Food Protein-Induced Enterocolitis Syndrome Across Lifespan: Focus on Adolescence.

Food protein-induced enterocolitis syndrome (FPIES) is a food-related hypersensitivity disorder characterized by delayed repeated vomiting that typically presents within the first years of life. Although FPIES has traditionally been considered a pediatric condition, it has more recently been observed also in teenagers and adults. Adult FPIES may be a continuation of childhood-onset disease or new-onset forms developing later in life.

Paediatric fish-chicken syndrome and its natural history.

We have described the case of a paediatric patient suffering from the so-called 'fish-chicken syndrome.' We assessed the clinical evolution from the onset of symptoms to the partial recovery that was unusually achieved within a few months. This allowed us not only to delve deeper into the natural history of the syndrome, which is currently, especially for paediatric patients, little known, but also pointed us towards new possibilities regarding the diagnosis and management of this type of allergy.

Sleep deprivation as a risk factor for anaphylaxis in children with food allergy.

Severity of food allergic reactions is unpredictable, and cofactors influence the development of food-induced anaphylaxis. A lot of cofactors might increase allergic reaction severity, and little is known about sleep deprivation as a possible cofactor in food allergy, especially in children. With the description of a case of a middle child, we want to emphasise the role that sleep deprivation might play as a cofactor, especially during oral immunotherapy (OIT).

Butter and Beef Tolerance in Children with IgE-Mediated Cow's Milk Allergy.

Butter and beef are often prejudicially forbidden for children affected by IgE-mediated cow's milk allergy (IgE-CMA). Children with IgE-CMA underwent prick-by-prick (PbP) test with clarified butter and normal butter, raw and cooked beef. In case of positivity of the PbP, an oral food challenge (OFC) with that food was proposed.

Severity Trend of Recurrence in Pediatric Food Protein-Induced Enterocolitis Syndrome.

Background: Reintroduction of the offending food in pediatric patients affected by food protein-induced enterocolitis syndrome (FPIES) is carried out in hospitals with an oral food challenge (OFC), which leads to a long waiting time and increases the societal burden of medical cost and human resources.

Objective: To assess the severity trend of acute FPIES adverse reactions over time in the same patient for possible outpatient or home reintroduction of the offending food.

Methods: All children (aged <18 years) with a diagnosis of acute FPIES referred to two Italian pediatric allergy clinics were retrospectively enrolled.

Can the CHOP-INTEND be used as An Outcome Measure in the First Months of Age? Implications for Clinical Trials and Real World Data.

Background: The CHOP-INTEND is an established outcome measure used to assess motor function in young and weak SMA patients previously validated in type I infants older than 3 months.

Objective: The aim of our study was to assess the maturation of the CHOP-INTEND scores in a group of healthy infants, establishing which items of the scale can be reliably used in individuals younger than 3 months.

Methods: This is a prospective observational study.

Changes in clinical, demographic, and outcome patterns of children hospitalized with non-SARS-CoV-2 viral low respiratory tract infections before and during the COVID pandemic in Rome, Italy.

Introduction: We performed this study aiming to evaluate changes in epidemiology, clinical presentation and outcomes of children hospitalized for viral lower respiratory tract infections (LRTI).

Methods: We performed a retrospective study of children younger than 18 years of age hospitalized for LRTIs with a positive respiratory viral testing from 2018 to 2022. We compared need of pediatric intensive care unit (PICU), invasive ventilation, and other respiratory support, viral etiologies, clinical presentations, imaging, and laboratory results in the precovid (2018-2019) and covid (2020-2022) period.

Personalization of Complementary Feeding in Children With Acute Food Protein-Induced Enterocolitis Syndrome.

Food protein-induced enterocolitis syndrome (FPIES) is a food allergy that results in repetitive vomiting, lethargy, and pallor within 1 to 4 hours of food ingestion. One of the issues in its management is the introduction of new foods. Over the past 25 years, suggestions have been made mainly based on the likelihood that a given food family could induce an episode of acute FPIES.

Cytokine Response to SARS-CoV-2 Infection in Children.

The causal connection between serum biomarkers and COVID-19 severity or pathogenicity in children is unclear. The aim of this study was to describe clinical and immunological features of children affected by COVID-19. The secondary aim was to evaluate whether these cytokines could predict severity of COVID-19.