Publications by authors named "Ellen A Nohr"

The transition to motherhood can be particularly challenging for women with limited socioeconomic resources or mental health concerns. The FAmily Clinic And Municipality (FACAM) intervention was designed to provide additional support through health visitors or family therapists, starting in pregnancy and continuing until the child reached school age. This paper evaluates the effects of the FACAM intervention on the secondary outcomes, maternal mental health and parental functioning during the child's first year of life.

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Introduction: Women with preeclampsia often deliver preterm (under 37 weeks of gestation). Preterm birth is associated with an increased risk of offspring kidney disease, but whether preeclampsia is independently associated with kidney disease risk is unknown. Here, we conducted a register-based cohort study to explore associations between maternal preeclampsia and offspring kidney disease after accounting for preterm birth.

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Background: Gestational diabetes mellitus (GDM) is a common pregnancy complication characterized by insulin resistance. A link has been suggested between insulin resistance and breast cancer, which is the most common cancer in women. Hence, women with previous GDM may be at increased risk of developing breast cancer, yet, the existing evidence is conflicting.

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  • The study aimed to explore the experiences of care professionals working with childbearing families in a collaborative and cross-sectorial setting, particularly within the FACAM project.
  • Researchers conducted eight focus groups with 32 multidisciplinary professionals and analyzed their discussions using positioning theory to identify key themes.
  • Two main themes emerged: the impact of collaboration on care provided and how interactions with families shape the assessment of their needs, highlighting the importance of trust, understanding vulnerable positions, and adapting care to individual family needs.
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  • Postpartum urinary incontinence (UI) affects many women, lowering their quality of life and self-esteem, with perineal tears potentially increasing this risk; however, research on this connection is limited.
  • A study in Denmark involving 603 first-time mothers assessed the relationship between the severity of perineal tears and the incidence of UI and stress urinary incontinence (SUI) one year after childbirth.
  • Results showed that women with more severe perineal tears (second, third, or fourth degree) experienced significantly higher rates of any UI and SUI compared to those with lesser tears, indicating a clear link between the severity of tearing and incontinence issues postpartum.
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Background: Research has shown caseload midwifery to increase the chance of vaginal birth, but this may not be the case in settings with high vaginal birth rates in standard care. This study investigated the association between caseload midwifery and birth mode, labor interventions, and maternal and neonatal outcomes at a large obstetric unit in Denmark.

Methods: Cohort study including medical records on live, singleton births fr om June 2018 until February 2022.

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  • Scientists looked at the timing of when girls start their periods (called menarche) and how it can affect their health later in life.
  • They studied about 800,000 women and found over a thousand genetic signals that influence when menstruation starts.
  • Some women have a much higher chance of starting their periods too early or too late based on their genetic makeup, suggesting that genes play a big role in this process!
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Health inequality can have a profound impact on a child's life. Maternal mental health challenges can hinder bonding, leading to impaired functioning and poorer child outcomes. To provide extra support for vulnerable pregnant women, the FACAM intervention offers the services of a health nurse or family therapist from pregnancy until the child starts school.

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  • - A study was conducted to assess substance use (including alcohol and nicotine) in pregnant women in Denmark, as there is limited verified data on this topic.
  • - The research involved urine samples and questionnaires from nearly 1900 pregnant women attending ultrasound scans; results showed that 25% tested positive for substances, with a confirmed prevalence of 10.8% for all substances, predominantly nicotine usage.
  • - The findings indicated that while self-reporting of nicotine was high, reporting for alcohol and cannabis was notably low, highlighting discrepancies between self-reported data and actual substance use detected through screening.
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Background: Higher maternal pre-pregnancy body mass index (BMI) is associated with adverse pregnancy and perinatal outcomes. However, whether these associations are causal remains unclear.

Methods: We explored the relation of maternal pre-/early-pregnancy BMI with 20 pregnancy and perinatal outcomes by integrating evidence from three different approaches (i.

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Introduction: The number of people adhering to plant-based diets has been increasing dramatically in recent years, fueled by both environmental and animal welfare concerns. Beneficial or possible adverse consequences of such diets, particularly the most restrictive forms during pregnancy, have been minimally explored. The aim of this prospective observational study was to examine associations between different forms of plant-based diets during pregnancy with birth outcomes and pregnancy complications.

