Impact of Climate Change on the Composition and Bioactivity of Essential Oils: In Vitro, , and ADME Analysis.

Medicinal plants, rich in secondary metabolites, play a crucial role in drug development. Climate change, driven by industrialization, affects plant growth and the production of these metabolites. The research explores how climate change influences the phytochemical profile as well as the antioxidant and antidiabetic activities of The three samples were subjected to contrasting climatic conditions, ranging from a normal climate to progressively intensified combined heat and drought stress over 4 years (Sample 1 under normal seasonal temperature and rainfall; Sample 2 with a 5 C temperature increase and 50% reduced irrigation; and Sample 3 exposed to a 10 C temperature rise and 75% water deficit).

Investigating the Influence of Drying Methods on the Quality and Bioactive Properties of Hemp ( L.) Seed Oil.

This research investigates how oven and microwave drying methods influence mass reduction, oil yield, chemical composition, and bioactivity of seed oil, from two L. varieties-Beldia and Critical-grown in Ketama and Taounate, Morocco. Microwave drying resulted in greater mass loss (2.

Unveiling the photothermal mechanism and therapeutic potential of quercetin-loaded MXene-ZMOF@Chitosan in MCF-7 breast cancer.

Breast cancer remains a significant global health challenge, necessitating innovative therapeutic strategies. This study introduces a novel Q-MX-ZMOF@CH nanocomposite, integrating MXene with zinc-based metal-organic frameworks (ZMOF) and chitosan (CH) to targeted quercetin (Q) delivery and enhanced photothermal therapy (PTT) for breast cancer therapy. TEM imaging of Q-MX-ZMOF@CH indicated spherical morphologies with size distribution (∼60 nm).

Healthy food choices in Morocco: A survey on knowledge, attitudes, and practices.

Objectives: Understanding the knowledge, attitudes, and practices (KAP) that shape adult eating behaviors is essential for improving nutrition outcomes. This study addresses this need by examining these factors among Moroccan adults-an area often overlooked in research that has primarily focused on nutrient and energy intake.

Methods: A cross-sectional online survey was conducted from October 2024 to January 2025 across all the 12 Moroccan regions.

ADMET-Guided Docking and GROMACS Molecular Dynamics of Phytochemicals Uncover Mutation-Agnostic Allosteric Stabilisers of the KRAS Switch-I/II Groove.

Oncogenic KRAS drives ~30% of solid tumours, yet the only approved G12C-specific drugs benefit ≈ 13% of KRAS-mutant patients, leaving a major clinical gap. We sought mutation-agnostic natural ligands from Ziziphus lotus, whose stereochemically rich phenolics may overcome this limitation by occupying the SI/II (Switch I/Switch II) groove and locking KRAS in its inactive state. Phytochemical mining yielded five recurrent phenolics, such as (+)-catechin, hyperin, astragalin, eriodictyol, and the prenylated benzoate amorfrutin A, benchmarked against the covalent inhibitor sotorasib.

Effect of Xanthan gum-based edible coating enriched with cloves and cinnamon for extending the shelf-life of pomegranate fruit during cold storage.

The edible coating used for preserving fruits during storage is receiving heightened interest due to its biodegradable properties and its effectiveness in extending shelf life. In the present study, we investigated the effect of Xanthan gum based edible coating, applied individually or enriched with clove or cinnamon essential oil, on the postharvest quality of pomegranate (cv. 'Sefri Ouled Abdellah') during cold storage at 4 °C for a period of 75 days.

Correlation between semen quality and the seminal biochemical markers: alpha-glucosidase, fructose, and zinc in infertile men compared with a normal population of men.

Introduction: The male reproductive tract's accessory glands produce seminal biochemical markers that can help diagnose reproductive disorders and assess male fertility. This study evaluated the relationship between seminal biochemical components and sperm parameters in 150 men, including 20 normospermic individuals and 130 infertile patients classified into oligozoospermia, azoospermia, asthenozoospermia, teratozoospermia, and oligoasthenoteratozoospermia (OAT) groups.

Methods: The patients underwent semen analysis and measurements of fructose, neutral alpha-glucosidase (NAG) and zinc in seminal plasma.

