Using Levothyroxin-Loaded Zn-Curcumin MOF to Achieve Collaborative Treatment of Hypothyroidic Encephalopathy through Reducing Oxidative Stress and Re-Building Synaptic Plasticity.

Hypothyroid encephalopathy refers to cognitive impairment caused by hypothyroidism, which is caused by low thyroid hormone signal in the brain, and further leads to an increase in oxidative stress level, a decrease in hippocampal synaptic plasticity, and even affects the signal transmission process between neurons. However, traditional hormone replacement therapy (HRT) only restores the thyroid hormone concentration in serum, not in the brain, which leads to damage to hippocampal synaptic plasticity in the brain that can't be repaired. In addition, there is also oxidative damage, which makes the symptoms of encephalopathy still persist, and indicates the need for a new collaborative treatment approach for hypothyroid encephalopathy disease.

Characteristics, immobilization of linoleic acid isomerase from Bifidobacterium breve and its application in rice bran oil.

The purpose of this paper is to reduce the acid value of rice bran crude oil and make a new rice bran oil (RBO) with conjugated linoleic acid (CLA). Linoleic acid isomerase from Bifidobacterium breve was immobilized on a magnetic nanoflower carrier of FeO-SiO-NFs. Molecular docking simulations were performed to investigate the interaction and binding mode conformation between isomerase and linoleic acid (LA) molecules by using computer software.

Ultrasound-assisted covalent cross-linking of egg white protein with ferulic acid: Structure, foaming, and application in chiffon cake.

Egg white protein is one of the most important functional proteins in daily life; however, owing to its slow foaming, small volume and easy instability, EWP foam has limited application in the food industry, and its foaming performance needs to be further improved. However, its foaming performance still needs further improvement due to its instability mechanism. In this study, egg white protein and ferulic acid were combined via ultrasound-assisted covalent cross-linking methods, and their structure, foaming performance, and application were studied.

Programmatic Strategies in the Retrosigmoid Approach for Koos Grade IV Vestibular Schwannomas: Exploring Surgical Anatomy, Technical Nuances, and Case Series.

Objective: Koos grade 4 vestibular schwannomas (KG4VSs) pose significant surgical challenges due to their complex anatomy and proximity to cranial nerves. Despite advances in neurosurgery, preserving facial and cochlear nerve functions remains difficult. This study introduces a novel surgical strategy for KG4VS that aims to minimize mechanical traction and maximize functional outcomes through systematic tumor dissection guided by anatomical landmarks in the cerebellopontine angle region.

Ultraviolet narrowband all-dielectric metasurface absorber with an ultra-thin absorption layer.

Ultraviolet (UV, 200-400 nm) detection with high efficiency and excellent spectral resolution is essential in spectral analysis. This Letter proposes a UV narrowband all-dielectric metasurface absorber with an ultra-thin absorption layer. The design incorporates lossless AlO resonators placed on a thin (20 nm) lossy GaO film, which enhances the absorption intensity at a specific wavelength.

Cellular and synaptic organization of the Octopus vertical lobe.

Understanding memory formation and its influence on behavior is a central challenge in neuroscience. Associative learning networks, including the mushroom body in insects, the cerebellum in mammals, and the vertical lobe (VL) in cephalopods, typically exhibit a 3-layered architecture, characterized by divergence (fan-out) followed by convergence (fan-in), facilitating sparse sensory coding (Babadi and Sompolinsky, 2014; Lin et al., 2014; Litwin-Kumar et al.

The Narrative Coherence of Autistic Children's Accounts of an Experienced Event in Response to Different Interviewer Prompts: A Longitudinal Study.

Purpose: This study explored the narrative coherence of the accounts of an experienced event produced by autistic and neurotypical children (ages 6-15 years) after delays of two weeks and two months.

Methods: The sample comprised 27 autistic children and 32 neurotypical peers, who were interviewed about the event using the Revised National Institute of Child Health and Human Development (NICHD) Investigative Interview Protocol. The study focused on assessing the narrative coherence of children's reports, emphasizing key story grammar elements and temporal features in their narratives.

Effective protection of biological tissues from severe blunt force injury by engineered nanoscale liquid flow.

Blunt force trauma (BFT), the injury of the body by forceful impacts such as falls, motor vehicle crashes and collisions, causes damage to bio-organs that can lead to life-threatening situations. To address the unmet need of bioprotection materials for BFT, we developed a novel, liquid nanofoam (LN)-based system. The LN system employs a unique mechanism of energy absorption, i.

