Igfbp2 Downregulation in PVT-CeA Glutamatergic Circuits Drives Neonatal Anesthesia-Induced Fear Memory Deficits.

Repeated neonatal general anesthesia results in long-term cognitive dysfunction; however, the underlying mechanisms remain unclear. This study finds that repeated neonatal anesthesia impaired fear memory in adolescent mice of both sexes, along with hypoactivated glutamatergic neurons in the paraventricular thalamus (PVT). Optogenetic activation of PVT glutamatergic neurons rescued fear memory deficits in anesthesia-treated mice, whereas optogenetic inhibition of these neurons recapitulated memory deficits in control mice.

LncRNA SOX21-AS1 Promotes the Progression of Pancreatic Cancer by Sponging miR-9-3p and Upregulating YOD1.

Pancreatic cancer (PC) is a highly aggressive malignancy of the digestive system. Recent studies have indicated that the long noncoding RNA SOX21-AS1 is significantly upregulated in PC tissue samples. This study aims to elucidate the biological role and underlying molecular mechanisms of SOX21-AS1 in PC progression.

Ultrasmall Nanoparticles Mitigate Tau Hyperphosphorylation to Restore Synaptic Integrity and Boost Cognitive Function in Alzheimer's Disease.

Tau hyperphosphorylation represents a critical pathological hallmark of Alzheimer's disease (AD), a prevalent neurodegenerative disorder characterized by progressive cognitive decline. The ubiquitin-specific proteases 14 (USP14) impairs proteasomal function and accelerates hyperphosphorylated Tau accumulation, making it an attractive therapeutic target for modulating the ubiquitin-proteasome pathway in AD treatment. In this study, it is reported that wogonoside-functionalized ultrasmall CuSe nanoparticles (CSPW NPs) significantly reduce hyperphosphorylated Tau accumulation and alleviate AD symptoms.

Adequate Consideration of Aerosol Hygroscopicity is Crucial for Evaluating Its Respiratory Deposition and Related Health Impacts.

Aerosol hygroscopicity is vitally important in governing the characteristics of particle deposition within the human respiratory tract (HRT) as it determines the particle size in humid environments. Based on direct hygroscopicity measurements conducted across diverse environments, this study quantified the impact of aerosol hygroscopicity on respiratory deposition utilizing the International Commission on Radiological Protection (ICRP) model. Our results demonstrate that hygroscopic growth of particles in the HRT notably reduces the total deposition fraction (TDF) for number by as much as 12%, whereas it significantly increases TDF for particle mass by up to 49% for submicrometer particles from various regional backgrounds.

Astragalin-functionalized ultrasmall nanoparticles modulate the complement pathway to inhibit microglial synaptic phagocytosis for reducing anesthetic neurotoxicity.

Synaptic impairment is identified as a primary pathology in sevoflurane-induced neurotoxicity, contributing to neurobehavioral and neurodevelopmental deficits. Synaptic loss in neurons occurs through microglia-mediated synaptic phagocytosis the complement pathway. Astragalin, a natural flavonoid compound, exhibits diverse bioactivities, such as anti-tumor, anti-complement, and anti-inflammatory effects.

How stepwise interventions in pre-hospital emergency care enhance out-of-hospital cardiac arrest management in a Megacity in China.

Objective: A series of improvements have been formulated and implemented to prompt the inadequate pre-hospital care capacity for out-of-hospital cardiac arrest (OHCA) management in China. The aim of this study is to investigate the combined association of those stepwise interventions with OHCA management in Shenzhen, as a representative city in China.

Methods: This registry-based retrospective study included emergency medical services (EMS)-treated adult OHCA patients with presumed cardiac etiology in Shenzhen, China, covering the period from January 1, 2011 to December 31, 2022.

Effect of intraoperative noise isolation on postoperative nausea and vomiting in patients undergoing gynecological laparoscopic surgery: protocol for a randomized controlled trial.

Background: Postoperative nausea and vomiting (PONV) are common complications following general anesthesia, particularly in gynecological laparoscopic surgeries. This study aims to evaluate the effect of intraoperative noise isolation on PONV incidence.

Method: This single-center, prospective, randomized controlled trial will enroll 192 adult patients undergoing laparoscopic gynecological surgery.

East Asian expatriate football players and national team success: Chinese, Japanese, and South Korean players in Europe (2000-2024).

This study investigated the influence of Chinese, Japanese, and South Korean football players' participation in European leagues on their national teams' FIFA rankings from 2000 to 2024. Utilizing data from 22,972 matches featuring 392 players across 36 European leagues and 12 tournaments or cup competitions, survival and conditional process analyses were conducted to explore the relationships between expatriate player counts, appearances, playing time, and FIFA rankings. The results demonstrated a significant correlation between the number of expatriate players, particularly in top-tier leagues, and national team rankings.

