HDL-C variability linked to depression risk in older Chinese adults: Insights from observational and Mendelian randomization studies.

Background: Depression is a significant public health concern, particularly among older adults. While variability in high-density lipoprotein cholesterol (HDL-C) has been associated with various health outcomes, its relationship with depression remains unclear. This study aimed to investigate the association between HDL-C variability and the risk of depression in a Chinese population, utilizing both observational data and Mendelian randomization (MR) analysis.

First Human Trial of Stem Cell Transplantation in Complex Arrays for Stroke Patients Using the Intracerebral Microinjection Instrument.

Background: In preclinical studies, the Intracerebral Microinjection Instrument (IMI) has demonstrated the ability to deliver therapeutics within the brain in 3-dimensional arrays from a single overlying penetration while incurring minimal localized trauma.

Objective: To evaluate the safety and performance of the IMI in its first use in humans to deliver stem cells in complex configurations within brain regions affected by ischemic injury.

Methods: As part of a phase 1 study, 3 chronically hemiparetic motor stroke patients received intracerebral grafts of the therapeutic stem cell line, NSI-566, using the IMI and its supporting surgical planning software.

Stereotactic Administration of Edaravone Ameliorates Collagenase-Induced Intracerebral Hemorrhage in Rat.

Background: Edaravone is widely used for treating ischemic stroke, but it is not still confirmed in intracerebral hemorrhage (ICH) as an ideal medication targeting the brain parenchyma. We aimed to investigate the neuroprotective effects of stereotactic administration of edaravone (SI) into the brain parenchyma.

Methods: Intracerebral hemorrhage rat models were established by infusion of collagenase into the caudate nucleus.