The lactylation-macrophage interplay: implications for gastrointestinal disease therapeutics.

Lactate, a key metabolic byproduct of the Warburg effect, has lately been recognized as a regulator of histone lysine lactylation, a unique post-translational modification that plays a crucial role in essential biological processes, including the regulation of gene transcription. Lactylation plays a crucial regulatory role in macrophage biology by influencing inflammatory responses, tumor immune evasion, and fibrotic development. This review methodically investigates the molecular mechanisms of lactate metabolism and lactylation modification, focusing on their roles in macrophage activation and polarization in relation to gastrointestinal disorders, such as gastric cancer, colorectal carcinoma, ulcerative colitis, postoperative ileus, and bacterial and viral gastrointestinal infections.

Giant transverse colonic mesenteric mucinous liposarcoma combined with rectal cancer and aortic coarctation: A case report and review of literature.

Background: Liposarcomas (LPSs) are malignant mesenchymal tumors originating from adipocytes. Myxoid LPS (MLPS), a common subtype, predominantly arises in the extremities, retroperitoneum, and deep soft tissues, with a rare occurrence in the gastrointestinal tract. Primary mesenteric LPS is particularly uncommon, especially in the transverse colonic mesentery.

Multi-trait GWAS identifies pleiotropic loci associated with colorectal cancer in East Asian populations.

Introduction: While genome-wide association studies (GWAS) have identified numerous susceptibility loci in Colorectal cancer (CRC), most findings are based on European populations. Additionally, CRC shares genetic architecture with other traits, and multi-trait analysis can improve the discovery of pleiotropic loci.

Materials And Methods: We conducted a multi-trait GWAS using the Multi-Trait Analysis of GWAS (MTAG) framework, leveraging large-scale genomic and phenotypic data from BioBank Japan (BBJ).

EEG analysis of speaking and quiet states during different emotional music stimuli.

Introduction: Music has a profound impact on human emotions, capable of eliciting a wide range of emotional responses, a phenomenon that has been effectively harnessed in the field of music therapy. Given the close relationship between music and language, researchers have begun to explore how music influences brain activity and cognitive processes by integrating artificial intelligence with advancements in neuroscience.

Methods: In this study, a total of 120 subjects were recruited, all of whom were students aged between 19 and 26 years.

Laparoscopic resection of a rare diaphragmatic haemangioma: a case report.

This case report describes the laparoscopic resection of a rare diaphragmatic haemangioma. A 45-year-old male patient was diagnosed incidentally with a left subphrenic mass by computed tomography. Laparoscopic left subphrenic mass excision was performed under general anaesthesia.

Gastric Cancer Growth Modulated by circSNTB2/miR-6938-5p/G0S2 and PDCD4.

Background: Gastric cancer (GC) is the third most common cause of cancer-related death worldwide. Increasing studies have indicated that circular RNAs (circRNAs) play critical roles in cancer progression. However, the precise mechanism and functions of most circRNAs are still unknown in gastric cancer.

Long Non-coding RNA LINC01503 Promotes Gastric Cancer Cell Proliferation and Invasion by Regulating Wnt Signaling.

Background: Previous studies have indicated that the dysregulation of long non-coding RNAs plays an important role in tumors. LINC01503 is a newly discovered lncRNA that promotes development of various tumor types. However, the function of LINC01503 in gastric cancer has not been reported yet.

Integration of whole-genome sequencing and functional screening identifies a prognostic signature for lung metastasis in triple-negative breast cancer.

Lung metastasis is one of the leading causes of death for triple-negative breast cancer (TNBC). We sought to characterize the genetic alterations underlying TNBC lung metastases by integrating whole-genome sequencing and functional screening. Furthermore, we aimed to develop a metastasis-related gene signature for TNBC patients to improve risk stratification.

Epidemiology and survival outcomes of mucinous adenocarcinomas: A SEER population-based study.

To investigate the epidemiology, demographics and survival of mucinous adenocarcinomas (MACs), we identified 80,758 MAC patients in the Surveillance, Epidemiology and End Results (SEER) database. The reported incidence of MACs ebbed and flowed over time; however, a significant increase in reported annual age-adjusted incidences of MACs in the appendix, lung and bronchus was observed from 1981 to 2014. The demographics and outcomes of MACs differed by anatomic sites.