A novel nanocomposite Lf-DA-MSN-PF127 aided the delivery of dopamine for the treatment of Parkinson's disease in a rat model.

Dopamine is a pivotal neurotransmitter in the central nervous system, which is instrumental in motor functions. Parkinson's Disease (PD) is a chronic, progressive, age-related neurodegenerative disorder marked by the progressive loss of dopaminergic neurons in the pars compacta of the in the midbrain, resulting in the reduction of dopamine levels. Levodopa is a prescribed medicine for symptomatic relief of PD, as it is an amino acid precursor of dopamine that readily crosses the Blood-Brain Barrier (BBB).

Synthesis, characterization, antimicrobial and antibiofilm potential of green copper silicate and zinc silicate nanoparticles: kinetic study and reaction mechanism determination.

The study explored an eco-friendly method to synthesize Cu silicate and zinc silicate nanoparticles (NPs) and characterize them using analytical instruments like transmission electron microscopy, DLS analysis, Zeta potential, EDX elemental analysis, and scanning electron microscopy with mapping. We tested how well Cu silicate and Zn silicate NPs can fight bacteria that cause wound infections and unicellular pathogenic fungi by checking their antimicrobial properties, the smallest amount needed to stop growth (minimum inhibitory concentration), and their ability to prevent biofilm formation. To investigate a potential mechanism of antimicrobial behavior, we applied the membrane leakage experiment.

Cancer cell membrane-coated quercetin-MXene-Au nanoparticles for smart drug delivery and enhanced photothermal therapy.

Cellmembrane-coated nanoparticles (NPs) have garnered significant attention because of their extended circulation time and ability to target similar cells through homotypic interactions. Herein, we fabricated cancer cell membrane (CCM)-coated quercetin (Q)-MXene-Au NPs, forming Q-MX-Au@CCM, as a promising approach for drug delivery (DD) and improved photothermal therapy (PTT). The Q-MX-Au@CCM nanocomposites serve as multifunctional nanoplatforms with a large surface area and excellent responsiveness to near-infrared (NIR) light thereby enhancing their efficacy in tumor treatment.

Rhizobacteria consortium improves growth, yield, and phytochemicals in Robusta coffee ( L.).

Introduction: Coffee is among the most sought-after and valued commodities because it has a high market value and serves as a soothing beverage. However, organically grown coffee remains limited. Most coffee farmers still use agrochemicals which, pose harmful effects.

Therapeutic Potential of Aqueous Extract in Managing Diabetes and Its Complications: Insights From Biochemical and In Silico Studies.

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia, commonly associated with dyslipidemia, oxidative stress, and complications affecting multiple organs, including the kidneys and liver. These complications result from prolonged insulin deficiency or resistance, leading to impaired glucose and lipid metabolism, as well as increased oxidative damage. Effective diabetes management requires not only glycemic control but also addressing associated metabolic and oxidative imbalances.

An insight into the impacts of pharmaceutical pollutants on the ecosystem and the potential role of bioremediation in mitigating pharmaceutical pollutants.

Pharmaceutical pollution increases day by day and poses a serious threat to the environment and organisms' health. Though the concentration of pharmaceutical pollutants in the environment is low, continuous release and long-term exposure make them a significant threat to both terrestrial and aquatic environments. Pharmaceutical pollutants are found in soil, surface water, groundwater, sewage water, wastewater and even in drinking water.

Multifunctional sorafenib-loaded MXene for enhanced cancer therapy: In vitro and in vivo study based on chemotherapy/photothermal therapy approach.

Cancer, characterized by uncontrolled cell proliferation, remains one of the deadliest diseases. Multifunctional hybrid nanosystems that combine drugs with photothermal therapy (PTT) offer enhanced tumor treatment options through localized thermal increase and smart drug delivery (SDD). MXene, a 2D inorganic nanomaterial consisting of titanium carbide (TiC), has garnered significant interest for cancer applications.

Probiotic significance of strains: a comprehensive review on health impacts, research gaps, and future prospects.

A rising corpus of research has shown the beneficial effects of probiotic on human health, contributing to the growing popularity of these microorganisms in recent decades. The gastrointestinal and urinary tracts are home to these bacteria, which play a vital role in the microbial flora of both humans and animals. The probiotic, i.

