Evaluation and analysis of theoretical knowledge proficiency and practical skills among parasitic disease practitioners in Hainan province: a cross-sectional survey.

Objective: This study aimed to evaluate both theoretical knowledge proficiency and practical skills among practitioners specializing in parasitic diseases in Hainan province, providing essential groundwork for ongoing capacity enhancement efforts.

Methods: A cross-sectional study using two-stage stratified random sampling was conducted in Hainan province. City or county-level representatives from Centers for Disease Control and Prevention and other institutes, as well as medical institutions focusing on parasitic diseases, participated in this subnational assessment process.

A Simple and Rapid Fluorescent Sensor Based on MoS Quantum Dots for Dopamine Detection.

In this study, molybdenum disulfide quantum dots (MoS QDs) were synthesized via a one-step hydrothermal method, and a simple, rapid fluorescent sensing platform for dopamine (DA) detection was established based on fluorescence quenching. Experimental results demonstrated that DA is oxidized to dopamine quinone under alkaline conditions, leading to fluorescence quenching of MoS QDs through the synergistic effects of inner filter effect (IFE) and electron transfer (ET). The optimized method exhibited a linear response at 434 nm (200-600 µM, R = 0.

Application of deep reinforcement learning in electricity demand response market: Demand response decision-making of load aggregator.

With the large-scale integration of renewable energy generation, developing the potential of demand response is becoming more and more significant. However, the number of consumers is huge, the electricity consumption behaviors are various and the information of consumers is incomplete, thus there are great difficulties in modeling and processing demand response by the conventional mathematical methods. Therefore, how to accurately predict the response behaviors of consumers and select the appropriate consumers for demand response is worthy of in-depth discussion.

A novel ratiometric colorimetric sensor for detecting hypochlorite and ascorbic acid based on cascade reaction.

Hypochlorite and ascorbic acid (AA), play an indispensable role in numerous physiological activities. Herein, a ratiometric colorimetric sensing strategy for the determination of hypochlorite and AA was developed via the catalytic oxidation and reduction of 3,3',5,5'-tetramethylbenzidine (TMB). Interestingly, in the presence of FeO-MOF-5(Fe) and hypochlorite, TMB complexes in acidic environments were oxidized to blue oxidized TMB and further diazotized to produce yellow-green diazotized TMB, resulting in the hypochlorite concentration-dependent ratiometric variation for the absorbance at 652 and 450 nm (A/A).

β-CD@AgNPs with peroxisase-like activity for colorimetric determination of chiral tryptophan.

Different enantiomer forms of amino acids play different roles in multifarious fields, and improper use will cause irreversible effects. Therefore, the identification of chiral amino acids is a vital issue in the field of pharmaceutical analysis. Herein, a chiral sensing system of β-cyclodextrin coated silver nanoparticle (β-CD@AgNPs) with peroxidase-like activity was designed for the fast and efficient colorimetric identification of tryptophan (Trp) enantiomers based on the difference in binding capacity between D/L-Trp and β-CD.

Dual detection and quantification of hypochlorite and sulfite ions via SERS spectroscopy by utilizing the redox reaction of tetramethylbenzidine.

We developed a highly efficient, ultra-sensitive, and selective dual detection sensor for hypochlorite (ClO) and sulfite (SO) ions based on surface-enhanced Raman scattering (SERS) spectroscopy. 3,3',5,5'-Tetramethylbenzidine (TMB) is oxidized by ClO under acidic conditions to diazotized oxTMB that, when electrostatically adsorbed onto Au nanoparticles (NPs), produces a strong Raman signal at 1605 cm. Meanwhile, oxTMB is reduced to TMB by SO, which significantly reduces the Raman signal.

Difunctional AuNPs@PVP with oxidase-like activity for SERRS detection of total antioxidant capacity.

Assessing the total antioxidant capacity (TAC) of foods plays a significant role in dietary guidance and disease risk reduction. Therefore, building a simple, rapid, and sensitive sensing method for detecting TAC possesses broad application prospects. Herein, we constructed a novel nanozyme catalyzed‒surface-enhanced Raman resonance scattering (SERRS) sensing strategy for analysis of TAC based on polyvinylpyrrolidone coated gold nanoparticles (AuNPs@PVP) that was synthesized by one step reduction method.

Nanozyme catalyzed-SERRS sensor for the recognition of dopamine based on AgNPs@PVP with oxidase-like activity.

Dopamine (DA), as one of the most significant neurotransmitters, is closely related to several diseases. Achieving rapid and sensitive detection of DA remains a challenge. Herein, we proposed a simple, fast, and sensitive method for DA recognition based on surface-enhanced resonance Raman scattering (SERRS) technique.

Surface plasmon-assisted catalytic reduction of p-nitrothiophenol for the detection of Fe by surface-enhanced Raman spectroscopy.

Herein, we developed a concise, time-efficient, and high selective assay for detecting Fe through its triggered surface plasmon-assisted reduction reaction of p-nitrothiophenol (PNTP) to p,p'-dimercaptoazobenzene (DMAB) on the surface of gold nanoparticles (AuNPs) based on surface-enhanced Raman scattering (SERS) spectroscopy. When Fe was added to the PNTP-AuNPs system, the appearance of three characteristic peaks at 1142, 1392, and 1440 cm attributed to DMAB demonstrated that Fe induced the catalytic coupling reaction of PNTP. The Raman intensity ratio of the peak at 1142 cm to the peak at 1336 cm and the concentration of Fe presented a good linear response from 10 to 100 μM with a limit of detection (LOD) of 0.

