Regulation of viral hepatitis by N6-methyladenosine RNA methylation.

Recent studies have shown that the presence of an RNA modification, N6-methyladenosine (mA), in viral RNAs during infection significantly impacts the outcome of viral replication and pathogenesis. In particular, various functions of mA have been elucidated in hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis delta virus (HDV). During viral infection, mA methylation not only directly affects the replication of these viruses but also regulates diverse cellular RNAs to control pathogenesis.

Microwave-Driven Crystallographic Alignment for Producing Metal (M) Thin Films with Highly-Oriented M(111) Surface.

Production of metal thin films exhibiting controlled crystallographic alignment is essential for catalysts, sensors, and substrates for the epitaxial growth of 2D materials (graphene, h-BN, metal chalcogenides, etc.). Conventional methods to produce aligned metal films necessitate specific substrates and high-temperature processing, which limits their applicability to thin films and accessible metal species.

Exploring the impact of forage-to-concentrate ratios on the ruminal bacteriome in vitro focusing on ciliate-associated bacteria.

Ruminal ciliates are linked to methane production and nitrogen utilization efficiency in ruminants due to their association with other ruminal microorganisms. However, research on the specific interplay between ruminal bacteria and ciliates is still limited, particularly in different dietary conditions. This study examines the effect of the forage-to-concentrate (F:C) ratio on the ruminal bacteriome in vitro, focusing on bacteria associated with Isotricha spp.

Recovering mechanoluminescence in SAOED/epoxy stress sensors with self-healing epoxy vitrimers.

In mechanoluminescence stress sensors, understanding the relationship between light emission performance and sensor structural stability is crucial to ensure the accuracy, sensitivity, and reliability of stress sensing during operation. Any minor structural damage or debonding at the particle-epoxy interface will reduce stress transfer capacity and hamper the light emission from SAOED particles. Instead of replacing the sensors with reduced light emission performance, self-healing epoxy vitrimers can open up new opportunities for recovering mechanoluminescence, offering durable and environmentally friendly high-performance stress sensors.

The Classification of Metastatic Spine Cancer and Spinal Compression Fractures by Using CNN and SVM Techniques.

Metastatic spine cancer can cause pain and neurological issues, making it challenging to distinguish from spinal compression fractures using magnetic resonance imaging (MRI). To improve diagnostic accuracy, this study developed artificial intelligence (AI) models to differentiate between metastatic spine cancer and spinal compression fractures in MRI images. MRI data from Gyeongsang National University Hospital, collected from January 2019 to April 2022, were processed using Otsu's binarization and Canny edge detection algorithms.

High Modulus Epoxy/GO-PANI Self-Healing Materials Without Catalyst by Molecular Engineering and Nanocomposite Fabrication.

Nowadays, self-healing materials have been studied actively in electronics, soft robotics, aerospace, and automobiles because they can prolong the life span of the materials. However, overcoming the trade-off relationship between mechanical properties and self-healing performance is challenging. Herein, graphene oxide-polyaniline (GO-PANI) filler was introduced to overcome this challenge because GO has a highly excellent modulus, and nitrogen atoms in PANI can endow a self-healing ability through hydrogen bonds.

Impact of Forage Sources on Ruminal Bacteriome and Carcass Traits in Hanwoo Steers During the Late Fattening Stages.

This study examined the effects of different forage sources on the ruminal bacteriome, growth performance, and carcass characteristics of Hanwoo steers during the fattening stage. In Korea, where high-concentrate feeding is common, selecting suitable forage is crucial for sustainable beef production. Fifteen 23-month-old Hanwoo steers, weighing an average of 679.

Recent Methods for Evaluating Crop Water Stress Using AI Techniques: A Review.

This study systematically reviews the integration of artificial intelligence (AI) and remote sensing technologies to address the issue of crop water stress caused by rising global temperatures and climate change; in particular, it evaluates the effectiveness of various non-destructive remote sensing platforms (RGB, thermal imaging, and hyperspectral imaging) and AI techniques (machine learning, deep learning, ensemble methods, GAN, and XAI) in monitoring and predicting crop water stress. The analysis focuses on variability in precipitation due to climate change and explores how these technologies can be strategically combined under data-limited conditions to enhance agricultural productivity. Furthermore, this study is expected to contribute to improving sustainable agricultural practices and mitigating the negative impacts of climate change on crop yield and quality.