Novel composite of nano zinc oxide and nano propolis as antibiotic for antibiotic-resistant bacteria: a promising approach.

This study proposes an innovative approach to combat the escalating threat of antibiotic resistance in bacteria by introducing a novel ZnO-propolis nanocomposite (ZnO-P NCs). The overuse of antibiotics, particularly during events like the COVID-19 pandemic, has intensified bacterial resistance, necessitating innovative solutions. The study employs a cost-effective and controllable biosynthesis method to produce ZnO nanoparticles (ZnO-NPs), with propolis extract crucially contributing to the reduction and stabilization of Zn ions.

Fabrication and optimization of naringin-loaded MOF-5 encapsulated by liponiosomes as smart drug delivery, cytotoxicity, and apoptotic on breast cancer cells.

Introduction: Cancers are regarded as hazardous due to their high worldwide death rate, with breast cancer (BC), which affects practically all cancer patients globally, playing a significant role in this statistic. The therapeutic approach for BC has not advanced using standard techniques, such as specialized naringin (NG) chemotherapy. Instead, a novel strategy has been utilized to enhance smart drug delivery (SDD) to tumors.

Structure-based virtual screening methods for the identification of novel phytochemical inhibitors targeting furin protease for the management of COVID-19.

The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, is a highly contagious respiratory disease with widespread societal impact. The symptoms range from cough, fever, and pneumonia to complications affecting various organs, including the heart, kidneys, and nervous system. Despite various ongoing efforts, no effective drug has been developed to stop the spread of the virus.

Anti-MRSA and cytotoxic activities of different solvent extracts from grown in Shubak, Jordan.

Background: Globally, resistance to antimicrobial drugs is a major hazard to public health. Infections that were once easily treatable with antibiotics are becoming harder to control, leading to prolonged illnesses, increased mortality rates, and higher healthcare costs.

Aim: This study intended to assess the antimicrobial, specifically the anti-Methicillin resistant (MRSA), and anticancer properties of different extracts obtained from (AHA).

Cellulose-based CoFe LDH composite as a nano-adsorbent for sulfamethoxazole and cefixime residues: Evaluation of performance, green metrics and cytotoxicity.

The increase in antibiotic residues poses a serious threat to ecological and aquatic environments, necessitating the development of cost-effective, convenient, and recyclable adsorbents. In our study, we used cellulose-based layered double hydroxide (LDH) as an efficient adsorbent and nanocarrier for both sulfamethoxazole (SMX) and cefixime (CFX) residues due to their biodegradability and biocompatibility. Chemical processes are measured according to green chemistry metrics to identify which features adhere to the principles.

Environmental epigenetics: Exploring phenotypic plasticity and transgenerational adaptation in fish.

Epigenetics plays a vital role in the interaction between living organisms and their environment by regulating biological functions and phenotypic plasticity. Considering that most aquaculture activities take place in open or natural habitats that are vulnerable to environmental changes. Promising findings from recent research conducted on various aquaculture species have provided preliminary evidence suggesting a link between epigenetic mechanisms and economically valuable characteristics.

Chemical profile, antiproliferative and pro-apoptotic activities of essential oils of against A549 lung cancer cell line.

has been traditionally utilized in folk medicine for various purposes such as ulcer treatments as well as antidiarrheal agent. Herein, the chemical profiles of essential oils (PAEOs) and the antiproliferative effect of PAEOs were investigated. Hydrodistillation was employed to prepare PAEOs which were then characterized by GC/MS, while the antiproliferative effects were investigated by MTT assay as well as flow cytometric and RT-PCR analysis.

Optimization of cationic nanoparticles stabilized by poloxamer 188: A potential approach for improving the biological activity of .

Aloe perryi (AP) has gained considerable interest as a medicinal herb in various biological applications due to its rich phytochemical composition. However, the therapeutic benefits of AP could be potentiated by utilizing nanotechnology. Moreover, cationic solid lipid nanoparticles (CSLNs) possess remarkable characteristics that can greatly enrich a variety of biological uses.

L. Attenuates Diabetic Neuropathy by Inhibiting Apoptosis and Oxidative Stress in Rats.

Background: Diabetic neuropathy is a debilitating manifestation of long-term diabetes mellitus. The present study explored the effects of the roots of L. ( L.