CD44-targeted RIP3 gene delivery strategy for enhanced cancer therapy via necroptosis and immune modulation.

Receptor-interacting protein kinase 3 (RIP3)-mediated necroptosis has attracted interest as a potential target for cancer therapy as it boosts tumor immunogenicity. Here, we synthesized a pH-sensitive polymer (CA) by conjugating aminopropyl imidazole (API) to chondroitin sulfate (CHS) for RIP3 gene delivery. CA can target cancer cells due to the specific binding ability of CHS to CD44 which is overexpressed in cancer cells.

Anti-obesity potential of chickpea fermented by Lactiplantibacillus sp. (PMS-A6) from salted oyster: UPLC-ESI-Q-TOF-MS profiling and in-vitro/in-vivo validation.

Obesity, a major public health concern, contributes to numerous metabolic disorders and increases the risk of chronic diseases such as diabetes and cardiovascular conditions. This study investigates the anti-adipogenic and anti-obesity potential of chickpea extracts, comparing raw and fermented chickpea extracts. Fermentation, using bacterial strains isolated from salted oysters, was optimized with Lactiplantibacillus plantarum (PMS-A6), which showed the highest total polyphenol content (26 °C, pH 6.

Lead (Pb) removal and suppression of Pb-induced inflammation by Lacticaseibacillus rhamnosus A6-6.

Lead (Pb) contamination poses serious environmental and health risks, necessitating effective remediation and protection strategies. This study evaluates the Pb removal efficiency of Lacticaseibacillus rhamnosus A6-6 and its protective effects against Pb-induced immunotoxicity. Pb adsorption studies demonstrated that L.

Doxycycline degradation by Enterobacter cloacae HS-08: A comparative analysis of biodegradation and bio-electrodegradation approaches with toxicity implications.

Doxycycline (DOX), a commonly prescribed antibiotic, poses a growing environmental concern due to its recalcitrant nature, insufficient removal by conventional treatment methods, and detrimental effects on ecosystems and living organisms. This study evaluates the comparative efficacy of biodegradation and bio-electrodegradation approaches for DOX removal using Enterobacter cloacae HS-08, focusing on degradation efficiency, intermediate toxicity, systemic impacts, and gut microbiome alterations. The results showed that biodegradation achieved 61% DOX removal (75 mg/L) within 8 days; however, HPLC-MS/MS analysis revealed the formation of toxic intermediates, resulting in residual toxicity.

Enhanced degradation of dibutyl phthalate using a synthetic mixed bacterial system and its impact on environmental toxicity.

Dibutyl phthalate (DBP) is widely used in plastic manufacturing to enhance the flexibility and durability of products. However, DBP is a toxic, persistent environmental pollutant that poses significant risks to ecosystems and human health. This study investigates the DBP degradation efficiency of a mixed bacterial system (MBS) consisting of Serratia sp.

Integrated bio-electrochemical approach to Norfloxacin (NFX) degradation: Efficacy, degradation mechanisms, and toxicological insights.

Norfloxacin (NFX), a widely used fluoroquinolone antibiotic, poses significant environmental concerns due to its persistence in ecosystems and its potential to foster antibiotic resistance. This study explores the degradation of NFX using a bio-electrochemical system (BES) facilitated by Bacillus subtilis isolated from animal waste sludge. Experimental parameters were optimized to maximize removal efficiency, with the optimal conditions determined as an NFX concentration of 200 mg/L, pH 7, and an applied potential of 1.

Paraoxonase-2 agonist vutiglabridin promotes autophagy activation and mitochondrial function to alleviate non-alcoholic steatohepatitis.

Background And Purpose: Only limited therapeutic agents have been developed for non-alcoholic steatohepatitis (NASH). Glabridin, a promising anti-obesity candidate, has only limited druggability due to its low in vivo chemical stability and bioavailability. Therefore, we developed vutiglabridin (VUTI), which is based on a glabridin backbone, and investigated its mechanism of action in treating NASH in animal models.