Entacapone alleviates muscle atrophy by modulating oxidative stress, proteolysis, and lipid aggregation in multiple mice models.

Background: Skeletal muscle atrophy significantly affects quality of life and has socio-economic and health implications. This study evaluates the effects of entacapone (ENT) on skeletal muscle atrophy linked with oxidative stress and proteolysis.

Methods: C2C12 cells were treated with dexamethasone (Dex) to simulate muscle atrophy.

Methane degassing in global river reservoirs and its impacts on carbon budgets and sustainable water management.

Degassing methane (CH) through reservoir water compromises hydroelectricity's presumed low-carbon status, which has emerged as a critical hotspot for global carbon dynamics. However, a comprehensive understanding of the involved pathways remains elusive, hindering the accurate estimation of global reservoirs' carbon budget (emission-to-burial ratio). This study presents a holistic upscaling approach to assess methane degassing in global river reservoirs and its impacts on carbon budgets.

Efficient Nitrate Formation in Fog Events Implicates Fog Interstitial Aerosols as Significant Drivers of Atmospheric Chemistry.

Clouds and fogs, consisting of tiny water droplets formed by the condensation of water in supersaturated air, are vital in atmospheric chemistry, as they facilitate multiphase reactions. While measuring high-altitude cloud is challenging, fog as ground-level clouds offer a unique opportunity for direct observation. In this study, we explored radiation fogs in the North China Plain using an advanced aerosol-fog sampling system to measure the chemical and physical properties of both inactivated interstitial aerosols and activated fog droplet residues.

Identification of differential m6A RNA methylomes and ALKBH5 as a potential prevention target in the developmental neurotoxicity induced by multiple sevoflurane exposures.

Sevoflurane, as a commonly used inhaled anesthetic for pediatric patients, has been reported that multiple sevoflurane exposures are associated with a greater risk of developing neurocognitive disorder. N6-Methyladenosine (m6A), as the most common mRNA modification in eukaryotes, has emerged as a crucial regulator of brain function in processes involving synaptic plasticity, learning and memory, and neurodevelopment. Nevertheless, the relevance of m6A RNA methylation in the multiple sevoflurane exposure-induced developmental neurotoxicity remains mostly elusive.

Heparin-Modified Superparamagnetic Iron Oxide Nanoparticles Suppress Lithium Chloride/Pilocarpine-Induced Temporal Lobe Epilepsy in Rats through Attenuation of Inflammation and Oxidative Stress.

The development of antiepileptic drugs is still a long process. In this study, heparin-modified superparamagnetic iron oxide nanoparticles (UFH-SPIONs) were prepared, and their antiepileptic effect and underlying mechanism were investigated. UFH-SPIONs are stable, homogeneous nanosystems with antioxidant enzyme activity that are able to cross the blood-brain barrier (BBB) and enriched in hippocampal epileptogenic foci.

Complement C1q-mediated microglial synaptic elimination by enhancing desialylation underlies sevoflurane-induced developmental neurotoxicity.

Background: Repeated neonatal sevoflurane exposures led to neurocognitive disorders in young mice. We aimed to assess the role of microglia and complement C1q in sevoflurane-induced neurotoxicity and explore the underlying mechanisms.

Methods: Neonatal mice were treated with sevoflurane on postnatal days 6, 8, and 10, and the Morris water maze was performed to assess cognitive functions.

Full-thickness nasolabial facial artery flap: A modified surgical approach for reconstruction of lower lip defects.

Objectives: Reconstruction of large lower lip defects remains challenging in terms of aesthetics, function and safety. The aim of this study is to explore a modified nasolabial flap to repair large lower lip defects.

Methods: The full-thickness nasolabial facial artery flap was used for reconstruction of defects in lip squamous cell carcinoma (LSCC) patients after tumor ablation.

Impact of COVID-19 on football attacking players' match technical performance: a longitudinal study.

This study examined the impact of COVID-19 on 28 indicators of match technical performance (MTP) for football attacking players upon their return to play. Analyzing data from 100 players in the Big Five European football leagues, covering 1500 matches each before and after COVID-19 over 3 years (2020-2023), revealed significant differences in 76% of players' MTP indicators. Notably, 14 indicators, particularly the five indicators linked to scoring, significantly decreased post-COVID-19.

The effect of sevoflurane exposure on cell-type-specific changes in the prefrontal cortex in young mice.