Residue-Free Orally Administered Drug Carrier Based on a Porous Aromatic Framework for Efficient Multisite Treatment.

Nowadays, oral medications are the primary method of treating disease due to their convenience, low cost, and safety, without the need for complex medical procedures. To maximize treatment effectiveness, almost all oral medications utilize drug carriers, such as capsules, liposomes, and sugar coatings. However, these carriers rely on dissolution or fragmentation to achieve drug release, which leads to drugs and carriers coabsorption in the body, causing unnecessary adverse drug reactions, such as nausea, vomiting, abdominal pain, and even death caused by allergy.

Hyperbaric Lidocaine Aggravates Diabetic Neuropathic Pain by Targeting p38 MAPK/ERK and PINK1/Parkin-Mediated Mitophagy Signaling Pathway.

Background: Diabetic neuropathic pain (DNP) is a complication of diabetes mellitus (DM). Hyperbaric lidocaine (HL), a local anesthetics drug, has neurotoxicity. The present study aims to study the effect and molecular mechanisms of HL on spinal nerve injury in DNP.

Longitudinal Imaging of Tumor Perfusion After Preoperative Endovascular Embolization in Meningiomas: Surgical Time Window Selecting, Clinical Consideration, and Outcomes.

Objective: To quantitatively investigate the longitudinal computed tomography perfusion (CTP) imaging in meningiomas preoperatively embolized using microcatheters.

Methods: This retrospective monocentric study included 27 patients with symptomatic supratentorial meningiomas. Quantitative computed tomography perfusion (CTP) images before and postembolization were evaluated and correlated with angiographic, immunohistochemical, and clinical data.

Oncolytic adenovirus encoding apolipoprotein A1 suppresses metastasis of triple-negative breast cancer in mice.

Background: Dysregulation of cholesterol metabolism is associated with the metastasis of triple-negative breast cancer (TNBC). Apolipoprotein A1 (ApoA1) is widely recognized for its pivotal role in regulating cholesterol efflux and maintaining cellular cholesterol homeostasis. However, further exploration is needed to determine whether it inhibits TNBC metastasis by affecting cholesterol metabolism.

Dynamics of polylactic acid under ultrafine nanoconfinement: The collective interface effect and the spatial gradient.

Polymers under nanoconfinement can exhibit large alterations in dynamics from their bulk values due to an interface effect. However, understanding the interface effect remains a challenge, especially in the ultrafine nanoconfinement region. In this work, we prepare new geometries with ultrafine nanoconfinement ∼10nm through controlled distributions of the crystalline phases and the amorphous phases of a model semi-crystalline polymer, i.

Testing adulterated liquid-egg: developing rapid detection techniques based on colorimetry, electrochemistry, and interfacial fingerprinting.

To develop rapid detection techniques for liquid eggs' adulteration, three types of adulterations were considered: water dilution, manipulation of yolk ratio in whole egg, and blending different varieties of egg white or yolk. Objective: Establish detection techniques utilizing colorimetry, electrochemistry, and interfacial fingerprinting for these adulterations, respectively. Results: Colorimetry allows for detection (1 min·sample) of water dilution through linear (R ≥ 0.

Preparation of magnetic dialdehyde starch-immobilized phospholipase A and acyl transfer in reflection.

In this paper, using a coprecipitation method to prepare FeO magnetic nanoparticles (FeO MNPS), magnetic dialdehyde starch nanoparticles with immobilized phospholipase A (MDSNIPLA) were successfully prepared by using green dialdehyde starch (DAS) instead of glutaraldehyde as the crosslinking agent. The FeO MNPS was characterized by infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), the Brunauer-Emmett-Teller (BET) surface area analysis method, thermogravimetric analysis (TGA), and transmission electron microscopy (TEM) et al. The results showed that the alkaline resistance and acid resistance of the enzyme were improved after the crosslinking of DAS.

Dynamic polarization-regulated metasurface with variable focal length.

Polarization and focal length are both critical optical parameters with many applications in many fields, such as optical communications and imaging. The development of metasurfaces provides a new realization of optical systems. In this paper, based on metasurfaces' powerful electromagnetic modulation capability, we integrate polarization conversion with continuous zoom function and propose a dynamic polarization-regulated metasurface with variable focal length.