Surface-tuning TiO NR photoanodes using CoO interlayers and NiFe-LDH cocatalysts for photoelectrochemical wastewater treatment.

Increasing multidrug-resistant pathogenic microbial around the world become a global problem, making it imperative to develop effective methods for bacterial inactivation in wastewater. In this study, we propose a multifunctional photoelectrochemical (PEC) system to successfully disinfect microbial cells and degrade orange (II) dyes. CoO NP were synthesized by spin-coating onto hydrothermally synthesized TiO nanorod arrays followed by electrodeposited NiFe-LDH to develop the NiFe-LDH/CoO NP-TiO NRs.

In-situ Hf/Zr co-doped FeO nanorod decorated with CuO/CoO: Enhanced photocatalytic performance for antibacterial and organic pollutants.

Herein, we successfully synthesized Hf/Zr co-doping on FeO nanorod photocatalyst by a hydrothermal process and quenching methods. The synergistic roles of Hf and Zr double-doping on the bacteria inactivation test and decomposition of organic pollutants were investigated in detail for the 1 wt% CoO loaded Hf/Zr-FeO NRs and CuO/CoO loaded Hf/Zr-FeO NRs photocatalyst. Initially, the rod-like porous morphology of the Hf/Zr-doped FeO NRs was produced via a hydrothermal method at various Hf co-doping (0, 2, 4, 7 and 10)%.

Bio-electrochemical degradation of carbamazepine (CBZ): A comprehensive study on effectiveness, degradation pathway, and toxicological assessment.

Recent attention on the detrimental effects of pharmaceutically active compounds (PhACs) in natural water has spurred researchers to develop advanced wastewater treatment methods. Carbamazepine (CBZ), a widely recognized anticonvulsant, has often been a primary focus in numerous studies due to its prevalence and resistance to breaking down. This study aims to explore the effectiveness of a bio-electrochemical system in breaking down CBZ in polluted water and to assess the potential harmful effects of the treated wastewater.

Evaluation of Lentilactobacillus parafarraginis A6-2 strain for aluminum removal and anti-inflammatory effects: implications for alleviating Al toxicity.

Aim: To assess the effectiveness of Lentilactobacillus parafarraginis A6-2 cell lysate for the removal of aluminum (Al), which induces neurotoxicity, and its protective effect at cellular level.

Methods And Results: The cell lysate of the selected L. parafarraginis A6-2 strain demonstrated superior Al removal compared to live or dead cells.

Applied potential assisted biodegradation of amoxicillin (AMX) using bacterial consortium isolated from a waste dump site.

Antibiotics have revolutionized modern day living with their ability to effectively treat infectious diseases in humans and animals. However, the release of antibiotic compounds into the environment has led to toxic consequences. To reduce this environmental impact, it is important to employ an inexpensive and rational technology to reduce the amount of antibiotics released into the ecosystem.

Lactiplantibacillus sp. D10-2: potential bacteria for eliminating bisphenol A and reducing BpA-induced lipid accumulation.

Bisphenol A (BpA) is an endocrine-disrupting substance commonly found in plastics and resins. It is reported that BpA exposure induces lipid accumulation in humans, similar to obesogenic compounds. The main objective of this study is to investigate the removal of BpA using Lactiplantibacillus sp.

Effect of fermentation on antioxidant, antimicrobial, anti-inflammatory, and anti- adhesion activity of var. root bark.

The limited yield of var. root bark (URB) extract is considered an economic loss to the food industry. Improving extraction yield and bioactivity through fermentation increase the industrial usage of URB.

sp. nov., a Powdery Mildew Species Found on .

A powdery mildew (Erysiphaceae) has been continuously collected on the leaves of in the southern part of the Korean Peninsula, where this shrub is indigenous. Microscopic examination of the asexual morphs revealed that the current collections are differentiated from the all known species on spp. by its longer conidiophores and longer conidia.

A combination of BR101801 and venetoclax enhances antitumor effect in DLBCL cells via c-Myc/Bcl-2/Mcl-1 triple targeting.