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Introduction And Hypothesis: The objective was to investigate how weight change across and after the childbearing years was associated with urinary incontinence (UI) in midlife.

Methods: Data were obtained from 35,645 women responding to the Maternal Follow-up questionnaire in the Danish National Birth Cohort in 2013-2014. Outcome was self-reported UI and its subtypes.

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Objective: The association between gestational diabetes mellitus (GDM) and incident kidney disease, the mediating effects of diabetes and hypertension, and the impact of severity of metabolic dysfunction during pregnancy on the risk of incident kidney disease were investigated in this study.

Research Design And Methods: This Danish, nationwide, register-based cohort study included all women giving birth between 1997 and 2018. Outcomes included chronic kidney disease (CKD) and acute kidney disease, based on diagnosis codes.

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Background: Cesarean birth has been associated with increased risks of short-term mental health problems. Little is known about whether these associations persist in the long term. This study aimed to estimate the associations between mode of birth and maternal mental health in midlife while considering mental health before and during pregnancy.

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Objectives: Our aim was to investigate the association between early environmental factors and the development of coeliac disease (CeD) in adolescents, recruited from a cohort nested in the Danish National Birth Cohort (DNBC).

Design: The study was designed as a prospective cohort study, nested in DNBC PARTICIPANTS: The Glutenfunen cohort comprises 1266 participants, nested in DNBC. All participants were screened for CeD, and in total, 28 cases of biopsy proven CeD were identified.

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Background: Although gynecological health issues are common and cause considerable distress, little is known about their causes. We examined how birth history is associated with urinary incontinence (UI), severe period pain, heavy periods, and endometriosis.

Methods: We studied 7700 women in the Australian Longitudinal Study on Women's Health with an average follow-up of 10.

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  • A healthy placenta is crucial for both the mother and fetus during pregnancy, and this study uses placental weight as a measure of its growth.
  • Genome-wide analyses across the genomes of mothers, fathers, and fetuses identified 40 genetic signals related to placental weight, revealing a mix of influences from both parents and the fetus.
  • The findings suggest that higher placental weight, driven by fetal genetics, is linked to an increased risk of preeclampsia and shorter pregnancy duration, highlighting the role of fetal insulin in regulating placental growth.
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  • Seasonal variations at birth can influence DNA methylation, which may affect health outcomes over a person’s lifetime.
  • A study involving multiple cohorts discovered specific DNA methylation patterns linked to different birth seasons, revealing 26 differentially methylated regions (DMRs) at birth and 32 in childhood.
  • Results suggested that geographic latitude plays a role in these associations, linking certain genes to conditions like schizophrenia and asthma, particularly in infants born in higher latitudes (≥50°N).
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  • The study aimed to analyze opioid prescription patterns among pregnant women in Denmark from 1997 to 2016, utilizing national health care registers.
  • Results indicated stable opioid usage rates among women with live births, but revealed a decline in codeine use and a significant increase in tramadol prescriptions.
  • Factors such as lower socioeconomic status, older age, obesity, and smoking were associated with higher odds of opioid use during pregnancy.
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Pubertal timing varies considerably and has been associated with a range of health outcomes in later life. To elucidate the underlying biological mechanisms, we performed multi-ancestry genetic analyses in ~800,000 women, identifying 1,080 independent signals associated with age at menarche. Collectively these loci explained 11% of the trait variance in an independent sample, with women at the top and bottom 1% of polygenic risk exhibiting a ~11 and ~14-fold higher risk of delayed and precocious pubertal development, respectively.

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Fractures account for the most frequent cause of hospitalization during childhood and numbers have increased over time. Of all fractures in childhood and young adulthood, 66% are recurrent fractures, suggesting that some people are predestined for fractures. The aim of this study was to investigate the association between maternal smoking during late pregnancy and the risk of fractures in the children.

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Background: The emergence of the COVID-19 pandemic and the derived changes in maternity care have created stress and anxiety among pregnant women in different parts of the world. In times of stress and crisis, spirituality, including spiritual and religious practices, may increase.

Objective: To describe if the COVID-19 pandemic influenced pregnant women's considerations and practises of existential meaning-making and to investigate such considerations and practices during the early pandemic in a large nationwide sample.

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