All-dielectric six-foci metalens for infrared polarization detection based on Stokes space.

The detection technology of infrared polarization has gained significant attention due to its ability to provide better identification and obtain more information about the target. In this paper, based on the expression of the full polarization state in Stokes space, we designed micro-nano metasurface functional arrays to calculate the polarization state of the incident light by reading the Stokes parameters (a set of parameters that describe the polarization state). Metalens with linear and circular polarization-dependent functions are designed based on the propagation and geometric phases of the dielectric Si meta-atoms in the infrared band, respectively.

Detector of UV light chirality based on a diamond metasurface.

Circularly polarized light (CPL) finds diverse applications in fields such as quantum communications, quantum computing, circular dichroism (CD) spectroscopy, polarization imaging, and sensing. However, conventional techniques for detecting CPL face challenges related to equipment miniaturization, system integration, and high-speed operation. In this study, we propose a novel design that addresses these limitations by employing a quarter waveplate constructed from a diamond metasurface, in combination with a linear polarizer crafted from metallic aluminum.

Preparation of meaty flavor additive from soybean meal through the Maillard reaction.

Meaty flavor additive was prepared from soybean meal hydrolysate and xylose in the method of Maillard reaction. Under the conditions of reaction temperature 120 ℃, time 120 min and cysteine addition 10%, the Maillard products had strong flavor of meat. The content of free amino acids was 4.

Connectomics of the vertical lobe provides insight into conserved and novel principles of a memory acquisition network.

Here, we present the first analysis of the connectome of a small volume of the vertical lobe (VL) a brain structure mediating the acquisition of long-term memory in this behaviorally advanced mollusk. Serial section electron microscopy revealed new types of interneurons, cellular components of extensive modulatory systems, and multiple synaptic motifs. The sensory input to the VL is conveyed via~1.

mEMbrain: an interactive deep learning MATLAB tool for connectomic segmentation on commodity desktops.

Connectomics is fundamental in propelling our understanding of the nervous system's organization, unearthing cells and wiring diagrams reconstructed from volume electron microscopy (EM) datasets. Such reconstructions, on the one hand, have benefited from ever more precise automatic segmentation methods, which leverage sophisticated deep learning architectures and advanced machine learning algorithms. On the other hand, the field of neuroscience at large, and of image processing in particular, has manifested a need for user-friendly and open source tools which enable the community to carry out advanced analyses.

Physical Mechanism of One-Photon Absorption, Two-Photon Absorption, and Electron Circular Dichroism of 1,3,5 Triazine Derivatives Based on Molecular Planarity.

We provide a method to regulate intramolecular charge transfer (ICT) through distorting fragment dipole moments based on molecular planarity and intuitively investigate the physical mechanisms of one-photon absorption (OPA), two-photon absorption (TPA), and electron circular dichroism (ECD) properties of the multichain 1,3,5 triazine derivatives o-Br-TRZ, m-Br-TRZ, and p-Br-TRZ containing three bromobiphenyl units. As the position of the C-Br bond on the branch chain becomes farther away, the molecular planarity is weakened, with the position of charge transfer (CT) on the branch chain of bromobiphenyl changing. The excitation energy of the excited states decreases, which leads to the redshift of the OPA spectrum of 1,3,5-triazine derivatives.

Pituitary adenoma with cavernous sinus compartment penetration and intracranial extension: surgical anatomy, approach, and outcomes.

Objectives: To understand the different characteristics and growth corridors of knosp grade 4 pituitary adenomas (Knosp4PA) with cavernous sinus (CS) compartments penetration and intracranial extension, aiming to improve the safety, effectiveness, and total resection rate of surgery.

Methods: A case series of 120 Knosp4PA patients with 187 invaded compartments were retrospectively reviewed. A novel surgery-relevant grading system was proposed according to the CS penetrating features.

Pathological pathway analysis in an experimental rheumatoid arthritis model and the tissue repair effect of acupuncture at ST36.

Rheumatoid arthritis (RA) is an autoimmune disease that generally affects the joints. In the face of inflammation-induced cartilage and bone damage, RA treatment remains insufficient. While research evidence indicates that acupuncture can exert anti-inflammatory and analgesic effects, improve the joint function of RA patients, and delay the disease, data on whether it can promote RA repair are lacking.