Pseudo-3D Topological Alignments Regulate Mechanotransduction and Maturation of Smooth Muscle Cells.

Smooth muscle cells (SMCs) sense and respond to mechanical stimuli in their extracellular microenvironments (ECMs), playing a crucial role in muscle tissue engineering. Increasing evidence from topological cues-mediated mechanotransduction of SMCs in ECMs has suggested some potential underlying mechanisms of how SMC functions and maturation are regulated by their mechanosensing leading to transduction. However, how the expression of yes-associated protein 1 (YAP) influences the phenotypic shift from synthetic to contractile is still controversial.

Analysis of N6-Methyladenosine Modification of HBV RNA by Methylated RNA Immunoprecipitation.

Of all the chemical modifications of RNAs, the N6-methyladenosine (mA) modification is the most prevalent and well-characterized RNA modification that is functionally implicated in a wide range of biological processes. The mA modification occurs in hepatitis B virus (HBV) RNAs and this modification regulates the HBV life cycle in several ways. Thus, understanding the mechanisms underlying m6A modification of HBV RNAs is crucial in understanding HBV infectious process and associated pathogenesis.

Effectiveness of sensory integration therapy in children, focusing on Korean children: A systematic review and meta-analysis.

Background: Sensory integration intervention is highly related to the child's effective interaction with the environment and the child's development. Currently, various sensory integration interventions are being applied, but research methodological problems are arising due to unsystematic protocols. This study aims to present the optimal intervention protocol by presenting scientific standards for sensory integration intervention through meta-analysis.

Development of a Parturition Detection System for Korean Native Black Goats.

Korean Native Black Goats deliver mainly during the cold season. However, in winter, there is a high risk of stunted growth and mortality for their newborns. Therefore, we conducted this study to develop a KNBG parturition detection system that detects and provides managers with early notification of the signs of parturition.

Characterization of and Using Efficient Gene Knockout Systems through Repeated Protoplasting and CRISPR/Cas9 Ribonucleoprotein Approaches in .

is the causal agent of sclerotinia stem rot in over 400 plant species. In a previous study, the group III histidine kinase gene of () revealed its involvement in iprodione and fludioxonil sensitivity and osmotic stress. To further investigate the fungicide sensitivity associated with the high-osmolarity glycerol (HOG) pathway, we functionally characterized , which is the downstream kinase of .

Monitoring of Benzimidazole Resistance in Botrytis cinerea Isolates from Strawberry in Korea and Development of Detection Method for Benzimidazole Resistance.

Botrytis cinerea is a major fungal plant pathogen that causes gray mold disease in strawberries, leading to a decrease in strawberry yield. While benzimidazole is widely used as a fungicide for controlling this disease, the increasing prevalence of resistant populations to this fungicide undermines its effectiveness. To investigate benzimidazole resistant B.

Analysis of the effectiveness of cognitive rehabilitation for patients with chronic mental illness: A meta-analysis.

Background: People suffering from chronic mental illness are sensitive to stressful stimuli, lack coping skills, and have low self-esteem due to problems such as social situations. They also experience depression, isolation, fear, and frustration. Due to cognitive dysfunction, people suffering from chronic mental illness have inadequate cognitive processes that lead to distorted thinking.

Proximate Content Monitoring of Black Soldier Fly Larval () Dry Matter for Feed Material using Short-Wave Infrared Hyperspectral Imaging.

Edible insects are gaining popularity as a potential future food source because of their high protein content and efficient use of space. Black soldier fly larvae (BSFL) are noteworthy because they can be used as feed for various animals including reptiles, dogs, fish, chickens, and pigs. However, if the edible insect industry is to advance, we should use automation to reduce labor and increase production.

Meta-analysis on the effectiveness of parent education for children with disabilities.

Background: Parents of children with disabilities often have difficulty understanding their child's behavior and are unable to do it appropriately because they do not know what to do. The more we properly understand children with disabilities, the more positive the importance of parent education becomes in various aspects.