Sevoflurane, the predominant pediatric anesthetic, has been linked to neurotoxicity in young mice, although the underlying mechanisms remain unclear. This study focuses on investigating the impact of neonatal sevoflurane exposure on cell-type-specific alterations in the prefrontal cortex (PFC) of young mice. Neonatal mice were subjected to either control treatment (60% oxygen balanced with nitrogen) or sevoflurane anesthesia (3% sevoflurane in 60% oxygen balanced with nitrogen) for 2 hours on postnatal days (PNDs) 6, 8, and 10.

"Needed but lacked": Exploring demand- and supply-side determinants of access to cardiopulmonary resuscitation training for the lay public in China.

Background: Despite years of public cardiopulmonary resuscitation (CPR) training efforts, the training rate and survival following out-of-hospital cardiac arrest (OHCA) have increased modestly in China. Access is imperative to increase the public CPR training rate, which is determined by both demand- (e.g.

Effect of a Targeted Ambulance Treatment Quality Improvement Programme on Outcomes from Out-of-Hospital Cardiac Arrest: A Metropolitan Citywide Intervention Study.

The performance of ambulance crew affects the quality of pre-hospital treatment, which is vital to the survival for out-of-hospital cardiac arrest (OHCA) patients, yet remains suboptimal in China. In this retrospective analysis study, we aimed to examine the effect of a citywide quality improvement programme on provision of prehospital advanced life support (ALS) by emergency medical service (EMS) system. EMS-treated adult OHCA patients after the implementation of the programme (1 January 2021 to 30 June 2022) were compared with historical controls (1 June 2019 to 31 August 2020) in Suzhou.

Maternal atmospheric particulate matter exposure and risk of adverse pregnancy outcomes: A meta-analysis of cohort studies.

Ambient air particulate exposure not only capable of elevating the risks of adverse pregnancy outcomes, but also has profound implications for human health, but the results are discrepant. This meta-analysis aimed to provide higher grade evidence on the impacts of air particulate on specific pregnancy outcomes. A total of 81 eligible cohort studies were included in this meta-analysis, of which the outcomes included preterm birth (PTB), moderate PTB, very PTB, extreme PTB, term low birth weight (TLBW), term birth weight (TBW), stillbirth (SB) and small for gestational age (SGA).

Building a knowledge base for colorectal cancer patient care using formal concept analysis.

Background: Colorectal cancer (CRC) is a heterogeneous disease with different responses to targeted therapies due to various factors, and the treatment effect differs significantly between individuals. Personalize medical treatment (PMT) is a method that takes individual patient characteristics into consideration, making it the most effective way to deal with this issue. Patient similarity and clustering analysis is an important aspect of PMT.

Uterine decidual stromal cell-derived exosomes mediate the indirect effects of 1-nitropyrene on trophoblast biological behaviors.

1-nitropyrene (1-NP) is representative nitropolycyclic aromatic hydrocarbon pollutant widely present in exhaust particles of internal combustion engine, which is known for its carcinogenicity and mutagenicity. Previous studies have demonstrated that 1-NP has reproductive toxicity, but the specific mechanism is unknown. In this study, Human decidual stromal cells (HDSCs) were treated by 1-NP, exosomes were extracted from the conditioned medium of HDSCs, which were then used to treat human chorionic trophoblast cells (HTR8/SVneo) for 24 h.

Can internet use change sport participation behavior among residents? Evidence from the 2017 Chinese General Social Survey.

Purpose: The popularization of the internet has promoted the implementation of China's national fitness strategy and created conditions for Chinese residents to participate in sports. The internet is an essential medium for disseminating sports knowledge, and the use of the internet can change sport participation behaviors. Therefore, the internet can be used to popularize sports knowledge and promote the participation of all people in sports and thus improve the health of the entire population.

Outdoor air pollution exposure and the risk of asthma and wheezing in the offspring.

According to the "fetal origin of disease" hypothesis, air pollution exposure in pregnancy may play an important role in stimulating the early programming of asthma and allergies. However, previous studies reported inconsistent findings. The aim of this meta-analysis was to provide higher grade evidence and quantitatively analyze the link between prenatal exposure to outdoor air pollutants and childhood asthma and wheezing.

Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study.

Background: Congenital hydrocephalus occurs with some inheritable characteristics, but the mechanisms of its development remain poorly understood. Animal models provide the opportunity to identify potential genetic causes in this condition. The Hydrocephalus-Texas (H-Tx) rat strain is one of the most studied animal models for investigating the causative genetic alterations and analyzing downstream pathogenetic mechanisms of congenital hydrocephalus.