Thus, finger joints should be passively mobilized through a wide range of motion (ROM) with physiotherapy. During passive mobilization, sequential flexion of the metacarpophalangeal (MCP) joint followed by the proximal interphalangeal (PIP) joint is recommended for maximizing tendon excursion. This paper presents a lightweight device for postoperative flexor tendon rehabilitation that uses a single motor to achieve sequential joint flexion movement. The device consists of an orthosis, a cable, and a single motor. The degree of spatial stiffness and cable path of the orthosis were designed to apply a flexion moment to the MCP joint prior to the PIP joint. The device was tested on both healthy individuals and a patient who had undergone flexor tendon repair surgery, and both flexion and extension movement could be achieved with a wide ROM and sequential joint flexion movement using a single motor.
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http://dx.doi.org/10.1109/TNSRE.2024.3367990 | DOI Listing |
Sustain Sci
June 2025
Agricultural Economics and Policy Group, ETH Zurich, Zurich, Switzerland.
To understand complex societal transformations, scholars have called for more interdisciplinary research in which researchers from various disciplines collaborate. To support the implementation of such collaborations, we introduce a novel typology of interdisciplinary collaborations developed from the literature and from structured reflection on our own research experience. The typology distinguishes (I) common base, (II) common destination, and (III) sequential link type of interdisciplinary collaborations.
View Article and Find Full Text PDFAim: To explore the factors affecting the sustainable improvement of nurses' evidence-based practice (EBP) competency after receiving an EBP training program.
Design: A sequential mixed-methods study.
Methods: Thirty-seven ICU nurses participated from an adult ICU in Egypt.
Front Med (Lausanne)
August 2025
Department of Global Public Health and Primary Care, Bergen Center for Ethics and Priority Settings (BCEPS), Bergen, Norway.
Rheumatoid arthritis is a chronic inflammatory joint disease with low treatment coverage in sub-Saharan Africa. Effective treatment strategies are available. We aimed to evaluate the cost effectiveness of six disease modifying anti-rheumatic drug (DMARD) treat-to-target treatment strategies for patients with rheumatoid arthritis in Zanzibar.
View Article and Find Full Text PDFFront Immunol
September 2025
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Ten Eleven Translocation (TET) proteins can oxidize 5-methylcytosine to generate in sequential steps oxidized forms of cytosine: 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine. Through their catalytic activity TET proteins promote active DNA demethylation. There are three TET proteins: TET1, TET2 and TET3.
View Article and Find Full Text PDFBiosens Bioelectron
August 2025
Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325000, China; Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, 1
The escalating threat of antimicrobial resistance is exacerbated by delayed diagnostics and improper antibiotics use, underscoring an urgent demand for rapid, versatile AST tools to support evidence-based prescribing. In this study, we present an innovative, generalizable phenotypic AST approach by quantifying bacterial gDNA copy number variations (CNVs) following 0.5-h-brief culturing with antibiotic exposure, termed spatially encapsulated emulsions (SEE)-phAST.
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