Aim: To demonstrate the effectiveness of parent education for children with disabilities in various aspects and present it as evidence that can be used clinically.

The Significance of N6-Methyladenosine RNA Methylation in Regulating the Hepatitis B Virus Life Cycle.

N6-methyladenosine (m6A) RNA methylation has recently emerged as a significant co-transcriptional modification involved in regulating various RNA functions. It plays a vital function in numerous biological processes. Enzymes referred to as m6A methyltransferases, such as the methyltransferaselike (METTL) 3-METTL14-Wilms tumor 1 (WT1)-associated protein (WTAP) complex, are responsible for adding m6A modifications, while m6A demethylases, including fat mass and obesity-associated protein (FTO) and alkB homolog 5 (ALKBH5), can remove m6A methylation.

Rapid Detection of Single- and Co-Contaminant Aflatoxins and Fumonisins in Ground Maize Using Hyperspectral Imaging Techniques.

Aflatoxins and fumonisins, commonly found in maize and maize-derived products, frequently co-occur and can cause dangerous illness in humans and animals if ingested in large amounts. Efforts are being made to develop suitable analytical methods for screening that can rapidly detect mycotoxins in order to prevent illness through early detection. A method for classifying contaminated maize by applying hyperspectral imaging techniques including reflectance in the visible and near-infrared (VNIR) and short-wave infrared (SWIR) regions, and fluorescence was investigated.

Durability and Performance Analysis of Polymer Electrolyte Membranes for Hydrogen Fuel Cells by a Coupled Chemo-mechanical Constitutive Model and Experimental Validation.

In this paper, a chemo-mechanically coupled behavior of Nafion 212 is investigated through predictive multiphysics modeling and experimental validation. Fuel cell performance and durability are critically determined by the mechanical and chemical degradation of a perfluorosulfonic acid (PFSA) membrane. However, how the degree of chemical decomposition affects the material constitutive behavior has not been clearly defined.

Development of a Mercury Bromide Birefringence Measurement System Based on Brewster's Angle.

Mercury bromide (HgBr) has been used to develop acousto-optic tunable filters (AOTFs) because it has several advantages, including a high refractive index, a broad optical bandwidth, and a relatively high figure of merit. Therefore, the measurement of its birefringence is a highly important factor for ensuring AOTF quality. However, for single crystals, it is difficult (at the millimeter scale) to quantify the birefringence using an ellipsometer, as this equipment is only designed to conduct measurements on thin films.

High-Performance Indium-Tin Oxide (ITO) Electrode Enabled by a Counteranion-Free Metal-Polymer Complex.

Although multicomponent inorganic thin films (metal-oxides, -carbides, -nitrides, and -chalcogenides) have been synthesized by polymer-assisted deposition (PAD), synthesis of high-performance transparent conducting oxides (TCOs) has been rarely reported. TCO requires (i) removal of impurities, (ii) high-density oxide film, (iii) homogeneity in crystal structures and film morphology, and (iv) controllable elemental doping. This study performs a systematic investigation on preparation of stable multicomponent metal-polymer complex solutions by removing the counteranions in the solution.

Epoxy-Based Catalyst-Free Self-Healing Elastomers at Room Temperature Employing Aromatic Disulfide and Hydrogen Bonds.

In this paper, catalyst-free room-temperature healing epoxy vitrimer-like materials (S-vitrimer) are introduced. The S-vitrimer can be healed at room temperature without any external stimuli such as solvent, pressure, heat, and catalyst through an aromatic disulfide exchange reaction and a hydrogen bond because the glass transition temperature of the S-vitrimer is lower than room temperature. Self-healing materials are attracting widespread attention nowadays with their potential to increase the durability of the materials.

CNT-Reinforced Self-Healable Epoxy Dynamic Networks Based on Disulfide Bond Exchange.

The design and utilization of polymers with healing capability have drawn increasing attention owing to their enhanced chain mobility and opportunity to heal minor cracks in composites. Rehealable thermoset polymers promise reduction in the maintenance cost and thus prolonged lifetime, reshaping, and recyclability. Introducing reversible covalent bonds is the mainstay strategy to achieve such plasticity in crosslinked polymers.