Double hit diffuse large B-cell lymphoma (DLBCL) with rearrangement and overexpression of both c-Myc and Bcl-2 responds poorly to standard R-CHOP therapy. In a recent phase I study, Venetoclax (ABT-199) targeting Bcl-2 also exhibited disappointing response rates in patients with relapsed/refractory DLBCL, suggesting that targeting only Bcl-2 is not sufficient for achieving successful efficacy due to the concurrent oncogenic function of c-Myc expression and drug resistance following an increase in Mcl-1. Therefore, co-targeting c-Myc and Mcl-1 could be a key combinatorial strategy to enhance the efficacy of Venetoclax.

Crystal Structure of H227A Mutant of Arginine Kinase in Suggests the Importance of Its Stability.

Arginine kinase (AK) plays a crucial role in the survival of , a water flea and a common planktonic invertebrate sensitive to water pollution, owing to the production of bioenergy. AK from (AK) has four highly conserved histidine residues, namely, H90, H227, H284, and H315 in the amino acid sequence. In contrast to AK WT (wild type), the enzyme activity of the H227A mutant decreases by 18%.

Elucidation of the electron transfer environment in the MMOR FAD-binding domain from 5.

By facilitating electron transfer to the hydroxylase diiron center, MMOR-a reductase-serves as an essential component of the catalytic cycle of soluble methane monooxygenase. Here, the X-ray structure analysis of the FAD-binding domain of MMOR identified crucial residues and its influence on the catalytic cycle.

Combination Therapy of the Active KRAS-Targeting Antibody inRas37 and a PI3K Inhibitor in Pancreatic Cancer.

KRAS activating mutations, which are present in more than 90% of pancreatic cancers, drive tumor dependency on the RAS/mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/AKT signaling pathways. Therefore, combined targeting of RAS/MAPK and PI3K/AKT signaling pathways may be required for optimal therapeutic effect in pancreatic cancer. However, the therapeutic efficacy of combined MAPK and PI3K/AKT signaling target inhibitors is unsatisfactory in pancreatic cancer treatment, because it is often accompanied by MAPK pathway reactivation by PI3K/AKT inhibitor.

Enhanced Ultraviolet Photoresponse Characteristics of Indium Gallium Zinc Oxide Photo-Thin-Film Transistors Enabled by Surface Functionalization of Biomaterials for Real-Time Ultraviolet Monitoring.

Indium gallium zinc oxide (IGZO) is one of the most promising materials for diverse optoelectronic applications based on thin-film transistors (TFTs) including ultraviolet (UV) photodetectors. In particular, the monitoring of UV-A (320-400 nm) exposure is very useful for healthcare applications because it can be used to prevent various human skin and eye-related diseases. However, the relatively weak optical absorption in the UV-A range and the persistent photoconductivity (PPC) arising from the oxygen vacancy-related states of IGZO thin films limit efficient UV monitoring.

Antimicrobial and Antibiofilm Effect of ε-Polylysine against Enteritidis, , and in Tryptic Soy Broth and Chicken Juice.

ε-Polylysine (ε-PL) is a safe food additive that is used in the food industry globally. This study evaluated the antimicrobial and antibiofilm activity of antibacterial peptides (ε-PL) against food poisoning pathogens detected in chicken ( Enteritidis, , and ). The results showed that minimum inhibitory concentrations (MICs) ranged between 0.

ANGPTL4 accelerates KRAS-Induced acinar to ductal metaplasia and pancreatic carcinogenesis.

Oncogenic KRAS induces neoplastic transformation of pancreatic acinar cells through acinar-to-ductal metaplasia (ADM) and pancreatic intraepithelial neoplasia (PanIN), and drives pancreatic ductal adenocarcinoma (PDAC). Angiopoietin-like 4 (ANGPTL4) is known to be involved in the regulation of cancer growth and metastasis. However, whether ANGPTL4 affects KRAS-mediated ADM and early PDAC intervention remains unknown.