Factors influencing the prevalence and death rate of COPD: a pan-database ecological study covering 201 countries and regions from 1990 to 2021.

Background: Chronic obstructive pulmonary disease (COPD) is a common, heterogeneous disease and may be influenced by diverse factors. However, gaps remain in previous studies regarding the exploration of potential influencing factors. This study aims to investigate the wide range of potential factors influencing COPD based on a pan-database ecological analysis.

Assessment of Preserved Ratio Impaired Spirometry (PRISm) Based on Different Definitions in the Early COPD Cohort.

Background: Preserved ratio impaired spirometry (PRISm), which identifies a population at high risk for COPD, has drawn increasing attention. However, definitions for PRISm vary across studies, and researches comparing these definitions are limited.

Objective: We aim to assess the agreement, the clinical features, and the prevalence of PRISm defined by restrictive spirometric pattern (RSP) method [that is forced vital capacity (FVC) method] versus forced expiratory volume in the first second (FEV) method and by fixed values versus the lower limit of normal (LLN).

Impaired Ventilatory Efficiency Identifies High-Risk Mild-to-Moderate Chronic Obstructive Pulmonary Disease.

Objectives: Identifying high-risk patients is fundamental to slowing disease progression in mild-to-moderate COPD. Over one-fifth of these patients have impaired ventilatory efficiency, strongly associated with advanced disease severity, while its unclear prognostic value for high-risk case identification persists.

Methods: This was a prospective cohort study conducted from July 2019 to September 2024 (encompassing the COVID-19 pandemic period) in China.

Elucidating the Relationship Between Body Fat Index and Pulmonary Health: Insights from Cross-Sectional Analysis and Mendelian Randomization.

Objective: To evaluate the relationship between body fat index and pulmonary health.

Methods: In the multiethnic population-based cross-sectional study, a multivariable linear regression model was adapted to assess the association of fat mass/percentage with forced expiratory volume in 1 second (FEV)/forced vital capacity (FVC). The Mendelian Randomization (MR) method was used to assess the causal associations of fat mass/percentage in specific body parts with FEV and COPD risk.

Clinical features and associated factors of impaired ventilatory efficiency: findings from the ECOPD study in China.

Background: Impaired ventilatory efficiency during exercise is a predictor of mortality in chronic obstructive pulmonary disease. However, little is known about the clinical features and associated factors of impaired ventilatory efficiency in China.

Methods: We conducted a cross-sectional community-based study in China and collected demographic and clinical information, cardiopulmonary exercise testing, spirometry, and CT data.

Mendelian randomization analysis identifies druggable genes and drugs repurposing for chronic obstructive pulmonary disease.

Background: Chronic obstructive pulmonary disease (COPD) is a prevalent condition that significantly impacts public health. Unfortunately, there are few effective treatment options available. Mendelian randomization (MR) has been utilized to repurpose existing drugs and identify new therapeutic targets.

The relationship of airflow limitation with lung squamous cell carcinoma: evidence from mendelian randomization analysis.

Background: Observational studies showed associations between smoking, and airflow limitation, with lung squamous cell carcinoma (LUSC). However, the causal association of airflow limitation with LUSC and the modification by smoking status for the association remains unclear.

Methods: Genetic summary data were obtained from large genome-wide association studies (GWAS).

Relationships Among Gut Microbiota, Ischemic Stroke and Its Risk Factors: Based on Research Evidence.

Stroke is a highly lethal disease and disabling illness while ischemic stroke accounts for the majority of stroke. It has been found that inflammation plays a key role in the initiation and progression of stroke, and atherosclerotic plaque rupture is considered to be the leading cause of ischemic stroke. Furthermore, chronic inflammatory diseases, such as obesity, type 2 diabetes mellitus (T2DM) and hypertension, are also considered as the high-risk factors for stroke.