A novel RhB@MOF-808 fluorescent probe for the rapid detection of dopamine and Fe.

Dopamine (DA) and Fe as the important bioactive ingredients, playing an indispensable role in human metabolism. Therefore, developing the accurate detection of DA and Fe is of great significance for disease screening. Herein, we put forward a simple, rapid, and sensitive fluorescent detection strategy for the detection of dopamine and Fe based on Rhodamine B-modified MOF-808 (RhB@MOF-808).

A sensitive surface-enhanced resonance Raman scattering sensor with bifunctional negatively charged gold nanoparticles for the determination of Cr(VI).

Hexavalent chromium (Cr(VI)) pollution in the water system has seriously endangered human health and the environment. Herein, we propose a rapid, simple and sensitive surface-enhanced resonance Raman scattering (SERRS) sensor with the bifunctional negatively charged gold nanoparticles ((-)AuNPs) which employ as not only the oxidoreductase-like nanozyme but also the substrate to determine Cr(VI). (-)AuNPs effectively promoted the conversion of 3,3',5,5'-tetramethylbenzidine (TMB) into the blue product of 3,3',5,5'-tetramethylbenzidine diamine (oxTMB) in the presence of Cr(VI) and generated a strong SERRS signal at 1611 cm.

In-Situ Synthesis of Methyl Cellulose Film Decorated with Silver Nanoparticles as a Flexible Surface-Enhanced Raman Substrate for the Rapid Detection of Pesticide Residues in Fruits and Vegetables.

The purpose of this study was to develop a flexible substrate methylcellulose-decorated silver nanoparticles (MC/Ag NPs) film and explore its application in fruits and vegetables by surface enhanced Raman spectroscopy (SERS) technology for rapid detection of pesticides. The performance of the MC/Ag NPs film substrate was characterized by Nile blue A (NBA), and the detection limit was as low as 10 M. The substrate also exhibited satisfactory Raman signal strength after two months of storage.

An ultrasensitive surface-enhanced Raman scattering sensor for the detection of hydrazine via the Schiff base reaction.

The development of convenient assays for the determination of hydrazine (NH) has drawn significant attention due to the high toxicity of this substance. Herein, we developed a concise, rapid and ultrasensitive surface-enhanced Raman scattering (SERS) sensor for NH detection based on alpha-cyclodextrin-silver nanoparticles (α-CD-AgNPs) modified by 4-mercaptobenzaldehyde (4-MBA). The 4-MBA molecules can specifically capture the NH molecules and undergo a Schiff base reaction.

Correlation between preoperative inflammatory markers, Ki-67 and the pathological grade of glioma.

To investigate the correlation between preoperative inflammatory markers, Ki-67 expression and the pathological grade of glioma, and to provide a reference for clinical prediction of glioma prognosis.A total of 45 glioma patients who underwent surgery with complete clinical and pathological data were in our hospital from January 2012 to December 2018 were enrolled. Glioma was divided into WHO grade I to IV.

Sulfite-triggered surface plasmon-catalyzed reduction of p-nitrothiophenol to p,p'-dimercaptoazobenzene.

The conversion of p-aminothiophenol (PATP) or p-nitrothiophenol (PNTP) to p,p'-dimercaptoazobenzene (DMAB) has been used as model reactions to study plasmon-catalyzed reaction on nanoparticles. Herein, we report the conversion of PNTP to DMAB which is triggered by SO ions on gold nanoparticles (AuNPs) for the first time. With the addition of SO, the Raman peaks at 1139, 1392, 1437 cm appears, which indicates the formation of DMAB.

Iridium-catalyzed diastereoselective amination of alcohols with chiral tert-butanesulfinamide by the use of a borrowing hydrogen methodology.

An iridium-catalyzed diastereoselective amination of alcohols with chiral tert-butanesulfinamide was developed under basic conditions, affording the optically active secondary sulfinamides in high yields and diastereoselectivities. The removal of the sulfinyl group from sulfonamides allowed a facile access to a wide range of α-chiral primary amines. This synthetic strategy was further applied in the synthesis of the marketed pharmaceuticals (S)-rivastigmine and NPS R-568.

Stereoconvergent, Redox-Neutral Access to Tetrahydroquinoxalines through Relay Epoxide Opening/Amination of Alcohols.

We present an economical catalytic procedure to convert readily available 1,2-diaminobenzenes and terminal epoxides into valuable 1,2,3,4-tetrahydroquinoxalines in a highly enantioselective fashion. This procedure operates through relay zinc and iridium catalysis, and achieves redox-neutral and stereoconvergent production of valuable chiral heterocycles from racemic starting materials with water as the only side product. The use of commercially available reagents and catalysts and a convenient procedure also make this catalytic method attractive for practical application.

Standardized Ginkgo biloba extract EGb 761® attenuates early brain injury following subarachnoid hemorrhage via suppressing neuronal apoptosis through the activation of Akt signaling.

Background: Early brain injury (EBI) plays a critical role in determining the outcome of subarachnoid hemorrhage (SAH). The present study was designed to investigate the role of EGb 761, a standardized extract of Ginkgo biloba, in SAH-induced EBI and to explore its potential mechanism of action.

Method: A rat SAH model was established by the endovascular perforation process.