Mendelian Randomization Study: The Impact of Gut Microbiota on Survival in HR+ Breast Cancer Patients Under Different Treatment Regimens Through the Modulation of Immune Cell Phenotypes.

Background: Emerging evidence suggests that the gut microbiota (GM) may influence the progression of breast cancer by modulating immune responses. Given the vast diversity of GM and immune cell phenotypes, this study aimed to utilize the most advanced and comprehensive data to explore the causal relationships among the GM, immune cell phenotypes, and survival rates in hormone receptor-positive (HR+) breast cancer patients under different treatment regimens.

Methods: We investigated the causal relationships between the GM, immune cell phenotypes, and survival rates in HR+ breast cancer patients treated with 11 distinct therapeutic strategies using Mendelian randomization.

Assessment of serum Ninj1 as a potential biomarker for predicting severity in patients with COVID-19.

Infection with SARS-CoV-2 elevates the expression of cytokines, resulting in a cytokine storm that serves as the primary factor for severe illness and mortality; however, effective markers for predicting disease severity and preventing are lacking. Thus, we investigated the association between serum levels of nerve injury-induced protein 1 (Ninj1), a mediator of plasma membrane rupture, and the extent of lung damage in COVID-19 patients was examined to anticipate the severity of SARS-CoV-2 infection. This study included 62 healthy participants and 264 patients with COVID-19.

Preparation and evaluation of anti-hepatocellular carcinoma activity of oridonin nanoparticles using Angelica sinensis polysaccharide and ursodeoxycholic acid as carrier.

Hepatocellular carcinoma (HCC) poses a serious threat to human life and health. Nowadays, liver-targeting drug delivery systems have been proven as a promising strategy in treating HCC. Angelica sinensis polysaccharide (ASP), a plant polysaccharide with good biocompatibility, has excellent aqueous solubility and intrinsic liver-targeted capability.

S100A4 Facilitates Radiation-Induced Tumor Repopulation by Driving Polyploid Giant Cancer Cells Budding.

Radiotherapy, a pivotal treatment for colorectal cancer, is compromised by tumor repopulation, which is characterized by accelerated growth and increased treatment resistance. Although radiation-induced DNA breaks eliminate most cells, a subset of polyploid giant cancer cells (PGCCs) evade death through massive genomic amplification, subsequently undergoing depolyploidization via a viral budding-like process to generate proliferative progeny. Critically, these PGCCs drive tumor repopulation and underpin therapeutic failure.

Evodiamine attenuates silica-induced pulmonary fibrosis via PI3K/AKT pathway suppression: Integrated computational and experimental validation.

Background: Silicosis, a devastating occupational lung disease caused by silica dust inhalation, lacks effective treatment options. Evodiamine (Evo), a bioactive alkaloid, has demonstrated anti-fibrotic potential in various diseases; however, its efficacy in silicosis and underlying mechanisms remain elusive. This study aims to systematically investigate Evo's therapeutic effects and mechanisms against silicosis.